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Submissions from 2021

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The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment, Melissa A Haendel, Philip R O Payne, and et al.

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The novel use of a commercially available video-conference platform to facilitate multidisciplinary target volume review and delineation for skull-base radiation therapy during the coronavirus disease 2019 pandemic, Amit Roy, Neal Andruska, Hilary L P Orlowski, Patrik Pipkorn, and Mackenzie D Daly

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The structure and diversity of strain-level variation in vaginal bacteria, Brett A Tortelli, Amanda L Lewis, and Justin C Fay

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Unwillingness of patients in Ghana to interrupt antiretroviral therapy for HIV cure research, Evelyn Y Bonney, Helena Lamptey, James O Aboagye, Christopher Zaab-Yen Abana, Anthony T Boateng, Darius N K Quansah, Adjoa Obo-Akwa, Vincent J Ganu, Peter Puplampu, George B Kyei, and H-CRIS Massive Action Team

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Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium, Michael D. Onken, Kendall J. Blumer, and John A. Cooper

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Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes, Richard Sherva, Congcong Zhu, Leah Wetherill, Howard J Edenberg, Emma Johnson, Louisa Degenhardt, Arpana Agrawal, Nicholas G Martin, Elliot Nelson, Henry R Kranzler, Joel Gelernter, and Lindsay A Farrer

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A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging, Neta Erez, Lena Israitel, Eliya Bitman-Lotan, Wing H. Wong, Gal Raz, Dayanne V. Cornelio-Parra, Salwa Danial, Na'ama Flint Brodsly, Elena Belova, Oksana Maksimenko, Pavel Georgiev, Todd Druley, Ryan D. Mohan, and Amir Orian

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The SWELL1-LRRC8 complex regulates endothelial AKT-eNOS signaling and vascular function, Ahmad F. Alghanem, Javier Abello, Joshua M. Maurer, Ashutosh Kumar, Chau My Ta, Susheel K. Gunasekar, Chen Kang, Litao Xie, Amber N. Stratman, Rajan Sah, and et al

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Association of opioid use disorder treatment with alcohol-related acute events, Kevin Y. Xu, Ned Presnall, Carrie M. Mintz, Jacob T. Borodovsky, Nisha R. Bhat, Laura J. Bierut, and Richard A. Grucza

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MEDALT: Single-cell copy number lineage tracing enabling gene discovery, Fang Wang, Qihan Wang, Vakul Mohanty, Shaoheng Liang, Jinzhuang Dou, Jincheng Han, Darlan Conterno Minussi, Ruli Gao, Li Ding, Nicholas Navin, and Ken Chen

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Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19, Davide Scozzi, Marlene Cano, Lina Ma, Dequan Zhou, Ji Hong Zhu, Jane A. O'Halloran, Charles Goss, Adriana M. Rauseo, Zhiyi Liu, Sanjaya K. Sahu, Mohsen Ibrahim, Ramsey Hachem, Daniel Kreisel, Philip A. Mudd, Hrishikesh S. Kulkarni, Andrew E. Gelman, and et al

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Defining phenotypic and functional heterogeneity of glioblastoma stem cells by mass cytometry, Luciano Galdieri, Arijita Jash, Olga Malkova, Diane D Mao, Patrick DeSouza, Yunli E Chu, Amber Salter, Jian L Campian, Kristen M Naegle, Cameron W Brennan, Hiroaki Wakimoto, Stephen T Oh, Albert H Kim, and Milan G Chheda

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Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease, Ella Katz-Kiriakos, Deborah F Steinberg, Colin E Kluender, Omar A Osorio, Catie Newsom-Stewart, Arjun Baronia, Derek E Byers, Michael J Holtzman, Dawn Katafiasz, Kristina L Bailey, Steven L Brody, Mark J Miller, and Jennifer Alexander-Brett

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The second NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy, Kevin F Bieniek, Nigel J Cairns, and et al.

