The Open Access Publications collection contains peer-reviewed articles authored by Washington University School of Medicine faculty that have been published in open access journals or authorized by the publishers for open access availability. Open access works are generally defined as being publicly available online and free of most licensing and copyright restrictions. The Bernard Becker Medical Library maintains this collection in support of Washington University’s commitment to the principles of open access publishing and making the scholarly work and research results of our faculty as widely and easily available as possible.

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Submissions from 2007

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Comparison of C. elegans and C. briggsae genome sequences reveals extensive conservation of chromosome organization and synteny, LaDeana W. Hiller, Raymond D. Miller, Scott E. Baird, Asif Chinwalla, Lucinda A. Fulton, Daniel C. Koboldt, and Robert H. Waterston

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Linkage and association analyses of principal components in expression data, Anthony L. Hinrichs, Robert Culverhouse, Carol H. Jin, and Brian K. Suarez

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Haplotyping a quantitative trait with a high-density map in experimental crosses, Wei Hou, John Stephen F. Yap, Song Wu, Tian Liu, James M. Cheverud, and Rongling Wu

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The cis-regulatory logic of the mammalian photoreceptor transcriptional network, Timothy H. Hsiau, Claudiu Diaconu, Connie A. Myers, Jongwoo Lee, Constance L. Cepko, and Joseph C. Corbo

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Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes, Ching-Yu Huang, Girdhar G. Sharma, Laura M. Walker, Craig H. Bassing, Tej K. Pandita, and Barry P. Sleckman

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Genetic and pharmacological factors that influence reproductive aging in nematodes, Stacie E. Hughes, Kimberley Evason, Chengjie Xiong, and Kerry Kornfeld

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Gene duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a, Keith A. Hultman, Nathan Bahary, Leonard I. Zon, and Stephen L. Johnson

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The Par-1/MARK family of protein kinases: From polarity to metabolism, Jonathan Hurov and Helen Piwnica-Worms

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Changing human visual field organization from early visual to extra-occipital cortex, Anthony I. Jack, Gaurav H. Patel, Serguei V. Astafiev, Abraham Z. Snyder, Erbil Akbudak, Gordon L. Shulman, and Maurizio Corbetta

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Genomic and gene regulatory signatures of cryptozoic adaptation: Loss of blue sensitive photoreceptors through expansion of long wavelength-opsin expression in the red flour beetle Tribolium castaneum, Magdalena Jackowska, Riyue Bao, Zhenyi Liu, Elizabeth C. McDonald, Tiffany A. Cook, and Markus Friedrich

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Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing, Verena Jantsch, Lois Tang, Pawel Pasierbek, Alexandra Penkner, Sudhir Nayak, Antoine Baudrimont, Tim Schedl, Anton Gartner, and Josef Loidl

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Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: Applications in diagnostic imaging and therapy, Hiroyuki Kashiwagi, Jonathan E. McDunn, Peter O. Simon Jr, Peter S. Goedegebuure, Jinbin Xu, Lynne Jones, Katherine Chang, Fabian Johnston, Kathryn Trinkaus, Richard S. Hotchkiss, Robert H. Mach, and William G. Hawkins

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Identification and characterization of an RTX toxin in the emerging pathogen Kingella kingae, Thomas E. Kehl-Fie and Joseph W. St. Geme III

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Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice, Jennifer Kelly, Aslam Ali Khan, Jiyi Yin, Thomas A. Ferguson, and Rajendra S. Apte

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Pancreatitis following Olanzapine Therapy: A Report of Three Cases, Thomas A. Kerr, Sreenivasa Jonnalagadda, Chandra Prakash, and Riad Azar

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Cell stress induced by the parkinsonian mimetic, 6-hydroxydopamine, is concurrent with oxidation of the chaperone, ERp57, and aggresome formation, Jeong Sook Kim-Han and Karen L. O'Malley

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Rheumatoid arthritis, item response theory, Blom transformation, and mixed models, Aldi T. Kraja, Jon Corbett, An Ping, Rosa S. Lin, Petra A. Jacobsen, Michael Crosswhite, Ingrid B. Borecki, and Michael A. Province

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Circumstances of patient falls and injuries in 9 hospitals in a midwestern healthcare system, Melissa J. Krauss, Sheila L. Nguyen, Wm. Claiborne Dunagan, Stanley Birge, Eileen Costantinou, Shirley Johnson, Barbara Caleca, and Victoria J. Fraser

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Polyamine permeation and rectification of kir4.1 channels, Yuri V. Kucheryavykh, Wade L. Pearson, Harley T. Kurata, Misty J. Eaton, Serguei N. Skatchkov, and Colin G. Nichols

