The Open Access Publications collection contains peer-reviewed articles authored by Washington University School of Medicine faculty that have been published in open access journals or authorized by the publishers for open access availability. Open access works are generally defined as being publicly available online and free of most licensing and copyright restrictions. The Bernard Becker Medical Library maintains this collection in support of Washington University’s commitment to the principles of open access publishing and making the scholarly work and research results of our faculty as widely and easily available as possible.

You can find more information about Washington University's Open Access Resolution in Becker Medical Library's Open Access subject guide “OA Resolution at WU

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Submissions from 2015

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Drosophila Muller F elements maintain a distinct set of genomic properties over 40 million years of evolution, Elaine R. Mardis, Sarah C.R. Elgin, and et al

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Finely tuned temporal and spatial delivery of GDNF promotes enhanced nerve regeneration in a long nerve defect model, Laura M. Marquardt, Xueping Ee, Nisha Iyer, Daniel Hunter, Susan E. Mackinnon, Matthew D. Wood, and Shelly E. Sakiyama-Elbert

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Dorsal inlay buccal mucosal graft (Asopa) urethroplasty for anterior urethral stricture, Stephen D. Marshall, Valary T. Raup, and Steven B. Brandes

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Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons, Pedro L. Martinez-Espinosa, Jianping Wu, Chengtao Yang, Vivian Gonzalez-Perez, Huifang Zhou, Xiao-Ming Xia, and Christopher J. Lingle

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Scimitar syndrome: Multimodal imaging before and after repair, Sara C. Martinez, Pirooz Eghtesady, Sanjeev Bhalla, and Philip A. Ludbrook

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Changes in knowledge of cervical cancer following introduction of human papillomavirus vaccine among women at high risk for cervical cancer, L. Stewart Massad, Charlesnika T. Evans, Kathleen M. Weber, Gypsyamber D'Souza, Nancy A. Hessol, Rodney L. Wright, Christine Colie, Howard D. Strickler, and Tracey E. Wilson

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Cyclotron production of high–specific activity 55Co and in vivo evaluation of the stability of 55Co metal-chelate-peptide complexes, Tara Mastren, Bernadette V. Marquez, Deborah E. Sultan, Elizabeth Bollinger, Paul Eisenbeis, Tom Voller, and Suzanne E. Lapi

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ProteomeScout: A repository and analysis resource for post-translational modifications and proteins, Matthew K. Matlock, Alex S. Holehouse, and Kristen M. Naegle

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Revolutionizing Alzheimer's disease and clinical trials through biomarkers, Niklas Mattsson, Maria C. Carrillo, Robert A. Dean, Michael D. Devous Sr., Tania Nikolcheva, Pedro Pesini, Hugh Salter, William Z. Potter, Reisa S. Sperling, Randall J. Bateman, Lisa J. Bain, and Enchi Liu

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Metastatic melanoma – A review of current and future treatment options, Emanual Maverakis, Lynn A. Cornelius, Glen M. Bowen, Tiffany Phan, Falin B. Patel, Sarah Fitzmaurice, Young He, Barbara Burrall, Christopher Duong, April M. Kloxin, Hawa Sultani, Reason Wilken, Steve R. Martinez, and Forum Patel

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Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress, Xlucul Ma, Halyan Liu, John T. Murphy, Sarah R. Foyil, Rebecca J. Godar, Haedar Abulrqeba, Carla J. Weinheimer, Philip M. Barger, and Abhinav Diwan

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Trial of short-course antimicrobial therapy for intraabdominal infection, J E. Mazuski and et al

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WSES guidelines for management of Clostridium difficile infection in surgical patients, John E. Mazuski and et al

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Development and piloting of a treatment foster care program for older youth with psychiatric problems, J. Curtis McMillen, Sarah Carter Narendorf, Debra Robinson, Judy Havlicek, Nicole Fedoravicius, Julie Bertram, and David McNelly

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Brown-pigmented Mycobacterium mageritense as a cause of prosthetic valve endocarditis and bloodstream infection, Allison R. McMullen, Caline Mattar, Nigar Kirmani, and Carey-Ann D. Burnham

