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Submissions from 2021

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2021 PACES expert consensus statement on the indications and management of cardiovascular implantable electronic devices in pediatric patients: Executive summary, Michael J Silka, Jennifer N Avari Silva, Aarti S Dalal, and Et al

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A risk assessment tool for resumption of research activities during the COVID-19 pandemic for field trials in low resource settings, Suzanne M Simkovich, Victor G Davila-Roman, Lisa de Las Fuentes, and et al.

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Progress towards antibiotic use targets in eight high-income countries, Bryony Simmons, Koya Ariyoshi, Norio Ohmagari, Celine Pulcini, Benedikt Huttner, Sumanth Gandra, Giovanni Satta, Lorenzo Moja, Michael Sharland, Nicola Magrini, Marisa Miraldo, and Graham Cooke

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Longitudinal metabolomics of human plasma reveals prognostic markers of COVID-19 disease severity, Miriam Sindelar, Ethan Stancliffe, Michaela Schwaiger-Haber, Dhanalakshmi S Anbukumar, Kayla Adkins-Travis, Charles W Goss, Jane A O'Halloran, Philip A Mudd, Wen-Chun Liu, Randy A Albrecht, Adolfo García-Sastre, Leah P Shriver, and Gary J Patti

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Host fecal mRNAs predicted environmental enteric dysfunction among children with moderate acute malnutrition in Sierra Leone, Akriti Singh, Isabel Potani, Stacy P Griswold, Devika Suri, Breanne Langlois, Ye Shen, Shelley M Walton, Kenneth Kwan Ho Chui, Mark J Manary, Patrick Webb, Beatrice L Rogers, and Irwin H Rosenberg

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Myeloid-derived suppressor cells mediate T cell dysfunction in nonhuman primate TB granulomas, Bindu Singh, Dhiraj K Singh, Shashank R Ganatra, Ruby A Escobedo, Shabaana Khader, Larry S Schlesinger, Deepak Kaushal, and Smriti Mehra

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Comparison of machine learning clustering algorithms for detecting heterogeneity of treatment effect in acute respiratory distress syndrome: A secondary analysis of three randomised controlled trials, Pratik Sinha, Alexandra Spicer, Kevin L Delucchi, Daniel F McAuley, Carolyn S Calfee, and Matthew M Churpek

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The use of dexmedetomidine in the emergency department: A cohort study, Joseph Sinnott, Christopher V Holthaus, Enyo Ablordeppey, Brian T Wessman, Brian W Roberts, and Brian M Fuller

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Excimer laser coronary angioplasty in coronary lesions: Use and safety from the NCDR/CATH PCI Registry, Marc Sintek, Edward Coverstone, Richard Bach, Alan Zajarias, John Lasala, Howard Kurz, Kevin Kennedy, and Jasvindar Singh

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Clinicians' perspectives on the functions of communication in pediatric oncology, Bryan A. Sisk, Ginny L. Schulz, Erica C. Kaye, Justin N. Baker, Jennifer W. Mack, and James M. DuBois

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Sotorasib for lung cancers with KRAS p.G12C mutation, Ferdinandos Skoulidis, Ramaswamy Govindan, and et al

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The transcriptional landscape of Shh medulloblastoma, Patryk Skowron, Joshua B. Rubin, and et al.

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Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis, Arthur C. Sletten, Jessica W. Davidson, Busra Yagabasan, Samantha Moores, Michaela Schwaiger-Haber, Hideji Fujiwara, Sarah Gale, Xuntian Jiang, Rohini Sidhu, Susan Gelman, Shuang Zhao, Gary Patti, Daniel S. Ory, and Jean E. Schaffer

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Identifying barriers to evidence-based care for sickle cell disease: Results from the Sickle Cell Disease Implementation Consortium cross-sectional survey of healthcare providers in the USA, Matthew Smeltzer, Kristen Howell, Marsha Treadwell, Liliana Preiss, Allison King, Jeffrey Glassberg, Paula Tanabe, Sherif Badawy, Lisa DiMartino, Robert Gibson, Julie Kanter, Lisa Klesges, Jane Hankins, and Sickle Cell Disease Implementation Consortium