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The role of the cytoplasmic pore in inward rectification of Kir2.1 channels, Harley T. Kurata, Wayland W. Cheng, Christine Arrabit, Paul A. Slesinger, and Colin G. Nichols

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Continued use of an integrated meter with electronic logbook maintains improvements in glycemic control beyond a randomized, controlled trial, Lori M. B. Laffel, William C. Hsu, Janet B. McGill, Luigi Meneghini, and Lisa K. Volkening

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The bandit, a new DNA transposon from a hookworm— possible horizontal genetic transfer between host and parasite, Thewarach Laha, Alex Loukas, Supatra Wattanasatitarpa, Jenjira Somprakhon, Nonglack Kewgrai, Paiboon Sithithaworn, Sasithorn Kaewkes, Makedonka Mitreva, and Paul J. Brindley

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Targeted discovery of novel human exons by comparative genomics, Laura Langton, Michael Stevens, Charles L.G. Comstock, Michael R. Brent, and et al

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The 14-3-3τ phosphoserine-binding protein is required for cardiomyocyte survival, Jeffrey M. C. Lau, Xiaohua Jin, Jie Ren, Joan Avery, Brian J. DeBosch, Ilya Treskov, Traian S. Lupu, Attila Kovacs, Carla Weinheimer, and Anthony J. Muslin

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Yersiniabactin is a virulence factor for Klebsiella pneumoniae during pulmonary infection, Matthew S. Lawlor, Christopher O'Connor, and Virginia L. Miller

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Clostridium difficile in the intensive care unit: Epidemiology, costs, and colonization pressure, Steven J. Lawrence, Laura A. Puzniak, Brooke N. Shadel, Kathleen N. Gillespie, Marin H. Kollef, and Linda M. Mundy

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Comparative analysis of the regulation of rovA from the pathogenic Yersiniae, Matthew B. Lawrenz and Virginia L. Miller

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Evaluation of a novel chromogenic agar medium for isolation and differentiation of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis isolates, Nathan A. Ledeboer, Kingshuk Das, Michael Eveland, Celine Roger-Dalbert, Sandrine Mailler, Sonia Chatellier, and William Michael Dunne

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Prevalence of cervical spine stenosis: Anatomic study in cadavers, Michael J. Lee, Ezequiel H. Cassinelli, and K. Daniel Riew

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A little stress is good: IFN-γ, demyelination, and multiple sclerosis, Jason R. Lees and Anne H. Cross

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Adaptor function of PapF depends on donor strand exchange in P-pilus biogenesis of Escherichia coli, Yvonne M. Lee, Karen W. Dodson, and Scott J. Hultgren

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Management of juvenile idiopathic scoliosis, Lawrence G. Lenke and Matthew B. Dobbs

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Calmodulin kinase II inhibition enhances ischemic preconditioning by augmenting ATP-sensitive K+ current, Jingdong Li, Celine Marionneau, Olha Koval, Leonid Zingman, Peter J. Mohler, Jeanne M. Nerbonne, and Mark E. Anderson

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PTEN and phosphorylated AKT expression and prognosis in early- and late-stage non-small cell lung cancer, W. T. Lim, W. H. Zhang, C. R. Miller, J. W. Watters, F. Gao, A. Viswanathan, R Govindan, and H. L. McLeod

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Vascular injury from an arterial closure device, Jeffrey P. C. Lin, Brian G. Rubin, and William D. Middleton

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Large-scale in silico mapping of complex quantitative traits in inbred mice, Pengyuan Liu, Haris Vikis, Yan Lu, Daolong Wang, and Ming You

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Functional association of Sun1 with nuclear pore complexes, Qian Liu, Nelly Pante, Tom Misteli, Mohamed Elsagga, Melissa Crisp, Didier Hodzic, Brian Burke, and Kyle J. Roux

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Acrochordon-like basal cell carcinomas in patients with basal cell nevus syndrome, David N. Lortscher, Roberta D. Sengelmann, and Shawn B. Allen

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Contribution of invariant residues to the function of Rgg family transcription regulators, Jennifer Loughman and Michael G. Caparon

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Diffusion tensor imaging predicts hyperacute spinal cord injury severity, David N. Loy, Joong Hee Kim, Mingqiang Xie, Robert E. Schmidt, Kathryn Trinkaus, and Sheng-Kwei Song

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Psychotropic prescriptions in a sample including both healthy and mood and disruptive disordered preschoolers: relationships to diagnosis, impairment, prescriber type, and assessment methods, Joan L. Luby, Melissa Meade Stalets, and Andy C. Belden