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Use of mechanical circulatory support devices among patients with acute myocardial infarction complicated by cardiogenic shock, Sanket S. Dhruva, Joseph S. Ross, Bobak J. Mortazavi, Nathan C. Hurley, Harlan M. Krumholz, Jeptha P. Curtis, Alyssa P. Berkowitz, Frederick A. Masoudi, John C. Messenger, Craig S. Parzynski, Che G. Ngufor, Saket Girotra, Amit P. Amin, Nilay D. Shah, and Nihar R. Desai

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Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice, Michael P Franczyk, Mai He, and Jun Yoshino

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The state of neuro-oncology during the COVID-19 pandemic: A worldwide assessment, Maciej M. Mrugala, Milan G. Chheda, and et al

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Photosensitivity reaction from operating room lights after oral administration of 5-aminolevulinic acid for fluorescence-guided resection of a malignant glioma, Alexander T. Yahanda, Gavin P. Dunn, and Michael R. Chicoine

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Evaluation of optimal blood culture incubation time to maximize clinically relevant results from a contemporary blood culture instrument and media system, Eric M Ransom, Zahra Alipour, Meghan A Wallace, and Carey-Ann D. Burnham

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Limited effects of long-term daily cranberry consumption on the gut microbiome in a placebo-controlled study of women with recurrent urinary tract infections, Timothy J Straub, Wen-Chi Chou, Abigail L Manson, Henry L Schreiber 4th, Bruce J Walker, Christopher A Desjardins, Sinéad B Chapman, Kerrie L Kaspar, Orsalem J Kahsai, Elizabeth Traylor, Karen W Dodson, Meredith A J Hullar, Scott J Hultgren, Christina Khoo, and Ashlee M Earl

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Racial residential segregation and colorectal cancer mortality in the Mississippi Delta Region, Aaron J Kruse-Diehr, Justin T McDaniel, Marquita W Lewis-Thames, Aimee S James, and Musa Yahaya

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Pharmacokinetic and pharmacodynamic profiling of minocycline for injection following a single infusion in critically ill adults in a phase IV open-label multicenter study (ACUMIN), Thomas P Lodise, Yasir Hamad, and et al

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Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1, Cuige Zhu, Sun-Joong Kim, Arshag Mooradian, Faliang Wang, Ziqian Li, Sean Holohan, Patrick L Collins, Keren Wang, Zhanfang Guo, Jeremy Hoog, Cynthia X Ma, Eugene M Oltz, Jason M Held, and Jieya Shao

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Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy, Ran Chen, Theresa Okeyo-Owuor, Riddhi M Patel, Emily B Casey, Andrew S Cluster, Wei Yang, and Jeffrey A Magee

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Microbiota restoration reduces antibiotic-resistant bacteria gut colonization in patients with recurrent Clostridioides difficile infection from the open-label PUNCH CD study, Amy Langdon, Drew J Schwartz, Christopher Bulow, Xiaoqing Sun, Tiffany Hink, Kimberly A Reske, Courtney Jones, Carey-Ann D Burnham, Erik R Dubberke, Gautam Dantas, and CDC Prevention Epicenter Program

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Reg4 and its downstream transcriptional activator CD44ICD in stage II and III colorectal cancer, Jared A. Sninsky, Kumar S. Bishnupuri, Iván González, Nikolaos A. Trikalinos, Ling Chen, and Brian K. Dieckgraefe

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Transcriptomic and functional analyses of mitochondrial dysfunction in pressure overload-induced right ventricular failure, HyunTae V Hwang, Nefthi Sandeep, Ramesh V Nair, Dong-Qing Hu, Mingming Zhao, Ingrid S Lan, Giovanni Fajardo, Scot J Matkovich, Daniel Bernstein, and Sushma Reddy

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Areas of metabolomic exploration for helminth infections, Jeffrey D Whitman, Judy A Sakanari, and Makedonka Mitreva

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Sense of coherence in adults with congenital heart disease in 15 countries: Patient characteristics, cultural dimensions and quality of life, Philip Moons, Kamila White, and et al.

