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Submissions from 2012

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Adverse metabolic response to regular exercise: Is it a rare or common occurrence?, Claude Bouchard, Steven N. Blair, Timothy S. Church, Conrad P. Earnest, James M. Hagberg, Keijo Hakkinen, Nathan T. Jenkins, Laura Karavirta, William E. Kraus, Arthur S. Leon, D. C. Rao, Mark A. Sarzynski, James S. Skinner, Cris A. Slentz, and Tuomo Rankinen

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A first step in determining appropriate amounts of obstetric anesthesia work, Swarup S. Varaday and Barbara L. Leighton

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Aflibercept in the treatment of metastatic colorectal cancer, Tzu-Fei Wang and Albert Craig Lockhart

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A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis, Alena V. Makarova, Joseph L. Stodola, and Peter M. Burgers

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African American parents' HPV vaccination intent and concerns, Vetta L. Sanders Thompson, Lauren D. Arnold, and Sheri R. Notaro

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A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales, A. C. Heath, P. A. F. Madden, and et al

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A glycosylphosphatidylinositol anchor is required for membrane localization but dispensable for cell wall association of chitin deacetylase 2 in Cryptococcus neoformans, Nicole M. Gilbert, Lorina G. Baker, Charles A. Specht, and Jennifer K. Lodge

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AHR and the transcriptional regulation of Type-17/22 ILC, Jacob S. Lee, Marina Cella, and Marco Colonna

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AKT1 loss correlates with episomal HPV16 in vulval intraepithelial neoplasia, Arucha L. Ekeowa-Anderson, Karin J. Purdie, Karen Gibbon, Carolyn R. Byrne, Jeffrey M. Arbeit, Catherine A. Harwood, and Ryan F. L. O'Shaughnessy

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Altered networks in bothersome tinnitus: A functional connectivity study, Harold Burton, Andre Wineland, Mousumi Bhattacharya, Joyce Nicklaus, Keith S. Garcia, and Jay F. Piccirillo

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Amacrine cells: Seeing the forest and the trees, Jeffrey S. Diamond and Peter D. Lukasiewicz

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A model of spatially restricted transcription in opposing gradients of activators and repressors, Michael A. White, Davis S. Parker, Scott Barolo, and Barak A. Cohen

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A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis, Peter U. Fischer, Ramakrishna U. Rao, and et al

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A multicenter study of Clostridium difficile infection-related colectomy, 2000-2006, Amelia M. Kasper, Humaa A. Nyazee, Deborah S. Yokoe, Jeanmarie Mayer, Julie E. Mangino, Yosef M. Khan, Bala Hota, Victoria J. Fraser, and Erik R. Dubberke

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Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development, Jennifer Govero, Balraj Doray, Hongdong Bai, and Stuart Kornfeld

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An analysis of the transcriptome of Teladorsagia circumcincta: Its biological and biotechnological implications, Ranjeeta Menon, Robin B. Gasser, Makedonka Mitreva, and Shoba Ranganathan

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An Australian twin study of cannabis and other illicit drug use and misuse, and other psychopathology, Michael T. Lynskey, Arpana Agrawal, Anjali Henders, Elliot C. Nelson, Pamela A.F. Madden, and Nicholas G. Martin

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An enhancer from the 8q24 prostate cancer risk region is sufficient to direct reporter gene expression to a subset of prostate stem-like epithelial cells in transgenic mice, Man-Chun Ting, Chun-Peng Liao, Chunli Yan, Li Jia, Susan Groshen, Baruch Frenkel, Pradip Roy-Burman, Gerhard A. Coetzee, and Robert Maxson

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An institutional perspective on the impact of recent antibiotic exposure on length of stay and hospital costs for patients with gram-negative sepsis, Scott Micek, Michael T. Johnson, Richard Reichley, and Marin H. Kollef

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A noncomplementation screen for quantitative trait alleles in Saccharomyces cerevisiae, Hyun Seok Kim, Juyoung Huh, Linda Riles, Alejandro Reyes, and Justin C. Fay

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A novel behavioral assay for measuring cold sensation in mice, Daniel S. Brenner, Judith P. Golden, and Robert W. Gereau IV

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Antiangiogenic and anticancer molecules in cartilage, Debabrata Patra and Linda J. Sandell

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Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis, Jungsu Kim, Adam E M Eltorai, Hong Jiang, Fan Liao, Philip B. Verghese, Jaekwang Kim, Floy R. Stewart, Jacob M. Basak, and David M. Holtzman

