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Submissions from 2016

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Cell density and actomyosin contractility control the organization of migrating collectives within an epithelium, Andrew J. Loza, Sarita Koride, Gregory V. Schimizzi, Bo Li, Sean X. Sun, and Gregory D. Longmore

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A common founding clone with TP53 and PTEN mutations gives rise to a concurrent germ cell tumor and acute megakaryoblastic leukemia, Charles Lu, Peter Riedell, Christopher A. Miller, Ian S. Hagemann, Peter Westervelt, Bradley A. Ozenberger, Michelle O'Laughlin, Vincent Magrini, Ryan T. Demeter, Eric J. Duncavage, Malachi Griffith, Obi L. Griffith, and Lukas D. Wartman

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Neuroimaging evidence of deficient axon myelination in Wolfram syndrome, Heather M. Lugar, Jonathan M. Koller, Jerrel Rutlin, Bess A. Marshall, Kohsuke Kanekura, Fumihiko Urano, Allison N. Bischoff, Joshua S. Shimony, Tamara Hershey, and Washington University Wolfram Syndrome Research Study Group

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Proline absorption and SGK1 expression are inhibited in intestinal tis7 transgenic mice, Jianyun Lu, Amy M. Garcia, Taylor Geisman, Derek Wakeman, Brad W. Warner, Elzbieta A. Swietlicki, Marc S. Levin, and Deborah C. Rubin

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Systematic review and meta-analysis of en bloc vertebrectomy compared with intralesional resection for giant cell tumors of the mobile spine, Panya Luksanapruksa, Jacob M. Buchowski, Weerasak Singhatanadgige, and David B. Bumpass

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Immunogenicity and protective efficacy against enterotoxigenic Escherichia coli colonization following intradermal, sublingual, or oral vaccination with EtpA adhesin, Qingwei Luo, Tim J. Vickers, and James M. Fleckenstein

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Stromal-initiated changes in the bone promote metastatic niche development, Xianmin Luo, Yujie Fu, Andrew J. Loza, Bhavna Murali, Kathleen M. Leahy, Megan K. Ruhland, Margery Gang, Xinming Su, Ali Zamani, Yu Shi, Kory J. Lavine, David M. Ornitz, Katherine N. Weilbaecher, Fanxin Long, Deborah V. Novack, Roberta Faccio, Gregory D. Longmore, and Sheila A. Stewart

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A narnavirus-like element from the trypanosomatid protozoan parasite Leptomonas seymouri, Lon-Fye Lye, Natalia S. Akopyants, Deborah E. Dobson, and Stephen M. Beverley

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Regenerated sciatic nerve axons stimulated through a chronically implanted macro-sieve electrode, Matthew R. MacEwan, Erik R. Zellmer, Jesse J. Wheeler, Harold Burton, and Daniel W. Moran

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Randomized phase II trial of fulvestrant alone or in combination with bortezomib in hormone receptor-positive metastatic breast cancer resistant to aromatase inhibitors: A New York Cancer Consortium trial, Cynthia X. Ma, Michael Naughton, and et al

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Subcortical neuromorphometry in schizophrenia spectrum and bipolar disorders, Daniel Mamah, Kathryn I. Alpert, Deanna M. Barch, John G. Csernansky, and Lei Wang

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Expression profiling of ascorbic acid–related transporters in human and mouse eyes, Nan Ma, Carla Siegfried, Miyuki Kubota, Jie Huang, Ying Liu, Margaret Liu, Belinda Dana, Andrew Huang, David Beebe, Hong Yan, and Ying-Bo Shui

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Concomitant immunity induced by persistent Leishmania major does not preclude secondary re-infection: Implications for genetic exchange, diversity and vaccination, Michael A. Mandell and Stephen M. Beverley

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Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis, Ani Manichaikul, Xin-Qun Wang, Wei Zhao, Mary K. Wojczynski, Kyle Siebenthall, John A. Stamatoyannopoulos, Danish Saleheen, Ingrid B. Borecki, Muredach P. Reilly, Stephen S. Rich, and Karin E. Bornfeldt

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Prostate MRI: A national survey of urologist’s attitudes and perceptions, Brandon J. Manley, John A. Brockman, Valary T. Raup, Kathryn J. Fowler, and Gerald L. Andriole

