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Submissions from 2022

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Outcomes for patients with severe chronic neutropenia treated with granulocyte colony-stimulating factor, David C Dale, Audrey Anna Bolyard, James A Shannon, James A Connelly, Daniel C Link, Mary Ann Bonilla, and Peter E Newburger

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Mitochondrial phenotypes in genetically diverse neurodegenerative diseases and their response to mitofusin activation, Xiawei Dang, Emily K Walton, Barbara Zablocka, Robert H Baloh, Michael E Shy, and Gerald W Dorn II

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Variation in ampicillin dosing for lower respiratory tract infections and neonatal bacterial infections in US children's hospitals, Elizabeth A Daniels, Christopher C McPherson, Jason G Newland, and Brian R Lee

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Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in the C. elegans germline, Debabrata Das, Jacob Seemann, David Greenstein, Tim Schedl, and Swathi Arur

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Identification of novel genes and proteoforms in Angiostrongylus costaricensis through a proteogenomic approach, Esdras Matheus Gomes da Silva, Karina Mastropasqua Rebello, Young-Jun Choi, Vitor Gregorio, Alexandre Rossi Paschoal, Makedonka Mitreva, James H McKerrow, Ana Gisele da Costa Neves-Ferreira, and Fabio Passetti

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JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency, Jui M. Dave, Robert Mecham, and et al

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Pleiotropic effects of simvastatin and losartan in preclinical models of post-traumatic elbow contracture, Michael A David, Alex J Reiter, Chelsey L Dunham, Ryan M Castile, James A Abraham, Leanne E Iannucci, Ishani D Shah, Necat Havlioglu, Aaron M Chamberlain, and Spencer P Lake

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Circulating tumour DNA characterisation of invasive lobular carcinoma in patients with metastatic breast cancer, Andrew A Davis, Katherine Clifton, Whitney L. Hensing, Nusayba A. Bagegni, Foluso O. Ademuyiwa, Ron Bose, Cynthia X. Ma, and et al.

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Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat, Jennifer L Davis, Nitin Kumar Pokhrel, Linda Cox, Nidhi Rohatgi, Roberta Faccio, and Deborah J Veis

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WormBase in 2022-data, processes, and tools for analyzing Caenorhabditis elegans, Paul Davis, Tim Schedl, and et al

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Modifications to student quarantine policies in K-12 schools implementing multiple COVID-19 prevention strategies restores in-person education without increasing SARS-CoV-2 transmission risk, January-March 2021, Patrick Dawson, Sara Malone, Stephanie A. Fritz, Brock K. Montgomery, Mary Boyle, Brett Maricque, Albert M. Lai, Julie A. Neidich, Rachel C. Orscheln, Jason G Newland, and et al.

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Investing in late-life Brain Capital, Walter D Dawson, Eric J Lenze, and et al.

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Immune deconvolution and temporal mapping identifies stromal targets and developmental intervals for abrogating murine low-grade optic glioma formation, Amanda de Andrade Costa, Jit Chatterjee, Olivia Cobb, Elizabeth Cordell, Astoria Chao, Suzanne Schaeffer, Andrea Goldstein, Sonika Dahiya, and David H Gutmann

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Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures, Joshua T Dearborn, Hemanth R Nelvagal, Nicholas R Rensing, Keigo Takahashi, Stephanie M Hughes, Thomas M Wishart, Jonathan D Cooper, Michael Wong, and Mark S Sands

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MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques, Jeremy D DeBarry, Xuntian Jiang, Daniel S Ory, and et al.

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Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium, Gabriel A de Erausquin, Carlos Cruchaga, Igor Zwir, and et al

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Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma, John F de Groot, Albert H Kim, and et al.

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Pilot study: PARP1 imaging in advanced prostate cancer, Farrokh Dehdashti, Melissa A. Reimers, Kooresh I. Shoghi, Delphine L. Chen, Jingqin Luo, Buck Rogers, Russell K. Pachynski, Sreeja Sreekumar, Cody Weimholt, and Dong Zhou

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Semiautomated analysis of an optical ATP indicator in neurons, Taher Dehkharghanian, Arsalan Hashemiaghdam, and Ghazaleh Ashrafi

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Measurement matters: An individual differences examination of family socioeconomic factors, latent dimensions of children's experiences, and resting state functional brain connectivity in the ABCD sample, Meriah L DeJoseph, Max P Herzberg, Robin D Sifre, Daniel Berry, and Kathleen M Thomas

