CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis

Authors

• Irenaeus C C Chan, Washington University School of Medicine in St. Louis
• Giulia Petrone, Washington University School of Medicine in St. Louis
• J Scott Beeler, Washington University School of Medicine in St. Louis
• Duc Tran, Washington University School of Medicine in St. Louis
• Griffen Mustion, Washington University School of Medicine in St. Louis
• Catrina Fronick, Washington University School of Medicine in St. Louis
• Carlos Cruchaga, Washington University School of Medicine in St. Louis
• Kelly L Bolton, Washington University School of Medicine in St. Louis
• et al.

Journal

Nature Genetics

Publication Date

3-1-2026

Volume

58

Issue

3

First Page

582

Last Page

592

Document Type

Open Access Publication

DOI

10.1038/s41588-026-02526-w

Rights and Permissions

Chan, I.C.C., Zhang, P., Pan, X. et al. CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis. Nat Genet 58, 582–592 (2026). https://doi.org/10.1038/s41588-026-02526-w This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Chan, Irenaeus C C; Petrone, Giulia; Beeler, J Scott; Tran, Duc; Mustion, Griffen; Fronick, Catrina; Cruchaga, Carlos; Bolton, Kelly L; and et al., "CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis." Nature Genetics. 58, 3. 582 - 592. (2026).
https://digitalcommons.wustl.edu/oa_4/7168

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.