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Arterial anatomy of the posterior tibial nerve in the tarsal tunnel, Mary Claire Manske, Kathleen E. McKeon, Jeremy J. McCormick, Jeffrey E. Johnson, and Sandra E. Klein

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Distinct effects of obesity and puberty on risk and age at onset of pediatric MS, Soe Mar and et al

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Genomic analysis reveals hidden biodiversity within colugos, the sister group to primates, Victor C. Mason, Gang Li, Patrick Minx, Jürgen Schmitz, Gennady Churakov, Liliya Doronina, Amanda D. Melin, Nathaniel J. Dominy, Norman T-L Lim, Mark S. Springer, Richard K. Wilson, Wesley C. Warren, Kristofer M. Helgen, and William J. Murphy

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Activity level and severity of dysplasia predict age at bernese periacetabular osteotomy for symptomatic hip dysplasia, Travis Matheney, Ira Zaltz, Young-Jo Kim, Perry Schoenecker, Michael Millis, David Podeszwa, David Zurakowski, Paul Beaule, and John Clohisy

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Common miR-590 variant rs6971711 present only in African Americans reduces miR-590 biogenesis, Scot J. Matkovich and et al.

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Chronic contractile dysfunction without hypertrophy does not provoke a compensatory transcriptional response in mouse hearts, Scot J. Matkovich, David R. Grubb, Julie R. McMullen, and Elizabeth A. Woodcock

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SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy, Allyson L. Mayer, Cassandra B. Higgins, Monique R. Heitmeier, Thomas E. Kraft, Xia Qian, Jan R. Crowley, Krzysztof L. Hyrc, Wandy L. Beatty, Kevin E. Yarasheski, Paul W. Hruz, and Brian J. DeBosch

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Nutritional quality and marketing strategies of fast food children’s combo meals in Guatemala, Sofia Mazariegos, Violeta Chacon, Adam Cole, and Joaquin Barnoya

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Antimicrobials: A global alliance for optimizing their rational use in intra-abdominal infections (AGORA), John E. Mazuski, Stephen Y. Liang, and et al

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion, Kyle S. McCommis, Wesley T. Hodges, Daniel K. Bricker, Dona R. Wisidagama, Vincent Compan, Maria S. Remedi, Carl S. Thummel, and Brian N. Finck

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Prevalence of non-febrile seizures in children with idiopathic autism spectrum disorder and their unaffected siblings: a retrospective cohort study, Lena M. McCue, Louise H. Flick, Kimberly A. Twyman, Hong Xian, and Thomas E. Conturo

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Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation, James I. McDonald, Hamza Celik, Lisa E. Rois, Gregory Fishberger, Tolison Fowler, Ryan Rees, Ashley Kramer, Andrew Martens, John R. Edwards, and Grant A. Challen

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Evaluation of the Vitek MS matrix-assisted laser desorption ionization–time of flight mass spectrometry system for identification of clinically relevant filamentous fungi, Allison R. McMullen, Meghan A. Wallace, David H. Pincus, Kathy Wilkey, and Carey-Ann Burnham

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The role of researchers in disseminating evidence to public health practice settings: A cross-sectional study, Allese B. McVay, Katherine A. Stamatakis, Julie A. Jacobs, Rachel G. Tabak, and Ross C. Brownson

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Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors, Yu Mei, Wenya Linda Bi, Noah F. Greenwald, Ziming Du, Nathalie Y. R. Agar, Ursula B. Kaiser, Whitney W. Woodmansee, David A. Reardon, Gordon J. Freeman, Peter E. Fecci, Edward R. Laws Jr, Sandro Santagata, Gavin P. Dunn, and Ian F. Dunn

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Impact of foot progression angle modification on plantar loading in individuals with diabetes mellitus and peripheral neuropathy, Ericka N. Merriwether, Mary K. Hastings, Kathryn L. Bohnert, John H. Hollman, Michael J. Strube, and David R. Sinacore

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Somatic variants in the human lens epithelium: A preliminary assessment, Rosana Mesa, Manoj Tyagi, George Harocopos, David Vollman, and Steven Bassnett