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Hippocampus guides adaptive learning during dynamic social interactions, Oriel FeldmanHall, David F. Montez, Elizabeth A. Phelps, Lila Davachi, and Vishnu P. Murty

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Focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN), Dezhuang Ye and Hong Chen

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Rates of gene conversions between Escherichia coli ribosomal operons, Isaac Gifford, Aurko Dasgupta, and Jeffrey E Barrick

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TRIM67 regulates exocytic mode and neuronal morphogenesis via SNAP47, Fabio L Urbina, Shalini Menon, Dennis Goldfarb, Reginald Edwards, M Ben Major, Patrick Brennwald, and Stephanie L Gupton

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Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site, Rajendra Uprety, Tao Che, Balázs R. Varga, Abdelfattah Faouzi, Sarah M. Bernhard, Susruta Majumdar, and et al

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Treatment of patients with chronic pruritus of unknown origin with dupilumab, Jiehyun Jeon, Fang Wang, Asima Badic, and Brian S Kim

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Investigating the relevance of major signaling pathways in cancer survival using a biologically meaningful deep learning model, Jiarui Feng, Heming Zhang, and Fuhai Li

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Sympathetic stimulation increases serum lactate concentrations in patients admitted with sepsis: Implications for resuscitation strategies, Nikhil Jagan, Lee E Morrow, Ryan W Walters, Robert W Plambeck, Tej M Patel, Douglas R Moore, and Mark A Malesker

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Biomarkers associated with blinatumomab outcomes in acute lymphoblastic leukemia, Andrew H Wei, Josep-Maria Ribera, Richard A Larson, David Ritchie, Armin Ghobadi, Yuqi Chen, Abraham Anderson, Cedric E Dos Santos, Janet Franklin, and Hagop Kantarjian

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Enhanced efficacy and increased long-term toxicity of CNS-directed, AAV-based combination therapy for Krabbe disease, Yedda Li, Christopher A Miller, Lauren K Shea, Xuntian Jiang, Miguel A Guzman, Randy J Chandler, Sai M Ramakrishnan, Stephanie N Smith, Charles P Venditti, Carole A Vogler, Daniel S Ory, Timothy J Ley, and Mark S Sands

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Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation, Emilie V. Russler-Germain, Jaeu Yi, Shannon Young, Katherine Nutsch, Harikesh S. Wong, Teresa L. Ai, Jiani N. Chai, Vivek Durai, Daniel H. Kaplan, Ronald N. Germain, Kenneth M. Murphy, and Chyi-Song Hsieh

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Seroprevalence of SARS-CoV-2 antibodies in children and adults in St. Louis, Missouri, USA, Brittany K Smith, Andrew B Janowski, Jonathan E Danis, Ian B Harvey, Haiyan Zhao, Ya-Nan Dai, Christopher W Farnsworth, Ann M Gronowski, Stephen Roper, Daved H Fremont, and David Wang

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SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance, Maurizio Fazio, Charles K. Kaufman, and et al

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ANA Webinars: Implementation of a conference-based virtual networking event, Bhooma Aravamuthan, Eric C Landsness, and Elizabeth Silbermann

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A timely call to arms: COVID-19, the circadian clock, and critical care, Jeffrey Haspel, Minjee Kim, Phyllis Zee, Tanja Schwarzmeier, Sara Montagnese, Satchidananda Panda, Adriana Albani, and Martha Merrow

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Capsule carbohydrate structure determines virulence in Acinetobacter baumannii, Yuli Talyansky, Travis B. Nielsen, Jun Yan, Ulrike Carlino-Macdonald, Gisela Di Venanzio, Somnath Chakravorty, Amber Ulhaq, Mario F. Feldman, Thomas A. Russo, Evgeny Vinogradov, Brian Luna, Meredith S. Wright, Mark D. Adams, and Brad Spellberg

