Submissions from 2021
Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice, Sanghyun P Kim, Sridhar N Srivatsan, Monique Chavez, Cara L Shirai, Brian S White, Tanzir Ahmed, Michael O Alberti, Jin Shao, Ryan Nunley, Lynn S White, Jeff Bednarski, John R Pehrson, and Matthew J Walter
Self-reported positive impact of mentored clinical research training is associated with academic success in hematology, Allison A. King, Sara K. Vesely, Grace Dadzie, Cecelia Calhoun, Adam Cuker, Wendy Stock, Alison Walker, Josel Fritz, and Lilian Sung
Predicting self-intercepted medication ordering errors using machine learning, Christopher Ryan King, Joanna Abraham, Bradley A. Fritz, Zhicheng Cui, William Galanter, Yixin Chen, and Thomas Kannampallil
Predicting alcohol use disorder remission: A longitudinal multimodal multi-featured machine learning approach, Sivan Kinreich, Vivia V. McCutcheon, Jessica L. Bourdon, Andrey P. Anokhin, Kathleen K. Bucholz, Meredith W. Francis, and et al.
Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans, Holly E. Kinser, Matthew C. Mosley, Isaac B. Plutzer, and Zachary Pincus
The effect of convalescent plasma therapy on mortality among patients with COVID-19: Systematic review and meta-analysis, Stephen A Klassen, Brenda J Grossman, Jeffrey P Henderson, and et al
Convalescent plasma therapy for COVID-19: A graphical mosaic of the worldwide evidence, Stephen A Klassen, Brenda J Grossman, Jeffrey P Henderson, and et al.
Encephalitic arboviruses of Africa: Emergence, clinical presentation and neuropathogenesis, Robyn S Klein
CT findings and patterns of e-cigarette or vaping product use-associated lung injury: A multicenter cohort of 160 cases, Seth J Kligerman, Constantine A Raptis, Kaitlin M Marquis, and et al.
Clinical prediction rule for SARS-CoV-2 infection from 116 U.S. emergency departments 2-22-2021, Jeffrey A. Kline, Stacey House, and et al.
Riociguat: Clinical research and evolving role in therapy, James R Klinger, Murali M Chakinala, David Langleben, Stephan Rosenkranz, and Olivier Sitbon
Idiopathic non-cirrhotic portal hypertension and porto-sinusoidal vascular disease: Review of current data, Michel Kmeid, Xiuli Liu, Samuel Ballentine, and Hwajeong Lee
Opening of a cryptic pocket in β-lactamase increases penicillinase activity, Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, and Gregory R Bowman
Commonalities across computational workflows for uncovering explanatory variants in undiagnosed cases, Shilpa Nadimpalli Kobren, Dustin Baldridge, Daniel J Wegner, Alexander J Paul, and et al.
Lack of association between acute stroke, post-stroke dementia, race, and β-amyloid status, Lauren N Koenig, Lena M McCue, Elizabeth Grant, Parinaz Massoumzadeh, Catherine M Roe, Chengjie Xiong, Krista L Moulder, Liang Wang, Allyson R Zazulia, Peggy Kelly, Aylin Dincer, Aiad Zaza, Joshua S Shimony, Tammie L S Benzinger, and John C Morris
Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan, Shinsuke Koike, Matthew F Glasser, David C Van Essen, and et al
