The Open Access Publications collection contains peer-reviewed articles authored by Washington University School of Medicine faculty that have been published in open access journals or authorized by the publishers for open access availability. Open access works are generally defined as being publicly available online and free of most licensing and copyright restrictions. The Bernard Becker Medical Library maintains this collection in support of Washington University’s commitment to the principles of open access publishing and making the scholarly work and research results of our faculty as widely and easily available as possible.

You can find more information about Washington University's Open Access Resolution in Becker Medical Library's Open Access subject guide “OA Resolution at WU

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Submissions from 2016

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MAVS expressed by hematopoietic cells is critical for control of West Nile virus infection and pathogenesis, Jincun Zhao, Rahul Vijay, Jingxian Zhao, Michael Gale Jr, Michael S. Diamond, and Stanley Perlman

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Frictional alopecia of the distal legs: case series and review, Johnny Zhao and Philip R. Cohen

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Commissioning and initial experience with the first clinical gantry-mounted proton therapy system, Tianyu Zhao, Baozhou Sun, Kevin Grantham, Leith Rankine, Bin Cai, Sreekrishna M. Goddu, Lakshmi Santanam, Nels Knutson, Tiezhi Zhang, Michael Reilly, Beth Bottani, Jeffrey Bradley, Sasa Mutic, and Eric E. Klein

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Is birthweight associated with total and aggressive/lethal prostate cancer risks? A systematic review and meta-analysis, Cindy Ke Zhou, Siobhan Sutcliffe, Judith Welsh, Karen Mackinnon, Diana Kuh, Rebecca Hardy, and Michael B. Cook

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Metagenomic approach for identification of the pathogens associated with diarrhea in stool specimens, Yangiao Zhou, Kristine M. Wylie, Rana E. El Feghaly, Kathie A. Mihindukulasuriya, Alexis Elward, David B. Haslam, Gregory A. Storch, and George M. Weinstock

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Lens ER-stress response during cataract development in Mip-mutant mice, Yuefang Zhou, Thomas M. Bennett, and Alan Shiels

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Role of WDHD1 in Human Papillomavirus-Mediated Oncogenesis Identified by Transcriptional profiling of E7-expressing cells, Yunying Zhou, Qishu Zhang, Ge Gao, Xiaoli Zhang, Yafei Liu, Shoudao Yuan, Xiaowei Wang, and Jason J. Chen

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Clinical implementation of multisequence MRI-based adaptive intracavitary brachytherapy for cervix cancer, Jacqueline E. Zoberi, Jose Garcia-Ramirez, Yanle Hu, Baozhou Sun, Carol G. Bertelsman, Pawel Dyk, Julie K. Schwarz, and Perry W. Grigsby

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Ketamine: NMDA receptors and beyond, Charles F. Zorumski, Yukitoshi Izumi, and Steven Mennerick

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A library of infectious hepatitis C viruses with engineered mutations in the E2 gene reveals growth-adaptive mutations that modulate interactions with scavenger receptor class B type I, Adam Zuiani, Kevin Chen, Megan C. Schwarz, James P. White, Vincent C. Luca, Daved H. Fremont, David Wang, Matthew J. Evans, and Michael S. Diamond

Submissions from 2015

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Construction and evaluation of novel rhesus monkey adenovirus vaccine vectors, Peter Abbink, Lori F. Maxfield, David Ng'ang'a, Erica N. Borducchi, M Justin Iampletro, Christine A. Bricault, Jeffrey E. Teigler, Stephen Blackmore, Lily Parenteau, Kshitij Wagh, Scott A. Handley, Guoyan Zhao, Herbert W. Virgin, Bette Korber, and Dan H. Barouch

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Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment, Sahar Abubucker, Yanjiao Zhou, Makedonka Mitreva, George M. Weinstock, Erica Sodergren, and et al

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Myosin binding protein-C slow phosphorylation is altered in Duchenne dystrophy and arthrogryposis myopathy in fast-twitch skeletal muscles, Maegan A. Ackermann, Christopher W. Ward, Christina Gurnett, and Aikaterini Kontrogianni-Konstantopoulos