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CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14, Bruce K Patterson, Philip A Mudd, and et al

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Characterization and localization of antigens for serodiagnosis of human paragonimiasis, Kurt C Curtis, Kerstin Fischer, Young-Jun Choi, Makedonka Mitreva, Gary J Weil, and Peter U Fischer

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Clinical validation of combinatorial pharmacogenomic testing and single-gene guidelines in predicting psychotropic medication blood levels and clinical outcomes in patients with depression, Anthony J Rothschild, Charles R Conway, and et al.

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Decoding visual information from high-density diffuse optical tomography neuroimaging data, Kalyan Tripathy, Zachary E Markow, Andrew K Fishell, Arefeh Sherafati, Tracy M Burns-Yocum, Mariel L Schroeder, Alexandra M Svoboda, Adam T Eggebrecht, Mark A Anastasio, Bradley L Schlaggar, and Joseph P Culver

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Evaluating cognitive relationships with resting-state and task-driven blood oxygen level-dependent variability, Peter R Millar, Beau M Ances, Brian A Gordon, Tammie L S Benzinger, John C Morris, and David A Balota

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Evaluation of tumor immunity after administration of conditionally replicative adenoviral vector in canine osteosarcoma patients, Payal Agarwal, Elizabeth A Gammon, Maninder Sandey, Stephanie S Lindley, Jey W Koehler, Brad M Matz, Annette N Smith, Elena A Kashentseva, Igor P Dmitriev, David T Curiel, and Bruce F Smith

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Flortaucipir (tau) PET in LGI1 antibody encephalitis, Gregory S Day, Brian A Gordon, Austin McCullough, Robert C Bucelli, Richard J Perrin, Tammie L S Benzinger, and Beau M Ances

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Fronto-cerebellar connectivity mediating cognitive processing speed, Clive H Y Wong, Jiao Liu, Tatia M C Lee, Jing Tao, Alex W K Wong, Bolton K H Chau, Lidian Chen, and Chetwyn C H Chan

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Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans, Holly E. Kinser, Matthew C. Mosley, Isaac B. Plutzer, and Zachary Pincus

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Liver transplantation: Expanding the donor and recipient pool, Ola Ahmed and M. B. Majella Doyle

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NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis, I M Berke, E Jain, B Yavuz, T McGrath, L Chen, M J Silva, G Mbalaviele, F Guilak, D L Kaplan, and L A Setton

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Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants, Elmo Christian Saarentaus, Lei Chen, Ira M Hall, and et al

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Prognostic and predictive effect of KRAS gene copy number and mutation status in early stage non-small cell lung cancer patients, Andrea S. Fung, Maryam Karimi, Stefan Michiels, Lesley Seymour, Elisabeth Brambilla, Thierry Le-Chevalier, Jean-Charles Soria, Robert Kratzke, Stephen L. Graziano, Siddhartha Devarakonda, Ramaswamy Govindan, Ming-Sound Tsao, Frances A. Shepherd, and LACE-Bio Collaborative Group

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Progress towards onchocerciasis elimination in Côte d'Ivoire: A geospatial modelling study, Obiora A. Eneanya, Benjamin G. Koudou, Meite Aboulaye, Aba Ange Elvis, Yeo Souleymane, Marie-Madeleine Kouakou, Gary J. Weil, and Peter U. Fischer

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Quantitative proteomic analysis of diabetes mellitus in heart failure with preserved ejection fraction, Thomas C Hanff, Ali Javaheri, and et al

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Robotic bronchoscopy for peripheral pulmonary lesions: A multicenter pilot and feasibility study (BENEFIT), Alexander C Chen, Nicholas J Pastis Jr, Amit K Mahajan, Sandeep J Khandhar, Michael J Simoff, Michael S Machuzak, Joseph Cicenia, Thomas R Gildea, and Gerard A Silvestri