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Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome, Amanda M. Smith, Taylor A. LaValle, Marwan Shinawi, Sai M. Ramakrishnan, Haley J. Abel, Cheryl A. Hill, Nicole M. Kirkland, Michael P. Rettig, Nichole M. Helton, Sharon E. Heath, Francesca Ferraro, David Y. Chen, Sangeeta Adak, Clay F. Semenkovich, Diana L. Christian, Jenna R. Martin, Harrison W. Gabel, Christopher A. Miller, and Timothy J. Ley

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Seroprevalence of SARS-CoV-2 antibodies in children and adults in St. Louis, Missouri, USA, Brittany K Smith, Andrew B Janowski, Jonathan E Danis, Ian B Harvey, Haiyan Zhao, Ya-Nan Dai, Christopher W Farnsworth, Ann M Gronowski, Stephen Roper, Daved H Fremont, and David Wang

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Progression of SARS-CoV-2 seroprevalence in St. Louis, Missouri, through January 2021, Brittany K Smith, Andrew B Janowski, Arim C Fremont, Lucas J Adams, Ya-Nan Dai, Christopher W Farnsworth, Ann M Gronowski, Stephen M Roper, David Wang, and Daved H Fremont

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Evaluation of a hybrid antimicrobial restriction process at a large academic medical center, Jesse D Smith, Linh H Nguyen, Tamara Krekel, Jerrica Waggoner, David J Ritchie, Michael J Durkin, Kevin Hsueh, and Elizabeth A Neuner

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Resting-state functional connectivity disruption as a pathological biomarker in autosomal dominant Alzheimer disease, Robert X. Smith, Jeremy F. Strain, Aaron Tanenbaum, Anne M. Fagan, Jason Hassenstab, Eric McDade, Suzanne E. Schindler, Brian A. Gordon, Chengjie Xiong, Celeste Karch, David M. Holtzman, Daniel S. Marcus, John C. Morris, Tammie L.S. Benzinger, Randall J. Bateman, Beau M. Ances, and et al.

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Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer, Jared A. Sninsky, Kumar S. Bishnupuri, Iván González, Nikolaos A. Trikalinos, Ling Chen, and Brian K. Dieckgraefe

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The impact of COVID-19 on dual-physician couples: A disproportionate burden on women physicians, Andrea Soares, Prashanth Thakker, Elena Deych, Shikha Jain, and Rakhee K. Bhayani

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Coronary artery calcification and plaque characteristics in people living with HIV: A systematic review and meta-analysis, Cullen Soares, Amjad Samara, Matthew F Yuyun, Justin B Echouffo-Tcheugui, Ahmad Masri, Ahmad Samara, Alan R Morrison, Nina Lin, Wen-Chih Wu, and Sebhat Erqou

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APOBEC1 mediated C-to-U RNA editing: Target sequence and trans-acting factor contribution to 177 RNA editing events in 119 murine transcripts in-vivo, Saeed Soleymanjahi, Valerie Blanc, and Nicholas Davidson

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Perceived barriers to assessing understanding and appreciation of informed consent in clinical trials: A mixed-method study, Erin D Solomon, Jessica Mozersky, Kari Baldwin, Matthew P Wroblewski, Meredith V Parsons, Melody Goodman, and James M DuBois

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Development of a resource guide to help patients receive appropriate care, Erin D Solomon, Heidi Walsh, Meredith Parsons, Tristan McIntosh, Jessica Mozersky, and James M DuBois

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The content and quality of publicly available information about congenital diaphragmatic hernia: Descriptive study, Frank Coyle Soltys, Kimi Spilo, and Mary C Politi

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Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease, Hari K Somineni, Rodney D Newberry, and et al.