Live imaging reveals the cellular events downstream of SARM1 activation, Kwang Woo Ko, Laura Devault, Yo Sasaki, Jeffrey Milbrandt, and Aaron DiAntonio
Function of mammalian M-cones depends on the level of CRALBP in Müller cells, Alexander V. Kolesnikov, Philip D. Kiser, Krzysztof Palczewski, and Vladimir J. Kefalov
Timing of antibiotic therapy in the ICU, Marin H Kollef, Andrew F Shorr, Matteo Bassetti, Jean-Francois Timsit, Scott T Micek, Andrew P Michelson, and Jose Garnacho-Montero
Test-retest reliability of neural correlates of response inhibition and error monitoring: An fMRI study of a stop-signal task, Ozlem Korucuoglu, Michael P Harms, Serguei V Astafiev, Semyon Golosheykin, James T Kennedy, Deanna M Barch, and Andrey P Anokhin
RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease, Robyn Laura Kosinsky, Maria Zerche, Rodney D Newberry, and et al
A role for IL-33-activated ILC2s in eosinophilic vasculitis, Maya E Kotas, Jérémie Dion, Steven Van Dyken, Roberto R Ricardo-Gonzalez, Claire J Danel, Camille Taillé, Luc Mouthon, Richard M Locksley, and Benjamin Terrier
Computerized tumor multinucleation index (MuNI) is prognostic in p16+ oropharyngeal carcinoma, Can F Koyuncu, Wade L Thorstad, R D Chernock, Jingqin Luo, and et al
Dengue and the lectin pathway of the complement system, Romchat Kraivong, Nuntaya Punyadee, M Kathryn Liszewski, John P Atkinson, and Panisadee Avirutnan
Microbiota signals suppress B lymphopoiesis with aging in mice, Joseph R Krambs, Darlene A Monlish, Feng Gao, Laura G Schuettpelz, and Daniel C Link
How do social needs cluster among low-income individuals?, Matthew W. Kreuter, Rachel Garg, Linda Li, Laura McNulty, Tess Thompson, Amy McQueen, and Alina A. Luke
Racial residential segregation and colorectal cancer mortality in the Mississippi Delta Region, Aaron J Kruse-Diehr, Justin T McDaniel, Marquita W Lewis-Thames, Aimee S James, and Musa Yahaya
Report dose-to-medium in clinical trials where available; A consensus from the Global Harmonisation Group to maximize consistency, Stephen F Kry, Jeff Michalski, and et al.
Contribution of noncanonical antigens to virulence and adaptive immunity in human infection with enterotoxigenic E. coli, F.M. Kuhlmann, R.O. Laine, S. Afrin, R. Nakajima, M. Akhtar, T. Vickers, K. Parker, N.N. Nizam, V. Grigura, C.W. Goss, P. L. Felgner, D. A. Rasko, F. Qadri, and J. M. Fleckenstein
Machine learning for modeling the progression of Alzheimer disease dementia using clinical data: A systematic literature review, Sayantan Kumar, Inez Oh, Suzanne Schindler, Albert M Lai, Philip R O Payne, and Aditi Gupta
Isolation and characterization of a novel bacteriophage WO from Allonemobius socius crickets in Missouri, Jonah Kupritz, John Martin, Kerstin Fischer, Kurt C. Curtis, Joseph R. Fauver, Yuefang Huang, Young-Jun Choi, Wandy L. Beatty, Makedonka Mitreva, and Peter U. Fischer
Genomic risk prediction for breast cancer in older women, Paul Lacaze, Yin Cao, and et al
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability, Vasiliki Lagou, Ping An, Michael A. Province, and et al.
