The Open Access Publications collection contains peer-reviewed articles authored by Washington University School of Medicine faculty that have been published in open access journals or authorized by the publishers for open access availability. Open access works are generally defined as being publicly available online and free of most licensing and copyright restrictions. The Bernard Becker Medical Library maintains this collection in support of Washington University’s commitment to the principles of open access publishing and making the scholarly work and research results of our faculty as widely and easily available as possible.

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Submissions from 2005

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Phenotypic and molecular analysis of tellurite resistance among enterohemorrhagic Escherichia coli O157:H7 and sorbitol-fermenting O157:NM clinical isolates, Martina Bielaszewska, Phillip I. Tarr, Helge Karch, Wenlan Zhang, and Werner Mathys

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Molecular profiling and phenotype analysis of Escherichia coli O26:H11 and O26:NM: Secular and geographic consistency of enterohemorrhagic and enteropathogenic isolates, Martina Bielaszewska, Wenlan Zhang, Phillip I. Tarr, Anne-Katharina Sonntag, and Helge Karch

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Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality, Valerie Blanc, Jeffrey O. Henderson, Elizabeth P. Newberry, Susan Kennedy, Jianyang Luo, and Nicholas O. Davidson

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The ethics and politics of stem cell research, James C. Bobrow

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An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism, Michael R. Bowl, Andrew Nesbit, Brian Harding, Elaine Levy, Andrew Jefferson, Emanuela Volpi, Karine Rizzoti, Robin Lovell-Badge, David Schlessinger, Michael P. Whyte, and Rajesh V. Thakker

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Objectives of undergraduate medical education in musculoskeletal surgery and medicine, Martin I. Boyer

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Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice, Robert P. Brendza, Brain J. Bacskai, John R. Cirrito, Kelly A. Simmons, Jesse M. Skoch, William E. Klunk, Chester A. Mathis, Kelly R. Bales, Steven M. Paul, Bradley T. Hyman, and David M. Holtzman

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What's new in spine surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, and Jeffrey C. Wang

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The DotL protein, a member of the TraG-coupling protein family, is essential for viability of Legionella pneumophila strain Lp02, Benjamin A. Buscher, Gloria M. Conover, Jennifer L. Miller, Sinae A. Vogel, Stacey N. Meyers, Ralph R. Isberg, and Joseph P. Vogel

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Replication protein A-directed unloading of PCNA by the Ctf18 cohesion establishment complex, Goran O. Bylund and Peter M. J. Burgers

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The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein, David A. Canton, Mary Ellen K. Olsten, Kyoungtae Kim, Amanda Doherty-Kirby, Gilles Lajoie, John A. Cooper, and David W. Litchfield

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Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: Randomised, double blind, placebo controlled trial, Heather Ciliberto, Michael Ciliberto, Andree Briend, Per Ashorn, Dennis Bier, and Mark Manary

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P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model, John R. Cirrito, Rashid Deane, Anne M. Fagan, Michael L. Spinner, Maia Parsadanian, Mary Beth Finn, Hong Jiang, Julie L. Prior, Abhay Sagare, Kelly R. Bales, Steven M. Paul, Berislav V. Zlokovic, David Piwinca-Worms, and David M. Holtzman

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Periacetabular osteotomy for the treatment of severe acetabular dysplasia, John C. Clohisy, Susan E. Barrett, J. Eric Gordon, Eliana D. Delgado, and Perry L. Schoenecker

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Architecture and adhesive activity of the Haemophilus influenzae Hsf adhesin, Shane E. Cotter, Hye-Jeong Yeo, Twyla Juehne, and Joseph W. St. Geme III

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Identification of functional transcription factor binding sites using closely related Saccharomyces species, Scott W. Doniger, Juyoung Huh, and Justin C. Fay

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CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood, Victor A. Drover, Mohammad Ajmal, Fatiha Nassir, Nicholas O. Davidson, Andromeda M. Nauli, Daisy Sahoo, Patrick Tso, and Nada A. Abumrad

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Use of several inducer and substrate antibiotic combinations in a disk approximation assay format to screen for AmpC induction in patient isolates of Pseudomonas aeruginosa, Enterobacter spp., Citrobacter spp., and Serratia spp., W. Michael Dunne Jr. and Daniel J. Hardin