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An approach for evaluating the effects of dietary fiber polysaccharides on the human gut microbiome and plasma proteome, Omar Delannoy-Bruno, Chandani Desai, Ruteja A Barve, Jiye Cheng, Nathan Han, Stacey Marion, Andrew C Heath, Michael J Barratt, Jeffrey I Gordon, and et al

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The future of AD clinical trials with the advent of anti-amyloid therapies: An CTAD Task Force report, J Delrieu, R J Bateman, J Touchon, M Sabbagh, and J Cummings

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FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells, Pan-Yue Deng, Ajeet Kumar, Valeria Cavalli, and Vitaly A Klyachko

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A short-term multicenter analysis of radiolucent lines in a single uncemented rotating platform implant for total knee arthroplasty, Jason Desmarais, David Dalury, Thomas L. Bernasek, David A. Fisher, Ryan M. Nunley, Marie-Claire Fickenscher, and Robert S Gorab

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Association of male hypogonadism with risk of hospitalization for COVID-19, Sandeep Dhindsa, Cosette Champion, Ekamjit Deol, Matthew Lui, Robert Campbell, Jennifer Newman, Aparna Yeggalam, Srikanth Nadella, Vaishaliben Ahir, Ekta Shrestha, Thomas Kannampallil, and Abhinav Diwan

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HDL composition, heart failure, and its comorbidities, Ahmed Diab, Carla Valenzuela Ripoll, Zhen Guo, and Ali Javaheri

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Choline, DHA, and diarrheal disease associated with growth faltering in a case-control study, Jenna N Diaz, Sherlie Jean Louis Dulience, Noah Wolthausen, Xuntian Jiang, Emmanuel Gyimah, Francesca J Marhône Pierre, F Matthew Kuhlmann, and Lora L Iannotti

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Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites, Noah M. Dietzen, Mark J. Arcario, Lawrence J. Chen, John T. Petroff, K. Trent Moreland, Kathiresan Krishnan, Grace Brannigan, Douglas F. Covey, and Wayland W.I. Cheng

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American Cochlear Implant Alliance Task Force guidelines for clinical assessment and management of adult cochlear implantation for single-sided deafness, Margaret T. Dillon, Armine Kocharyan, Ghazal S. Daher, Matthew L. Carlson, William H. Shapiro, Hillary A. Snapp, and Jill B. Firszt

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Comparative proteomics of adult Paragonimus kellicotti excretion/secretion products released in vitro or present in the lung cyst nodule, Lucia S. Di Maggio, Kurt C. Curtis, Petra Erdmann-Gilmore, Robert S. W. Sprung, R. Reid Townsend, Gary J. Weil, and Peter U. Fischer

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RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells, Orsola Di Martino, Margaret A. Ferris, Gayla Hadwiger, Soyi Sarkar, Anh Vu, María P. Menéndez-Gutiérrez, Mercedes Ricote, and John S Welch

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An overview of treatment options for patients with relapsed/refractory multiple myeloma and renal impairment, Meletios A Dimopoulos, Joseph Mikhael, Evangelos Terpos, Xavier Leleu, Philippe Moreau, Joan Bladé, Jin Seok Kim, Keith Stockerl-Goldstein, and Paul G Richardson

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Macrophage depletion blocks congenital SARM1-dependent neuropathy, Caitlin B Dingwall, Amy Strickland, Sabrina W Yum, Aldrin Ky Yim, Jian Zhu, Peter L. Wang, Yurie Yamada, Robert E. Schmidt, Yo Sasaki, A. Joseph Bloom, Aaron DiAntonio, and Jeffrey Milbrandt

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Association of molecular senescence markers in late-life depression with clinical characteristics and treatment outcome, Breno S Diniz, Benoit H Mulsant, Charles F Reynolds, Daniel M Blumberger, Jordan F Karp, Meryl A Butters, Ana Paula Mendes-Silva, Erica L Vieira, George Tseng, and Eric J Lenze

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Genomic surveillance of clinical Pseudomonas aeruginosa isolates reveals an additive effect of carbapenemase production on carbapenem resistance, Luke Diorio-Toth, Sidra Irum, Robert F Potter, Meghan A Wallace, Muhammad Arslan, Tehmina Munir, Saadia Andleeb, Carey-Ann D Burnham, and Gautam Dantas

