Serine/threonine protein kinase phosphorylation of DosR alters target gene transcription mechanics and regulates Mycobacterium tuberculosis response to nitric oxide stress

Authors

• Natalie R. Sontag, Tufts University
• Ana Ruiz Manzano, Washington University School of Medicine in St. Louis
• Alwyn M. V. Ecker, Tufts University
• Eric A. Galburt, Washington University School of Medicine in St. Louis
• Shumin Tan, Tufts University

Journal

PLoS Genetics

Publication Date

2-1-2026

Volume

22

Issue

2

First Page

e1012043

Document Type

Open Access Publication

DOI

10.1371/journal.pgen.1012043

Rights and Permissions

Sontag NR, Ruiz Manzano A, Ecker AMV, Galburt EA, Tan S. Serine/threonine protein kinase phosphorylation of DosR alters target gene transcription mechanics and regulates Mycobacterium tuberculosis response to nitric oxide stress. PLoS Genet. 2026 Feb 12;22(2):e1012043. doi: 10.1371/journal.pgen.1012043. © 2026 Sontag et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Recommended Citation

Sontag, Natalie R.; Ruiz Manzano, Ana; Ecker, Alwyn M. V.; Galburt, Eric A.; and Tan, Shumin, "Serine/threonine protein kinase phosphorylation of DosR alters target gene transcription mechanics and regulates Mycobacterium tuberculosis response to nitric oxide stress." PLoS Genetics. 22, 2. e1012043 (2026).
https://digitalcommons.wustl.edu/oa_4/7444

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.