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Three clinical cases of DSM-IV mania symptoms in preschoolers, Joan Luby, Mini Tandon, and Ginger Nicol

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Ivermectin resistance in Onchocerca volvulus: Toward a genetic basis, Sara Lustigman and James P. McCarter

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Common human cancer genes discovered by integrated gene-expression analysis, Yan Lu, Yijun Yi, Pengyuan Liu, Weidong Wen, Michael James, Daolong Wang, and Ming You

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Psychometric properties of DSM assessments of illicit drug abuse and dependence: Results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), M. T. Lynskey and A. Agrawal

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Mutations in α-tubulin confer dinitroaniline resistance at a cost to microtubule function, Christopher Ma, Catherine Li, Lakshmi Ganesan, Jean Oak, Susan Tsai, David Sept, and Naomi S. Morrissette

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Clamping the Mec1/ATR checkpoint kinase into action, Jerzy Majka and Peter M.J. Burgers

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Case-control study of surgical site infections associated with pacemakers and implantable cardioverter-defibrillators, Jonas Marschall, Diane Hopkins-Broyles, Marilyn Jones, Victoria J. Fraser, and David K. Warren

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Catheter-associated bloodstream infections in general medical patients outside the intensive care unit: A surveillance study, Jonas Marschall, Carole Leone, Marilyn Jones, Deborah Nihill, Victoria J. Fraser, and David K. Warren

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Regulation of KATP channel expression and activity by the SUR1 Nucleotide Binding Fold 1, Ricard Masia, George Caputa, and Colin G. Nichols

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Nectin-like proteins mediate axon-Schwann cell interactions along the internode and are essential for myelination, Patrice Maurel, Steven Einheber, Jolanta Galinska, Pratik Thaker, Isabel Lam, Marina B. Rubin, Steven S. Scherer, Yoshinuri Murakami, David H. Gutmann, and James L. Salzer

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Preparation of antidepressants for use in preclinical research, Jonathan E. McConathy, Catherine Capello, Nachwa Jarkas, Zachary N. Stowe, and Michael J. Owens

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Whole-mount techniques to evaluate subepithelial cellular populations in the adult mouse intestine, Keely G. McDonald and Rodney D. Newberry

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Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4, Michael D. McLellan, Yumi Kasai, Tracie L. Milner, Ginger A. Fewell, Lucinda L. Fulton, Elaine R. Mardis, Richard K. Wilson, and et al.

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PI3K(p110α) inhibitors as anti-cancer agents: Minding the heart, Julie R. McMullen and Patrick Y. Jay

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Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model, Samuel G. Melendez-Lopez, Scott Herdman, Ken Hirata, Min-Ho Choi, Youngchool Choe, Charles Craik, Conor R. Caffrey, Elisabeth Hansell, Jianhua Guo, Samuel L. Stanley Jr., Bibiana Chavez-Munguia, Yen Ting Chen, William R. Roush, James McKerrow, and et al.

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Health care-associated pneumonia and community-acquired pneumonia: A single-center experience, Scott T. Micek, Katherine E. Kollef, Richard M. Reichley, Nareg Roubinian, and Marin H. Kollef

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Addition of vasopressin to norepinephrine as independent predictor of mortality in patients with refractory septic shock: An observational study, Scott T. Micek, Poorvi Shah, James M. Hollands, Rina A. Shah, William D. Shannon, and Marin H. Kollef

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Exploring the inter-relationship of smoking age-at-onset, cigarette consumption and smoking persistence: Genes or environment?, Katherine I. Morley, Michael T. Lynskey, Pamela A F Madden, Susan A. Treloar, Andrew C. Heath, and Nicholas G. Martin

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Defining limits of treatment with humanized neutralizing monoclonal antibody for West Nile virus neurological infection in a hamster model, John D. Morrey, Venkatraman Siddharthan, Aaron L. Olsen, Hong Wang, Justin G. Julander, Jeffery O. Hall, Hua Li, Jeffrey L. Nordstrom, Scott Koenig, Syd Johnson, and Michael S. Diamond

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Haplotype-based association analysis of the MAPT locus in Late Onset Alzheimer's disease, Odity Mukherjee, John SK Kauwe, Kevin Mayo, John C. Morris, and Alison M. Goate

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Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii, Kisaburo Nagamune, Wandy L. Beatty, and L. David Sibley

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Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis, Kisaburo Nagamune, Silvia N.J. Moreno, and L. David Sibley