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Antibodies against the envelope glycoprotein promote infectivity of immature Dengue Virus Serotype 2, Julia M. da Silva Voorham, Izabela A. Rodenhuis-Zybert, Nilda Vanesa Ayala Nunez, Tonya M. Colpitts, Heidi van der Ende-Metselaar, Erol Fikrig, Michael S. Diamond, Jan Wilschut, and Jolanda M. Smit

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AP-3 regulates PAR1 ubiquitin-independent MVB/lysosomal sorting via an ALIX-mediated pathway, Michael R. Dores, May M. Paing, William A. Montagne, Adriano Marchese, JoAnn Trejo, and Huilan Lin

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Apolipoprotein e, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide, Tadafumi Hashimoto, Alberto Serrano-Pozo, Yukiko Hori, Kenneth W. Adams, Shuko Takeda, Adrian Olaf Banerji, Akinori Mitani, Daniel Joyer, Diana H. Thyssen, Brian J. Bacskai, Matthew P. Frosch, Tara L. Spires-Jones, Mary Beth Finn, David M. Holtzman, and Bradley T. Hyman

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A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis, Jonathan S. Boomer, Jennifer Shuherk-Shaffer, and Jonathan M. Green

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Aptamers in virology: Recent advances and challenges, Jennifer M. Binning, Daisy W. Leung, and Gaya K. Amarasinghe

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A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilatorassociated pneumonia, Marin H. Kollef, Jean Chastre, Marc Clavel, Marcos I. Restrepo, Bart Michiels, Kone Kaniga, Iolanda Cirillo, Holly Kimko, and Rebecca Redman

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A role for the membrane Golgi protein Ema in autophagy, Sungsu Kim and Aaron DiAntonio

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Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: A PLCO Study, G. L. Andriole and et al.

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Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data, Elaine R. Mardis, Richard K. Wilson, and et al

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Association between human papillomavirus DNA and temporal arteritis, Amir Mohammadi, John D. Pfeifer, and James S. Lewis

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Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro, Devon C. Crawford, Xiaoping Jiang, Amanda Taylor, and Steven Mennerick

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A survey tool for measuring evidence-based decision making capacity in public health agencies, Julie A. Jacobs, Paula F. Clayton, Cassandra Dove, Tanya Funchess, Ellen Jones, Ghazala Perveen, Brandon Skidmore, Victor Sutton, Sarah Worthington, Elizabeth A. Baker, Anjali D. Deshpande, and Ross C. Brownson

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A systematic study of gene expression variation at single-nucleotide resolution reveals widespread regulatory roles for uAUGs, Yue Yun, T.M. Ayodele Adesanya, and Robi D. Mitra

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A tetravalent dengue nanoparticle stimulates antibody production in mice, Elisangela F. Silva, Mariana Orsi, Angela L. Andrade, Rosana Z. Domingues, Breno M. Silva, Helena RC de Araujo, Paulo FP Pimenta, Michael S. Diamond, Eliseu SO Rocha, Erna G. Kroon, Luiz CC Malaquias, and Luiz FL Coelho

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ATG16L1 and pathogenesis of urinary tract infections, Caihong Wang, Jane W. Symington, and Indira U. Mysorekar

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Attempted endoscopic closure of a pancreaticocolonic fistula with an over-the-scope clip, Darrell M. Gray II and Daniel K. Mullady

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Attention deficit hyperactivity disorder in Australian adults: Prevalence, persistence, conduct problems and disadvantage, Jane L. Ebejer, Sarah E. Medland, Julius van der Werf, Cedric Gondro, Anjali K. Henders, Michael Lynskey, Nicholas G. Martin, and David L. Duffy

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Auricular point acupressure for chronic low back pain: A feasibility study for 1-week treatment, Chao-Hsing Yeh, Lung-Chang Chien, Yi-Chien Chiang, and Li-Chun Huang

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Automated web-based request mechanism for workflow enhancement in an academic customer-focused biorepository, Sandra A. McDonald, Benjamin J. Ryan, Amy Brink, and Victoria L. Holtschlag

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Autophagy is impaired in cardiac ischemia-reperfusion injury, Xiucui Ma, Haiyan Liu, Sarah R. Foyil, Rebecca J. Godar, Carla J. Weinheimer, and Abhinav Diwan

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A window into domain amplification through Piccolo in teleost fish, Michael L. Nonet

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Bcl-x Pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia, Qingli Xiao, Andria L. Ford, Jan Xu, Ping Yan, Kuang-Yung Lee, Ernesto Gonzales, Tim West, David M. Holtzman, and Jin-Moo Lee

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Beyond 30 days: Does limiting the duration of surgical site infection follow-up limit detection?, Julie D. Lankiewicz, Deborah S. Yokoe, Margaret A. Olsen, Fallon Onufrak, Victoria J. Fraser, Kurt Stevenson, Yosef Khan, David Hooper, Richard Platt, and Susan S. Huang

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Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain, Adam W. Bero, Adam O. Bauer, Floy R. Stewart, Brian R. White, John R. Cirrito, Marcus E. Raichle, Joseph P. Culver, and David M. Holtzman

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BNip3 regulates mitochondrial function and lipid metabolism in the liver, Danielle Glick, Wenshuo Zhang, Michelle Beaton, Glenn Marsboom, Michaela Gruber, M. Celeste Simon, John Hart, Gerald W. Dorn II, Matthew J. Brady, and Kay F. Macleod

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Bone marrow transplantation alters the tremor phenotype in the murine model of globoid-cell leukodystrophy, Adarsh S. Reddy, David F. Wozniak, Nuri B. Farber, Joshua T. Dearborn, Stephen C. Fowler, and Mark S. Sands

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Cancer control needs of 2-1-1 callers in Missouri, North Carolina, Texas, and Washington, Jason Q. Purnell, Matthew W. Kreuter, Katherine S. Eddens, Kurt M. Ribisl, Peggy Hannon, Rebecca S. Williams, Marie E. Fernandez, David Jobe, Susan Gemmel, Marti Morris, and Debbie Fagin

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Cancer immunoediting by the innate immune system in the absence of adaptive immunity, Timothy O'Sullivan, Robert Saddawi-Konefka, William Vermi, Catherine M. Koebel, Cora Arthur, J. Michael White, Ravi Uppaluri, Daniel M. Andrews, Shin Foong Ngiow, Michele W. L. Teng, Mark J. Smith, Robert D. Schreiber, and Jack D. Bui

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Cannabis or alcohol first? Differences by ethnicity and in risk for rapid progression to cannabis-related problems in women, C. E. Sartor, A. Agrawal, M. T. Lynskey, A. E. Duncan, J. D. Grant, E. C. Nelson, P. A. Madden, A. C. Heath, and K. K. Bucholz

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Causal links between dorsal medial superior temporal area neurons and multisensory heading perception, Yong Gu, Gregory C. DeAngelis, and Dora E. Angelaki

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CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke, Ann M. Stowe, Bradley K. Wacker, Petra D. Cravens, Jennifer L. Perfater, Min K. Li, Ruilong Hu, Angela B. Freie, Olaf Stuve, and Jeffrey M. Gidday

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Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain, Lara W. Crock, Benedict J. Kolber, Clinton D. Morgan, Katelyn E. Sadler, Sherri K. Vogt, Michael R. Bruchas, and Robert W. Gereau IV

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Challenging presentations of cavernous sinus thrombophlebitis, Courtney L. Kraus and Susan M. Culican

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Changing epidemiology of methicillin-resistant Staphylococcus aureus colonization in paediatric intensive-care units, C. R. Hermos, T. J. Sandora, L. E. Williams, N. Mosammaparast, and A. J. McAdam

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Characterization of scale-free properties of human electrocorticography in awake and slow wave sleep states, John M. Zempel, David G. Politte, Matthew Kelsey, Ryan Verner, Tracy S. Nolan, Abbas Babajani-Feremi, Fred Prior, and Linda J. Larson-Prior

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Chemokine GPCR signaling inhibits beta-catenin during Zebrafish axis formation, Shu-Yu Wu, Jimann Shin, Diane S. Sepich, and Lilianna Solnica-Krezel

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CHFR is important for the first wave of ubiquitination at DNA damage sites, Chao Liu, Jiaxue Wu, Sharad C. Paudyal, Zhongsheng You, and Xiaochun Yu

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Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy, Pierre-Emmanuel Joubert, Scott Werneke, Claire de la Calle, Florence Guivel-Benhassine, Alessandra Giodini, Lucie Peduto, Beth Levine, Olivier Schwartz, Deborah Lenschow, and Matthew L. Albert

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Chikungunya virus-induced autophagy delays caspase-dependent cell death, Pierre-Emmanuel Joubert, Scott W. Werneke, Claire de la Calle, Florence Guivel-Benhassine, Alessandra Giodini, Lucie Peduto, Beth Levine, Olivier Schwartz, Deborah J. Lenschow, and Matthew L. Albert

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Childhood school segregation and later life sense of control and physical performance in the African American Health cohort, Fredric D. Wolinsky, Elena M. Andresen, Theodore K. Malmstrom, J. P. Miller, Mario Schootman, and Douglas K. Miller

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Chronic intestinal inflammation: Inflammatory bowel disease and colitis-associated colon cancer, Deborah C. Rubin, Anisa Shaker, and Marc S. Levin

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CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies, Barbara Schroeder, Subhashini Srivatsan, Andrey Shaw, Daniel Billadeau, and Mark A. McNiven

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Clinical and biomarker changes in dominantly inherited Alzheimer's disease, Randall J. Bateman, Anne M. Fagan, David M. Holtzman, Anna Santacruz, Virginia Buckles, Angela Oliver, Krista Moulder, John C. Morris, and et al

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Clinical application of heart rate variability after acute myocardial infarction, Heikki V. Huikuri and Phyllis K. Stein

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Clinical characteristics, comorbidities, and response to treatment of veterans with obstructive sleep apnea, Cincinnati Veterans Affairs Medical Center, 2005-2007, Pamela Samson, Kenneth R. Casey, James Knepler, and Ralph J. Panos

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Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy, Michael A. Ciliberto, Judith L.Z. Weisenberg, and Michael Wong

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Clonal architecture of secondary acute myeloid leukemia, Matthew J. Walter, Dong Shen, Li Ding, Jin Shao, Daniel C. Koboldt, Ken Chen, David E. Larson, Michael D. McLellan, David Dooling, Rachel Abbott, Robert Fulton, Vincent Magrini, Heather Schmidt, Joelle Kalicki-Veizer, Michelle O'Laughlin, Xian Fan, Marcus Grillot, Sarah Witowski, Sharon Heath, John L. Frater, William Eades, Michael Tomasson, Peter Westervelt, John F. DiPersio, Daniel C. Link, Elaine R. Mardis, Timothy J. Ley, Richard K. Wilson, and Timothy A. Graubert

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Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism, Nicole M. Chumbler, Melissa A. Farrow, Lynne A. Lapierre, Jeffrey L. Franklin, David Haslam, James R. Goldenring, and D. Borden Lacy

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Clustering of resting state networks, Megan H. Lee, Carl D. Hacker, Abraham Z. Snyder, Maurizio Corbetta, Dongyang Zhang, Eric C. Leuthardt, and Joshua S. Shimony

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Colony organization in the green alga Botryococcus braunii (Race B) is specified by a complex extracellular matrix, Taylor L. Weiss, Robyn Roth, Carrie Goodson, Stanislav Vitha, Ian Black, Parastoo Azadi, Jannette Rusch, Andreas Holzenburg, Timothy P. Devarenne, and Ursula Goodenough

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Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy, Gerald L. Andriole and et al

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Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice, Pascale S. Guiton, Corinne K. Cusumano, Kimberly A. Kline, Karen W. Dodson, Zhenfu Han, James W. Janetka, Jeffrey P. Henderson, Michael G. Caparon, and Scott J. Hultgren

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Common data elements for pediatric traumatic brain injury: Recommendations from the working group on demographics and clinical assessment, P. David Adelson, Jose Pineda, Michael J. Bell, Nicholas S. Abend, Rachel P. Berger, Christopher C. Giza, Gillian Hotz, and Mark S. Wainwright

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Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion, P. A. F. Madden, A. C. Heath, and et al

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Comparing the mitochondrial genomes of Wolbachia-dependent and independent filarial nematode species, Samantha N. McNulty, Andrew S. Mullin, Jefferson A. Vaughan, Vasyl V. Tkach, Gary J. Weil, and Peter U. Fischer

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Comparison of accelerated partial breast irradiation via multicatheter interstitial brachytherapy versus whole breast radiation, Daniel J. Ferraro, Adam A. Garsa, Todd A. DeWees, Julie A. Margenthaler, Michael Naughton, Rebecca Aft, William E. Gillanders, Timothy Eberlein, Melissa A. Matesa, and Imran Zoberi