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Inhibitor of growth protein 3 epigenetically silences endogenous retroviral elements and prevents innate immune activation, Yanhua Song, Gaopeng Hou, Jonathan Diep, Yaw Shin Ooi, Natalia S. Akopyants, Stephen M. Beverley, Jan E. Carette, Harry B. Greenberg, and Siyuan Ding

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Neutralisation of SARS-CoV-2 lineage P.1 by antibodies elicited through natural SARS-CoV-2 infection or vaccination with an inactivated SARS-CoV-2 vaccine: An immunological study, William M Souza, Michael S Diamond, and et al.

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Directed flow of beta band communication during reorienting of attention within the dorsal attention network, Sara Spadone, Miroslaw Wyczesany, Stefania Della Penna, Maurizio Corbetta, and Paolo Capotosto

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Response-adapted therapy with infusional EPOCH chemotherapy plus rituximab in HIV-associated, B-cell non-Hodgkin's lymphoma, Joseph A. Sparano, Jeannette Y. Lee, Lawrence D. Kaplan, Juan Carlos Ramos, Richard F. Ambinder, William Wachsman, David Aboulafia, Ariela Noy, David H. Henry, Lee Ratner, Ethel Cesarman, Amy Chadburn, Ronald Mitsuyasu, and AIDS Malignancy Consortium

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Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration, Larry D. Spears, Sangeeta Adak, Guifang Dong, Xiaochao Wei, George Spyropoulos, Qiang Zhang, Li Yin, Chu Feng, Donghua Hu, Irfan J. Lodhi, Fong-fu Hsu, Rithwick Rajagopal, Kevin K. Noguchi, Carmen M. Halabi, Lindsey Brier, Annie R. Bice, Brian V. Lananna, Erik S. Musiek, Oshri Avraham, Valeria Cavalli, Jerrah K. Holth, David M. Holtzman, David F. Wozniak, Joseph P. Culver, and Clay F. Semenkovich

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Development of a library of laminin-mimetic peptide hydrogels for control of nucleus pulposus cell behaviors, Julie E Speer, Marcos N Barcellona, Michael Y Lu, Zizhen Zha, Liufang Jing, Munish C Gupta, Jacob M Buchowski, Michael P Kelly, and Lori A Setton

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High optode-density wearable diffuse optical probe for monitoring paced breathing hemodynamics in breast tissue, Samuel S. Spink, Fei Teng, Vivian Pera, Hannah M. Peterson, Tim Cormier, Alexis Sauer-Budge, David Chargin, Sam Brookfield, Adam T. Eggebrecht, Naomi Ko, and Darren Roblyer

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The Azithromycin to Prevent Wheezing following severe RSV bronchiolitis-II clinical trial: Rationale, study design, methods, and characteristics of study population, Mythili Srinivasan, Leonard B Bacharier, Charles W Goss, Yanjiao Zhou, Jonathan Boomer, Sarah Bram, Dana Burgdorf, Carey-Ann Burnham, Timothy Casper, Mario Castro, Andrea Coverstone, Matthew Haslam, Watcharoot Kanchongkittiphon, Cadence Kuklinski, Qinghua Lian, Kenneth Schechtman, Gregory A Storch, Kelly true, Meghan A Wallace, Huiqing Yin-DeClue, Elizabeth Ahrens, Jinli Wang, and Avraham Beigelman

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Home hazard removal to reduce falls among community-dwelling older adults: A randomized clinical trial, Susan Stark, Marian Keglovits, Emily Somerville, Yi-Ling Hu, Abigail Barker, Dave Sykora, and Yan Yan

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A retrospective look at the predictions and recommendations from the 2009 AMIA Policy Meeting: Did we see EHR-related clinician burnout coming?, Justin B Starren, William M Tierney, Marc S Williams, Paul Tang, Charlene Weir, Ross Koppel, Philip Payne, George Hripcsak, and Don E Detmer

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Factors influencing implementation of blood transfusion recommendations in pediatric critical care units, Katherine M Steffen, Philip C Spinella, Laura M Holdsworth, Mackenzie A Ford, Grace M Lee, Steven M Asch, Enola K Proctor, and Allan Doctor

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Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections, Timothy J Straub, Wen-Chi Chou, Abigail L Manson, Henry L Schreiber 4th, Bruce J Walker, Christopher A Desjardins, Sinéad B Chapman, Kerrie L Kaspar, Orsalem J Kahsai, Elizabeth Traylor, Karen W Dodson, Meredith A J Hullar, Scott J Hultgren, Christina Khoo, and Ashlee M Earl

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Fluvoxamine: A review of its mechanism of action and its role in COVID-19, Vikas P Sukhatme, Angela M Reiersen, Sharat J Vayttaden, and Vidula V Sukhatme

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Genomic characterization of emerging bacterial uropathogen Neisseria meningitidis, which was misidentified as Neisseria gonorrhoeae by nucleic acid amplification testing, Kimberley V Sukhum, Sophonie Jean, Meghan Wallace, Neil Anderson, C A Burnham, and Gautam Dantas

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Manure microbial communities and resistance profiles reconfigure after transition to manure pits and differ from those in fertilized field soil, Kimberley V Sukhum, Rhiannon C Vargas, Manish Boolchandani, Alaric W D'Souza, Sanket Patel, Akhil Kesaraju, Gretchen Walljasper, Harshad Hegde, Zhan Ye, Robert K Valenzuela, Paul Gunderson, Casper Bendixsen, Gautam Dantas, and Sanjay K Shukla

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Frontal-posterior functional imbalance and aberrant function developmental patterns in schizophrenia, Dandan Sun, Fay Y. Womer, and et al

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Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits, Daokun Sun, Yun Ju Sung, Karen Schwander, Lisa de Las Fuentes, C Charles Gu, Laura Bierut, Dabeeru C. Rao, and et al

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Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment, Hua Sun, Song Cao, R. Jay Mashl, Chia-Kuei Mo, Sherri R. Davies, Tina M. Primeau, Jeremy Hoog, Jacqueline L. Mudd, Matthew A. Wyczalkowski, Reyka G. Jayasinghe, Fernanda Martins Rodrigues, Nadezhda V. Terekhanova, Yize Li, Kian-Huat Lim, Andrea Wang-Gillam, Brian A. Van Tine, Cynthia X. Ma, Katherine C. Fuh, John F. DiPersio, Julie Belmar, Jason Held, Rose Tipton, Yige Wu, Lijun Yao, Daniel Cui Zhou, Feng Chen, Shunqiang Li, Ramaswamy Govindan, Li Ding, Michael C. Wendl, Rebecca Aft, Julie K. Schwarz, Jose P. Zevallos, Sidharth V. Puram, Jingqin Luo, Ryan C. Fields, and et al

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Neutralizing monoclonal antibodies that target the spike receptor binding domain confer Fc receptor-independent protection against SARS-CoV-2 infection in Syrian hamsters, Wen Su, Sin Fun Sia, Aaron J Schmitz, Traci L Bricker, Tyler N Starr, Allison J Greaney, Jackson S Turner, Bassem M Mohammed, Zhuoming Liu, Ka Tim Choy, Tamarand L Darling, Astha Joshi, Ka Man Cheng, Alvina Y L Wong, Houda H Harastani, John M Nicholls, Sean P J Whelan, Jesse D Bloom, Hui-Ling Yen, Ali H Ellebedy, and Adrianus C M Boon

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Breast cancer derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment, Xinming Su, Yalin Xu, Gregory C Fox, Jingyu Xiang, Kristin A Kwakwa, Jennifer L Davis, Jad I Belle, Wen-Chih Lee, Wing H Wong, Francesca Fontana, Leonel Hernandez-Aya, Takayuki Kobayashi, Helen M Tomasson, Junyi Su, Suzanne J Bakewell, Sheila A Stewart, Christopher Egbulefu, Partha Karmakar, Melissa A Meyer, Deborah J Veis, David G DeNardo, Gregory M Lanza, Samuel Achilefu, and Katherine N Weilbaecher

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6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro, Caleb D Swaim, Varun Dwivedi, Yi-Chieh Perng, Xu Zhao, Larissa A Canadeo, Houda H Harastani, Tamarand L Darling, Adrianus C M Boon, Deborah J Lenschow, Viraj Kulkarni, and Jon M Huibregtse

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Autophagy of mucin granules contributes to resolution of airway mucous metaplasia, J.M. Sweeter, K. Kudrna, K. Hunt, P. Thomas, B. F. Dickey, S. L. Brody, and J. D. Dickinson

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Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages, Gabriela Sycz, Gisela Di Venanzio, Jesus S. Distel, Mariana G. Sartorio, Nguyen-Hung Le, Nichollas E. Scott, Wandy L. Beatty, and Mario F. Feldman

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Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study, Jeffrey J. Szymanski, R. Taylor Sundby, Paul A. Jones, Divya Srihari, Noah Earland, Peter K. Harris, Wenjia Feng, Faridi Qaium, Haiyan Lei, David Roberts, Michele Landeau, Jamie Bell, Yi Huang, Leah Hoffman, Melissa Spencer, Matthew B. Spraker, Li Ding, Brigitte C. Widemann, Jack F. Shern, Angela C. Hirbe, and Aadel A. Chaudhuri

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Social determinants of health discussed with mothers during personal visits before and during the COVID-19 pandemic, Rachel G Tabak, Cynthia D Schwarz, Allison Kemner, Shelly Johnston, Adriana Aramburu, and Debra Haire-Joshu

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ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer, Rokana Taftaf, Andrew A. Davis, and et al

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SARS-CoV-2 E gene variant alters analytical sensitivity characteristics of viral detection using a commercial reverse transcription-PCR assay, Stephen Tahan, Bijal A Parikh, Lindsay Droit, Meghan A. Wallace, Carey-Ann D Burnham, and David Wang

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Promoting coronavirus disease 2019 (COVID-19) vaccination among healthcare personnel: A multifaceted intervention at a tertiary-care center in Japan, Akane Takamatsu, Hitoshi Honda, Tomoya Kojima, Kengo Murata, and Hilary M Babcock

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Capsule carbohydrate structure determines virulence in Acinetobacter baumannii, Yuli Talyansky, Travis B. Nielsen, Jun Yan, Ulrike Carlino-Macdonald, Gisela Di Venanzio, Somnath Chakravorty, Amber Ulhaq, Mario F. Feldman, Thomas A. Russo, Evgeny Vinogradov, Brian Luna, Meredith S. Wright, Mark D. Adams, and Brad Spellberg

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Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with esophageal adenocarcinoma: Results from a phase 1 cohort, Benjamin Tan, Adnan Khattak, Enriqueta Felip, Karen Kelly, Patricia Rich, Ding Wang, Christoph Helwig, Isabelle Dussault, Laureen S Ojalvo, and Nicolas Isambert

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Directed evolution of an enhanced POU reprogramming factor for cell fate engineering, Daisylyn Senna Tan, Gary D Stormo, and et al.

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A decade in review after Idiopathic Scoliosis was first called a complex trait-A tribute to the late Dr. Yves Cotrel for his support in studies of etiology of scoliosis, Nelson L S Tang, Matthew B Dobbs, Christina A Gurnett, Yong Qiu, T P Lam, Jack C Y Cheng, and Nancy Hadley-Miller

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Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes, Joel M. J. Tan, Michael S. Diamond, and et al

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Current state of scientific evidence on Internet-based interventions for the treatment of depression, anxiety, eating disorders and substance abuse: An overview of systematic reviews and meta-analyses, C Barr Taylor, Andrea K Graham, Rachael E Flatt, Karin Waldherr, and Ellen E Fitzsimmons-Craft