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The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with G alpha(12/13) and RhoA, Sarah D. Ackerman, Cynthia Garcia, Xianhua Piao, David H. Gutmann, and Kelly R. Monk

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Central venous catheterization: Are we using ultrasound guidance?, Srikar Adhikari, Daniel Theodoro, Christopher Raio, Mathew Nelson, Matthew Lyon, Stephen Leech, Saadia Akhtar, and Uwe Stolz

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Complement in the homeostatic and ischemic brain, Ali Alawieh, Andrew Elvington, and Stephen Tomlinson

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TBX6 null variants and a common hypomorphic allele in congenital scoliosis, H. Al-Kateb, S. Kulkarni, and et al

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Inguinoscrotal herniation of the ureter: Description of five cases, E. S. Allam, D. Y. Johnson, S. G. Grewal, and F. E. Johnson

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Dietary inference from upper and lower molar morphology in platyrrhine primates, Kari L. Allen, Siobhan B. Cooke, Lauren A. Gonzales, and Richard F. Kay

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Myopathy with anti-HMGCR antibodies: Perimysium and myofiber pathology, Ali Alshehri, Rati Choksi, Robert Bucelli, and Alan Pestronk

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Reassessing the evolutionary history of the 17q21 inversion polymorphism, Joao M. Alves, Ana C. Lima, Isa A. Pais, Nadir Amir, Ricardo Celestino, Giovanna Piras, Maria Monne, David Comas, Peter Heutink, Lounes Chikhi, Antonio Amorim, and Alexandra M. Lopes

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Whole genome sequence of multiple myeloma-prone C57BL/KaLwRij mouse strain suggests the origin of disease involves multiple cell types, Sarah R. Amend, William C. Wilson, Liang Chu, Lan Lu, Xinming Su, Yalin Xu, Julie O'neal, Michelle Hurchla, Graham Colditz, Ravi Vij, Katherine N. Weilbaecher, Michael H. Tomasson, and et al

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Regulation of neuronal morphogenesis and positioning by ubiquitin-specific proteases in the cerebellum, Julius Anckar and Azad Bonni

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Participation in college laboratory research apprenticeships among students considering careers in medicine, Dorothy A. Andriole, Donna B. Jeffe, and Robert H. Tai

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Two susceptibility loci identified for prostate cancer aggressiveness, Gerald Andriole and et al.

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Neural correlates of error monitoring in adolescents prospectively predict initiation of tobacco use, Andrey P. Anokhin and Simon Golosheykin

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Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility, Ping An, Jacek Czajkowski, Aldi T. Kraja, Michael A. Province, Ingrid B. Borecki, and et al

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A case report of adrenocorticotropic hormone to treat recurrent focal segmental glomerular sclerosis post-transplantation and biomarker monitoring, Siddiq Anwar, Derek S. Larson, Nimi Naimi, Muhammad Ashraf, Nancy Culiberk, Helen Liapis, Changli Wei, Jochen Reiser, and Daniel C. Brennan

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FoxP1 orchestration of ASD-relevant signaling pathways in the striatum, Daniel J. Araujo, Ashley G. Anderson, Stefano Berto, Wesley Runnels, Matthew Harper, Simon Ammanuel, Michael A. Rieger, Hung-Chung Huang, Kacey Rajkovich, Kristofer W. Loerwald, Joseph D. Dekker, Haley O. Tucker, Joseph D. Dougherty, Jay R. Gibson, and Genevieve Konopka

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Reproductive and hormonal factors and mortality among women with colorectal cancer in the NIH-AARP Diet and Health Study, H. Arem, Y. Park, A. S. Felix, A. Zervoudakis, L. A. Brinton, C. E. Matthews, and M. J. Gunter

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Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr), Christopher M. Armstrong, David J. Meyers, Leah S. Imlay, Caren Freel Meyers, and Audrey R. Odom

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A tale of two community networks program centers: Operationalizing and assessing CBPR principles and evaluating partnership outcomes, Cassandra Arroyo-Johnson, Michele L. Allen, Graham A. Colditz, G. Ali Hurtado, Cynthia S. Davey, Vetta L. Sanders Thompson, Bettina F. Drake, Maria Veronica Svetaz, Maira Rosas-Lee, and Melody S. Goodman