Weight and body mass index change after switching to integrase inhibitors or tenofovir alafenamide among women living with HIV, Cecile D. Lahiri, Jane O'Halloran, and et al
Machine learning analytics of resting-state functional connectivity predicts survival outcomes of glioblastoma multiforme patients, Bidhan Lamichhane, Andy G S Daniel, John J Lee, Daniel S Marcus, Joshua S Shimony, and Eric C Leuthardt
Multi-modal biomarkers of low back pain: A machine learning approach, Bidhan Lamichhane, Dinal Jayasekera, Rachel Jakes, Matthew F Glasser, Justin Zhang, Chunhui Yang, Derayvia Grimes, Tyler L Frank, Wilson Z Ray, Eric C Leuthardt, and Ammar H Hawasli
Functional disruptions of the brain in low back pain: A potential imaging biomarker of functional disability, Bidhan Lamichhane, Dinal Jayasekera, Rachel Jakes, Wilson Z Ray, Eric C Leuthardt, and Ammar H Hawasli
Are Fc gamma receptor polymorphisms important in HIV-1 infection outcomes and latent reservoir size?, Helena Lamptey, Evelyn Y Bonney, Bright Adu, and George B Kyei
Calcium carbonate nanoparticles stimulate cancer cell reprogramming to suppress tumor growth and invasion in an organ‑on‑a‑chip system, Sandra F. Lam, Kevin W. Bishop, Rachel Mintz, Lei Fang, and Samuel Achilefu
Friends and foes: Extracellular vesicles in aging and rejuvenation, Brian V Lananna and Shin-Ichiro Imai
Estimating the effects of race and social vulnerability on hospital admission and mortality from COVID-19, Joshua M Landman, Karen Steger-May, Karen E Joynt Maddox, Gmerice Hammond, Aditi Gupta, Adriana M Rauseo, Min Zhao, and Randi E Foraker
Microbiota restoration reduces antibiotic-resistant bacteria gut colonization in patients with recurrent Clostridioides difficile infection from the open-label PUNCH CD study, Amy Langdon, Drew J Schwartz, Christopher Bulow, Xiaoqing Sun, Tiffany Hink, Kimberly A Reske, Courtney Jones, Carey-Ann D Burnham, Erik R Dubberke, Gautam Dantas, and CDC Prevention Epicenter Program
Trajectory of long-term outcome in severe pediatric diffuse axonal injury: An exploratory study, Shih-Shan Lang, Todd Kilbaugh, Stuart Friess, Susan Sotardi, Chong Tae Kim, Vanessa Mazandi, Bingqing Zhang, Phillip B Storm, Gregory G Heuer, Alexander Tucker, Steve B Ampah, Heather Griffis, Ramesh Raghupathi, and Jimmy W Huh
Adolescent animal product intake in relation to later prostate cancer risk and mortality in the NIH-AARP Diet and Health Study, Tuo Lan, Yikyung Park, Graham A Colditz, Jingxia Liu, Rashmi Sinha, Molin Wang, Kana Wu, Edward Giovannucci, and Siobhan Sutcliffe
Pre-clinical common data elements for traumatic brain injury research: Progress and use cases, Michelle C. LaPlaca, Stuart H. Friess, and et al.
Redox-responsive hyaluronic acid-based nanogels for the topical delivery of the visual chromophore to retinal photoreceptors, Amine M. Laradji, Alexander V. Kolesnikov, Bedia B. Karakoçak, Vladimir J. Kefalov, and Nathan Ravi
Analysis of post-transplant lymphoproliferative disorder (PTLD) outcomes with Epstein-Barr virus (EBV) assessments-a single tertiary referral center experience and review of literature, Eric Lau, Lawrence Liu, and et al
Adrenal vein sampling for ACTH-producing pheochromocytomas, Nicholas Leader, Alexander Ushinsky, and Christopher D Malone
A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection, Tania Lebratti, Ying Shiang Lim, Adjoa Cofie, Prabhakar Andhey, Xiaoping Jiang, Jason Scott, Maria Rita Fabbrizi, Ayşe Naz Ozantürk, Christine Pham, Regina Clemens, Maxim Artyomov, Mary Dinauer, and Haina Shin
Predicting mortality risk for preterm infants using random forest, Jennifer Lee, Jinjin Cai, Fuhai Li, and Zachary A. Vesoulis
Cardiac stereotactic ablative radiotherapy for control of refractory ventricular tachycardia: Initial UK multicentre experience, Justin Lee, Clifford Robinson, Phillip Cuculich, Geoffrey Hugo, and et al
Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota, Sanghyun Lee, Gowri Kalugotla, Harshad Ingle, Rachel Rodgers, Yating Wang, Yuhao Li, Nicolette R Borella, Hongju Deng, Lindsay Droit, Ryan Hill, Stefan T Peterson, Chandni Desai, Dylan Lawrence, Megan T Baldridge, and et al
Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis, Whasil Lee, Robert J. Nims, Alireza Savadipour, Qiaojuan Zhang, Holly A. Leddy, Fang Liu, Amy L. McNulty, Yong Chen, Farshid Guilak, and Wolfgang B. Liedtke
Rectal cancer treatment management: Deep-learning neural network based on photoacoustic microscopy image outperforms histogram-feature-based classification, Xiandong Leng, Eghbal Amidi, Sitai Kou, Hassam Cheema, Ebunoluwa Otegbeye, William Chapman Jr, Matthew Mutch, and Quing Zhu
Evaluation of patient-reported delays and affordability-related barriers to care in head and neck cancer, Nicholas R Lenze, Jeannette T Bensen, Laura Farnan, Siddharth Sheth, Jose P Zevallos, Wendell G Yarbrough, and Adam M Zanation
Teaching for implementation: A framework for building implementation research and practice capacity within the translational science workforce, Aaron L Leppin, Ana A Baumann, Maria E Fernandez, Brittany N Rudd, Kathleen R Stevens, David O Warner, Bethany M Kwan, and Rachel C Shelton
Exploring intentional medication non-adherence in patients with systemic lupus erythematosus: The role of physician-patient interactions, Jerik Leung, Elizabeth A Baker, and Alfred H J Kim
Development of a digital toolkit to improve quality of life of patients with systemic lupus erythematosus, Jerik Leung, Laura Kloos, Alfred H Kim, and Elizabeth A Baker
Defining surgical terminology and risk for brain computer interface technologies, Eric C Leuthardt, Daniel W Moran, and Tim R Mullen
Evaluation of diffusion-weighted MRI and geometric distortion on a 0.35T MR-LINAC at multiple gantry angles, Benjamin Lewis, Anamaria Guta, Stacie Mackey, H Michael Gach, Sasa Mutic, Olga Green, and Taeho Kim
Epigenetic regulation during human cortical development: Seq-ing answers from the brain to the organoid, Emily M A Lewis, Komal Kaushik, Luke A Sandoval, Irene Antony, Sabine Dietmann, and Kristen L Kroll
Predictors of annual prostate-specific antigen (PSA) screening among black men: Results from an urban community-based prostate cancer screening program, Marquita W. Lewis-Thames, Saira Khan, Veronica Hicks, and Bettina F. Drake
Developmental variation in testosterone: Cortisol ratio alters cortical- and amygdala-based cognitive processes, Jimin Lew, Sherri Lee Jones, Christina Caccese, Isobel Orfi, Charlotte Little, Kelly N Botteron, James T McCracken, and Tuong-Vi Nguyen
Effect of a novel smartphone application on breastfeeding rates among low-income, first-time mothers intending to exclusively breastfeed: Secondary analysis of a randomized controlled trial, Adam K. Lewkowitz, Julia D. López, Erika F. Werner, Megan L. Ranney, George A. Macones, Dwight J. Rouse, David A. Savitz, and Alison G. Cahill
Tofacitinib, an oral Janus kinase inhibitor: Analysis of malignancy (excluding nonmelanoma skin cancer) events across the ulcerative colitis clinical program, Gary R Lichtenstein, Gerhard Rogler, Matthew A Ciorba, Chinyu Su, Gary Chan, Ronald D Pedersen, Nervin Lawendy, Daniel Quirk, Chudy I Nduaka, Andrew J Thorpe, and Julian Panés
Endoplasmic reticulum-associated biomarkers for molecular phenotyping of rare kidney disease, Chuang Li and Ying Maggie Chen
Suspected metal allergy and femoral loosening after total knee arthroplasty: A diagnostic dilemma, Elizabeth G Lieberman, Robert L Barrack, and Thomas P Schmalzried
Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide, Sook-Lei Liew, Catherine E Lang, Anup K Bhattacharya, and et al.