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Suspected metal allergy and femoral loosening after total knee arthroplasty: A diagnostic dilemma, Elizabeth G Lieberman, Robert L Barrack, and Thomas P Schmalzried

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The effect of the COVID-19 pandemic on hip and knee arthroplasty patients in the United States: A multicenter update to the previous survey, Timothy S Brown, Christopher A Anthony, and et al

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The role of endometrial sampling for surveillance of recurrence in postmenopausal patients with medically inoperable stage I endometrial cancer, Angelina Carey-Love, Mary M Mullen, Abigail Zamorano, Stephanie Markovina, Andrea R Hagemann, Katherine C Fuh, Premal H Thaker, David G Mutch, Matthew A Powell, and Lindsay M Kuroki

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"It's way more than just writing a prescription": A qualitative study of preferences for integrated versus non-integrated treatment models among individuals with opioid use disorder, Elizabeth C Saunders, Sarah K Moore, Olivia Walsh, Stephen A Metcalf, Alan J Budney, Patricia Cavazos-Rehg, Emily Scherer, and Lisa A Marsch

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Mapping the immune environment in clear cell renal carcinoma by single-cell genomics, Nicholas Borcherding, Ajaykumar Vishwakarma, Andrew P Voigt, Andrew Bellizzi, Jacob Kaplan, Kenneth Nepple, Aliasger K Salem, Russell W Jenkins, Yousef Zakharia, and Weizhou Zhang

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Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma, Richa Rathore, Katharine E Caldwell, Charles Schutt, Caitlyn B Brashears, Bethany C Prudner, William R Ehrhardt, Cheuk Hong Leung, Heather Lin, Najat C Daw, Hannah C Beird, Abigail Giles, Wei-Lien Wang, Alexander J Lazar, John S A Chrisinger, J Andrew Livingston, and Brian A Van Tine

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Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination, Julianna Han, Aaron J Schmitz, Sara T Richey, Ya-Nan Dai, Hannah L Turner, Bassem M Mohammed, Daved H Fremont, Ali H Ellebedy, and Andrew B Ward

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Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder, Xiaoming Jia, Fernando S Goes, Adam E Locke, Duncan Palmer, Weiqing Wang, and et al

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Genomic characterization of emerging bacterial uropathogen Neisseria meningitidis, which was misidentified as Neisseria gonorrhoeae by nucleic acid amplification testing, Kimberley V Sukhum, Sophonie Jean, Meghan Wallace, Neil Anderson, C A Burnham, and Gautam Dantas

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Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy, Kinan Alhallak, Jennifer Sun, Katherine Wasden, Nicole Guenthner, Julie O'Neal, Barbara Muz, Justin King, Daniel Kohnen, Ravi Vij, Samuel Achilefu, John F DiPersio, and Abdel Kareem Azab

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Central venous catheter adverse events are not associated with crowding indicators, Daniel L Theodoro, Niraj Vyas, Enyo Ablordeppey, Brian Bausano, Stephanie Charshafian, Phillip Asaro, and Richard T Griffey

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Implications of oligomeric amyloid-beta (oAβ42) signaling through α7β2-nicotinic acetylcholine receptors (nAChRs) on basal forebrain cholinergic neuronal intrinsic excitability and cognitive decline, Andrew A George, Jaime M Vieira, Cameron Xavier-Jackson, Michael T Gee, John R Cirrito, Heather A Bimonte-Nelson, Marina R Picciotto, Ronald J Lukas, and Paul Whiteaker

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Naturalistic language input is associated with resting-state functional connectivity in infancy, Lucy S. King, M. Catalina Camacho, David F. Montez, Kathryn L. Humphreys, and Ian H. Gotlib

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Short-term effects of appropriate empirical antimicrobial treatment with ceftolozane/tazobactam in a swine model of nosocomial pneumonia, Ana Motos, Marin Kollef, and et al