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Differential effects of tango versus Dance for PD in Parkinson disease, Marie E. McNeely, Marina M. Mai, Ryan P. Duncan, and Gammon M. Earhart

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Carpal tunnel syndrome and computer exposure at work in two large complementary cohorts, Z. Mediouni, J. Bodin, Ann Marie Dale, E. Herquelot, M. Carton, A. Leclerc, N. Fouquet, C. Dumontier, Y. Roquelaure, Bradley A. Evanoff, and A. Descatha

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Research priorities to improve the management of acute malnutrition in infants aged less than six months (MAMI), Sagar Mehta and et al

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Association of lower fractional flow reserve values with higher risk of adverse cardiac events for lesions deferred revascularization among patients with acute coronary syndrome, Shriti Masrani Mehta, Jeremiah P. Depta, Eric Novak, Jayendrakumar S. Patel, Yogesh Patel, David Raymer, Gabrielle Facey, Alan Zajarias, John M. Lasala, Jasvindar Singh, Richard G. Bach, and Howard I. Kurz

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Neck pain following laminoplasty, Addisu Mesfin, Moon-Soo Park, Chaiwat Piyaskulkaew, Tapanut Chuntarapas, Kwang S. Song, Han J. Kim, and K. Daniel Riew

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Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors, Talibah U. Metcalf, Rafael A. Cubas, Khader Ghneim, Michael J. Cartwright, Julien Van Grevenynghe, Justin M. Richner, David P. Olagnier, Peter A. Wilkinson, Mark J. Cameron, Byung S. Park, John B. Hiscott, Michael S. Diamond, Anne M. Wertheimer, Janko Nikolich-Zugich, and Elias K. Haddad

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Prevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia, Caroline T. Meyer, Irma K. Bauer, Martin Antonio, Mitchell Adeyemi, Debasish Saha, Joseph O. Oundo, John B. Ochieng, Richard Omore, O. Colin Stine, David Wang, and Lori R. Holtz

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Evidence for intermolecular interactions between the intracellular domains of the Arabidopsis receptor-like kinase ACR4, its homologs and the Wox5 transcription factor, Matthew R. Meyer, Shweta Shah, J. Zhang, Henry Rohrs, and A. Gururaj Rao

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Leber hereditary optic neuropathy: Current perspectives, Cherise Meyerson, Greg Van Stavern, and Collin McClelland

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De novo transcriptome analysis of Medicago falcata reveals novel insights about the mechanisms underlying abiotic stress-responsive pathway, Zhenyan Miao, Wei Xu, Daofeng Li, Xiaona Hu, Jiaxing Liu, Rongxue Zhang, Zongyong Tong, Jiangli Dong, Zhen Su, Liwei Zhang, Min Sun, Wenjie Li, Zhenglin Du, Songnian Hu, and Tao Wang

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Pseudomonas aeruginosa nosocomial pneumonia: Impact of pneumonia classification, Scott T. Micek, Marin H. Kollef, Antoni Torres, Catherine Chen, Jordi Rello, Jean Chastre, Massimo Antonelli, Tobias Welte, Bernard Clair, Helmut Ostermann, Esther Calbo, Richard Wunderink, Francesco Menichetti, Garrett Schramm, and Vandana Menon

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An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: Impact of multidrug resistance, Scott T. Micek, Richard G. Wunderink, Marin H. Kollef, Catherine Chen, Jordi Rello, Jean Chastre, Massimo Antonelli, Tobias Welte, Bernard Clair, Helmut Ostermann, Esther Calbo, Antoni Torres, Francesco Menichetti, Garrett E. Schramm, and Vandana Menon

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slan/M-DC8+ cells constitute a distinct subset of dendritic cells in human tonsils, Alessandra Micheletti, Giulia Finotti, Federica Calzetti, Silvia Lonardi, Elisa Zoratti, Mattia Bugatti, Stefania Stefini, William Vermi, and Marco A. Cassatella

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Functional heterogeneity in CD4+ T cell responses against a bacterial pathogen, Ashley Viehmann Milam and Paul M. Allen

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Colorectal cancer: Advances in prevention and early detection, Anne Miles, Franzel van Duijnhoven, Amy McQueen, and Raymond Oliphant