Physical activity, weight, and outcomes in patients receiving chemotherapy for metastatic breast cancer (C40502/Alliance), Jennifer A. Ligibel, Luke Huebner, Hope S. Rugo, Harold J. Burstein, Debra L. Toppmeyer, Carey K. Anders, Cynthia Ma, William T. Barry, Vera Suman, Lisa A. Carey, Ann H. Partridge, Clifford A. Hudis, and Eric P. Winer
Bidirectional regulation of glial potassium buffering - glioprotection versus neuroprotection, Hailun Li, Lorenzo Lones, and Aaron DiAntonio
Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases, Huifangjie Li, William C. Knight, and Jinbin Xu
Associations between education and dementia in the Caribbean and the United States: An international comparison, Jing Li, Jorge J Llibre-Guerra, Amal Harrati, Jordan Weiss, Ivonne Z Jiménez-Velázquez, Daisy Acosta, Juan de Jesús Llibre-Rodriguez, Mao-Mei Liu, and William H Dow
Colonoscopy polyp detection and classification: Dataset creation and comparative evaluations, Kaidong Li, Mohammad I. Fathan, Krushi Patel, Tianxiao Zhang, Cuncong Zhong, Ajay Bansal, Amit Rastogi, Jean S. Wang, and Guanghui Wang
Improved integration of single-cell transcriptome and surface protein expression by LinQ-View, Lei Li, Christopher Nelson, Daved H Fremont, and et al.
Optimized polyepitope neoantigen DNA vaccines elicit neoantigen-specific immune responses in preclinical models and in clinical translation, Lijin Li, Xiuli Zhang, Xiaoli Wang, Samuel W Kim, John M Herndon, Michelle K Becker-Hapak, Beatriz M Carreno, Nancy B Myers, Mark A Sturmoski, Michael D McLellan, Christopher A Miller, Tanner M Johanns, Benjamin R Tan, Gavin P Dunn, Timothy P Fleming, Ted H Hansen, S Peter Goedegebuure, and William E Gillanders
Critical care service delivery across healthcare systems in low-income and low-middle-income countries: Protocol for a systematic review, Andrew George Lim, Nicole Benzoni, and et al
Cerebrospinal fluid NCAM-1 concentration is associated with neurodevelopmental outcome in post-hemorrhagic hydrocephalus of prematurity, David D. Limbrick, Diego M. Morales, and et al.
Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium, Bridget M. Lin, Lisa de Las Fuentes, and et al
Context-responsive anticoagulation reduces complications in pediatric extracorporeal membrane oxygenation, John C Lin, Lauren M Barron, Adam M Vogel, Ryan M Colvin, Sirine A Baltagi, Allan Doctor, Avihu Z Gazit, Mary Mehegan, Nicole O'Connor, Ahmed S Said, Mark Shepard, Michael Wallendorf, and Philip C Spinella
Longitudinal Growth Differentiation Factor 15 (GDF15) and long-term intraocular pressure fluctuation in glaucoma: A pilot study, Jonathan B. Lin, Arsham Sheybani, Andrea Santeford, and Rajendra S. Apte
Loss of angiotensin II type 2 receptor improves blood pressure in elastin insufficiency, Michelle Lin, Robyn A Roth, Beth A Kozel, Robert P Mecham, and Carmen M Halabi
Disordered eating, food insecurity, and weight status among transgender and gender nonbinary youth and young adults: A Cross-sectional study using a nutrition screening protocol, Whitney R. Linsenmeyer, Ian M. Katz, Jamie L. Reed, Andrea M. Giedinghagen, Christopher B. Lewis, and Sarah K. Garwood
Older adults with newly diagnosed high-risk/secondary AML who achieved remission with CPX-351: Phase 3 post hoc analyses, Tara L. Lin, Geoffrey L. Uy, and et al.
