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Submissions from 2015

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Inducible nitric oxide synthase mediates DNA double strand breaks in Human T-Cell Leukemia Virus Type 1-induced leukemia/lymphoma, Hicham H. Baydoun, Mathew A. Cherian, Patrick Green, and Lee Ratner

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Induction and processing of the radiation-induced gamma-H2AX signal and Its link to the underlying pattern of DSB: A combined experimental and modelling study, Francesco Tommasino, Thomas Friedrich, Burkhard Jakob, Barbara Meyer, Marco Durante, and Michael Scholz

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Inflammatory pain promotes increased opioid self-administration: Role of dysregulated ventral tegmental area µ opioid receptors, Lucia Hipolito, Adrianne Wilson-Poe, Yolanda Campos-Jurado, Elaine Zhong, Jose Gonzalez-Romero, Laszlo Virag, Robert Whittington, Sandra D. Comer, Susan M. Carlton, Brendan M. Walker, Michael R. Bruchas, and Jose A. Moron

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Influence of home and school environments on specific dietary behaviors among postpartum, high-risk teens, 27 states, 2007-2009, Megan A. Clarke, Debra L. Haire-Joshu, Cynthia D. Schwarz, Rachel G. Tabak, and Corinne E. Joshu

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Influence of model boundary conditions on blood flow patterns in a patient specific stenotic right coronary artery, Biyue Liu, Jie Zheng, Richard Bach, and Dalin Tang

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Influence of physical education on moderate-to-vigorous physical activity of urban public school children in St. Louis, Missouri, 2011–2014, Susan B. Racette, Tiffany C. Dill, M. Leanne White, Jacqueline C. Castillo, Mary L. Uhrich, Cindi L. Inman, Nicholas C. DuPont, and B. Ruth Clark

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Informatics for RNA sequencing: A web resource for analysis on the cloud, Malachi Griffith, Jason R. Walker, Nicholas C. Spies, Benjamin J. Ainscough, and Obi L. Griffith

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Inguinoscrotal herniation of the ureter: Description of five cases, E. S. Allam, D. Y. Johnson, S. G. Grewal, and F. E. Johnson

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Inherited CHST11/MIR3922 deletion is associated with a novel recessive syndrome presenting with skeletal malformation and malignant lymphoproliferative disease, Nathan Stitziel and et al

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Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children, Elaine Mardis, Robert Fulton, and et al.

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Inhibition of P-Selectin and PSGL-1 using humanized monoclonal antibodies increases the sensitivity of multiple myeloma cells to bortezomib, Barbara Muz, Feda Azab, Pilar de la Puente, Scott Rollins, Richard Alvarez, Ziad Kawar, and Abdel Kareem Azab

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Inhibitory-based method for detection of Klebsiella pneumoniae carbapenemase Acinetobacter baumannii isolated from burn patients, Leila Azimi, Abdolaziz Rastegar Lari, Malihe Talebi, Parviz Owlia, Reza Alaghehbandan, Babak Asghari, and Elnaz Rastegar Lari

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Insulin, central dopamine D2 receptors, and monetary reward discounting in obesity, Sarah A. Eisenstein, Danuta M. Gredysa, Jo Ann Antenor-Dorsey, Leonard Green, Ana Maria Arbelaez, Jonathan M. Koller, Kevin J. Black, Joel S. Perlmutter, Stephen M. Moerlein, and Tamara Hershey

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Intermediate DNA methylation is a conserved signature of genome regulation, GiNell Elliott, Xiaoyun Xing, Xin Zhou, Daofeng Li, Gary D. Stormo, Ting Wang, and et al

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Interring gas dynamic analysis of piston in a diesel engine considering the thermal effect, Wanyou Li, Yibin Guo, Tao He, Xiqun Lu, and Dequan Zou

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Interventions to slow aging in humans: Are we ready?, Samuel Klein and et al