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An automated motion detection and reward system for animal training, Brad Miller, Audrey N. Lim, Arnold F. Heidbreder, and Kevin J. Black

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HIF-1α mediates isoflurane-induced vascular protection in subarachnoid hemorrhage, Eric Milner, Andrew W. Johnson, James W. Nelson, Michael D. Harries, Jeffrey M. Gidday, Byung Hee Han, and Gregory J. Zipfel

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The Physarum polycephalum genome reveals extensive use of prokaryotic two-component and metazoan-type tyrosine kinase signaling, Pat Minx, Catrina Fronick, Lucinda Fulton, Chad Tomlinson, Wesley C. Warren, Richard K. Wilson, and et al

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Propagated infra-slow intrinsic brain activity reorganizes across wake and slow wave sleep, Anish Mitra, Abraham Z. Snyder, Enzo Tagliazucchi, Helmut Laufs, and Marcus E. Raichle

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An unusual cause of acute anemia in an immunosuppressed patient, Jamak Modaresi Esfeh, Whitney Jackson, Kianoush Ansari-Gilani, and Brian Putka

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Neurocognitive outcomes and school performance in solid tumor cancer survivors lacking therapy to the central nervous system, Caroline Mohrmann, Jennifer Henry, Marnie Hauff, and Robert J. Hayashi

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Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma, Jeffrey F. Moley and et al

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Binocular Goggle Augmented Imaging and Navigation System provides real-time fluorescence image guidance for tumor resection and sentinel lymph node mapping, Suman B. Mondal, Shengkui Gao, Nan Zhu, Gail P. Sudlow, Kexian Liang, Avik Som, Walter J. Akers, Ryan C. Fields, Julie Margenthaler, Rongguang Liang, Viktor Gruev, and Samuel Achilefu

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Neurons in the primate medial basal forebrain signal combined information about reward uncertainty, value, and punishment anticipation, Ilya E. Monosov, David A. Leopold, and Okihide Hikosaka

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A disorder of surfactant metabolism without identified genetic mutations, Silvia Montella, Timothy J. Vece, Claire Langston, Paola Carrera, Lawrence M. Nogee, Aaron Hamvas, Angelo Manna, Mara Cervasio, and Francesca Santamaria

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Increased exclusivity of breastfeeding associated with reduced gut inflammation in infants, Eshia Moodley-Govender, Helen Mulol, Jennifer Stauber, Mark Manary, and Anna Coutsoudis

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Gut resistome development in healthy twin pairs in the first year of life, Aimee M. Moore, Sara Ahmadi, Sanket Patel, Molly K. Gibson, Bin Wang, Malick I. Ndao, Elena Deych, William Shannon, Phillip I. Tarr, Barbara B. Warner, and Gautam Dantas

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Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice, David J. Morales, Kristen Monte, Lulu Sun, Jessica J. Struckhoff, Eugene Agapov, Michael J. Holtzman, Thaddeus S. Stappenbeck, and Deborah J. Lenschow

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Cerebrospinal fluid levels of amyloid precursor protein are associated with ventricular size in post-hemorrhagic hydrocephalus of prematurity, Diego M. Morales, Richard Holubkov, Terri E. Inder, Haejun C. Ahn, Deanna Mercer, Rakesh Rao, James P. McAllister II, David M. Holtzman, and David D. Limbrick Jr.

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Personality and well-being in adolescents, Paulo A.S. Moreira, C. Robert Cloninger, Liliana Dinis, Laura Sa, Joao T. Oliveira, Adelaide Dias, and Joana Oliveira

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Antimicrobial susceptibility profiles of Staphylococcus aureus isolates recovered from humans, environmental surfaces, and companion animals in households of children with community-onset methicillin-resistant S. aureus infections, John J. Morelli, Patrick G. Hogan, Melanie L. Sullivan, Carol E. Muenks, Jeffrey W. Wang, Ryley M. Thompson, Carey-Ann D. Burnham, and Stephanie A. Fritz

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Bone-immune cell crosstalk: Bone diseases, Giorgio Mori, Patrizia D'Amelio, Roberta Faccio, and Giacomina Brunetti

Large-scale genomics unveil polygenic architecture of human cortical surface area, John Morris, Marc Raichle, Davie Holtzman, Nigel J. Cairns, Erin Householder, Lisa Taylor-Reinwald, and et al.

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Identification and analysis of divergent immune gene families within the Tasmanian devil genome, Katrina M. Morris, Yuanyuan Cheng, Wesley Warren, Anthony T. Papenfuss, and Katherine Belov

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Asymmetric protonation of EmrE, Emma A. Morrison, Anne E. Robinson, Yongjia Liu, and Katherine A. Henzler-Wildman

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Trial of early, goal-directed resuscitation for septic shock, Paul R. Mouncey, Tiffany M. Osborn, G. Sarah Power, David A. Harrison, M. Zia Sadique, Richard D. Grieve, Rahi Jahan, Sheila E. Harvey, Derek Bell, Julian F. Bion, Timothy J. Coats, Mervyn Singer, J. Duncan Young, and Kathryn M. Rowan

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Personality and intelligence: Persistence, not self-directedness, cooperativeness or self-transcendence, is related to twins’ cognitive abilities, Fariba Mousavi, Sandor Rozsa, Thomas Nilsson, Trevor Archer, Henrik Anckarsater, and Danilo Garcia

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Multi-platform profiling of over 2000 sarcomas: Identification of biomarkers and novel therapeutic targets, Sujana Movva, Wenhsiang Wen, Wangjuh Chen, Sherri Z. Millis, Zoran Gatalica, Sandeep Reddy, Margaret von Mehren, and Brian A. Van Tine

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Role of cortactin homolog HS1 in transendothelial migration of Natural Killer cells, Suranjana Mukherjee, Joanna Kim, Olivia L. Mooren, Stefanie T. Shahan, Megan Cohan, and John A. Cooper

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Atypical propylthiouracil-induced ANCA-positive vasculitis: report of a case with unusual clinical and histopathologic findings, Jamie L. Mull, Jason F. Solus, Misha M. Mutizwa, Herbert C. Chiang, Ilana S. Rosman, and Amy Musiek

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Circadian clock disruption in neurodegenerative diseases: Cause and effect?, Erik S. Musiek

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Sleep, circadian rhythms, and the pathogenesis of Alzheimer Disease, Erik S. Musiek, David D. Xiong, and David M. Holtzman

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Inhibition of P-Selectin and PSGL-1 using humanized monoclonal antibodies increases the sensitivity of multiple myeloma cells to bortezomib, Barbara Muz, Feda Azab, Pilar de la Puente, Scott Rollins, Richard Alvarez, Ziad Kawar, and Abdel Kareem Azab

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The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy, Barbara Muz, Pilar de la Puente, Feda Azab, and Abdel K. Azab

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IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis, Rei Nakamura, Abdoulaye Sene, Andrea Santeford, Abdelaziz Gdoura, Shunsuke Kubota, Nicole Zapata, and Rajendra S. Apte

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Genome-wide profiling of PARP1 reveals an interplay with gene regulatory regions and DNA methylation, Narasimharao Nalabouthula, Taha Al-jumaily, Abdallah M. Eteleeb, Robert M. Flight, Shao Xiaorong, Hunter Moseley, Eric C. Rouchka, and Yvonne N. Fondufe-Mittendorf

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Sumoylation is developmentally regulated and required for cell pairing during conjugation in Tetrahymena thermophila, Amjad M. Nasir, Qianyi Yang, Douglas L. Chalker, and James D. Forney

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Structural conservation and functional diversity of the Poxvirus Immune Evasion (PIE) domain superfamily, Christopher A. Nelson, Megan L. Epperson, Sukrit Singh, Jabari I. Elliott, and Daved H. Freemont

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Spatial and temporal characteristics of error-related activity in the human brain, Maital Neta, Francis M. Miezin, Steven M. Nelson, Joseph W. Dubis, Nico U. F. Dosenbach, Bradley L. Schlaggar, and Steven E. Petersen

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SPEAR Trial: Smartphone Pediatric ElectrocARdiogram Trial, Hoang H. Nguyen, George F. Van Hare, Michael Rudokas, Tammy Bowman, and Jennifer N. A. Silva

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Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides, Igor Nikolskiy, Donald F. Conrad, Sung Chun, Justin C. Fay, James M. Cheverud, and Heather A. Lawson