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Microsatellites versus single-nucleotide polymorphisms in linkage analysis for quantitative and qualitative measures, Gerald Dunn, Anthony L. Hinrichs, Sarah Bertelsen, Carol H. Jin, John SK Kauwe, Brian K. Suarez, and Laura J. Bierut

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A model of the statistical power of comparative genome sequence analysis, Sean R. Eddy

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‘‘Antedisciplinary’’ science, Sean R. Eddy

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Gene finding in the chicken genome, Eduardo Eyras, Alexandre Reymond, Robert Castelo, Jacqueline M. Bye, Francisco Camara, Paul Flicek, Elizabeth J. Huckle, Genis Parra, David D. Shteynberg, Carine Wyss, Jane Rogers, Stylianos E. Antonarakis, Ewan Birney, Roderic Guigo, and Michael R. Brent

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Effects of combined diethylcarbamazine and albendazole treatment of bancroftian filariasis on parasite uptake and development in Culex pipiens L., Hoda A. Farid; Ragaa E. Hammad; Marah M. Hassan; Reda M.R, Ramzy; Maged El Setouhy; and Gary J. Weil

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Evidence for domesticated and wild populations of saccharomyces cerevisiae, Justin C. Fay and Joseph A. Benavides

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The LIM protein Ajuba influences interleukin-1-induced NF-κB activation by affecting the assembly and activity of the protein kinase Cζ/p62/TRAF6 signaling complex, Yungfeng Feng and Gregory D. Longmore

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Dominant negative effects of the AML1/ETO fusion oncoprotein, Timothy S. Fenske, Gina Pengue, and Timothy A. Graubert

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Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases, Angela M. Ferguson, Lynn S. White, Peter J. Donovan, and Helen Piwnica-Worms

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Patterns and predictors of inpatient falls and fall-related injuries in a large academic hospital, Irene D. Fischer, Melissa J. Krauss, William Claiborne Dunagan, Stanley Birge, Eileen Hitcho, Shirley Johnson, Eileen Constantinou, and Victoria J. Fraser

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Pseudomonas aeruginosa acquires biofilm-like properties within airway epithelial cells, Raquel Garcia-Medina, W. Michael Dunne, Pradeep K. Singh, and Steven L. Brody

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How the cell deals with DNA nicks, Parie Garg and Peter M.J. Burgers

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Computational technique for improvement of the position-weight matrices for the DNA/protein binding sites, Naum I. Gershenzon, Gary D. Stormo, and Illya P. Ioshikhes

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Discovery, validation, and genetic dissection of transcription factor binding sites by comparative and functional genomics, Jason Gertz, Linda Riles, Peter Turnbaugh, Su-Wen Ho, and Barak A. Cohen

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Analysis of memory T lymphocyte activity following stimulation with overlapping HLA-A*2402, A*0101 and Cw*0402 restricted CMV pp65 peptides, Monica Ghei, David F. Stroncek, and Maurizio Provenzano

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Reporting quality of randomized trials in the diet and exercise literature for weight loss, Cheryl A. Gibson, Erik P. Kirk, James D. LeCheminant, Bruce W. Bailey Jr, Guoyuan Huang, and Joseph E. Donnelly

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The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression, Nathan A. Gillespie, John B. Whitfield, Ben Williams, Andrew C. Heath, and Nicholas G. Martin

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Upper-extremity phocomelia reexamined: A longitudinal dysplasia, Charles A. Goldfarb, Paul R. Manske, Riccardo Busa, Janith Mills, Peter Carter, and Marybeth Ezaki

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Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites, Jennifer L. Gordon and L David Sibley

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Comprehensive treatment of late-onset tibia vara, J. Eric Gordon, Fred P. Heidenreich, Chris J. Carpenter, Jill Kelly-Hahn, and Perry L. Schoenecker

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Adolescent alcohol use is a risk factor for adult alcohol and drug dependence: Evidence from a twin design, Julia D. Grant, Jeffrey F. Scherrer, Michael T. Lynskey, Michael J. Lyons, Seth A. Eisen, Ming T. Tsuang, William R. true, and Kathleen K. Bucholz

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Rfam: Annotating non-coding RNAs in complete genomes, Sam Griffiths-Jones, Simon Moxon, Mhairi Marshall, Ajay Khanna, Sean R. Eddy, and Alex Bateman

