Spatial control of parathyroid hormone receptor-1 signaling dictates ligand-specific biological outcomes

Authors

• Jakob Höppner, Harvard University
• Harald Jüppner, Harvard University
• Monica Reyes, Harvard University
• Prem Swaroop Yadav, Harvard University
• Dian Wang, University of Pennsylvania
• Thomas Dean, Harvard University
• Patrick Hanna, Harvard University
• Roberto Civitelli, Washington University School of Medicine in St. Louis
• Asuka Inoue, Tohoku University
• Ernestina Schipani, University of Pennsylvania
• Ignacio Portales-Castillo, Washington University School of Medicine in St. Louis
• Thomas J Gardella, Harvard University

Journal

Signal Transduction and Targeted Therapy

Publication Date

9-11-2026

Volume

11

Issue

1

First Page

376

Document Type

Open Access Publication

DOI

10.1038/s41392-026-02795-1

Rights and Permissions

Höppner, J., Jüppner, H., Reyes, M. et al. Spatial control of parathyroid hormone receptor-1 signaling dictates ligand-specific biological outcomes. Sig Transduct Target Ther 11, 376 (2026). https://doi.org/10.1038/s41392-026-02795-1 This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Recommended Citation

Höppner, Jakob; Jüppner, Harald; Reyes, Monica; Yadav, Prem Swaroop; Wang, Dian; Dean, Thomas; Hanna, Patrick; Civitelli, Roberto; Inoue, Asuka; Schipani, Ernestina; Portales-Castillo, Ignacio; and Gardella, Thomas J, "Spatial control of parathyroid hormone receptor-1 signaling dictates ligand-specific biological outcomes." Signal Transduction and Targeted Therapy. 11, 1. 376 (2026).
https://digitalcommons.wustl.edu/oa_4/7651

Department

ICTS (Institute of Clinical and Translational Sciences)

Additional Links

Supplemental material is available for this article at publisher site.