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Intracellular FGF14 (iFGF14) is required for spontaneous and evoked firing in cerebellar Purkinje neurons and for motor coordination and balance, Marie K. Bosch, Yarimar Carrasquillo, Joseph L. Ransdell, Ajay Kanakamedala, David M. Ornitz, and Jeanne M. Nerbonne

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In vivo creatine kinase reaction kinetics at rest and stress in type II diabetic rat heart, Adil Bashir, Andrew R. Coggan, and Robert J. Gropler

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In vivo kinetic approach reveals slow SOD1 turnover in the CNS, Matthew J. Crisp, Kwasi G. Mawuenyega, Bruce W. Patterson, Naveen C. Reddy, Robert Chott, Wade K. Self, Conrad C. Weihl, Jennifer Jockel-Balsarotti, Arun S. Varadhachary, Robert C. Bucelli, Kevin E. Yarasheski, Randall J. Bateman, and Rimothy M. Miller

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IRF-5-dependent signaling restricts Orthobunyavirus dissemination to the central nervous system, Jose Luiz Proenca-Modena, Jennifer L. Hyde, Renata Sesti-Costa, Tiffany Lucas, Amelia K. Pinto, Justin M. Richner, Matthew J. Gorman, Helen M. Lazear, and Michael S. Diamond

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Iterative phase retrieval algorithms. I: Optimization, Changliang Guo, Shi Liu, and John T. Sheridan

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Joint MiRNA/mRNA expression profiling reveals rhanges consistent with development of dysfunctional corpus luteum after weight gain, Andrew P. Bradford, Kenneth Jones, Katerina Kechris, Justin Chosich, Michael Montague, Wesley C. Warren, Margaret C. May, Zain Al-Safi, Satu Kuokkanen, Susan E. Appt, and Alex J. Polotsky

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Kappa Opioid receptor-induced aversion requires p38 MAPK activation in VTA dopamine neurons, Jonathan M. Ehrich, Daniel I. Messinger, Cerise R. Knakal, Jamie R. Kuhar, Selena S. Schatteuer, Michael R. Bruchas, Larry S. Zweifel, Brigitte L. Kieffer, Paul E M Phillips, and Charles Chavkin

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Ketamine infusion for patients receiving extracorporeal membrane oxygenation support: A case series, Bethany Tellor, Nicole Shin, Thomas J. Graetz, and Michael S. Avidan

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Knocking on closed doors: Host interferons dynamically regulate blood-brain barrier function during viral infections of the central nervous system, Brian P. Daniels and Robyn S. Klein

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Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons, Pedro L. Martinez-Espinosa, Jianping Wu, Chengtao Yang, Vivian Gonzalez-Perez, Huifang Zhou, Xiao-Ming Xia, and Christopher J. Lingle

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KPC and NDM-1 genes in related Enterobacteriaceae strains and plasmids from Pakistan and the United States, Mitchell W. Pesesky, Tahir Hussain, Meghan Wallace, Bin Wang, Saadia Andleeb, Carey-Ann D. Burnham, and Gautam Dantas

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Lack of neuroinflammation in the HIV-1 transgenic rat: An [18 F]-DPA714 PET imaging study, Dianne E. Lee, Xuyi Yue, Wael G. Ibrahim, Margaret R. Lentz, Kristin L. Peterson, Elaine M. Jagoda, Michael Kassiou, Dragan Maric, William C. Reid, and Dima A. Hammoud

Large-scale genomics unveil polygenic architecture of human cortical surface area, John Morris, Marc Raichle, Davie Holtzman, Nigel J. Cairns, Erin Householder, Lisa Taylor-Reinwald, and et al.