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Prevalence of elevated serum fatty acid synthase in chronic limb‑threatening ischemia, Shirli Tay, Gayan S. De Silva, Connor M. Engel, NIkolai Harroun, Amanda S. Penrose, Kshitij A. Desai, Yan Yan, Clay F. Semenkovich, and Mohamed A. Zayed

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Antibiotic-driven intestinal dysbiosis in pediatric short bowel syndrome is associated with persistently altered microbiome functions and gut-derived bloodstream infections, Robert Thänert, Anna Thänert, Jocelyn Ou, Adam Bajinting, Carey-Ann D Burnham, Holly J Engelstad, Maria E Tecos, I Malick Ndao, Carla Hall-Moore, Colleen Rouggly-Nickless, Mike A Carl, Deborah C Rubin, Nicholas O Davidson, Phillip I Tarr, Barbara B Warner, Gautam Dantas, and Brad W Warner

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Central venous catheter adverse events are not associated with crowding indicators, Daniel L Theodoro, Niraj Vyas, Enyo Ablordeppey, Brian Bausano, Stephanie Charshafian, Phillip Asaro, and Richard T Griffey

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Kdm6a deficiency restricted to mouse hematopoietic cells causes an age- and sex-dependent myelodysplastic syndrome-like phenotype, Ling Tian, Monique Chavez, Gue Su Chang, Nichole M. Helton, Casey D. S. Katerndahl, Christopher A. Miller, and Lukas D. Wartman

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Polatuzumab vedotin in previously untreated diffuse large B-cell lymphoma, Hervé Tilly, Neha Mehta-Shah, and et al

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Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: Subset analysis of the ASPECT-NP randomized, controlled phase 3 trial, Jean-François Timsit, Jennifer A Huntington, Richard G Wunderink, Nobuaki Shime, Marin H Kollef, Ülo Kivistik, Martin Nováček, Álvaro Réa-Neto, Ignacio Martin-Loeches, Brian Yu, Erin H Jensen, Joan R Butterton, Dominik J Wolf, Elizabeth G Rhee, and Christopher J Bruno

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Evaluation of total body weight versus adjusted body weight liposomal amphotericin B dosing in obese patients, Michelle H Ting, Andrej Spec, Scott T Micek, David J Ritchie, and Tamara Krekel

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Detection of β-amyloid positivity in Alzheimer's Disease Neuroimaging Initiative participants with demographics, cognition, MRI and plasma biomarkers, Duygu Tosun, James Bollinger, Vitaliy Ovod, Kwasi G Mawuenyega, Randall J Bateman, and et al.

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Quality of life analyses in patients with multiple myeloma: Results from the Selinexor (KPT-330) Treatment of Refractory Myeloma (STORM) phase 2b study, Gabriel Tremblay, Ravi Vij, and et al.

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Decoding visual information from high-density diffuse optical tomography neuroimaging data, Kalyan Tripathy, Zachary E Markow, Andrew K Fishell, Arefeh Sherafati, Tracy M Burns-Yocum, Mariel L Schroeder, Alexandra M Svoboda, Adam T Eggebrecht, Mark A Anastasio, Bradley L Schlaggar, and Joseph P Culver

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Inhibition of NOX1 mitigates blood pressure increases in elastin insufficiency, Angela Troia, Russell H Knutsen, Carmen M Halabi, Daniela Malide, Zu Xi Yu, Amanda Wardlaw-Pickett, Elise K Kronquist, Kit Man Tsang, Attila Kovacs, Robert P Mecham, and Beth A Kozel

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Non-invasive monitoring of arthritis treatment response via targeting of tyrosine-phosphorylated annexin A2 in chondrocytes, Shaw-Wei D Tsen, Luke E Springer, Krishna Sharmah Gautam, Rui Tang, Kexian Liang, Gail Sudlow, Amir Kucharski, Christine T N Pham, and Samuel Achilefu

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Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions, Ko Tsutsui, Hiroki Machida, Asako Nakagawa, Kyungmin Ahn, Ritsuko Morita, Kiyotoshi Sekiguchi, Jeffrey H. Miner, and Hironobu Fujiwara

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Mycobacterium tuberculosis Rv3160c is aTetR‑like transcriptional repressor that regulates expression of the putative oxygenase Rv3161c, Hasan Tükenmez, Souvik Sarkar, Saber Anoosheh, Anastasiia Kruchanova, Isabel Edström, Gregory A. Harrison, Christina L. Stallings, Fredrik Almqvist, and Christer Larsson

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IL-7 immunotherapy in a nonimmunocompromised patient with intractable fungal wound sepsis, Isaiah R. Turnbull, Monty B. Mazer, Mark H. Hoofnagle, John P. Kirby, Jennifer M. Leonard, Carlos Mejia-Chew, Andrej Spec, Jane Blood, Sydney M. Miles, Eric M. Ransom, Robert F. Potter, Joseph P. Gaut, Kenneth E. Remy, and Richard S. Hotchkiss

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Cognitive dysfunction after analgesia and sedation: Out of the operating room and into the pediatric intensive care unit, Ashley D Turner, Travis Sullivan, Kurt Drury, Trevor A Hall, Cydni N Williams, Kristin P Guilliams, Sarah Murphy, and A M Iqbal O'Meara

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Electrophysiological and molecular mechanisms of sinoatrial node mechanosensitivity, Daniel Turner, Chen Kang, Pietro Mesirca, Juan Hong, Matteo E Mangoni, Alexey V Glukhov, and Rajan Sah

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An integrated approach to identify new anti-filarial leads to treat river blindness, a neglected tropical disease, Rahul Tyagi, Christina A Bulman, Fidelis Cho-Ngwa, Chelsea Fischer, Chris Marcellino, Michelle R Arkin, James H McKerrow, Case W McNamara, Matthew Mahoney, Nancy Tricoche, Shabnam Jawahar, James W Janetka, Sara Lustigman, Judy Sakanari, and Makedonka Mitreva

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PIR-B regulates CD4+ IL17a+ T-cell survival and restricts T-cell–dependent intestinal inflammatory responses, Jazib Uddin, Rodney Newberry, and et al

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Augmented reality in spinal surgery: Highlights from augmented reality lectures at the Emerging Technologies annual meetings, Syed-Abdullah Uddin, George Hanna, Lindsey Ross, Camilo Molina, Timur Urakov, Patrick Johnson, Terrence Kim, and Doniel Drazin

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A comprehensive review of tic disorders in children, Keisuke Ueda and Kevin J Black

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Paroxysmal kinesigenic dyskinesia in twins with chromosome 16p11.2 duplication syndrome, Keisuke Ueda, Marwan Shinawi, and Toni S. Pearson

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Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site, Rajendra Uprety, Tao Che, Balázs R. Varga, Abdelfattah Faouzi, Sarah M. Bernhard, Susruta Majumdar, and et al

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Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors, Roman V Uzhachenko, Vijaya Bharti, Zhufeng Ouyang, Ashlyn Blevins, Stacey Mont, Nabil Saleh, Hunter A Lawrence, Chengli Shen, Sheau-Chiann Chen, Gregory D Ayers, David G DeNardo, Carlos Arteaga, Ann Richmond, and Anna E Vilgelm

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Glembatumumab vedotin for patients with metastatic, gpNMB overexpressing, triple-negative breast cancer (“METRIC”): A randomized multicenter study, Linda T. Vahdat, Cynthia Ma, and et al.

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Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses, Laura A. VanBlargan, John M. Errico, Natasha M. Kafai, Prashant N. Jethva, Christopher A. Nelson, David Wang, Scott A. Handley, Michael L. Gross, Daved H. Fremont, Michael S. Diamond, and et al

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Tricuspid valve intervention at the time of pulmonary valve replacement in adults with congenital heart disease: A systematic review and meta-analysis, Jef Van den Eynde, Connor P Callahan, Mauro Lo Rito, Nabil Hussein, Horacio Carvajal, Alvise Guariento, Arjang Ruhparwar, Alexander Weymann, Werner Budts, Marc Gewillig, Michel Pompeu Sá, and Shelby Kutty

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CCR2 signaling restricts SARS-CoV-2 infection, Abigail Vanderheiden, Jeronay Thomas, Allison L Soung, Meredith E Davis-Gardner, Katharine Floyd, Fengzhi Jin, David A Cowan, Kathryn Pellegrini, Pei-Yong Shi, Arash Grakoui, Robyn S Klein, Steven E Bosinger, Jacob E Kohlmeier, Vineet D Menachery, and Mehul S Suthar

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Trichomonas vaginalis detection in urogenital specimens from symptomatic and asymptomatic men and women by use of the cobas TV/MG test, Barbara Van Der Pol, David Eisenberg, and et al

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NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation, Sjoerd van der Post, George M H Birchenough, and Jason M Held

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Phase II study of dacarbazine given with modern prophylactic anti-emetics and growth factor support to patients with metastatic, resistant soft tissue, and bone sarcoma, Brian Van Tine, Mia Weiss, Angela Hirbe, Peter Oppelt, Sarah Abaricia, Kathryn Trinkaus, Jingqin Luo, Shellie Berry, Tyler Ruff, Cheryl Callahan, Jacqui Toensikoetter, Jessica Ley, Marilyn Siegel, Farrokh Dehdashti, Barry Siegel, and Douglas Adkins

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MOMENTUM: Momelotinib vs danazol in patients with myelofibrosis previously treated with JAKi who are symptomatic and anemic, Srdan Verstovsek, Stephen T Oh, and Et al

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Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe, Alexandre T. Vessoni, Tianpeng Zhang, Annabel Quinet, Ho-Chang Jeong, Michael Munroe, Matthew Wood, Enzo Tedone, Alessandro Vindigni, Jerry W. Shay, Roger A. Greenberg, and Luis F.Z. Batista

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HIF1α is required for NK cell metabolic adaptation during virus infection, Francisco Victorino, Tarin M. Bigley, Eugene Park, Cong-Hui Yao, Jeanne Benoit, Li-Ping Yang, Sytse J. Piersma, Elvin J. Lauron, Rebecca M. Davidson, Gary J. Patti, and Wayne M. Yokoyama

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Scissor-type knife improves the safety of endoscopic submucosal dissection (ESD) among endoscopists without experience in ESD: A randomized ex vivo study, Kavel Visrodia, Tarek Sawas, Liam Zakko, Juan Reyes Genere, Cadman Leggett, Lori Lutzke, and Kenneth K. Wang

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Trajectory of emotion dysregulation in positive and negative affect across childhood predicts adolescent emotion dysregulation and overall functioning, Alecia C. Vogel, Rebecca Tillman, Nourhan M. El-Sayed, Joshua J. Jackson, Susan B. Perlman, Deanna M. Barch, and Joan L. Luby

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Blood leukocytes recapitulate diabetogenic peptide-MHC-II complexes displayed in the pancreatic islets, Anthony N. Vomund, Cheryl F. Lichti, Orion J. Peterson, Ana Maria Arbelaez, Xiaoxiao Wan, and Emil R. Unanue

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Non-motor phenotypic subgroups in adult-onset idiopathic, isolated, focal cervical dystonia, Megan E Wadon, Joel S Perlmutter, and et al

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U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice, Brian A Wadugu, Sridhar Nonavinkere Srivatsan, Amanda Heard, Michael O Alberti, Matthew Ndonwi, Jie Liu, Sarah Grieb, Joseph Bradley, Jin Shao, Tanzir Ahmed, Cara L Shirai, Ajay Khanna, Christopher A Miller, Matthew J Walter, and et al