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Hydroxychloroquine/chloroquine for the treatment of hospitalized patients with COVID-19: An individual participant data meta-analysis, Leon Di Stefano, Jane A. O'Halloran, Adriana M. Rauseo, and et al

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Cardiovascular tropism and sequelae of SARS-CoV-2 infection, Oleksandr Dmytrenko and Kory J Lavine

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The metabolism of human soluble Amyloid Precursor Protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method, Justyna A Dobrowolska Zakaria, Randall J Bateman, Monika Lysakowska, Ammaarah Khatri, Dinorah Jean-Gilles, Matthew E Kennedy, and Robert Vassar

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Challenges and progress in research, diagnostics, and therapeutics in Alzheimer's disease and related dementias, Nikolay V Dokholyan, Richard C Mohs, and Randall J Bateman

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Diptoindonesin G is a middle domain HSP90 modulator for cancer treatment, Kristine Donahue, Haibo Xie, Miyang Li, Ang Gao, Min Ma, Yidan Wang, Rose Tipton, Nicole Semanik, Tina Primeau, Shunqiang Li, Lingjun Li, Weiping Tang, and Wei Xu

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A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells, Chen Dong, Shuhua Fu, Rowan M Karvas, Brian Chew, Laura A Fischer, Xiaoyun Xing, Jessica K Harrison, Pooja Popli, Ramakrishna Kommagani, Ting Wang, Bo Zhang, and Thorold W Theunissen

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A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells, Chen Dong, Shuhua Fu, Rowan M Karvas, Brian Chew, Laura A Fischer, Xiaoyun Xing, Jessica K Harrison, Pooja Popli, Ramakrishna Kommagani, Ting Wang, Bo Zhang, and Thorold W Theunissen

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Whole-exome sequencing reveals damaging gene variants associated with hypoalphalipoproteinemia, Weilai Dong, Sheng Chih Jin, and et al.

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Mutation spectrum of congenital heart disease in a consanguineous Turkish population, Weilai Dong, Hande Kaymakcalan, Sheng Chih Jin, Nicholas S Diab, Cansaran Tanıdır, Ali Seyfi Yalim Yalcin, A Gulhan Ercan-Sencicek, Shrikant Mane, Murat Gunel, Richard P Lifton, Kaya Bilguvar, and Martina Brueckner

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Coordination of sustainable financing for evidence-based youth mental health treatments: Protocol for development and evaluation of the fiscal mapping process, Alex R Dopp, Marylou Gilbert, Jane Silovsky, Jeanne S Ringel, Susan Schmidt, Beverly Funderburk, Ashley Jorgensen, Byron J Powell, Douglas A Luke, David Mandell, Daniel Edwards, Mellicent Blythe, and Dana Hagele

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Integrating the OHIF Viewer into XNAT: Achievements, challenges and prospects for quantitative imaging studies, Simon J. Doran, Woonchan Cho, Dan Marcus, and et al

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Predicting mitochondrial dynamic behavior in genetically defined neurodegenerative diseases, Gerald W Dorn II and Xiawei Dang

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Nuclear morphometry and chromatin texture changes in hepatocellular carcinoma samples may predict outcomes of liver transplanted patients, Jordan Boeira Dos Santos, Rodrigo Tzovenos Starosta, Emily Ferreira Salles Pilar, Jefferson Daniel Kunz, Joelson Tomedi, Carlos Thadeu Schmidt Cerski, and Rúbia Denise Ruppenthal

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Can the "female protective effect" liability threshold model explain sex differences in autism spectrum disorder?, Joseph D Dougherty, Natasha Marrus, Susan E Maloney, Benjamin Yip, Sven Sandin, Tychele N Turner, Din Selmanovic, Kristen L Kroll, David H Gutmann, John N Constantino, and Lauren A Weiss

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Inhibiting Mycobacterium abscessus cell wall synthesis: Using a novel diazabicyclooctane β-lactamase inhibitor to augment β-lactam action, Khalid M Dousa, David C Nguyen, Sebastian G Kurz, Magdalena A Taracila, Christopher R Bethel, William Schinabeck, Barry N Kreiswirth, Sheldon T Brown, W Henry Boom, Richard S Hotchkiss, Kenneth E Remy, Frank J Jacono, Charles L Daley, Steven M Holland, Alita A Miller, and Robert A Bonomo

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A pharmacokinetic analysis of tobramycin in patients less than five years of age with cystic fibrosis: Assessment of target attainment with extended-interval dosing through simulation, Kevin J Downes, Austyn Grim, Laura Shanley, Ronald C Rubenstein, Athena F Zuppa, and Marc R Gastonguay

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Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus, Jeffrey Downey, Haley E Randolph, Erwan Pernet, Kim A Tran, Shabaana A Khader, Irah L King, Luis B Barreiro, and Maziar Divangahi

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Isolation of a potently neutralizing and protective human monoclonal antibody targeting yellow fever virus, Michael P Doyle, Joseph R Genualdi, Adam L Bailey, Nurgun Kose, Christopher Gainza, Jessica Rodriguez, Kristen M Reeder, Christopher A Nelson, Prashant N Jethva, Rachel E Sutton, Robin G Bombardi, Michael L Gross, Justin G Julander, Daved H Fremont, Michael S Diamond, and James E Crowe

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Strategies to achieve breast health equity in the St. Louis region and beyond over 15+ years, Bettina Drake, Aimee James, Heidi Miller, Akila Anandarajah, Kia L Davis, Sheryll Jackson, Graham A Colditz, and Vetta Sanders Thompson

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A phase I first-in-human study of ABBV-383, a B-cell maturation antigen × CD3 bispecific T-cell redirecting antibody, in patients with relapsed/refractory multiple myeloma, Anita D'Souza, Ravi Vij, and et al.

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Functional characterization of enhancer activity during a long terminal repeat's evolution, Alan Y Du, Xiaoyu Zhuo, Vasavi Sundaram, Nicholas O Jensen, Hemangi G Chaudhari, Nancy L Saccone, Barak A Cohen, and Ting Wang

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Impact of updated clinical practice guidelines on outpatient treatment for Clostridioides difficile infection and associated clinical outcomes, Erik R Dubberke, Justin T Puckett, Engels N Obi, Sachin Kamal-Bahl, Kaushal Desai, Bruce Stuart, and Jalpa A Doshi

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Risk of early versus later rebleeding from dural arteriovenous fistulas with cortical venous drainage, Andrew J Durnford, Ridhima Guniganti, Akash P Kansagra, Gregory J Zipfel, and et al

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Evolution of multiple domains of the HIV-1 envelope glycoprotein during coreceptor switch with CCR5 antagonist therapy, Yueqi Du, Ellen Wu, Xiang Gao, Jie Zhang, John C Martin, Bruce A Rosa, Makedonka Mitreva, and Lee Ratner

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Stakeholder engagement in eight comparative effectiveness trials in African Americans and Latinos with asthma, Tiffany Dy, Winifred J Hamilton, C Bradley Kramer, Andrea Apter, Jerry A Krishnan, James W Stout, Stephen J Teach, Alex Federman, John Elder, Tyra Bryant-Stephens, Rebecca J Bruhl, Shawni Jackson, and Kaharu Sumino

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Trial of Ultrasound guided carpal tunnel release versus Traditional Open Release (TUTOR), Kyle R. Eberlin, Christopher J. Dy, Mark D. Fischer, James L. Gluck, F. Thomas D. Kaplan, Thomas J. McDonald, Larry E. Miller, Alexander Palmer, Marc E. Walker, and James F. Watt

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Development and validation of a novel anaerobic carbapenem inactivation method (Ana-CIM) for the detection of carbapenemase production in Bacteroides fragilis, Allison R Eberly, Meghan A Wallace, Samantha Shannon, Angela K Heitman, Audrey N Schuetz, Carey-Ann D Burnham, and Sophonie Jean

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Control of aging by the renin-angiotensin system: A review of C. elegans, Drosophila, and mammals, Brian M Egan, Andrea Scharf, Franziska Pohl, and Kerry Kornfeld

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Characteristics of antifungal utilization for hospitalized children in the United States, Lourdes Eguiguren, Brian R Lee, Jason G Newland, Matthew P Kronman, Adam L Hersh, Jeffrey S Gerber, Grace M Lee, and Hayden T Schwenk

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Plasma neurofilament light chain levels are elevated in children and young adults with Wolfram syndrome, Sarah A Eisenstein, Raveena S Boodram, Courtney L Sutphen, Heather M Lugar, Brian A Gordon, Bess A Marshall, Fumihiko Urano, Anne M Fagan, and Tamara Hershey

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Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease, Jaclyn M Eissman, Carlos Cruchaga, and et al.

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Persistence of onchocerciasis in villages in Enugu and Ogun states in Nigeria following many rounds of mass distribution of ivermectin, Uwem F Ekpo, Obiora A Eneanya, Edith N Nwankwo, Islamiat Y Soneye, Gary J Weil, Peter U Fischer, and Obioma C Nwaorgu

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Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease, Mohamed Elagawany, Ayman Abo Elmaaty, Ahmed Mostafa, Noura M Abo Shama, Eman Y Santali, Bahaa Elgendy, and Ahmed A Al-Karmalawy

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Importance of CSF-based Aβ clearance with age in humans increases with declining efficacy of blood-brain barrier/proteolytic pathways, Donald L Elbert, Bruce W Patterson, Brendan P Lucey, Tammie L S Benzinger, and Randall J Bateman

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SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice, Salima El Chehadeh, Dorothy K Grange, and et al

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Shiny GATOM: Omics-based identification of regulated metabolic modules in atom transition networks, Mariia Emelianova, Anastasiia Gainullina, Nikolay Poperechnyi, Alexander Loboda, Maxim Artyomov, and Alexey Sergushichev

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Community-based trial assessing the impact of annual versus semiannual mass drug administration with ivermectin plus albendazole and praziquantel on helminth infections in northwestern Liberia, Obiora A Eneanya, Lincoln Gankpala, Charles W Goss, Aaron T Momolu, Enoch S Nyan, Emmanuel B Gray, Kerstin Fischer, Kurt Curtis, Fatorma K Bolay, Gary J Weil, and Peter U Fischer

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Altered Peroxisome Proliferator-Activated Receptor alpha signaling in variably diseased peripheral arterial segments, Connor Engel, Rodrigo Meade, Nikolai Harroun, Amanda Penrose, Mehreen Shafqat, Xiaohua Jin, Gayan DeSilva, Clay Semenkovich, and Mohamed Zayed

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Accuracy of chest computed tomography in distinguishing cystic pleuropulmonary blastoma from benign congenital lung malformations in children, Abigail J Engwall-Gill, Jacqueline M Saito, Rebecca L Hulett Bowling, and et al.

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Association of the receptor for activated C-kinase 1 with ribosomes in Plasmodium falciparum, Jessey Erath and Sergej Djuranovic

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A virtual community of practice: An international educational series in pediatric neurocritical care, Jennifer C Erklauer, Jennifer L Griffith, Kristin P Guilliams, and Et al

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Adolescent and young adult preferences for financial incentives to support adherence to antiretroviral therapy in Kenya: A mixed methods study, Ingrid Eshun-Wilson, Eliud Akama, Fridah Adhiambo, Zachary Kwena, Bertha Oketch, Sarah Obatsa, Sarah Iguna, Jayne L Kulzer, James Nyanga, Everlyne Nyandieka, Ally Scheve, Elvin H Geng, Elizabeth A Bukusi, and Lisa Abuogi

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A Living Database of HIV Implementation Research (LIVE project): Protocol for rapid living reviews, Ingrid Eshun-Wilson, Nathan Ford, Noelle Le Tourneau, Stefan Baral, Sheree Schwartz, Christopher Kemp, and Elvin Geng

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Dietary patterns are associated with improved ovarian reserve in overweight and obese women: A cross-sectional study of the Lifestyle and Ovarian Reserve (LORe) cohort, Ashley M Eskew, Bronwyn S Bedrick, Jorge E Chavarro, Joan K Riley, and Emily S Jungheim

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A whole-genome sequencing study implicates GRAMD1B in multiple sclerosis susceptibility, Federica Esposito, Bryan Bollman, Laura Piccio, and et al.

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Prostate cancer therapy personalization via multi-modal deep learning on randomized phase III clinical trials, Andre Esteva, Jeff M Michalski, and et al

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LINC00355 regulates p27 KIP expression by binding to MENIN to induce proliferation in late-stage relapse breast cancer, Abdallah M Eteleeb, Prasanth K Thunuguntla, Kyla Z Gelev, Emily B Rozycki, Alexander Miller, Reyka G Jayasinghe, Ha X Dang, Nicole M White, Li Ding, Jessica M Silva-Fisher, Christopher A Maher, and et al

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Targeting the autophagy-lysosome pathway in a pathophysiologically relevant murine model of reversible heart failure, Sarah Evans, Xiucui Ma, Xiqiang Wang, Yana Chen, Chen Zhao, Carla J Weinheimer, Attila Kovacs, Brian Finck, Abhinav Diwan, and Douglas L Mann

