Inflammaging in aged tissues drives remodeling of the CD8+ T cell compartment

Authors

• Irina Shchukina, Washington University School of Medicine in St. Louis
• Carlos J Rodriguez-Hernandez, Washington University School of Medicine in St. Louis
• Heather S Ruiz, Washington University School of Medicine in St. Louis
• Maksim Kleverov, Washington University School of Medicine in St. Louis
• Rachel L Mintz, Washington University School of Medicine in St. Louis
• Katsutaka Mineura, Washington University School of Medicine in St. Louis
• Subhadra C Gunawardana, Washington University School of Medicine in St. Louis
• Sunnie Hsiung, Washington University School of Medicine in St. Louis
• Bishan Bhattarai, Washington University School of Medicine in St. Louis
• Veronika Vachova, Washington University School of Medicine in St. Louis
• Jan Kossl, Washington University School of Medicine in St. Louis
• Denis A Mogilenko, Washington University School of Medicine in St. Louis
• Rachael L Field, Washington University School of Medicine in St. Louis
• Tran H Nguyen, Washington University School of Medicine in St. Louis
• Quazim A Alayo, Washington University School of Medicine in St. Louis
• Christopher G Huckstep, Washington University School of Medicine in St. Louis
• Barbora Vander Wielen, Washington University School of Medicine in St. Louis
• Jonathan R Brestoff, Washington University School of Medicine in St. Louis
• Sheila A Stewart, Washington University School of Medicine in St. Louis
• David W Piston, Washington University School of Medicine in St. Louis
• Takeshi Egawa, Washington University School of Medicine in St. Louis
• Daniel Kreisel, Washington University School of Medicine in St. Louis
• Gwendalyn J Randolph, Washington University School of Medicine in St. Louis
• Maxim N Artyomov, Washington University School of Medicine in St. Louis

Journal

Cell Reports

Publication Date

5-26-2026

Volume

45

Issue

5

First Page

117303

Document Type

Open Access Publication

DOI

10.1016/j.celrep.2026.117303

Rights and Permissions

Shchukina I, Rodriguez-Hernandez CJ, Ruiz HS, Kleverov M, Mintz RL, Mineura K, Gunawardana SC, Hsiung S, Bhattarai B, Vachova V, Kossl J, Mogilenko DA, Field RL, Nguyen TH, Alayo QA, Huckstep CG, Vander Wielen B, Brestoff JR, Stewart SA, Piston DW, Egawa T, Kreisel D, Randolph GJ, Artyomov MN. Inflammaging in aged tissues drives remodeling of the CD8+ T cell compartment. Cell Rep. 2026 May 26;45(5):117303. doi: 10.1016/j.celrep.2026.117303. © 2026 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Recommended Citation

Shchukina, Irina; Rodriguez-Hernandez, Carlos J; Ruiz, Heather S; Kleverov, Maksim; Mintz, Rachel L; Mineura, Katsutaka; Gunawardana, Subhadra C; Hsiung, Sunnie; Bhattarai, Bishan; Vachova, Veronika; Kossl, Jan; Mogilenko, Denis A; Field, Rachael L; Nguyen, Tran H; Alayo, Quazim A; Huckstep, Christopher G; Vander Wielen, Barbora; Brestoff, Jonathan R; Stewart, Sheila A; Piston, David W; Egawa, Takeshi; Kreisel, Daniel; Randolph, Gwendalyn J; and Artyomov, Maxim N, "Inflammaging in aged tissues drives remodeling of the CD8+ T cell compartment." Cell Reports. 45, 5. 117303 (2026).
https://digitalcommons.wustl.edu/oa_4/6737

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.