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The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells, Thomas E. Grys, Matthew B. Siegel, Wyndham W. Lathem, and Rodney A. Welch

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Involvement of human MOF in ATM function, Arun Gupta, Girdhar G. Sharma, Charles S. H. Young, Manjula Agarwal, Edwin R. Smith, Tanya T. Paull, John C. Lucchesi, Kum Kum Khanna, Thomas Ludwig, and Tej K. Pandita

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Paternal alcoholism and offspring conduct disorder: Evidence for the 'common genes' hypothesis, Jon R. Haber, Theodore Jacob, and Andrew C. Heath

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Yersinia enterocolitica invasin-dependent and invasin-independent mechanisms of systemic dissemination, Scott A. Handley, Rodney D. Newberry, and Virginia L. Miller

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Deep-etch EM reveals that the early poxvirus envelope is a single membrane bilayer stabilized by a geodetic "honeycomb" surface coat, John Heuser

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Pharmacokinetic and maximum tolerated dose study of micafungin in combination with fluconazole versus fluconazole alone for prophylaxis of fungal infections in adult patients undergoing a bone marrow or peripheral stem cell transplant, J. Hiemenz, P. Cagnoni, D. Simpson, S. Devine, N. Chao, J. Keirns, W. Lau, D. Facklam, and D. Buell

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Genomics in C. elegans: So many genes, such a little worm, LaDeana W. Hillier, Alan Coulson, John I. Murray, Zhirong Bao, John E. Sulston, and Robert H. Waterston

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Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps, Anthony L. Hinrichs, Sarah Bertelsen, Laura J. Bierut, Gerald Dunn, Carol H. Jin, John S. Kauwe, and Brian K. Suarez

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Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death, William A. Holtz, Jay M. Turetzky, and Karen L. O'Malley

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Ultrasonic songs of male mice, Timothy E. Holy and Zhongsheng Guo

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Punctuated duplication seeding events during the evolution of human chromosome 2p11, Julie E. Horvath, Cassandra L. Gulden, Rhea U. Vallente, Marla Y. Eichler, Mario Ventura, John D. McPherson, Tina A. Graves, Richard K. Wilson, Stuart Schwartz, Mariano Rocchi, and Evan E. Eichler

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Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli, David A. Hunstad, Sheryl S. Justice, Chia S. Hung, Scott R. Lauer, and Scott J. Hultgren

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Mitochondrial energy metabolism in heart failure: A question of balance, Janice M. Huss and Daniel P. Kelly

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The type Iα inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane, Ivan Ivetac, Adam D. Munday, Marina V. Kisseleva, Xiang-Ming Zhang, Susan Luff, Tony Tiganis, James C. Whisstock, Tony Rowe, Phillip W. Majerus, and Christina A. Mitchell

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An improved internal mammary irradiation technique in radiation treatment of locally advanced breast cancers, Jian-Yue Jin, Eric E. Klein, Feng-Ming Kong, and Zuofeng Li

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The multiple biological roles of the 3’→5’ exonuclease of Saccharomyces cerevisiae DNA polymerase δ require switching between the polymerase and exonuclease domains, Yong Hawn Jin, Parie Garg, Carrie M. W. Stith, Hanan Al-Refai, Joan F. Sterling, Laura J. W. Murray, Thomas A. Kunkel, Michael A. Resnick, Peter M. Burgers, and Dmitry A. Gordenin

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Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection, Manohar John, Indira T. Kudva, Robert W. Griffin, Allen W. Dodson, Bethany McManus, Bryan Krastins, David Sarracino, Ann Progulske-Fox, Jeffrey D. Hillman, Martin Handfield, Phillip I. Tarr, and Stephen B. Calderwood

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The IrgA homologue adhesin Iha is an Escherichia coli virulence factor in murine urinary tract infection, James R. Johnson, Srdjan Jelacic, Laura M. Schoening, Connie Clabots, Nurmohammad Shaikh, Harry L.T. Mobley, and Phillip I. Tarr

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Arthrodesis techniques in the management of stage-II and III acquired adult flatfoot deformity, Jeffrey E. Johnson and James R. Yu

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Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA Is required for pilus biogenesis in Escherichia coli, Sheryl S. Justice, David A. Hunstad, Jill Reiss Harper, Amy R. Duguay, Jerome S. Pinkner, James Bann, Carl Frieden, Thomas J. Silhavy, and Scott J. Hultgren