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Coxsackievirus B3 infection early in pregnancy induces congenital heart defects through suppression of fetal cardiomyocyte proliferation, Vipul Sharma, Lisa S Goessling, Anoop K Brar, Chetanchandra S Joshi, Indira U Mysorekar, and Pirooz Eghtesady

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Death and myocardial infarction following initial revascularization versus optimal medical therapy in chronic coronary syndromes with myocardial ischemia: A systematic review and meta-analysis of contemporary randomized controlled trials, Andrea Soares, William E Boden, Whady Hueb, Maria M Brooks, Helen E A Vlachos, Kevin O'Fee, Angela Hardi, and David L Brown

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SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike, Jenna J Guthmiller, Ya-Nan Dai, Christopher A Nelson, Paige D Hall, Daved H Fremont, and et al

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Designing and undertaking randomised implementation trials: Guide for researchers, Luke Wolfenden, Robbie Foy, Justin Presseau, Jeremy Grimshaw, Noah Ivers, Byron Powell, Monica Taljaard, John Wiggers, Rachel Sutherland, Nicole Nathan, Christopher Williams, Melanie Kingsland, Andrew Milat, Rebecca Hodder, and Sze Lin Yoong

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Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism, J L Fachi, L P Pral, J A C Dos Santos, A C Codo, S de Oliveira, J S Felipe, F F F Zambom, N O S Câmara, P M M M Vieira, M Colonna, and M A R Vinolo

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Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition, Allison J. Greaney, Paul W. Rothlauf, Zhuoming Liu, Sean P. J. Whelan, and et al.

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Randomized controlled trial of oral vancomycin treatment in Clostridioides difficile-colonized patients, Skye R S Fishbein, Tiffany Hink, Kimberly A Reske, Candice Cass, Emily Struttmann, Zainab Hassan Iqbal, Sondra Seiler, Jennie H Kwon, C A Burnham, Gautam Dantas, and Erik R Dubberke

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Developmental stage-specific changes in protein synthesis differentially sensitize hematopoietic stem cells and erythroid progenitors to impaired ribosome biogenesis, Jeffrey A Magee and Robert A J Signer

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Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH, Sabine Daemen, Anastasiia Gainullina, Gowri Kalugotla, Li He, Mandy M Chan, Joseph W Beals, Kim H Liss, Samuel Klein, Ariel E Feldstein, Brian N Finck, Maxim N Artyomov, and Joel D Schilling

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Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade, Sharmila Nair, Luciano Mazzoccoli, Arijita Jash, Jennifer Govero, Sachendra S Bais, Tong Hu, Camila R Fontes-Garfias, Chao Shan, Hideho Okada, Sujan Shresta, Jeremy N Rich, Pei-Yong Shi, Michael S Diamond, and Milan G Chheda

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The Dark Kinase Knowledgebase: An online compendium of knowledge and experimental results of understudied kinases, Matthew E. Berginski, Nienke Moret, Changchang Liu, Dennis Goldfarb, Peter K. Sorger, and Shawn M. Gomez

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Relationship between clinicopathologic factors and FDG avidity in radioiodine-negative recurrent or metastatic differentiated thyroid carcinoma, Le Ngoc Ha, Amir Iravani, Nguyen Thi Nhung, Ngo Thi Minh Hanh, Febby Hutomo, and Mai Hong Son

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Application of systems dynamics and group model building to identify barriers and facilitators to acute care delivery in a resource limited setting, Fiona Muttalib, Ellis Ballard, Josephine Langton, Sara Malone, Yudy Fonseca, Andreas Hansmann, Kenneth Remy, Peter Hovmand, and Allan Doctor

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Small molecule SARM1 inhibitors recapitulate the SARM1 -/- phenotype and allow recovery of a metastable pool of axons fated to degenerate, Robert O Hughes, Todd Bosanac, Xianrong Mao, Thomas M Engber, Aaron DiAntonio, Jeffrey Milbrandt, Rajesh Devraj, and Raul Krauss

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Function of mammalian M-cones depends on the level of CRALBP in Müller cells, Alexander V. Kolesnikov, Philip D. Kiser, Krzysztof Palczewski, and Vladimir J. Kefalov

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4β-Hydroxycholesterol is a prolipogenic factor that promotes SREBP1c expression and activity through the liver X receptor, Ofer Moldavski, Peter-James H. Zushin, Charles A. Berdan, Robert J. Van Eijkeren, Xuntian Jiang, Mingxing Qian, Daniel S. Ory, Douglas F. Covey, Daniel K. Nomura, Andreas Stahl, Ethan J. Weiss, and Roberto Zoncu

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AAPM medical physics practice guideline 3.b.: Levels of supervision for medical physicists in clinical training, Douglas Pfeiffer, Hania Al-Hallaq, Per Halvorsen, Kristi Hendrickson, Zheng Feng Lu, Melissa Carol Martin, Beth Schueler, Jillian Shuman, and Jacqueline E Zoberi

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Ablative five-fraction stereotactic body radiation therapy for inoperable pancreatic cancer using online MR-guided adaptation, Comron Hassanzadeh, Soumon Rudra, Ani Bommireddy, William G Hawkins, Andrea Wang-Gillam, Ryan C Fields, Bin Cai, Justin Park, Olga Green, Michael Roach, Lauren Henke, and Hyun Kim

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A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease, Xiao Zhang, Hero Robles, Kristann L. Magee, Madelyn R. Lorenz, Zhaohua Wang, Charles A. Harris, Clarissa S. Craft, and Erica L. Scheller

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Academic performance of children with sickle cell disease in the United States: A meta-analysis, Andrew M Heitzer, Latacha Hamilton, Claire Stafford, Jeffrey Gossett, Lara Ouellette, Ana Trpchevska, Allison A King, Guolian Kang, and Jane S Hankins

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A canker barking at the wrong knee: Thyronectria austroamericana septic arthritis, Sasinuch Rutjanawech, Carlos Mejia-Chew, Chapelle Ayres, and Andrej Spec

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Acanthamoeba keratitis, pathology, diagnosis and treatment, Nicholas Fanselow, Nadia Sirajuddin, Xiao-Tang Yin, Andrew J W Huang, and Patrick M Stuart

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Acaricidal activity of Foeniculum vulgare against Rhipicephalus annulatus is mainly dependent on its constituent from trans-anethone, Shawky M. Aboelhadid, Waleed M. Arafa, Abdel-Azeem S. Abdel-Baki, Atalay Sokmen, Saleh Al-Quraishy, Ahmed O. Hassan, and Asmaa A. Kamel

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A Casz1–NuRD complex regulates temporal identity transitions in neural progenitors, Pierre Mattar, Christine Jolicoeur, Thanh Dang, Sujay Shah, Brian S. Clark, and Michel Cayouette

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Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease, Julie Gonneaud, Brian A. Gordon, Carlos Cruchaga, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, Susan Brandon, Virginia Buckles, Tamara Donahue, Anne Fagan, Gigi Flynn, Erin Franklin, Cortaiga Gant, Julia Gray, Alexander Groves, Jason Hassenstab, Laura Hoechst-Swisher, David Holtzman, Russ Hornbeck, Gina Jerome, Celeste Karch, Denise Maue-Dreyfus, Eric McDade, Joanne Norton, Richard Perrin, Marc Raichle, Wendy Sigurdson, Peter Wang, Chengjie Xiong, Xiong Xu, Nigel J. Cairns, Erin Householder, Lisa Taylor Reinwald, Beau Ances, Maria Carroll, Sue Leon, Mark A. Mintun, Stacy Schneider, and et al