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Translational control by lysine-encoding A-rich sequences, Laura L. Arthur, Slavica Pavlovic-Djuranovic, Kristin S. Koutmou, Rachel Green, Pawel Szczesny, and Sergej Djuranovic

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Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells, Maxim N. Artyomov, Adiel Munk, Laurent Gorvel, Daniel Korenfeld, Marina Cella, Thomas Tung, and Eynav Klechevsky

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Alzheimer disease cerebrospinal fluid biomarkers moderate baseline differences and predict longitudinal change in attentional control and episodic memory composites in the adult children study, Andrew J. Aschenbrenner, David A. Balota, Anne M. Fagan, Janet M. Duchek, Tammie L S Benzinger, and John C. Morris

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Abnormal white matter blood-oxygen-level-dependent signals in chronic mild traumatic brain injury, Serguei V. Astafiev, Gordon L. Shulman, Nicholas V. Metcalf, Jennifer Rengachary, Christine L. MacDonald, Deborah L. Harrington, Jun Maruta, Joshua S. Shimony, Jamshid Ghajar, Mithun Diwakar, Ming-Xiong Huang, Roland R. Lee, and Maurizio Corbetta

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Excess body weight increases the burden of age-associated chronic diseases and their associated health care expenditures, Vincenzo Atella, Joanna Kopinska, Gerardo Medea, Federico Belotti, Valeria Tosti, Andrea Piano Mortari, Claudio Cricelli, and Luigi Fontana

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Hepatocyte growth factor and MET support mouse enteric nervous system development, the peristaltic response, and intestinal epithelial proliferation in response to injury, Marina Avetisyan, Hongtao Wang, Ellen Merrick Schill, Saya Bery, John R. Grider, John A. Hassell, Thaddeus Stappenbeck, and Robert O. Heuckeroth

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Inhibitory-based method for detection of Klebsiella pneumoniae carbapenemase Acinetobacter baumannii isolated from burn patients, Leila Azimi, Abdolaziz Rastegar Lari, Malihe Talebi, Parviz Owlia, Reza Alaghehbandan, Babak Asghari, and Elnaz Rastegar Lari

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Measuring participation for persons with mental illness: A systematic review assessing relevance of existing scales for low and middle income countries, Ganesh M. Babulal, Parul Bakhshi, Sunyata Kopriva, Sarah A. Ali, Susan A. Goette, and Jean-Francois Trani

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Physical mapping and refinement of the painted turtle genome (chrysemys picta) inform amniote genome evolution and challenge turtle-bird chromosomal conservation, Daleen Badenhorst, LaDeana W. Hillier, Robert Literman, Eugenia Elisabet Montiel, Srihari Radhakrishnan, Yingjia Shen, Patrick Minx, Daniel E. Janes, Wesley C. Warren, Scott V. Edwards, and Nicole Valenzuela

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IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease, Jea-Hyun Baek, Rui Zeng, Julia Weinmann-Menke, M.Todd Valerius, Yukihiro Wada, Amrenda K. Ajay, Marco Colonna, and Vicki R. Kelley

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Zoonotic potential of simian arteriviruses, Adam L. Bailey, Michael Lauck, Samuel D. Sibley, Thomas C. Friedrich, Jens H. Kuhn, Nelson B. Freimer, Anna J. Jasinska, Jane E. Phillips-Conroy, Clifford J. Jolly, Preston A. Marx, Cristian Apetrei, Jeffrey Rogers, Tony L. Goldberg, and David H. O'Connor

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Characteristics of tumor infiltrating lymphocyte and circulating lymphocyte repertoires in pancreatic cancer by the sequencing of T cell receptors, Xueli Bai, Qi Zhang, Song Wu, Xiaoyu Zhang, Mingbang Wang, Fusheng He, Tao Wei, Jiaqi Yang, Yu Lou, Zhiming Cai, and Tingbo Liang

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Tuberous Sclerosis complex protein 2-independent activation of mTORC1 by human cytomegalovirus pUL38, Yadan Bai, Baoqin Xuan, Haiyan Liu, Jin Zhong, Dong Yu, and Zhikang Qian

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Long-term functional recovery after facial nerve transection and repair in the rat, Caroline A. Banks, Christopher Knox, Daniel A. Hunter, Susan E. Mackinnon, Marc H. Hohman, and Tessa A. Hadlock

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The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study, Llida Barata, Mary F. Feitosa, Jacek Czajkowski, Jeannette Simino, Pamela A. F. Madden, Yun Ju Sung, Andrew C. Heath, Treva K. Rice, D. C. Rao, and et al.