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Perceptions of telemedicine and costs incurred by a visit to a general infectious diseases clinic: A survey, Emily C. Evers, Stephanie A. Fritz, Graham A. Colditz, and Jason P. Burnham

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Genome scanning of behavioral selection in a canine olfactory detection breeding cohort, Alexander W Eyre, Isain Zapata, Elizabeth Hare, Katharine M N Lee, Claire Bellis, Jennifer L Essler, Cynthia M Otto, James A Serpell, and Carlos E Alvarez

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Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction, Lubov A. Ezerskiy, Kathleen M. Schoch, Chihiro Sato, Mariana Beltcheva, Kanta Horie, Frank Rigo, Ryan Martynowicz, Celeste M. Karch, Randall J. Bateman, and Timothy M. Miller

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Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations, Mina Farag, Samuel R Cohen, Wade M Borcherds, Anne Bremer, Tanja Mittag, and Rohit V Pappu

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Program adaptation by health departments, Louise Farah Saliba, Peg Allen, Stephanie L Mazzucca, Emily Rodriguez Weno, Sarah Moreland-Russell, Margaret Padek, and Ross C Brownson

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Subcortical-cortical dynamical states of the human brain and their breakdown in stroke, Chiara Favaretto, Michele Allegra, Gustavo Deco, Nicholas V Metcalf, Joseph C Griffis, Gordon L Shulman, Andrea Brovelli, and Maurizio Corbetta

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Failed targeted muscle reinnervation: Findings at revision surgery and concepts for success, John M Felder, Stahs Pripotnev, Ivica Ducic, Rachel Skladman, Austin Y Ha, and Mitchell A Pet

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The SIEA SHRIMP flap: An ultrathin axial pattern free flap useable in obese patients, John M Felder 3rd, Brooke E Willborg, and William Y Zhu

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Measuring retention within the adolescent brain cognitive development (ABCD)SM study, Sarah W Feldstein Ewing, Genevieve F Dash, Wesley K Thompson, Chase Reuter, Vanessa G Diaz, Andrey Anokhin, Linda Chang, Linda B Cottler, Gayathri J Dowling, Kimberly LeBlanc, Robert A Zucker, Susan F Tapert, Sandra A Brown, and Hugh Garavan

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First-in-human, open-label, phase 1/2 study of the monoclonal antibody programmed cell death protein-1 (PD-1) inhibitor cetrelimab (JNJ-63723283) in patients with advanced cancers, Enriqueta Felip, Daniel Morgensztern, and et al.

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Accumulation of copy-back viral genomes during respiratory syncytial virus infection is preceded by diversification of the copy-back viral genome population followed by selection, Sébastien A Felt, Emna Achouri, Sydney R Faber, and Carolina B López

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Transgenic force sensors and software to measure force transmission across the mammalian nuclear envelope in vivo, Kelli D Fenelon, Evan Thomas, Mohammad Samani, Min Zhu, Hirotaka Tao, Yu Sun, Helen McNeill, and Sevan Hopyan

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Modification of neurogenic colonic motor behaviours by chemogenetic ablation of calretinin neurons, Jing Feng, Tim J Hibberd, Jialie Luo, Pu Yang, Zili Xie, Lee Travis, Nick J Spencer, and Hongzhen Hu

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The differences in the susceptibility patterns to triclabendazole sulfoxide in field isolates of Fasciola hepatica are associated with geographic, seasonal, and morphometric variations, Martha V Fernandez-Baca, Cristian Hoban, Rodrigo A Ore, Pedro Ortiz, Young-Jun Choi, César Murga-Moreno, Makedonka Mitreva, and Miguel M Cabada

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Self-hybridization in Leishmania major, Tiago R Ferreira, Ehud Inbar, Jahangheer Shaik, Brendan M Jeffrey, Kashinath Ghosh, Deborah E. Dobson, Stephen M. Beverley, and David Sacks

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Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay, Sara M Fielder, Jill A Rosenfeld, Lindsay C Burrage, Lisa Emrick, Seema Lalani, Ruben Attali, Joshua N Bembenek, Hieu Hoang, Dustin Baldridge, Gary A Silverman, Undiagnosed Diseases Network, Tim Schedl, and Stephen C Pak

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Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19, Daniel Clark Files, Frank Tacke, Alexandra O'Sullivan, Patrick Dorr, William G. Ferguson, and William G. Powderly