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Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: A randomized controlled trial in non-obese humans, Simin N. Meydani, Sai K. Das, Carl F. Pieper, Michael R. Lewis, Sam Klein, Vishwa D. Dixit, Alok K. Gupta, Dennis T. Villareal, Manjushri Bhapkar, Megan Huang, Paul J. Fuss, Susan B. Roberts, John O. Holloszy, and Luigi Fontana

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Histone H3 lysine 9 acetylation obstructs ATM activation and promotes ionizing radiation sensitivity in normal stem cells, Barbara Meyer, Maria Rita Fabbrizi, Suyash Raj, Cheri L. Zobel, Dennis E. Hallahan, and Girdhar G. Sharma

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Alkaline phosphatase and hypophosphatasia, José Luis Millán and Michael P. Whyte

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Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers, Christopher A. Miller, Yevgeniy Gindin, Charles Lu, Obi L. Griffith, Malachi Griffith, Dong Shen, Jeremy Hoog, Tiandao Li, David E. Larson, Mark Watson, Sherri R. Davies, Jacqueline Snider, Thomas Walsh, Graham A. Colditz, Katherine DeSchryver, Richard K. Wilson, Elaine R. Mardis, Matthew J. Ellis, and et al

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Visualizing tumor evolution with the fishplot package for R, Christopher A. Miller, Joshua McMichael, Ha X. Dang, Christopher A. Maher, Li Ding, Timothy J. Ley, Elaine R. Mardis, and Richard K. Wilson

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Gradient-based algorithm for determining tumor volumes in small animals using planar fluorescence imaging platform, Jessica P. Miller, Christopher Egbulefu, Julie L. Prior, Mingzhou Zhou, and Samuel Achilefu

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Zika virus infection in mice causes panuveitis with shedding of virus in tears, Jonathan J. Miner, Abdoulaye Sene, Justin M. Richner, Amber M. Smith, Andrea Santeford, Norimitsu Ban, James Weger-Lucarelli, Francesca Manzella, Claudia Ruckert, Jennifer Govero, Kevin K. Noguchi, Gregory D. Ebel, and Michael S. Diamond

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Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease, Myles R. Minter, Can Zhang, Vanessa Leone, Daina L. Ringus, Xiaoqiong Zhang, Paul Oyler-Castrillo, Mark W. Musch, Fan Liao, Joseph F. Ward, David M. Holtzman, Eugene B. Chang, Rudolph E. Tanzi, and Sangram S. Sisodia

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Genome sequence of the basal haplorrhine primate Tarsius syrichta reveals unusual insertions, Patrick Minx, Michael J. Montague, Richard K. Wilson, Wesley C. Warren, and et al

Functional consequences of mannos and asialoglycoprotein receptor ablation, Yiling Mi, Marcy Coonce, Dorothy Fiete, Lindsay Steirer, Gabriela Dveksler, R. Reid Townsend, and Jacques U. Baenziger

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Functional consequences of mannose and asialoglycoprotein receptor ablation, Yiling Mi, Marcy Coonce, Dorothy Fiete, Lindsay Steirer, Gabriela Dveksler, R. Reid Townsend, and Jacques U. Baenziger

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Adenoviral expression of a bispecific VHH-based neutralizing agent that targets protective antigen provides prophylactic protection from anthrax in mice, Mahtab Moayeri, Jacqueline M. Tremblay, Michelle Debatis, Igor P. Dmitriev, Elena A. Kashentseva, Anthony J. Yeh, Gordon Y.C. Cheung, David T. Curiel, Stephen Leppla, and Charles B. Shoemaker

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Metastatic granulosa cell tumor of the testis: Clinical presentation and management, Anand Mohapatra, Aaron M. Potretzke, Brent A. Knight, Min Han, and Robert S. Figenshau

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Ethical challenges in preclinical Alzheimer's disease observational studies and trials: Results of the Barcelona summit, Jose L. Molinuevo, Jordi Cami, Xavier Carne, Maria C. Carrillo, Jean Georges, Maria B. Isaac, Zaven Khachaturian, Scott Y.H. Kim, John C. Morris, Florence Pasquier, Craig Ritchie, Reisa Sperling, and Jason Karlawish

