Rapid antidepressant potential of nitrous oxide: Current state and major questions

Authors

• Charles F Zorumski, Washington University School of Medicine in St. Louis
• Joseph Cichon, University of Pennsylvania
• Yukitoshi Izumi, Washington University School of Medicine in St. Louis
• Thomas Zeffiro, University of Maryland - Baltimore
• Steven Mennerick, Washington University School of Medicine in St. Louis
• Peter Nagele, University of Chicago
• Charles R Conway, Washington University School of Medicine in St. Louis

Journal

Molecular Psychiatry

Publication Date

6-1-2026

Volume

31

Issue

6

First Page

3022

Last Page

3032

Document Type

Open Access Publication

DOI

10.1038/s41380-025-03439-6

Rights and Permissions

Zorumski, C.F., Cichon, J., Izumi, Y. et al. Rapid antidepressant potential of nitrous oxide: current state and major questions. Mol Psychiatry 31, 3022–3032 (2026). https://doi.org/10.1038/s41380-025-03439-6 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Zorumski, Charles F; Cichon, Joseph; Izumi, Yukitoshi; Zeffiro, Thomas; Mennerick, Steven; Nagele, Peter; and Conway, Charles R, "Rapid antidepressant potential of nitrous oxide: Current state and major questions." Molecular Psychiatry. 31, 6. 3022 - 3032. (2026).
https://digitalcommons.wustl.edu/oa_4/7490

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.