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Late gastrointestinal tissue effects after hypofractionated radiation therapy of the pancreas, Adnan Elhammali, Mukund Patel, Benjamin Weinberg, Vivek Verma, Jingxia Liu, Jeffrey R. Olsen, and Hiram A. Gay

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Leber hereditary optic neuropathy: Current perspectives, Cherise Meyerson, Greg Van Stavern, and Collin McClelland

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Let-7 represses carcinogenesis and a stem cell phenotype in the intestine via regulation of Hmga2, Blair B. Madison, Arjun N. Jeganathan, Rei Mizuno, Monte M. Winslow, Antoni Castells, Miriam Cuatrecasas, and Anil K. Rustgi

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Levamisole/cocaine induced systemic vasculitis and immune complex glomerulonephritis, Lohit Garg, Sagar Gupta, Abhishek Swami, and Ping Zhang

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Leveraging existing data sets to generate new insights into Alzheimer’s disease biology in specific patient subsets, Kevin D. Fowler, Jason M. Funt, Maxim N. Artyomov, Benjamin Zeskind, and Sarah E. Kolitz

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Longitudinal analysis of the premature infant intestinal microbiome prior to necrotizing enterocolitis: A case-control study, Yanjiao Zhou, Gururaj Shan, Erica Sodergren, George Weinstock, W. Allen Walker, and Katherine E. Gregory

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Longitudinal associations between physical and cognitive performance among community-dwelling older adults, Magdalena I. Tolea, John C. Morris, and James E. Galvin

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Long-term functional recovery after facial nerve transection and repair in the rat, Caroline A. Banks, Christopher Knox, Daniel A. Hunter, Susan E. Mackinnon, Marc H. Hohman, and Tessa A. Hadlock

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Long-term neural and physiological phenotyping of a single human, Timothy O. Laumann, Evan Gordon, Abraham Z. Snyder, Babatunde Adeyemo, Steven E. Petersen, and et al

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Long-term safety and efficacy of antithymocyte globulin induction: Use of integrated national registry data to achieve ten-year follow-up of 10-10 Study participants, Krista L. Lentine, Mark A. Schnitzler, Huiling Xiao, and Daniel C. Brennan

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Loss of local astrocyte support disrupts action potential propagation and glutamate release synchrony from unmyelinated hippocampal axon terminals in vitro, Courtney Sobieski, Xiaoping Jiang, Devon C. Crawford, and Steven Mennerick

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Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility, Ping An, Jacek Czajkowski, Aldi T. Kraja, Michael A. Province, Ingrid B. Borecki, and et al

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Low-order non-spatial effects dominate second-order spatial effects in the texture quantifier analysis of 18F-FDG-PET images, Frank J. Brooks and Perry W. Grigsby

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Lung cancer treatment outcomes in recipients of lung transplant, Lingling Du, Nathan A. Pennell, Paul Elson, and Nooshin Hashemi-Sadraei

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Macrophage recruitment and epithelial repair following hair cell injury in the mouse utricle, Tejbeer Kaur, Keiko Hirose, Edwin W. Rubel, and Mark E. Warchol

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Magnetic nanotechnology to study and promote axon growth, Wolfgang Pita-Thomas

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Malaria parasites produce volatile mosquito attractants, Megan Kelly, Chih-Ying Su, Chad Schaber, Jan R. Crowley, Fong-Fu Hsu, John R. Carlson, and Audrey R. Odom

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Mammograms on-the-go—predictors of repeat visits to mobile mammography vans in St Louis, Missouri, USA: A case–control study, Bettina F. Drake, Salmafatima S. Abadin, Sarah Lyons, Su-Hsin Chang, Lauren T. Steward, Susan Kraenzle, and Melody S. Goodman

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Management and outcomes of traumatic hemothorax in children, Pamela M. Choi, Shannon Farmakis, Thomas J. Desmarais, and Martin S. Keller

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Matching behavior as a tradeoff between reward maximization and demands on neural computation, Jan Kubanek and Lawrence H. Snyder

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Maternal obesity and rectovaginal group B streptococcus colonization at term, Shelby M. Kleweis, Alison G. Cahill, Anthony O. Odibo, and Methodius G. Tuuli

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MC1R gene variants and non-melanoma skin cancer: A pooled-analysis from the M-SKIP project, Anne Bowcock, Lynn Cornelius, Martha Laurin Council, and et al

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Mcl-1 is a key regulator of the ovarian reserve, S Omari, M Waters, T Naranian, K Kim, A L. Perumalsamy, M Chi, E Greenblatt, K H. Moley, J T. Opferman, and A Jurisicova

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Measuring participation for persons with mental illness: A systematic review assessing relevance of existing scales for low and middle income countries, Ganesh M. Babulal, Parul Bakhshi, Sunyata Kopriva, Sarah A. Ali, Susan A. Goette, and Jean-Francois Trani

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Mental illness, poverty and stigma in India: A case–control study, Jean-Francois Trani, Parul Bakhshi, Jill Kuhlberg, Sreelatha S. Narayanan, Hemalatha Venkataraman, Nagendra N. Mishra, Nora E. Groce, Sushrut Jadhav, and Smita Deshpande

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Metabolically normal obese people are protected from adverse effects following weight gain, Elisa Fabbrini, Jun Yoshino, Mihoko Yoshino, Faidon Magkos, Courtney T. Luecking, Dmitri Samovski, Gemma Fraterrigo, Adewole L. Okunade, Bruce W. Patterson, and Samuel Klein

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Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment, Sahar Abubucker, Yanjiao Zhou, Makedonka Mitreva, George M. Weinstock, Erica Sodergren, and et al

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Metastatic melanoma – A review of current and future treatment options, Emanual Maverakis, Lynn A. Cornelius, Glen M. Bowen, Tiffany Phan, Falin B. Patel, Sarah Fitzmaurice, Young He, Barbara Burrall, Christopher Duong, April M. Kloxin, Hawa Sultani, Reason Wilken, Steve R. Martinez, and Forum Patel

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MicroRNA-223 regulates granulopoiesis but is not required for HSC maintenance in mice, Maria C. Trissal, Ricardo A. DeMoya, Amy P. Schmidt, and Daniel C. Link

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MicroRNA-33 regulates apoE lipidation and amyloid-β metabolism in the brain, Jaekwang Kim, Hyejin Yoon, Jack M. Burchett, Jessica L. Restivo, Philip B. Verghese, David M. Holtzman, John R. Cirrito, Jungsu Kim, and et al

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miRDB: An online resource for microRNA target prediction and functional annotations, Nathan Wong and Xiaowei Wang

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Misinterpretation of the American College of Radiology white paper on managing incidental thyroid nodules, Jenny K. Hoang, Jill E. Langer, William D. Middleton, Carol C. Wu, Lynnwood W. Hammers, John J. Cronan, Franklin N. Tessler, Edward G. Grant, and Lincoln L. Berland

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Missouri mothers and their children: A family study of the effects of genetics and the prenatal environment, Valerie S. Knopik, Andrew C. Heath, Kristine Marceau, Rohan H C Palmer, John E. McGeary, Alexandre Todorov, and Allison S. Evans

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Mitochondrial biogenesis and dynamics in the developing and diseased heart, Gerald W. Dorn II, Rick B. Vega, and Daniel P. Kelly

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Mitochondrial dynamism and heart disease: Changing shape and shaping change, Gerald W. Dorn II

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Mobility and safety issues in drivers with dementia, David B. Carr and Desmond O'Neill

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Model-driven mapping of transcriptional networks reveals the circuitry and dynamics of virulence regulation, Ezekiel J. Maier, Brian C. Haynes, Stacey R. Gish, Zhuo A. Wang, Michael L. Skowyra, Alyssa L. Marulli, Tamara L. Doering, and Michael R. Brent

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Modeling epoxidation of drug-like molecules with a deep machine learning network, Tyler B. Hughes, Grover P. Miller, and S. Joshua Swamidass

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Modular design of the selectivity filter pore loop in a novel family of prokaryotic ‘inward rectifier’ (NirBac) channels, Lejla Zubcevic, Shizhen Wang, Vassiliy N. Bavro, Sun-Joo Lee, Colin G. Nichols, and Stephen J. Tucker