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Stress reactivity and personality in extreme sport athletes: The psychobiology of BASE jumpers, Erik Monasterio, Omer Mei-Dan, Anthony C. Hackney, Amy R. Lane, Igor Zwir, Sandor Rozsa, and C. Robert Cloninger

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The role of toll-like receptors in hematopoietic malignancies, Darlene A. Monlish, Sima T. Bhatt, and Laura G. Schuettpelz

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Adherence to pre-exposure prophylaxis for HIV prevention in a clinical setting, Madeline C. Montgomery, Catherine E. Oldenburg, Amy S. Nunn, Leandro Mena, Peter Anderson, Teri Lieger, Kenneth H. Mayer, Rupa Patel, Alexi Almonte, and Philip A. Chan

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Cardiac myocyte-specific knock-out of calcium-independent phospholipase A2γ (iPLA2γ) decreases oxidized fatty acids during ischemia/reperfusion and reduces infarct size, Sung Ho Moon, David J. Mancuso, Harold F. Sims, Xinping Liu, Annie L. Nguyen, Kui Yang, Shaoping Guan, Beverly Gibson Dilthey, Christopher M. Jenkins, Carla J. Weinheimer, Attila Kovacs, Dana Abendschein, and Richard W. Gross

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Inflammatory biomarker score and cancer: A population-based prospective cohort study, Leavitt Morrison, Jari A. Laukkanen, Kimmo Ronkainen, Sudhir Kurl, Jussi Kauhanen, and Adetunji T. Toriola

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Changes in the plasma proteome at asymptomatic and symptomatic stages of autosomal dominant Alzheimer’s disease, Julia Muenchhoff, Anne Poljak, Anbupalam Thalamuthu, Veer B. Gupta, Pratishtha Chatterjee, Mark Raftery, Colin L. Masters, John C. Morris, Randall J. Bateman, Anne M. Fagan, Ralph N. Martins, and Perminder S. Sachdev

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Functional connectivity of the amygdala and subgenual cingulate during cognitive reappraisal of emotions in children with MDD history is associated with rumination, Eric R. Murphy, Deanna M. Barch, David Pagliaccio, Joan L. Luby, and Andy C. Belden

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Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy, Erik S. Musiek, David D. Xiong, Tirth Patel, Yo Sasaki, Yinong Wang, Adam Q. Bauer, Risham Singh, Samantha L. Finn, Joseph P. Culver, Jeffrey Milbrandt, and David M. Holtzman

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CoA protects against the deleterious effects of caloric overload in Drosophila, Laura Palanker Musselman, Jill L. Fink, and Thomas J. Baranski

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Spotlight on ixazomib: Potential in the treatment of multiple myeloma, Barbara Muz, Rachel N. Ghazarian, Monica Ou, Micha J. Luderer, Hubert D. Kusdono, and Abdel K. Azab

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Percutaneous pulmonary valve implantation alters electrophysiologic substrate, Hoang H. Nguyen, Shabana Shahanavaz, George F. Van Hare, David T. Balzer, Ramzi Nicolas, and Jennifer N. Avari Silva

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Type I interferon receptor deficiency in dendritic cells facilitates systemic murine norovirus persistence despite enhanced adaptive immunity, Timothy J. Nice, Lisa C. Osborne, Vesselin T. Tomov, David Artis, E. John Wherry, and Herbert W. Virgin

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Modification of claims-based measures improves identification of comorbidities in non-elderly women undergoing mastectomy for breast cancer: A retrospective cohort study, Katelin B. Nickel, Anna E. Wallace, David K. Warren, Kelly E. Ball, Daniel Mines, Victoria J. Fraser, and Margaret A. Olsen

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Behavioral weight loss treatment for youth treated with antipsychotic medications, Ginger E. Nicol, Rachel P. Kolko, Monica Mills, Thrudur Gunnarsdottir, MIchael D. Yingling, Julia A. Schweiger, Eric J. Lenze, John W. Newcomer, and Denise Wilfley

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Getting to more effective weight management in antipsychotic-treated youth: a survey of barriers and preferences, Ginger Nicol, Elizabeth Worsham, Debra Haire-Joshu, Alexis Duncan, Julia Schweiger, Michael Yingling, and Eric Lenze

