Proteomic profiling identifies systemic drivers of blood-brain barrier injury in sickle cell disease

Authors

• Yan Wang, Washington University School of Medicine in St. Louis
• Serguei Astafiev, Washington University School of Medicine in St. Louis
• Jinsheng Yu, Washington University School of Medicine in St. Louis
• Slim Fellah, Washington University School of Medicine in St. Louis
• Martin N Reis, Washington University School of Medicine in St. Louis
• Vivian Chen, Washington University School of Medicine in St. Louis
• Amy E Mirro, Washington University School of Medicine in St. Louis
• Chunwei Ying, Washington University School of Medicine in St. Louis
• Kristin P Guilliams, Washington University School of Medicine in St. Louis
• Melanie E Fields, Washington University School of Medicine in St. Louis
• Allison A King, Washington University School of Medicine in St. Louis
• Yasheng Chen, Washington University School of Medicine in St. Louis
• Robert A Campbell, Washington University School of Medicine in St. Louis
• Jorge Di Paola, Washington University School of Medicine in St. Louis
• Carlos Cruchaga, Washington University School of Medicine in St. Louis
• Jin-Moo Lee, Washington University School of Medicine in St. Louis
• Hongyu An, Washington University School of Medicine in St. Louis
• Andria L Ford, Washington University School of Medicine in St. Louis

Journal

Blood

Publication Date

9-10-2026

Volume

148

Issue

11

First Page

1481

Last Page

1494

Document Type

Open Access Publication

DOI

10.1182/blood.2025032856

Rights and Permissions

Wang Y, Astafiev S, Yu J, Fellah S, Reis MN, Chen V, Mirro AE, Ying C, Guilliams KP, Fields ME, King AA, Chen Y, Campbell RA, Di Paola J, Cruchaga C, Lee JM, An H, Ford AL. Proteomic profiling identifies systemic drivers of blood-brain barrier injury in sickle cell disease. Blood. 2026 Sep 10;148(11):1481-1494. doi: 10.1182/blood.2025032856. © 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

Recommended Citation

Wang, Yan; Astafiev, Serguei; Yu, Jinsheng; Fellah, Slim; Reis, Martin N; Chen, Vivian; Mirro, Amy E; Ying, Chunwei; Guilliams, Kristin P; Fields, Melanie E; King, Allison A; Chen, Yasheng; Campbell, Robert A; Di Paola, Jorge; Cruchaga, Carlos; Lee, Jin-Moo; An, Hongyu; and Ford, Andria L, "Proteomic profiling identifies systemic drivers of blood-brain barrier injury in sickle cell disease." Blood. 148, 11. 1481 - 1494. (2026).
https://digitalcommons.wustl.edu/oa_4/7448

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.