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Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis, Jindrich Soltys and Xiaobo Wu

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Complete genome sequence of Enterococcus faecium strain TX16 and comparative genomic analysis of Enterococcus faecium genomes, Erica Sodergren, George M. Weinstock, and et al

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Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 alpha (HNF4alpha) pathways to regulate liver lipid metabolism, Zhouji Chen, Matthew C. Gropler, Mayurranjan S. Mitra, and Brian N. Finck

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Compound heterozygous mutations in the SUR1 (ABCC 8) subunit of pancreatic KATP channels cause neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits, Yu-Wen Lin, Alejandro Akrouh, YeouChing Hsu, Nkecha Hughes, Colin G. Nichols, and Diva D. De Leon

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Conserved motifs and prediction of regulatory modules in Caenorhabditis elegans, Guoyan Zhao, Nnamdi Ihuegbu, Mo Lee, Larry Schriefer, Ting Wang, and Gary D. Stormo

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Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice, Sheri L. Bonar, Susannah D. Brydges, James L. Mueller, Matthew D. McGeough, Carla Pena, Debbie Chen, Susan K. Grimston, Cynthia L. Hickman-Brecks, Soumya Ravindran, Audrey McAlinden, Deborah V. Novack, Daniel L. Kastner, Roberto Civitelli, Hal M. Hoffman, and Gabriel Mbalaviele

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Constitutively active canonical NF-kB pathway induces severe bone loss in mice, Jesse E. Otero, Tim Chen, Kaihua Zhang, and Yousef Abu-Amer

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Cooperative role of antibodies against heat-labile toxin and the EtpA adhesin in preventing toxin delivery and intestinal colonization by enterotoxigenic Escherichia coli, Koushik Roy, David J. Hamilton, and James M. Fleckenstein

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Coronary CT angiography versus standard evaluation in acute chest pain, Pamela Woodard, Michael E. Mullins, and et al

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Correlates of weight gain during long-term risperidone treatment in children and adolescents, Chadi A. Calarge, Ginger Nicol, Diqiong Xie, and Bridget Zimmerman

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Correlations of coronary plaque wall thickness with wall pressure and wall pressure gradient: A representative case study, Biyue Liu, Jie Zheng, Richard Bach, and Dalin Tang

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Cost-effectiveness of peer-delivered interventions for cocaine and alcohol abuse among women: A randomized controlled trial, Jennifer Prah Ruger, Arbi Ben Abdallah, Craig Luekens, and Linda Cottler

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Co-survival of the fittest few: Mosaic amplification of receptor tyrosine kinases in glioblastoma, Chen Feng and Li Ding

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Cotinine inhibits the pro-inflammatory response initiated by multiple cell surface Toll-like receptors in monocytic THP cells, Juhi Bagaitkar, Iris Zeller, Diane E. Renaud, and David A. Scott

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Critical role for interferon regulatory factor 3 (IRF-3) and IRF-7 in type i interferon-mediated control of murine norovirus replication, Larissa B. Thackray, Erning Duan, Helen M. Lazear, Amal Kambal, Robert D. Schreiber, Michael S. Diamond, and Herbert W. Virgin

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Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+ /CD8α+ dendritic cells, Masahiro Azuma, Takashi Ebihara, Hiroyuki Oshiumi, Misako Matsumoto, and Tsukasa Seya

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Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer, Christina N. Bennett, Christine C. Tomlinson, Aleksandra M. Michalowski, Isabel M. Chu, Dror Luger, Lara R. Mittereder, Olga Aprelikova, James Shou, Helen Piwnica-Worms, Melinda G. Hollingshead, and Jeffrey E. Green

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c-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeleton, Takashi Izawa, Wei Zou, Jean C. Chappel, Jason W. Ashley, Xu Feng, and Steven L. Teitelbaum

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Current perspectives on skeletal health and cancer progression across the disease continuum in breast cancer—The role of bisphosphonates, R. Aft

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CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma, Shyam Rao, Rajarshi Sengupta, Eun Joo Choe, B. Mark Woerner, Erin Jackson, Tao Sun, Jeffrey Leonard, David Piwnica-Worms, and Joshua B. Rubin

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Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway, Audrey Chong, Tara D. Wehrly, Robert Child, Bryan Hansen, Seungmin Hwang, Herbert W. Virgin, and Jean Celli