UNMASC: Tumor-only variant calling with unmatched normal controls, Paul Little, Heejoon Jo, Alan Hoyle, Angela Mazul, Xiaobei Zhao, Ashley H Salazar, Douglas Farquhar, Siddharth Sheth, Maheer Masood, Michele C Hayward, Joel S Parker, Katherine A Hoadley, Jose Zevallos, and D Neil Hayes
Impact of new UNOS allocation criteria on heart transplant practices and outcomes, Jason Liu, Bin Q. Yang, Akinobu Itoh, Mohammed Faraz Masood, Justin C. Hartupee, and Joel D. Schilling
Role of SIRT1 in isoflurane conditioning-induced neurovascular protection against delayed cerebral ischemia secondary to subarachnoid hemorrhage, Meizi Liu, Keshav Jayaraman, Tusar Giri, Gregory J Zipfel, and Umeshkumar Athiraman
Dosimetric impact of range uncertainty in passive scattering proton therapy, Ruirui Liu, Baozhou Sun, Tiezhi Zhang, Jeffery F Williamson, Joseph A O'Sullivan, and Tianyu Zhao
Co-evolution of tumor and immune cells during progression of multiple myeloma, Ruiyang Liu, Qingsong Gao, Steven M. Foltz, Jared S. Fowles, Lijun Yao, Julia Tianjiao Wang, Song Cao, Hua Sun, Michael C. Wendl, Sunantha Sethuraman, Amila Weerasinghe, Michael P. Rettig, Erik P. Storrs, Christopher J. Yoon, Matthew A. Wyczalkowski, Joshua F. McMichael, Daniel R. Kohnen, Justin King, Scott R. Goldsmith, Julie O'Neal, Robert S. Fulton, Catrina C. Fronick, Timothy J. Ley, Reyka G. Jayasinghe, Mark A. Fiala, Stephen T. Oh, John F. DiPersio, Ravi Vij, and Li Ding
Alternative pre-mRNA splicing of the mu opioid receptor gene, OPRM1: Insight into complex mu opioid actions, Shan Liu, Wen-Jia Kang, Anna Abrimian, Jin Xu, Luca Cartegni, Susruta Majumdar, Patrick Hesketh, Alex Bekker, and Ying-Xian Pan
AIAP: A quality control and integrative analysis package to improve ATAC-seq data analysis, Shaopeng Liu, Daofeng Li, Cheng Lyu, Paul M Gontarz, Benpeng Miao, Pamela A F Madden, Ting Wang, and Bo Zhang
Rethinking immune checkpoint blockade: Beyond the T cell, Xiuting Liu, Graham D Hogg, and David G DeNardo
Pyrazole scaffold synthesis, functionalization, and applications in Alzheimer's disease and Parkinson's disease treatment (2011-2020), Xuefei Li, Yanbo Yu, and Zhude Tu
Enhanced efficacy and increased long-term toxicity of CNS-directed, AAV-based combination therapy for Krabbe disease, Yedda Li, Christopher A Miller, Lauren K Shea, Xuntian Jiang, Miguel A Guzman, Randy J Chandler, Sai M Ramakrishnan, Stephanie N Smith, Charles P Venditti, Carole A Vogler, Daniel S Ory, Timothy J Ley, and Mark S Sands
The dark side of the gut: Virome-host interactions in intestinal homeostasis and disease, Yuhao Li, Scott A. Handley, and Megan T. Baldridge
New perspectives on antimicrobial agents: Ceftolozane-tazobactam, Bryan D Lizza, Kevin D Betthauser, David J Ritchie, Scott T Micek, and Marin H Kollef
Frontotemporal dementias in Latin America: History, epidemiology, genetics, and clinical research, Jorge J Llibre-Guerra, Angela Hardi, and et al
Axicabtagene ciloleucel as second-line therapy for large B-cell lymphoma, Frederick L Locke, Armin Ghobadi, and et al
Pharmacokinetic and pharmacodynamic profiling of minocycline for injection following a single infusion in critically ill adults in a phase IV open-label multicenter study (ACUMIN), Thomas P Lodise, Yasir Hamad, and et al
Overlapping but disparate inflammatory and immunosuppressive responses to SARS-CoV-2 and bacterial sepsis: An immunological time course analysis, Tyler J Loftus, Ricardo Ungaro, Marvin Dirain, Philip A Efron, Monty B Mazer, Kenneth E Remy, Richard S Hotchkiss, Luer Zhong, Rhonda Bacher, Petr Starostik, Lyle L Moldawer, and Scott C Brakenridge
Formylglycine-generating enzyme-like proteins constitute a novel family of widespread type VI secretion system immunity proteins, Juvenal Lopez, Nguyen-Hung Le, Ki Hwan Moon, Dor Salomon, Eran Bosis, and Mario F Feldman
