MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state

Authors

• Helen C Wang, Washington University School of Medicine in St. Louis
• Ran Chen, Washington University School of Medicine in St. Louis
• Wei Yang, Washington University School of Medicine in St. Louis
• Rohini Muthukumar, Washington University School of Medicine in St. Louis
• Tingting Hu, Washington University School of Medicine in St. Louis
• Riddhi M Patel, Washington University School of Medicine in St. Louis
• Emily B Casey, Washington University School of Medicine in St. Louis
• Elisabeth Denby, Washington University School of Medicine in St. Louis
• Run Zhang, Washington University School of Medicine in St. Louis
• Guojia Xie, National Institutes of Health
• Kai Ge, National Institutes of Health
• Grant A Challen, Washington University School of Medicine in St. Louis
• Jeffrey J Bednarski, Washington University School of Medicine in St. Louis
• Jeffrey A Magee, Washington University School of Medicine in St. Louis

Journal

Blood

Publication Date

7-30-2026

Volume

148

Issue

5

First Page

560

Last Page

573

Document Type

Open Access Publication

DOI

10.1182/blood.2025032969

Rights and Permissions

Wang HC, Chen R, Yang W, Muthukumar R, Hu T, Patel RM, Casey EB, Denby E, Zhang R, Xie G, Ge K, Challen GA, Bednarski JJ, Magee JA. MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state. Blood. 2026 Jul 30;148(5):560-573. doi: 10.1182/blood.2025032969. Published by Elsevier Inc. on behalf of American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

Recommended Citation

Wang, Helen C; Chen, Ran; Yang, Wei; Muthukumar, Rohini; Hu, Tingting; Patel, Riddhi M; Casey, Emily B; Denby, Elisabeth; Zhang, Run; Xie, Guojia; Ge, Kai; Challen, Grant A; Bednarski, Jeffrey J; and Magee, Jeffrey A, "MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state." Blood. 148, 5. 560 - 573. (2026).
https://digitalcommons.wustl.edu/oa_4/7447

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.