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MultiCode-PLx system for multiplexed detection of seventeen respiratory viruses, Frederick S. Nolte, David J. Marshall, Christopher Rasberry, Sabina Schievelbein, Grier G. Banks, Gregory A. Storch, Max Q. Arens, Richard S. Buller, and James R. Prudent

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Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells, Alex S. Nord, Karen Vranizan, Whittemore Tingley, Alexander C. Zambon, Kristina Hanspers, Loren G. Fong, Yan Hu, Peter Bacchetti, Thomas E. Ferrin, Patricia C. Babbitt, Scott W. Doniger, William C. Skarnes, Stephen G. Young, and Bruce R. Conklin

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Rapid maturation of effector T cells in tumors, but not lymphoid organs, during tumor regression, Lyse A. Norian and Paul M. Allen

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Relationship of functional gastrointestinal disorders and psychiatric disorders: Implications for treatment, Carol S. North, Barry A. Hong, and David H. Alpers

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Phylogenetic diversity and microsphere array-based genotyping of human pathogenic fusaria, including isolates from the multistate contact lens-associated U.S. keratitis outbreaks of 2005 and 2006, Kerry O'Donnell, Brice A. Sarver, Mary Brandt, Douglas C. Chang, Judith Noble-Wang, Benjamin J. Park, Deanna A. Sutton, Lynette Benjamin, Mark Lindsley, Arvind Padhye, David M. Geiser, and Todd J. Ward

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Compartmental pharmacokinetic analysis of oral amprenavir with secondary peaks, Olanrewaju Okusanya, Alan Forrest, Robin DiFrancesco, Sanela Bilic, Susan Rosenkranz, Michael F. Para, Elizabeth Adams, Kevin E. Yarasheski, Richard C. Reichman, Gene D. Morse, and ACTG 5043 Protocol Team

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Shigella flexneri phagosomal escape is independent of invasion, Susanne Paetzold, Sebastian Lourido, Barbel Raupach, and Arturo Zychlinsky

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MAGED2: A novel p53-dissociator, Chris Papageorgio, Rainer Brachmann, Jue Zeng, Robert Culverhouse, Wanghai Zhang, and Howard McLeod

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The association of the activation-inducible tumor necrosis factor receptor and ligand with lumbar disc hermiation, Moon-Soo Park, Hwan-Mo Lee, Soo-Bong Hahn, Seong-Hwan Moon, Yung-Tae Kim, Choon-Sung Lee, Hyo-Won Jung, Byoung-Se Kwon, and K. Daniel Riew

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Site-1 protease is essential for endochondral bone formation in mice, Debabrata Patra, Xiaoyun Xing, Sherri Davies, Jennifer Bryan, Carl Franz, Ernst B. Hunziker, and Linda J. Sandell

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Toward an understanding of risk factors for anorexia nervosa: A case-control study, K. M. Pike, A. Hilbert, D. E. Wilfley, C. G. Fairburn, F. A. Dohm, B. T. Walsh, and R. Striegel-Moore

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Clinical significance of αII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury, Jose A. Pineda, Stephen B. Lewis, Alex B. Valadka, Linda Papa, H. Julia Hannay, Shelley C. Heaton, Jason A. Demery, Ming Cheng Liu, Jada M. Aikman, Veronica Akle, Gretchen M. Brophy, Joseph J. Tepas III, Kevin K. W. Wang, Claudia S. Robertson, and Ronald L. Hayes

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Genetic and environmental factors affecting self-esteem from age 14 to 17: A longitudinal study of Finnish twins, Anu Raevuori, Danielle M. Dick, Anna Keski-Rahkonen, Lea Pulkkinen, Richard J. Rose, Aila Rissanen, Jaakko Kaprio, Richard J. Viken, and Karri Silventoinen

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Intracellular mediators of transforming growth factor β superfamily signaling localize to endosomes in chicken embryo and mouse lenses in vivo, Ramya Rajagopal, Shunsuke Ishii, and David C. Beebe

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Polony analysis of gene expression in ES cells and blastocysts, C. Rieger, R. Poppino, R. Sheridan, K. Moley, R. Mitra, and D. Gottlieb

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Molecular refinement of gibbon genome rearrangements, Roberta Roberto, Oronzo Capozzi, Richard K. Wilson, Elaine R. Mardis, Mariana Lomiento, Eray Tuzun, Ze Cheng, Alan R. Mootnick, Nicoletta Archidiacono, Mariano Rocchi, and Evan E. Eichler

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Oxytocin in the circadian timing of birth, Jeffrey Roizen, Christina E. Luedke, Erik D. Herzog, and Louis J. Muglia

