Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease-associated immune receptor TREM2

Authors

• Hunter B Dean, University of Alabama, Birmingham
• Ryan A Tuckey, University of Alabama, Birmingham
• Rory A Greer, University of Alabama, Birmingham
• Jessica A Greven, Washington University School of Medicine in St. Louis
• Shan-Zhong Yang, University of Alabama, Birmingham
• Daniel S Elston, University of Alabama, Birmingham
• Gunnar N Eastep, University of Alabama, Birmingham
• Yuwei Song, University of Alabama, Birmingham
• Thomas J Brett, Washington University School of Medicine in St. Louis
• Yuhua Song, University of Alabama, Birmingham
• Erik D Roberson, University of Alabama, Birmingham

Journal

Neurotherapeutics

Publication Date

3-1-2026

Volume

23

Issue

2

First Page

e00867

Document Type

Open Access Publication

DOI

10.1016/j.neurot.2026.e00867

Rights and Permissions

Dean HB, Tuckey RA, Greer RA, Greven JA, Yang SZ, Elston DS, Eastep GN, Song Y, Brett TJ, Song Y, Roberson ED. Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease-associated immune receptor TREM2. Neurotherapeutics. 2026 Mar;23(2):e00867. doi: 10.1016/j.neurot.2026.e00867. © 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Recommended Citation

Dean, Hunter B; Tuckey, Ryan A; Greer, Rory A; Greven, Jessica A; Yang, Shan-Zhong; Elston, Daniel S; Eastep, Gunnar N; Song, Yuwei; Brett, Thomas J; Song, Yuhua; and Roberson, Erik D, "Cholecalciferol (vitamin D3) is an agonist of the Alzheimer's disease-associated immune receptor TREM2." Neurotherapeutics. 23, 2. e00867 (2026).
https://digitalcommons.wustl.edu/oa_4/7227

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.