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Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): Exome sequencing of trios, monozygotic twins and tumours, Sarah F. Barclay, Casey M. Rand, Lauren A. Borch, Lisa Nguyen, Paul A. Gray, William T. Gibson, Richard J.A. Wilson, Paul M.K. Gordon, Zaw Aung, Elizabeth M. Berry-Kravis, Diego Ize-Ludlow, Debra E. Weese-Mayer, and N. Torben Bech-Hansen

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A participatory regional partnership approach to promote nutrition and physical activity through environmental and policy change in rural Missouri, Ellen K. Barnidge, Elizabeth A. Baker, Amy Estlund, Freda Motton, Pamela R. Hipp, and Ross C. Brownson

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Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia, N. L. Bartlett and et al

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Exome sequencing identifies a rare HSPG2 variant associated with familial idiopathic scoliosis, Erin E. Baschal, Cambria I. Wethey, Kandice Swindle, Robin M. Baschal, Katherine Gowan, Nelson L.S. Tang, David M. Alvarado, Gabe E. Haller, Matthew B. Dobbs, Matthew R.G. Taylor, Christina A. Gurnett, Kenneth L. Jones, and Nancy H. Miller

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In vivo creatine kinase reaction kinetics at rest and stress in type II diabetic rat heart, Adil Bashir, Andrew R. Coggan, and Robert J. Gropler

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Absolute quantification of human liver phosphorus-containing metabolites in vivo using an inhomogeneous spoiling magnetic field gradient, Adil Bashir, Robert Gropler, and Joseph Ackerman

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Evolutionary divergence of gene and protein expression in the brains of humans and chimpanzees, Amy L. Bauernfeind, Erik J. Soderblom, Meredith E. Turner, Arthur M. Moseley, John J. Ely, Patrick R. Hof, Chet C. Sherwood, Gregory A. Wray, and Courtney C. Babbitt

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Mucinous adenocarcinoma of the bladder associated with long term suprapubic tube: A case report, Tyler M. Bauman, Theodora A. Potretzke, Aaron M. Potretzke, Cary L. Siegel, and Steven B. Brandes

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Inducible nitric oxide synthase mediates DNA double strand breaks in Human T-Cell Leukemia Virus Type 1-induced leukemia/lymphoma, Hicham H. Baydoun, Mathew A. Cherian, Patrick Green, and Lee Ratner

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GPR18 controls reconstitution of mouse small intestine intraepithelial lymphocytes following bone marrow transplantation, Amy M. Becker, Derrick J. Callahan, Justin M. Richner, Jaebok Choi, John F. DiPersio, Michael S. Diamond, and Deepta Bhattacharya

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The Drosophila prosecretory transcription factor dimmed is dynamically regulated in adult enteroendocrine cells and protects against Gram-negative infection, Katherine Beebe, Dongkook Park, Paul H. Taghert, and Craig A. Micchelli

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Renal DCE-MRI model selection using Bayesian probability theory, Scott C. Beeman, Patrick Osei-Owusu, Duan Chong, John Engelbah, Larry G. Bretthorst, Joseph J. H Ackerman, Kendall J. Blumer, and Joel R. Garbow

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Rhoptry proteins ROP5 and ROP18 are major murine virulence factors in genetically divergent South American strains of Toxoplasma gondii, Michael S. Behnke, Asis Khan, Elvin J. Lauron, John R. Jimah, Qiuling Wang, Niraj H. Tolia, and L. David Sibley

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Genetic mapping reveals that sinefungin resistance in Toxoplasma gondii is controlled by a putative amino acid transporter locus that can be used as a negative selectable marker, Michael S. Behnke, Asis Khan, and David Sibley

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Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss, Bruno A. Benitez, Nigel J. Cairns, Robert E. Schmidt, John C. Morris, Joanne B. Norton, Carlos Cruchaga, and Mark S. Sands

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Plasma endotoxin core antibody concentration and linear growth are unrelated in rural Malawian children aged 2–5 years, Nicole Benzoni, Poonum Korpe, Chrissie Thakwalakwa, Ken Maleta, Kevin Stephenson, Micah Manary, and Mark Manary

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How genetic and other biological factors interact with smoking decisions, Laura Bierut and David Cesarini

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Immediate postoperative pain: An atypical presentation of dropped gallstones after laparoscopic cholecystectomy, Samba Binagi, Jason Keune, and Michael Awad

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Positive testing for Neisseria gonorrhoeae and Chlamydia trachomatis and the risk of pelvic inflammatory disease in IUD users, Natalia E. Birgisson, Qiuhong Zhao, Gina M. Secura, Tessa Madden, and Jeffrey F. Peipert

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Preventing unintended pregnancy: The contraceptive CHOICE project in review, Natalia E. Birgisson, Qiuhong Zhao, Gina M. Secura, Tessa Madden, and Jeffrey F. Peipert

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Selective cognitive and psychiatric manifestations in Wolfram Syndrome, Allison N. Bischoff, Angela M. Reiersen, Anna Buttlaire, Amal Al-lozi, Tasha Doty, Bess A. Marshall, Tamara Hershey, and Washington University Wolfram Syndrome Research Group

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Ciliated hepatic foregut cyst: A report of 6 cases and a review of the English literature, Katherine C. Bishop, Carmen M. Perrino, Marianna B. Ruzinova, and Elizabeth M. Brunt

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Levodopa effects on [(11)C]raclopride binding in the resting human brain, Kevin J. Black, Marilyn L. Piccirillo, Jonathan M. Koller, Tiffany Hseih, Lei Wang, and Mark A. Mintun

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GABA-A inhibition shapes the spatial and temporal response properties of Purkinje cells in the macaque cerebellum, Pablo M. Blazquez and Tatyana A. Yakusheva

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Higher throughput quantification of neutralizing antibody to herpes simplex viruses, Tamara P. Blevins, Michelle C. Mitchell, Maria Korom, Hong Wang, Yinyi Yu, Lynda A. Morrison, and Robert B. Belshe

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Pressure ulcer-related pelvic osteomyelitis: A neglected disease?, Phani Bodavula, Stephen Y. Liang, Jiami Wu, Paige VanTassell, Jonas Marschall, and Centers for Disease Control and Prevention

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Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study, Ingrid B. Borecki and et al

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Parent-of-origin effects of the APOB gene on adiposity in young adults, Ingrid B. Borecki, Felicia Gomez, and et al

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Intracellular FGF14 (iFGF14) is required for spontaneous and evoked firing in cerebellar Purkinje neurons and for motor coordination and balance, Marie K. Bosch, Yarimar Carrasquillo, Joseph L. Ransdell, Ajay Kanakamedala, David M. Ornitz, and Jeanne M. Nerbonne

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Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life, Kelly Botteron and et al

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MC1R gene variants and non-melanoma skin cancer: A pooled-analysis from the M-SKIP project, Anne Bowcock, Lynn Cornelius, Martha Laurin Council, and et al

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Feasibility of a randomized clinical trial for treatment of femoroacetabular impingement of the hip, Gloria N. Boye, Kerri Murray, John C. Clohisy, and Young-Jo Kim

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Volar locking-plate and kirschner-wire fixation did not differ in terms of functional outcomes after dorsally displaced distal radial fracture, Martin Boyer

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A review of gene therapy in canine and feline models of lysosomal storage disorders, Allison M. Bradbury, Brittney L. Gurda, Margret L. Casal, Katherine P. Ponder, Charles H. Vite, and Mark E. Haskins

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Joint MiRNA/mRNA expression profiling reveals rhanges consistent with development of dysfunctional corpus luteum after weight gain, Andrew P. Bradford, Kenneth Jones, Katerina Kechris, Justin Chosich, Michael Montague, Wesley C. Warren, Margaret C. May, Zain Al-Safi, Satu Kuokkanen, Susan E. Appt, and Alex J. Polotsky

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Survival outcome according to KRAS mutation status in newly diagnosed patients with stage IV non-small cell lung cancer treated with platinum doublet chemotherapy, Anna K. Brady, Jonathan D. McNeill, Brendan Judy, Joshua Bauml, Tracey L. Evans, Roger B. Cohen, Corey Langer, Anil Vachani, and Charu Aggarwal

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IMAGES IN CLINICAL MEDICINE. Gastric pneumatosis, Ann-Christina Brady and Patrick A. Dillon

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Cutaneous metastasis from penile squamous cell carcinoma resembling carcinoma en cuirasse, Kimberly L. Brady, Glynis A. Scott, and Elaine S. Gilmore

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What's new in Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Han Jo Kim, Alexander Vaccaro, and Jeffrey C. Wang

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Low-order non-spatial effects dominate second-order spatial effects in the texture quantifier analysis of 18F-FDG-PET images, Frank J. Brooks and Perry W. Grigsby

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Factors associated with infection following anterior cruciate ligament reconstruction, Robert H. Brophy, Rick W. Wright, Laura J. Huston, Samuel K. Nwosu, the MOON Knee Group, and Kurt P. Spindler

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IARC monographs: 40 years of evaluating carcinogenic hazards to humans, Ross C. Brownson and et al.

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Pathogenesis of bone diseases: The role of immune system, Giacomina Brunetti, Giorgio Mori, Patrizia D'Amelio, and Roberto Faccio

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Biphenotypic (hepatobiliary) primary liver carcinomas: The work in progress, Elizabeth M. Brunt, Valerie Paradis, Christine Sempoux, and Neil D. Theise

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Comparison of the next-generation Xpert MRSA/SA BC assay and the GeneOhm StaphSR assay to routine culture for identification of Staphylococcus aureus and methicillin-resistant S. aureus in positive-blood-culture broths, Blake W. Buchan, Stephen Allen, Carey-Ann D. Burnham, Erin McElvania TeKippe, Thomas Davis, Michael Levi, Donna Mayne, Preeti Pancholi, Ryan F. Relich, Richard Thomson, and Nathan A. Ledeboer

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T cell metabolism drives immunity, Michael D. Buck, David O'Sullivan, and Erika L. Pearce

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How do you know it is true? integrity in research and publications: AOA critical issue, Joseph A. Buckwalter, Vernon T. Tolo, and Regis J. O'Keefe

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Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease, Chandana Buddhala, Susan K. Loftin, Brandon M. Kuley, Nigel J. Cairns, Meghan C. Campbell, Joel S. Perlmutter, and Paul T. Kotzbauer

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Evaluating diabetes mobile applications for health literate designs and functionality, 2014, Charlene A. Caburnay, Kaitlin Graff, Jenine K. Harris, Amy McQueen, Madeleine Smith, Maggie Fairchild, and Matthew W. Kreuter

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Effects of dietary acid load on exercise metabolism and anaerobic exercise performance, Susan L. Caciano, Cynthia L. Inman, Elizabeth E. Gockel-Blessing, and Edward P. Weiss

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The pancreas anatomy conditions the origin and properties of resident macrophages, Boris Calderon, Javier A. Carrero, Stephen T. Ferris, Dorothy K. Sojka, Lindsay Moore, Slava Epelman, Kenneth M. Murphy, Wayne M. Yokoyama, Gwendalyn J. Randolph, and Emil R. Unanue

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Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding, Muqing Cao, Jue Ning, Carmen I. Hernandez-Lara, Olivier Belzile, Qian Wang, Susan K. Dutcher, Yanjie Liu, and William J. Snell

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Dynamics of EEG rhythms support distinct visual selection mechanisms in parietal cortex: A simultaneous transcranial magnetic stimulation and EEG study, Paolo Capotosto, Sara Spadone, Annalisa Tosoni, Carlo Sestieri, Gian Luca Romani, Stefania Della Penna, and Maurizio Corbetta