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Anionic lipids enriched at the ExPortal of Streptococcus pyogenes, Jason W. Rosch, Fong Fu Hsu, and Michael G. Caparon

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Detection of intracellular bacterial communities in human urinary tract infection, David A. Rosen, Thomas M. Hooton, Walter E. Stamm, Peter A. Humphrey, and Scott J. Hultgren

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Antiretroviral drug levels and interactions affect lipid, lipoprotein, and glucose metabolism in HIV-1 seronegative subjects: A pharmacokinetic- pharmacodynamic analysis, Susan Rosenkranz, Kevin E. Yarasheski, Michael F. Para, Richard C. Reichman, and Gene D. Morse

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Identification and characterization of small molecules that inhibit intracellular toxin transport, Jose B. Saenz, Teresa A. Doggett, and David B. Haslam

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Conduct disorder among Asians and Native Hawaiian/Pacific Islanders in the USA, J. T. Sakai, N. K. Risk, C. A. Tanaka, and R. K. Price

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GenMAPP 2: New features and resources for pathway analysis, Nathan Salomonis, Kristina Hanspers, Alexander C. Zambon, Karen Vranizan, Steven C. Lawlor, Kam D. Dahlquist, Scott W. Doniger, Josh Stuart, Bruce R. Conklin, and Alexander R. Pico

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Fine mapping of mouse QTLs for fatness using SNP data, Armin O. Schmitt, Hadi Al-Hasani, James M. Cheverud, Daniel Pomp, Lutz Bünger, and Gudrun A. Brockmann

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Increasing incidence of sterile-site infections due to non-multidrug- resistant, oxacillin-resistant Staphylococcus aureus among hospitalized patients, Garrett E. Schramm, Jennifer A. Johnson, Joshua A. Doherty, Scott T. Micek, and Marin H. Kollef

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Effect of chlorhexidine/silver sulfadiazine-impregnated central venous catheters in an intensive care unit with a low blood stream infection rate after implementation of an educational program: A before-after trial, Douglas J E Schuerer, Ingrid B. Borecki, David K. Warren, Victoria J. Fraser, John E. Mazuski, Walter A. Boyle, Timothy G. Buchman, Craig M. Coppersmith, and et al

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X-linked idiopathic infantile nystagmus associated with a missense mutation in FRMD7, Alan Shiels, Thomas M. Bennett, Jessica B. Prince, and Lawrence Tychsen

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DLGH1 is a negative regulator of T-lymphocyte proliferation, Linda M. Stephenson, Benedicte Sammut, Daniel B. Graham, Joaquim Chan-Wang, Karry L. Brim, Alan S. Huett, Ana V. Miletic, Tracie Kloeppel, Aimee Landry, Ramnik Xavier, and Wojciech Swat

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Correlates of stimulus-response congruence in the posterior parietal cortex, Gijsbert Stoet and Lawrence H. Snyder

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A novel mutation of the Keratin 12 gene responsible for a severe phenotype of Meesmann’s corneal dystrophy, Lori S. Sullivan, Eric B. Baylin, Ramon Font, Stephen P. Daiger, Jay S. Pepose, Thomas E. Clinch, Hisashi Nakamura, Xinping C. Zhao, and Richard W. Yee

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Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice, Jiusong Sun, Galina K. Sukhova, Min Yang, Paul J. Wolters, Lindsey A. MacFarlane, Peter Libby, Chingxiu Sun, Yadong Zhang, Jian Liu, Terri L. Ennis, Rebecca Knispel, Wanfen Xiong, Robert W. Thompson, B. Timothy Baxter, and Guo-Ping Shi

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Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats, P. Suryanarayana, Megha Saraswat, J. Mark Petrash, and G. Bhanuprakash Reddy

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Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability, Elizabeth M. H. Tank, David A. Harris, Amar A. Desai, and Heather L. true

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A tale of two templates: Automatically resolving double traces has many applications, including efficient PCR-based elucidation of alternative splices, Aaron E. Tenney, Jia Qian Wu, Laura Langton, Paul Klueh, Ralph Quatrano, and Michael R. Brent

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The neuroendocrine impact of chronic stress on cancer, Premal H. Thaker, Susan K. Lutgendorf, and Anil K. Sood

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Apigenin prevents UVB-induced cyclooxygenase 2 expression: Coupled mRNA stabilization and translational inhibition, Xin Tong, Rukiyah T. Van Dross, Adnan Abu-Yousif, Aubrey R. Morrison, and Jill C. Pelling

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Vascular biology and bone formation: Hints from HIF, Dwight A. Towler