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ATX-LPA 1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation, Tatsuji Nishioka, Naoaki Arima, Kuniyuki Kano, Kotaro Hama, Eriko Itai, Hiroshi Yukiura, Ryoji Kise, Asuka Inoue, Seok-Hyung Kim, Lilianna Solnica-Krezel, Wouter H. Moolenaar, Jerold Chun, and Junken Aoki

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Incessant tachycardia in a patient with advanced heart failure and left ventricular assist device: What is the mechanism?, Amit Noheria, Siva K. Mulpuru, Peter A. Noseworthy, and Samuel J. Asirvatham

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Rapid and efficient generation of regulatory T cells to commensal antigens in the periphery, Katherine Nutsch, Jiani N. Chai, Teresa L. Ai, Emilie Russler-Germain, Taylor Feehle, Cathryn R. Nagler, and Chyi-Song Hsieh

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CD4 receptor is a key determinant of divergent HIV-1 sensing by plasmacytoid dendritic cells, Meagan O'Brien, Olivier Manches, Craig Wilen, Ramya Gopal, Rumana Huq, Vernon Wu, Nicole Sunsen, and Nina Bhardwaj

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CrxRdy cat: A large animal model for CRX-associated Leber congenital amaurosis, Laurence M. Occelli, Nicholas M. Tran, Kristina Narfstrom, Shiming Chen, and Simon M. Peteresen-Jones

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Cartilage-specific knockout of the mechanosensory ion channel TRPV4 decreases age-related osteoarthritis, Christopher J. O'Conor, Sendhilnathan Ramalingam, Nicole A. Zelenski, Halei C. Benefield, Isaura Rigo, Dianne Little, Chia-Lung Wu, Di Chen, Wolfgang Liedtke, Amy L. McNulty, and Farshid Guilak

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Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic, Kerri A. Ohman, Yassar M. Hashim, Suwanna Vangveravong, Timothy M. Nywening, Darren R. Cullinan, S. Peter Goedegebuure, Jingxia Liu, Brian A. Van Tine, Herve Tiriac, David A. Tuveson, David G. DeNardo, Dirk Spitzer, Robert H. Mach, and William G. Hawkins

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A 66-year-old woman with a progressive, longitudinally extensive, tract specific, myelopathy, Elizabeth O'Keefe, Katherine E. Schwetye, John Nazarian, Richard Perrin, Robert E. Schmidt, and Robert Bucelli

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Mechanisms of Zika virus infection and neuropathogenesis, David Olagnier, Michela Muscolini, Carolyn B. Coyne, Michael S. Diamond, and John Hiscott

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The burden of Clostridium difficile infection: Estimates of the incidence of CDI from U.S. Administrative databases, Margaret A. Olsen, Yinong Young-Xu, Dustin Stwalley, Ciaran P. Kelly, Dale N. Gerding, Mohammed J. Saeed, Cedric Mahe, and Erik R. Dubberke

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Subversion of host innate immunity by uropathogenic Escherichia coli, Patrick D. Olson and David A. Hunstad

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A central line care maintenance bundle for the prevention of central line–associated bloodstream infection in non–intensive care unit settings, Caroline O'Neil, Kelly Ball, Helen Wood, Kathleen McMullen, Pamala Kremer, S. Reza Jafarzadeh, Victoria Fraser, and David Warren

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Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration, Patrick R. O'Neill, Vani Kalyanaraman, and N. Gautam

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Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele, Eileen N. Oni, Apoorva Halikere, Guohui Li, Alana J. Toro-Ramos, Mavis R. Swerdel, Jessica L. Verpeut, Jennifer C. Moore, Nicholas T. Bello, Laura J. Bierut, Alison Goate, Jay A. Tischfield, Zhiping P. Pang, and Ronald P. Hart

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Sarcoidosis presenting as granulomatous myositis in a 16-year-old adolescent, Amir B. Orandi, Eric Eutsler Eutsler, Cole Ferguson, Andrew J. White, and Maleewan Kitcharoensakkul

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Drug delivery approaches for the treatment of cervical cancer, Farideh Ordikhani, Mustafa Erdem Arslan, Raymundo Marcelo, Ilyas Sahin, Perry Grigsby, Julie K. Schwarz, and Abdel Kareem Azab

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The value of early and comprehensive diagnoses in a human fetus with hydrocephalus and progressive obliteration of the aqueduct of Sylvius: Case Report, Eduardo Ortega, Rosa I. Munoz, Nelly Luza, Francisco Geurra, Monserrat Guerra, Karin Vio, Roberto Henzi, Jaime Jaque, Sara Rodriguez, James P. McAllister, and Esteban Rodriguez

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Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway [version 1; referees: 2 approved, 2 approved with reservations], Daniel S. Ory and et al

Spinolaminar line test as a screening tool for C1 stenosis, Yasushi Oshima, Michael P. Kelly, Kwang-Sup Song, Moon Soo Park, Tapanut Chuntarapas, Katie D. Vo, Jin S. Yeom, Katsushi Takeshita, and K. Daniel Riew

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Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of β-amyloid (1–42) in human cerebrospinal fluid, Richard E. Ostlund Jr., David Gibson, and et al

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Atg5 Is essential for the development and survival of innate lymphocytes, Timothy E. O'Sulivan, Clair D. Geary, Orr-El Weizman, Theresa L. Geiger, Moritz Rapp, Gerald W. Dorn II, Michael Overholtzer, and Joseph C. Sun

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Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families, Joshua Page, John Nicholas Constantino, Katherine Zambrana, Eden Martin, Ilker Tunc, Yi Zhang, Anna Abbacchi, and Daniel Messinger

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De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females, E E Palmer, D K Grange, L Manwaring, and et al

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Plasmodium falciparum histidine-rich protein II compromises brain endothelial barriers and may promote cerebral malaria pathogenesis, Priya Pal, Brian P. Daniels, Anna Oskman, Michael S. Diamond, Robyn S. Klein, and Daniel E. Goldberg

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Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery, Dipanjan Pan, Christine T.N. Pham, Katherine N. Weilbaecher, Michael H. Tomasson, Samuel A. Wickline, and Gregory M. Lanza

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Inhibition of DNA methyltransferases blocks mutant huntingtin-induced neurotoxicity, Yanchun Pan, Takuji Daito, Yo Sasaki, Yong Hee Chung, Xiaoyun Xing, Santhi Pondugula, S. Joshua Swamidass, Ting Wang, Albert H. Kim, and Hiroko Yano

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Efficacy and safety of radium-223 dichloride in symptomatic castration-resistant prostate cancer patients with or without baseline opioid use from the phase 3 ALSYMPCA trial, Christopher Parker, Steven E. Finkelstein, Jeff M. Michalski, Joe M. O'Sullivan, Oyvind Bruland, Nicholas J. Vogelzang, Robert E. Coleman, Sten Nilsson, Oliver Sartor, Rui Li, Monica A. Seger, and David Bottomley

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Urinary metabolomics identifies a molecular correlate of interstitial cystitis/bladder pain syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Cohort, Kaveri S. Parker, Jan R. Crowley, Alisa J. Stephens-Shields, Adrie van Bokhoven, M. Scott Lucia, H. Henry Lai, Gerald L. Andriole, Thomas M. Hooton, Chris Mullins, and Jeffrey P. Henderson

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Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy, Haeseong Park and et al

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Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo, See-Hyoung Park, Young Min Chung, Jessica Ma, Qin Yang, Jonathan S. Berek, and Mickey C-T Hu

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Anthropometric factors and thyroid cancer risk by histological subtype: pooled analysis of 22 prospective studies, Yikyung Park and et al

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Case report: Severe cutaneous leishmaniasis in a human immunodeficiency virus patient coinfected with Leishmania braziliensis and its endosymbiotic virus, Laurent Parmentier, Alexia Cusini, Norbert Müller, Haroun Zangger, Mary-Anne Hartley, Chantal Desponds, Patrik Castiglioni, Patrick Dubach, Catherine Ronet, Stephen M. Beverley, and Nicolas Fasel

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More than ataxia: Hyperkinetic movement disorders in childhood autosomal recessive ataxia syndromes, Toni S Pearson

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Characterization of candidate genes in inflammatory bowel disease-associated risk loci, Joanna M. Peloquin, Gautam Goel, Lingjia Kong, Hailiang Huang, Talin Haritunians, R. Balfour Sartor, Mark J. