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Submissions from 2014

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Rationing lung transplants--procedural fairness in allocation and appeals, Keren Ladin and Douglas W. Hanto

RB1 gene inactivation by chromothripsis in human retinoblastoma, Charles Lu, Robert S. Fulton, Lucinda L. Fulton, Xin Hong, David J. Dooling, Kerri Ochoa, Elaine R. Mardis, Richard K. Wilson, and et al

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Reactivation of multiple viruses in patients with sepsis, Andrew H. Walton, Jared T. Muenzer, David Rasche, Jonathan S. Boomer, Bryan Sato, Bernard H. Brownstein, Alexandre Pachot, Terrence L. Brooks, Elena Deych, William D. Shannon, Jonathan M. Green, Gregory A. Storch, and Richard S. Hotchkiss

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Reassessing the impact of smoking on preeclampsia/eclampsia: Are there age and racial differences?, Jen Jen Chang, Jerome F. Strauss III, Jon P. Deshazo, Fidelma B. Rigby, David P. Chelmow, and George A. Macones

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Recurrent epimutations activate gene body promoters in primary glioblastoma, Raman P. Nagarajan, Bo Zhang, Robert J.A. Bell, Brett E. Johnson, Adam B. Olshen, Vasavi Sundaram, Daofeng Li, Ashley E. Graham, Aaron Diaz, Shaun D. Fouse, Ivan Smirnov, Jun Song, Pamela L. Paris, Ting Wang, and Joseph F. Costello

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Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma, Charles Lu, Li Ding, Elaine R. Mardis, Richard K. Wilson, and et al

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Red blood cell invasion by Plasmodium vivax: Structural basis for DBP engagement of DARC, Joseph D. Batchelor, Brian M. Malpede, Natalie S. Omattage, Gregory T. DeKoster, Katherine A. Henzler-Wildman, and Niraj H. Tolia

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Regulation of the Hsp104 middle domain activity is critical for yeast prion propagation, Jennifer E. Dulle, Kevin C. Stein, and Heather L. true

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Regulatory network decoded from epigenomes of surface ectoderm-derived cell types, Rebecca F. Lowdon, Bo Zhang, Misha Bilenky, Thea Mauro, Daofeng Li, Philippe Gascard, Mahvash Sigaroudinia, Peggy J. Farnham, Boris C. Bastian, Thea D. Tlsty, Marco A. Marra, Martin Hirst, Joseph F. Costello, Ting Wang, and Jeffrey B. Cheng

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Rehabilitation following arthroscopic rotator cuff repair: A prospective randomized trial of immobilization compared with early motion, Jay D. Keener, Leesa M. Galatz, Georgia Stobbs-Cucchi, Rebecca Patton, and Ken Yamaguchi

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Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker, Xuntian Jiang, Rohini Sidhu, Daniel S. Ory, Danielle te Vruchte, Anneliese O. Speak, Kerri L. Wallom, Nada Al Eisa, David A. Smith, Christian J. Hendriksz, Louise Simmons, Robin H. Lachmann, Alison Cousins, Ralf Hartung, Eugen Mengel, and et al.

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Relative mortality in U.S. Medicare beneficiaries with Parkinson disease and hip and pelvic fractures, Marcie Harris-Hayes, Allison W. Willis, Sandra E. Klein, Sylvia Czuppon, Beth Crowner, and Brad A. Racette

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Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci, Daniel C. Koboldt, David E. Larson, Qunyuan Zhang, Ling Lin, Li Ding, Michael D. McLellan, Michele O'Laughlin, Catrina Fronick, Lucinda L. Fulton, Vincent Magrini, Robert S. Fulton, Richard K. Wilson, and et al

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Resistin stimulates expression of chemokine genes in chondrocytes via combinatorial regulation of C/EBPβ and NF-κB, Ziji Zhang, Zhiqi Zhang, Yan Kang, Changhe Hou, Xin Duan, Puyi Sheng, Linda J. Sandell, and Weiming Liao

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Responsibility and cooperativeness are constrained, not determined, Danilo Garcia, Alva Stråge, Sebastian Lundström, Susanna Radovic, Sven Brändström, Maria Råstam, Thomas Nilsson, C. Robert Cloninger, Nóra Kerekes, and Henrik Anckarsäter

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Resting state functional connectivity in early blind humans, Harold Burton, Abraham Z. Snyder, and Marcus E. Raichle

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Resting-state modulation of alpha rhythms by interference with angular gyrus activity, Paolo Capotosto, Claudio Babiloni, Gian Luca Romani, and Maurizio Corbetta

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Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea, Benjamin R. Thiede, Zoë F. Mann, Weise Chang, Yuan-Chieh Ku, Yena K. Son, Michael Lovett, Matthew W. Kelley, and Jeffrey T. Corwin

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Retinopathy and clinical outcomes in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia, Natalie A. Bello, Marc A. Pfeffer, Hicham Skali, Janet B. McGill, Jerome Rossert, Kurt A. Olson, Larry Weinrauch, Mark E. Cooper, Dick de Zeeuw, Peter Rossing, John J. V. McMurray, Scott D. Solomon, and Trial to Reduce cardiovascular Events with Aranesp Therapy (TREAT) Investigators

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Retreatment with brentuximab vedotin in patients with CD30-positive hematologic malignancies, Nancy L. Bartlett, Robert Chen, Michelle A. Fanale, Pauline Brice, Ajay Gopal, Scott E. Smith, Ranjana Advani, Jeffrey V. Matous, Radhakrishnan Ramchandren, Joseph D. Rosenblatt, Dirk Huebner, Pamela Levine, Laurie Grove, and Andres Forero-Torres

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Revision total hip arthroplasty with retained acetabular component, Muyibat A. Adelani, Nathan A. Mall, Humaa Nyazee, John C. Clohisy, Robert L. Barrack, and Ryan M. Nunley

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Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II, Hanako Yashiro, Andrew J. Loza, James B. Skeath, and Gregory D. Longmore

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Risk-factor analysis of adjacent-segment pathology requiring surgery following anterior, posterior, fusion, and nonfusion cervical spine operations: Survivorship analysis of 1358 patients, Jae Chul Lee, Sang-Hun Lee, Colleen Peters, and K. Daniel Riew

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Risk factors for recurrent Clostridium difficile infection (CDI) hospitalization among hospitalized patients with an initial CDI episode: A retrospective cohort study, Marya D. Zilberberg, Kimberly Reske, Margaret Olsen, Yan Yan, and Erik R. Dubberke

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Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy, Aaron D. Schenone, Jingqin Luo, Luke Montgomery, Daniel Morgensztern, Douglas R. Adkins, and Brian A. Van Tine

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Role of liver biopsy in nonalcoholic fatty liver disease, ILKe Nalbantoglu and Elizabeth M. Blunt

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Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and Major Depressive Disorder, Andrew J. Schrage, Michele L. Pergadia, Pamela A. F. Madden, and et al

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Role of NKG2D in obesity-induced adipose tissue inflammation and insulin resistance, Jun-Jae Chung, Mary A. Markiewicz, Bojan Polic, and Andrey S. Shaw

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Roles of ON cone bipolar cell subtypes in temporal coding in the mouse retina, Tomomi Ichinose, Bozena Fyk-Kolodziej, and Jesse Cohn

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RON5 is critical for organization and function of the Toxoplasma moving junction complex, Josh R. Beck, Allan L. Chen, Elliot W. Kim, and Peter J. Bradley

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Routine testing for anaerobic bacteria in cerebrospinal fluid cultures improves recovery of clinically significant pathogens, Meredith E. Pittman, Benjamin S. Thomas, Meghan A. Wallace, Carol J. Weber, and Carey-Ann D. Burnham

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SciClone: Inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution, Christopher A. Miller, Brian A. White, Nathan D. Dees, Malachi Griffith, John S. Welch, Obi L. Griffith, Ravi Vij, Michael H. Tomasson, Timothy A. Graubert, Matthew J. Walter, Matthew J. Ellis, William Schierding, John F. DiPersio, Timothy J. Ley, Elaine R. Mardis, Richard K. Wilson, and Li Ding

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Secondhand smoke exposure and severity of attention-deficit/hyperactivity disorder in preschoolers: A pilot investigation, Mini Tandon, Christina N. Lessov-Schlaggar, Rebecca Tillman, Melbourne F. Hovell, and Joan Luby

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Septic arthritis of a native knee joint due to Corynebacterium striatum, Lars F. Westblade, Farah Shams, Scott Duong, Oosman Tariq, Alan Bulbin, Dava Klirsfeld, Wei Zhen, Smita Sakaria, Bradley A. Ford, Carey-Ann D. Burnham, and Christine C. Ginocchio

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Sequence specificity incompletely defines the genome-wide occupancy of Myc, Jiannan Guo, Tiandao Li, Joshua Schipper, Kyle A. Nilson, Francis K. Fordjour, Jeffrey J. Cooper, Raluca Gordan, and David H. Price

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Sequencing of idiopathic pulmonary fibrosis-related genes reveals independent single gene associations, Meghan A. Coghlan, Adrian Shifren, Howard J. Huang, Tonya D. Russell, Robi D. Mitra, Qunyuan Zhang, Daniel J. Wegner, F. Sessions Cole, and Aaron Hamvas

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Seroepidemiology of astrovirus MLB1, Lori R. Holtz, Irma K. Bauer, Hongbing Jiang, Robert Belshe, Pamela Freiden, Stacey L. Schultz-Cherry, and David Wang

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Sex dependent risk factors for mortality after myocardial infarction: Individual patient data meta-analysis, Robert M. Carney, Kenneth E. Freedland, and et al

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Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males, Tao Sun, Nicole M. Warrington, Jingqin Luo, Michael D. Brooks, Sonika Dahiya, Steven C. Snyder, Rajarshi Sengupta, and Joshua B. Rubin

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Shiga toxin-producing Escherichia coli: A single-center, 11-year pediatric experience, Emily I. Schindler, Patricia Sellenriek, Gregory A. Storch, Phillip I. Tarr, and Carey-Ann D. Burnham

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Shiga toxin/verocytotoxin-producing Escherichia coli infections: practical clinical perspectives, T. K. Davis, Nicole C.A. J. Van De Kar, and Phillip I. Tarr

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Short communication: The veterans aging cohort study index is an effective tool to assess baseline frailty status in a contemporary cohort of HIV-infected persons, Gerome V. Escota, Pragna Patel, John T. Brooks, Tim Bush, Lois Conley, Jason Baker, Erna M. Kojic, John Hammer, and Nur F. Önen

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SigFuge: Single gene clustering of RNA-seq reveals differential isoform usage among cancer samples, Patrick K. Kimes, Christopher R. Cabanski, Matthew D. Wilkerson, Ni Zhao, Amy R. Johnson, Charles M. Perou, Liza Makowski, Christopher A. Maher, Yufeng Liu, J. S. Marron, and D. Neil Hayes

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Significance of asymptomatic persistent epstein-barr viral load in pediatric renal transplant recipients: North American pediatric renal trials and collaborative studies report, Asha Moudgil, Karen Martz, Therese Moore, William E. Harmon, and Vikas R. Dharnidharka

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Simultaneous bilateral or unilateral carpal tunnel release? A prospective cohort study of early outcomes and limitations, Daniel A. Osei, Ryan P. Calfee, Jeffrey G. Stepan, Martin I. Boyer, Charles A. Goldfarb, and Richard H. Gelberman

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Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe, Xudong Qiu, James R. Johnson, Bradley S. Wilson, Seth T. Gammon, David Piwnica-Worms, and Edward M. Barnett

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Single haplotype assembly of the human genome from a hydatidiform mole, Karyn Meltz Steinberg, Valerie A. Schneider, Tina A. Graves-Lindsay, Robert S. Fulton, Richa Agarwala, John Huddleston, Sergey A. Shiryev, Aleksandr Morgulis, Urvashi Surti, Wesley C. Warren, Deanna M. Church, Evan E. Eichler, and Richard K. Wilson

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Single nucleotide variants in transcription factors associate more tightly with phenotype than with gene expression, Priya Sudarsanam and Barak A. Cohen

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SIRT6 is required for normal retinal function, Dafne M. Silberman, Kenneth Ross, Pablo H. Sande, Shunsuke Kubota, Sridhar Ramaswamy, Rajendra S. Apte, and Raul Mostoslavsky

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slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells, William Vermi, Alessandra Micheletti, Silvia Lonardi, Claudio Costantini, Federica Calzetti, Riccardo Nascimbeni, Mattia Bugatti, Manuela Codazzi, Patrick C. Pinter, Knut Schäkel, Nicola Tamassia, and Marco A. Cassatella

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Slope of the anterior mitral valve leaflet: A new measurement of left ventricular unloading for left ventricular assist devices and systolic dysfunction, Sara C. Martinez, Elisa A. Bradley, Eric L. Novak, Ravi Rasalingam, Ari M. Cedars, Gregory A. Ewald, Scott C. Silvestry, and Susan M. Joseph

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Smokers’ beliefs about the tobacco control potential of “a gene for smoking”: A focus group study, Erika A. Waters, Linda Ball, Kimberly Carter, and Sarah Gehlert

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Smoking cessation is associated with lower rates of mood/anxiety and alcohol use disorders, P. A. Cavazos-Rehg, N. Breslau, D. Hatsukami, M. J. Krauss, E. L. Spitznagel, R. A. Grucza, P. Salyer, S. M. Hartz, and L. J. Bierut

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Soft-tissue abnormalities associated with treatment-resistant and treatment-responsive clubfoot: Findings of MRI analysis, Daniel K. Moon, Christina A. Gurnett, Hyuliya Aferol, Marilyn J. Siegel, Paul K. Commean, and Matthew B. Dobbs

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Somatostatin analogues for receptor targeted photodynamic therapy, Slavka Kascakova, Leo J. Hofland, Henriette S. De Bruijn, Yunpeng Ye, Samuel Achilefu, Katy van der Wansem, Angelique van der Ploeg-van den Heuvel, Peter M. van Koetsveld, Michael P. Brugts, Aart-Jan van der Lelij, Henricus J. C. M. Strerenborg, Timo L. M. ten Hagen, Dominic J. Robinson, and Martin P. van Hagen

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Some personal and historical notes on the utility of "deep-etch" electron microscopy for making cell structure/function correlations, John E. Heuser

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Sonography of acute appendicitis and its mimics in children, Kiran M. Sargar and Marilyn J. Siegel

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Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia, Kevin J. Black, Abraham Z. Snyder, Jonathan W. Mink, Veeral N. Tolia, Fredy J. Revilla, Stephen M. Moerlein, and Joel S. Perlmutter

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Species D human adenovirus type 9 exhibits better virus-spread ability for antitumor efficacy among alternative serotypes, Junji Uchino, David T. Curiel, and Hideyo Ugai

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Speckle contrast optical tomography: A new method for deep tissue three-dimensional tomography of blood flow, Hari M. Varma, Claudia P. Valdes, Anna K. Kristoffersen, Joseph P. Culver, and Turgut Durduran

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Spike-timing computation properties of a feed-forward neural network model, Drew B. Sinha, Noah M. Ledbetter, and Dennis L. Barbour

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Spread of activation and deactivation in the brain: Does age matter?, Brian A. Gordon, Chun-Yu Tse, Gabriele Gratton, and Monica Fabiani

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SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons, Cong L. Li, Aruna Sathyamurthy, Anna Oldenborg, Dharmesh Tank, and Narendrakumar Ramanan

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State practitioner insights into local public health challenges and opportunities in obesity prevention: A qualitative study, Katherine A. Stamatakis, Moira Lewis, Elaine C. Khoong, and Claire LaSee

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Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution, Nalinikanth Kotagiri and Jin-Woo Kim

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Sterol biosynthesis is required for heat resistance but not extracellular survival in Leishmania, Wei Xu, Fong-Fu Hsu, Eda Baykal, Juyang Huang, and Kai Zhang

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Strategies to prevent central line-associated bloodstream infections in acute care hospitals: 2014 update, Jonas Marschall, Leonard A. Mermel, Mohamed Fakih, Lynn Hadaway, Alexander Kallen, Naomi P. O'Grady, Ann Marie Pettis, Mark E. Rupp, Thomas Sandora, Lisa L. Maragakis, and Deborah S. Yokoe

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Strategies to prevent Clostridium difficile infections in acute care hospitals: 2014 update, Erik R. Dubberke, Philip Carling, Curtis J. Donskey, Vivian G. Loo, L. Clifford McDonald, Lisa L. Maragakis, Thomas J. Sandora, David J. Weber, Deborah S. Yokoe, and Dale N. Gerding

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Streptococcus pyogenes polymyxin B-resistant mutants display enhanced exportal integrity, Gary C. Port, Luis A. Vega, Andrew B. Nylander, and Michael G. Caparon

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Stress mediates the relationship between sexual orientation and behavioral risk disparities, Jennifer M. Jabson, Grant W. Farmer, and Deborah J. Bowen

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Structure of cellular ESCRT-III spirals and their relationship to HIV budding, Anil G. Cashikar, Soomin Shim, Robyn Roth, Michael R. Maldazys, John E. Heuser, and Phyllis I. Hanson

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Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer, Shixuan Liu, Wei Cheng, Ronald Fowle Grider, Guomin Shen, and Weikai Li

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Studies of inactivation mechanism of non-enveloped icosahedral virus by a visible ultrashort pulsed laser, Shaw-Wei D. Tsen, David H. Kingsley, Christian Poweleit, Samuel Achilefu, Douglas S. Soroka, T. C. Wu, and Kong-Thon Tsen

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Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration, Patrick R. O'Neill and N. Gautam

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Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline, Nicholas Stong, Zhong Deng, Ravi Gupta, Sufen Hu, Shiela Paul, Amber K. Weiner, Evan E. Eichler, Tina Graves, Catrina C. Fronick, Laura Courtney, Richard K. Wilson, Paul M. Lieberman, Ramana V. Davuluri, and Harold Riethman

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Suicide genes: Monitoring cells in patients with a safety switch, Linda G. Eissenberg, Michael Rettig, Farrokh Dehdashti, David Piwnica-Worms, and John F. DiPersio

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Symptoms of pain do not correlate with rotator cuff tear severity, Robert H. Brophy, Matthew V. Smith, Rick W. Wright, and et al

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Synthesis of dye conjugates to visualize the cancer cells using fluorescence microscopy, Yang Pu, Rui Tang, Jianpeng Xue, W. B. Wang, Baogang Xu, and Samuel I. Achilefu

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Systematic shifts in the balance of excitation and inhibition coordinate the activity of axial motor pools at different speeds of locomotion, Sandeep Kishore, Martha W. Bagnall, and David L. McLean

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Systems biology studies of adult Paragonimus lung flukes facilitate the identification of immunodominant parasite antigens, Samantha N. McNulty, Peter U. Fischer, R Reid Townsend, Kurt C. Curtis, Gary J. Weil, and Makedonka Mitreva

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Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia., L. Ding, C. Lu, R. S. Fulton, E. Mardis, R. K. Wilson, and et al

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Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth, Thanh U. Barbie, Shunqiang Li, Xiuli Zhang, John Herndon, Timothy Fleming, Matthew J. Ellis, William E. Gillanders, and et al

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Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system, Jessica L. Williams, Jigisha R. Patel, Brian P. Daniels, and Robyn S. Klein

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Targeting hepatic glycerolipid synthesis and turnover to treat fatty liver disease, George G. Schweitzer and Brian N. Finck

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Targeting the programmed cell death 1: Programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis, Katherine Chang, Catherine Svabek, Cristina Vazquez-Guillamet, Bryan Sato, David Rasche, Strother Wilson, Paul Robbins, Nancy Ulbrandt, JoAnn Suzich, Jonathan Green, Andriani C. Patera, Wade Blair, Subramaniam Krishnan, and Richard Hotchkiss

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Tax inflicts DNA damage through activation of Nitric Oxide production, Hicham H. Baydoun and Lee Ratner

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TCAB1: A potential target for diagnosis and therapy of head and neck carcinomas, Chong-kui Sun, Xiao-bo Luo, Ya-ping Gou, Ling Hu, Kun Wang, Chao Li, Zhen-ting Xiang, Ping Zhang, Xiang-li Kong, Chao-liang Zhang, Qin Yang, Jing Li, Li-ying Xiao, Yan Li, and Qian-ming Chen

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T cell immunodominance is dictated by the positively selecting self-peptide, Wan-Lin Lo, Benjamin D. Solomon, David L. Donermeyer, Chyi-Song Hsieh, and Paul M. Allen

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Telavancin for hospital-acquired pneumonia: Clinical response and 28-day survival, G. Ralph Corey, Marin H. Kollef, Andrew F. Shorr, Ethan Rubinstein, Martin E. Stryjewski, Alan Hopkins, and Steven L. Barriere

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Telomerase enzymatic component hTERT shortens long telomeres in human cells, Yun-Ling Zheng, Fan Zhang, Bing Sun, Juan Du, Chongkui Sun, Jie Yuan, Ying Wang, Lian Tao, Krishna Kota, Xuefeng Liu, Richard Schlegel, and Qin Yang

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The 2013 symposium on pathology data integration and clinical decision support and the current state of field, Rakesh Nagarajan and et al.

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The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function, Ya-Juan Wang, Bamidele O. Tayo, Anupam Bandyopadhyay, Heming Wang, Tao Feng, Nora Franceschini, Hua Tang, Jianmin Gao, Yun Ju Sung, COGENT BP consortium, Robert C. Elston, Scott M. Williams, Richard S. Cooper, Ting-Wei Mu, and Xiaofeng Zhu

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The bacterial amyloid curli Is associated with urinary source bloodstream infection, Chia Hung, Jonas Marschall, Carey-Ann D. Burnham, Albert S. Byun, and Jeffrey P. Henderson

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The Ca2+-activated K+ current of human sperm is mediated by Slo3, Christoph Brenker, Yu Zhou, Astrid Muller, Fabio Andres Echeverry, Christian Trotschel, Ansgar Poetsch, Xiao-Ming Xia, Wolfgang Bonigk, Christopher J. Lingle, U. Benjamin Kaupp, and Timo Strunker

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The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites, Jana Dorfman Marcette, Jessica Jie Chen, and Michael L. Nonet

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The cavefish genome reveals candidate genes for eye loss, Suzanne E. McGaugh, Patrick Minx, Wesley C. Warren, and et al

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The changing immune system in sepsis: Is individualized immuno-modulatory therapy the answer?, Jonathan S. Boomer, Jonathan M. Green, and Richard S. Hotchkiss

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The circuitry of abulia: Insights from functional connectivity MRI, J. S. Siegel, A. Z. Snyder, N. V. Metcalf, R. P. Fucetola, C. D. Hacker, J. S. Shimony, G. L. Shulman, and M. Corbetta

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The conjunctival microbiome in health and trachomatous disease: A case control study, Yanjiao Zhou, Martin J. Holland, Pateh Makalo, Hassan Joof, Chrissy H. Roberts, David C.W. Mabey, Robin L. Bailey, Matthew J. Burton, George M. Weinstock, and Sarah E. Burr

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The cure: Design and evaluation of a crowdsourcing game for gene selection for breast cancer survival prediction, Benjamin M. Good, Salvatore Loguercio, Obi L. Griffith, Max Nanis, Chunlei Wu, and Andrew I. Su