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An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II–restricted T cells in the absence of CD4, Henry Kao and Paul M. Allen

Comparing low coverage random shotgun sequence data from Brassica oleracea and Oryza sativa genome sequence for their ability to add to the annotation of Arabidopsis thaliana, Manpreet S. Katari, Vivekanand Balija, Richard K. Wilson, Robert A. Martienssen, and W. Richard McCombie

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Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice, Andrew L. Kau, Steven M. Martin, William Lyon, Ericka Hayes, Michael G. Caparon, and Scott J. Hultgren

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The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure, John SK Kauwe, Sarah Bertelsen, Laura Jean Bierut, Gerald Dunn, Anthony L. Hinrichs, Carol H. Jin, and Brian K. Suarez

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Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii, Asis Khan, Sonya Taylor, Chunlei Su, Aaron J. Mackey, Jon Boyle, Robert Cole, Darius Glover, Keliang Tang, Ian T. Paulsen, Matt Berriman, John C. Boothroyd, Elmer R. Pfefferkorn, J. P. Dubey, James W. Ajioka, David S. Roos, John C. Wooton, and L. D. Sibley

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Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of type I strains, A. Khan, C. Su, M. German, G. A. Storch, D. B. Clifford, and L. David Sibley

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Eradication of methicillin-resistant Staphylococcus aureus from a neonatal intensive care unit by active surveillance and aggressive infection control measures, Jad Khoury, Marilyn Jones, Autumn Grim, Wm. Michael Dunne Jr., and Vicky Fraser

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Mitochondrial uncoupling proteins in the central nervous system, Jeong Sook Kim-Han and Laura L. Dugan

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A transcription factor for cold sensation!, Susan J. Kim, Zhican Qu, Jeffrey Milbrandt, and Min Zhuo

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Pulmonary function in adolescent idiopathic scoliosis relative to the surgical procedure, Yongjung J. Kim, Lawrence G. Lenke, Keith H. Bridwell, Kyoungnam L. Kim, and Karen Steger-May

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Interchromosomal segmental duplications of the pericentromeric region on the human Y chromosome, Stefan Kirsch, Birgit Weiß, Tracie L. Miner, Robert H. Waterston, Royden A. Clark, Evan E. Eichler, Claudia Münch, Werner Schempp, and Gudrun Rappold

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LL5β: A regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction, Masashi Kishi, Terrance T. Kummer, Stephen J. Eglen, and Joshua R. Sanes

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The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKIα, Marina Kisselva, Yungfeng Feng, Michael Ward, Chunhua Song, Richard A. Anderson, and Gregory D. Longmore

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M-CSF mediates TNF-induced inflammatory osteolysis, Hideki Kitaura, Ping Zhou, Hyun-Ju Kim, Deborah V. Novack, Patrick Ross, and Steven L. Teitelbaum

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Errors in radiation oncology: a study in pathways and dosimetric impact, Eric E. Klein, Robert E. Drzymala, James A. Purdy, and Jeff M. Michalski

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Contributions of parental alcoholism, prenatal substance exposure, and genetic transmission to child ADHD risk : A female twin study, Valerie S. Knopik, Elizabeth P. Sparrow, Pamela A F Madden, Kathleen K. Bucholz, James J. Hudziak, Wendy Reich, Wendy S. Slutske, Julia D. Grant, Tara L. McLaughlin, Alexandre Todorov, Richard D. Todd, and Andrew C. Heath

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Noncapsulated Klebsiella pneumoniae bearing mannose-containing O antigens is rapidly eradicated from mouse lung and triggers cytokine production by macrophages following opsonization with surfactant protein D, Elena Kostina, Itzhak Ofek, Erika Crouch, Rotem Friedman, Lea Sirota, Gil Klinger, Hany Sahly, and Yona Keisari

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Microsatellite linkage analysis, single-nucleotide polymorphisms, and haplotype associations with ECB21 in the COGA data, Aldi T. Kraja, Ingrid B. Borecki, and Michael A. Province

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An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program, Aldi T. Kraja, DC Rao, Alan B. Weder, Thomas H. Mosley, Stephen T. Turner, Chao Agnes Hsiung, Thomas Quertermous, Richard Cooper, J David Curb, and Michael A. Province

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Neutrophil elastase is important for PML-retinoic acid receptor α activities in early myeloid cells, Andrew A. Lane and Timothy J. Ley

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Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis, Robert A. Larsen, Peter G. Pappas, John Perfect, Judith A. Aberg, Arturo Casadevall, Gretchen A. Cloud, Robert James, Scott Filler, and William E. Dismukes

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The offloading model for dynein function: differential function of motor subunits, Wei-Lih Lee, Michelle A. Kaiser, and John A. Cooper

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis, Teresa C. Leone, John J. Lehman, Brian N. Finck, Paul J. Schaeffer, Adam R. Wende, Sihem Boudina, Michael Courtois, David F. Wozniak, Nandakumar Sambandam, Carlos Bernal-Mizrachi, Zhouji Chen, John O. Holloszy, Denis M. Medeiros, Robert E. Schmidt, Jeffrey E. Saffitz, E. D. Abel, Clay F. Semenkovich, and Daniel P. Kelly

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Comparison of running and interrupted vesicourethral anastomoses in a porcine model, David Lieber, Veronique Tran, Jay Belani, Caroline Ames, Kevin Morissey, Yan Yan, Peter Humphrey, Ramakrishna Venkatesh, and Jaime Landman

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Combining SELEX with quantitative assays to rapidly obtain accurate models of protein-DNA interactions, Jiajian Liu and Gary D. Stormo

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Quantitative analysis of EGR proteins binding to DNA: Assessing additivity in both the binding site and the protein, Jiajian Liu and Gary D. Stormo

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A surface groove essential for viral Bcl-2 function during chronic infection in vivo, Joy Loh, Qiulong Huang, Andrew M. Petros, David Nettesheim, Linda F. van Dyk, Lucia Labrada, Samuel H. Speck, Beth Levine, Edward T. Olejniczak, and Herbert W. Virgin IV

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YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence, Zhi Hong Lu, Jason T. Books, and Timothy J. Ley

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hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation, Mary Lynch, Li Chen, Michael J. Ravitz, Sapna Mehtani, Kevin Korenblat, Michael J. Pazin, and Emmett V. Schmidt

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Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins, Michael T. Lynskey, Elliot C. Nelson, Rosalind J. Neuman, Kathleen K. Bucholz, Pamela A.F. Madden, Valerie S. Knopik, Wendy Slutske, John B. Whitfield, Nicholas G. Martin, and Andrew C. Heath

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ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation, A. J. MacQueen, J. J. Baggett, N. Perumov, R. A. Bauer, T. Januszewski, L. Schriefer, and J. A. Waddle

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Complications of fluoroscopically guided extraforaminal cervical nerve blocks: An analysis of 1036 injections, Daniel J. Ma III, Louis A. Gilula, and K. Daniel Riew

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Clinical challenges and unmet needs in the management of complicated intra-abdominal infections, John E. Mazuski

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A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase, Michael A. Meehl, Jerome S. Pinkner, Patricia J. Anderson, Scott J. Hultgren, and Michael G. Caparon

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Phylogeography and population strucure of Aedes aegypti in Arizona, Samuel A. Merrill, Frank B. Ramberg, and Henry H. Hagedorn

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Pseudomonas aeruginosa bloodstream infection: Importance of appropriate initial antimicrobial treatment, Scott T. Micek, Ann E. Lloyd, David J. Ritchie, Richard M. Reichley, Victoria J. Fraser, and Marin H. Kollef

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Mutant kinesin-2 motor subunits increase chromosome loss, Mark S. Miller, Jessica M. Esparza, Andrew M. Lippa, Fordyce G. Lux III, Douglas G. Cole, and Susan K. Dutcher

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Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species, Pat Minx, Holly Cordum, Richard Wilson, and et al

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Investigating hookworm genomes by comparative analysis of two Ancylostoma species, Makedonka Mitreva, James P. McCarter, Prema Arasu, John Hawdon, John Martin, Mike Dante, Todd Wylie, Jian Xu, Jason E. Stajich, Wadim Kapulkin, Sandra W. Clifton, Robert H. Waterston, and Richard K. Wilson

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Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: A potential risk factor for hospital mortality, Matthew Morrell, Victoria J. Fraser, and Marin H. Kollef