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Ultrasound-aided multi-parametric photoacoustic microscopy of the mouse brain, Bo Ning, Naidi Sun, Ruimin Chen, K Kirk Shung, John A. Hossack, Jin-Moo Lee, Qifa Zhou, Song Hu, and Rui Cao

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Improving breast cancer services for African-American women living in St. Louis, Lailea Noel, Shahnjayla K. Connors, Melody S. Goodman, and Sarah Gehlert

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Case report: Typhoid fever complicated by hemophagocytic lymphohistiocytosis and rhabdomyolysis, Lemuel R. Non, Rupa Patel, Amir Esmaeeli, and Vladimir Despotovic

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Predictors of pathological complete response to neoadjuvant chemotherapy in stage II and III breast cancer: The impact of chemotherapeutic regimen, Iheoma Y. Nwaogu, Oluwadamilola M. Fayanju, Donna B. Jeffe, and Julie A. Margenthaler

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Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research, Pankaj Oberoi and et al

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ERK2 alone drives inflammatory pain but cooperates with ERK1 in sensory neuron survival, Daniel E. O'Brien, Benedict J. Alter, Maiko Satomoto, Clinton D. Morgan, Steve Davidson, Sherri K. Vogt, Megan E. Norman, Graydon B. Gereau, Joseph A. Demaro III, Gary E. Landreth, Judith P. Golden, and Robert W. Gereau IV

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Deletion of macrophage vitamin D receptor promotes insulin resistance and monocyte cholesterol transport to accelerate atherosclerosis in mice, Jisu Oh, Amy E. Riek, Isra Darwech, Katsuhiko Funai, JianSu Shao, Kathleen Chin, Oscar L. Sierra, Geert Carmeliet, Richard E. Ostlund Jr., and Carlos Bernal-Mizrachi

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Identification of medically actionable secondary findings in the 1000 genomes, Emily Olfson, Catherine E. Cottrell, Nicholas O. Davidson, Christina A. Gurnett, Jonathan W. Heusel, Nathan O. Stitziel, Li-Shiun Chen, Sarah Hartz, Rakesh Nagarajan, Nancy L. Saccone, and Laura J. Bierut

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Incidence of surgical site infection following mastectomy with and without immediate reconstruction using private insurer claims data, Margaret A. Olsen, Katelin B. Nickel, Ida K. Fox, Julie A. Margenthaler, Kelly E. Ball, Daniel Mines, Anna E. Wallace, and Victoria J. Fraser

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Stratification of surgical site infection by operative factors and comparison of infection rates after hernia repair, Margaret A. Olsen, Katelin B. Nickel, Anna E. Wallace, Daniel Mines, Victoria J. Fraser, and David K. Warren

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Mcl-1 is a key regulator of the ovarian reserve, S Omari, M Waters, T Naranian, K Kim, A L. Perumalsamy, M Chi, E Greenblatt, K H. Moley, J T. Opferman, and A Jurisicova

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The effect of dietary resistant starch type 2 on the microbiota and markers of gut inflammation in rural Malawi children, M. Isabel Ordiz, Thaddaeus D. May, Kathie Mihindukulasuriya, John Martin, Jan Crowley, Phillip I. Tarr, Kelsey Ryan, Elissa Mortimer, Geetha Gopalsamy, Ken Maleta, Makedonka Mitreva, Graeme Young, and Mark J. Manary

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Fibroblast growth factor signaling in skeletal development and disease, David M. Ornitz and Pierre J. Marie

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Physical activity affects brain integrity in HIV+ individuals, Mario Ortega, Laurie M. Baker, Florin Vaida, Robert Paul, Brian Basco, and Beau M. Ances

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Regulation of renal hemodynamics and function by RGS2, Patrick Osei-Owusu, Elizabeth A. Owens, Li Jie, Janaina S. Reis, Steven J. Forrester, Tatsuo Kawai, Satoru Eguchi, Harpreet Singh, and Kendall J. Blumer

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Full thickness macular hole case after intravitreal aflibercept treatment, Yuji Oshima, Rajendra S. Apte, Shintaro Nakao, Shigeo Yoshida, and Tatsuro Ishibashi

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A nationwide non-interventional epidemiological data registry on myelodysplastic syndromes in Lebanon, Zaher K. Otrock and et al.

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Fmrp targets or not: Long, highly brain-expressed genes tend to be implicated in autism and brain disorders, Rebecca L. Ouwenga and Joseph Dougherty

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Developing educational competencies for dissemination and implementation research training programs: An exploratory analysis using card sorts, Margaret Padek, Graham Colditz, Maureen Dobbins, Nikolas Koscielniak, Enola K. Proctor, Anne E. Sales, and Ross C. Brownson

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Streptococcus pyogenes malate degradation pathway links pH regulation and virulence, Elyse Paluscio and Michael G. Caparon

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Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing, Bijal A. Parikh, Diana L. Beckman, Swapneel J. Patel, J. Michael White, and Wayne M. Yokoyama

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Dual requirement of cytokine and activation receptor triggering for cytotoxic control of murine cytomegalovirus by NK cells, Bijal A. Parikh, Sytse J. Piersma, Melissa A. Pak-Wittel, Liping Yang, Robert D. Schreiber, and Wayne M. Yokoyama

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Surgical anatomy of the uncinate process and transverse foramen determined by computer tomography, Moon S. Park, Seong-Hwan Moon, Tae-Hwan Kim, Jae K. Oh, Jae K. Jung, Hyung J. Kim, and K. Daniel Riew

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Asymptomatic stenosis in the cervical and thoracic spines of patients with symptomatic lumbar stenosis, Moon S. Park, Seong-Hwan Moon, Tae-Hwan Kim, Jae K. Oh, Ho D. Lyu, Jae-Hoo Lee, and K. Daniel Riew

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Delayed surgical intervention in central cord syndrome with cervical stenosis, Moon S. Park, Seong-Hwan Moon, Hwan-Mo Lee, Tae-Hwan Kim, Jae K. Oh, Bo-Kyung Suh, Seung J. Lee, and K. D. Riew

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The nutrition transition in Colombia over a decade: A novel household classification system of anthropometric measures, Diana C. Parra, Lora Iannotti, Luis F. Gomez, Helena Pachon, Debra Haire-Joshu, Olga L. Sarmiento, Anne Sebert Kuhlmann, and Ross C. Brownson

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Thyroid cancer and nonsteroidal anti-inflammatory drug use: a pooled analysis of patients older than 40 years of age, Dhaval Patel, Cari M. Kitahara, Yikyung Park, Linda M. Liao, Martha Linet, Electron Kebebew, and Naris Nilubol

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Travel advice for the immunocompromised traveler: prophylaxis, vaccination, and other preventive measures, Rupa R. Patel, Stephen Y. Liang, Pooja Koolwal, and Frederick Matthew Kuhlmann

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Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids, Gary J. Patti and et al

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Comparison of chromogenic media for recovery of carbapenemase-producing enterobacteriaceae (CPE) and evaluation of CPE prevalence at a tertiary care academic medical center, Morgan A. Pence, Tiffany Hink, and Carey-Ann D. Burnham

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Rice Xa21 primed genes and pathways that are critical for combating bacterial blight infection, Hai Peng, Zheng Chen, Zhiwei Fang, Junfei Zhou, Zhihui Xia, Lifen Gao, Lihong Chen, Lili Li, Tiantian Li, Wenxue Zhai, and Weixiong Zhang

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Perilesional edema in radiation necrosis reflects axonal degeneration, Carlos J. Perez-Torres, Liya Yuan, Robert E. Schmidt, Keith M. Rich, Joseph JH Ackerman, and Joel R. Garbow

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Increased reward-related behaviors during sleep and wakefulness in sleepwalking and idiopathic nightmares, Lampros Perogamvros, Kristoffer Aberg, Marianne Gex-Fabry, Stephen Perrig, C. Robert Cloninger, and Sophie Schwartz

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Functional characterization of bacteria isolated from ancient Arctic soil exposes diverse resistance mechanisms to modern antibiotics, Gabriel G. Perron, Lyle Whyte, Peter J. Turnbaugh, Jacqueline Goordial, William P. Hanage, Gautam Dantas, and Michael M. Desai