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Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells, Maxim N. Artyomov, Adiel Munk, Laurent Gorvel, Daniel Korenfeld, Marina Cella, Thomas Tung, and Eynav Klechevsky

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Morphological and stress vulnerability indices for human coronary plaques and their correlations with cap thickness and lipid percent: An IVUS-based fluid-structure interaction multi-patient study, Liang Wang, Jie Zheng, Akiko Maehara, Chun Yang, Kristen L. Billiar, Zheyang Wu, Richard Bach, David Muccigrosso, Gary S. Mintz, and Dalin Tang

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Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties, Yi-Hsien Chen, Lucy D'Agostino McGowan, Patrick J. Cimino, Sonika Dahiya, Jeffrey R. Leonard, Da Yong Lee, and David H. Gutmann

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Moving from capstones toward cornerstones: Successes and challenges in applying systems biology to identify mechanisms of autism spectrum disorders, Nathan Kopp, Sharlee Climer, and Joseph D. Dougherty

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mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer, Harrison Cash, Sujay Shah, Ellen Moore, Andria Caruso, Ravindra Uppaluri, Carter Van Waes, and Clint Allen

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mTORC1 signaling promotes osteoblast differentiation from preosteoblasts, Jianquan Chen and Fanxin Long

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Mucinous adenocarcinoma of the bladder associated with long term suprapubic tube: A case report, Tyler M. Bauman, Theodora A. Potretzke, Aaron M. Potretzke, Cary L. Siegel, and Steven B. Brandes

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Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis, Nicholas A. Manieri, Madison R. Mack, Molly D. Himmelrich, Daniel L. Worthley, Elaine M. Hanson, Lars Eckmann, Timothy C. Wang, and Thaddeus S. Stappenbeck

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Multi-platform assessment of transcriptional profiling technologies utilizing a precise probe mapping methodology, Jinsheng Yu, Paul F. Cliften, Twyla I. Juehne, Toni M. Sinnwell, Chris S. Sawyer, Mala Sharma, Andrew Lutz, Eric Tycksen, Mark R. Johnson, Matthew R. Minton, Elliott T. Klotz, Andrew E. Schriefer, Wei Yang, Michael E. Heinz, Seth D. Crosby, and Richard D. Head

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Multiplatform molecular profiling identifies potentially targetable biomarkers in malignant phyllodes tumors of the breast, Zoran Gatalica, Semir Vranic, Anatole Ghazalpour, Joanne Xiu, Idris Tolgay Ocal, John McGill, Ryan P. Bender, and Erin Discianno

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Multi-platform profiling of over 2000 sarcomas: Identification of biomarkers and novel therapeutic targets, Sujana Movva, Wenhsiang Wen, Wangjuh Chen, Sherri Z. Millis, Zoran Gatalica, Sandeep Reddy, Margaret von Mehren, and Brian A. Van Tine

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Murine versus human apolipoprotein E4: Differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models, Fan Liao, Tony J. Zhang, Hong Jiang, Katheryn B. Lefton, Grace O. Robinson, Robert Vassar, Patrick M. Sullivan, and David M. Holtman

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Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice, T H-P Chen, G Swarnkar, G Mbalaviele, and Y Abu-Amer

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Myopathy with anti-HMGCR antibodies: Perimysium and myofiber pathology, Ali Alshehri, Rati Choksi, Robert Bucelli, and Alan Pestronk

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Myosin binding protein-C slow phosphorylation is altered in Duchenne dystrophy and arthrogryposis myopathy in fast-twitch skeletal muscles, Maegan A. Ackermann, Christopher W. Ward, Christina Gurnett, and Aikaterini Kontrogianni-Konstantopoulos

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Nab-paclitaxel-based compared to docetaxel-based induction chemotherapy regimens for locally advanced squamous cell carcinoma of the head and neck, Amy Schell, Jessica Ley, Ningying Wu, Kathryn Trinkaus, Tanya Marya Wildes, Loren Michel, Wade Thorstad, Hiram Gay, James Lewis, Jason Rich, Jason Diaz, Randal C. Paniello, Brian Nussenbaum, and Douglas R. Adkins

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NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells, Rama P. Kotipatruni, Xuan Ren, Dinesh Thotala, and Jerry J. Jaboin

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Neck pain following laminoplasty, Addisu Mesfin, Moon-Soo Park, Chaiwat Piyaskulkaew, Tapanut Chuntarapas, Kwang S. Song, Han J. Kim, and K. Daniel Riew

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Necrotic myocardial cells release damage-associated molecular patterns that provoke fibroblast activation in vitro and trigger myocardial inflammation and fibrosis in vivo, Weili Zhang, Kory J. Lavine, Slava Epelman, Sarah A. Evans, Carla J. Weinheimer, Philip M. Barger, and Douglas L. Mann

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Neural correlates of error monitoring in adolescents prospectively predict initiation of tobacco use, Andrey P. Anokhin and Simon Golosheykin

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Neurocognitive outcomes and school performance in solid tumor cancer survivors lacking therapy to the central nervous system, Caroline Mohrmann, Jennifer Henry, Marnie Hauff, and Robert J. Hayashi

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Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways, Yi-Hsien Chen, Scott M. Gianino, and David H. Gutmann

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Neuronal-targeted TFEB accelerates lysosomal degradation of app, reducing Aβ generation and amyloid plaque pathogenesis, Qingli Xiao, Ping Yan, Xiucui Ma, Haiyan Liu, Ronaldo Perez, Alec Zhu, Ernesto Gonzales, Danielle L. Tripoli, Leah Czerniewski, Andrea Ballabio, John R. Cirrito, Abhinav Diwan, and Jin-Moo Lee

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Neurons in the primate medial basal forebrain signal combined information about reward uncertainty, value, and punishment anticipation, Ilya E. Monosov, David A. Leopold, and Okihide Hikosaka

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Neutralizing monoclonal antibodies block chikungunya virus entry and release by targeting an epitope critical to viral pathogenesis, Julie M. Fox

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No association between the common calcium-sensing receptor polymorphism rs1801725 and irritable bowel syndrome, Philipp Romero, Stefanie Schmitteckert, Mira W. Wouters, Lesley A. Houghton, Bastian Czogalla, Gregory S. Sayuk, Guy E. Boeckxstaens, Patrick Guenther, Stefan Holland-Cunz, and Beate Niesler

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Non-alcoholic steatohepatitis: Pathogenesis and clinical management, Federico Salomone, Shira Zelber-Sagi, Fabio Galvano, and Elisa Fabbrini

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Nonmodifiable factors and complications contribute to length of stay in robot-assisted partial nephrectomy, Jeffrey A. Larson, Jihad H. Kaouk, Michael D. Stifelman, Craig G. Rogers, Mohamad E. Allaf, Aaron Potretzke, Susan Marshall, Homayoun Zargar, Mark W. Ball, and Sam B. Bhayani

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Nonverbal reasoning in preschool children: Investigating the putative risk of secondhand smoke exposure and attention-deficit/hyperactivity disorder as a mediator, Duneesha De Alwis, Mini Tandon, Rebecca Tillman, and Joan Luby

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Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9, Anat Kohn, Timothy P. Rutkowski, Zhaoyang Liu, Anthony J. Mirando, Michael J. Zuscik, Regis J. O'Keefe, and Matthew J. Hilton

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Not so fast: Co-requirements for sonic hedgehog induced brain tumorigenesis, Stacey A. Ward and Joshua B. Rubin

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Novel APC promoter and exon 1B deletion and allelic silencing in three mutation-negative classic familial adenomatous polyposis families, Yiing Lin, Shin Lin, Melanie D. Baxter, Lawrence Lin, Susan M. Kennedy, Zhengyan Zhang, Paul J. Goodfellow, William C. Chapman, and Nicholas O. Davidson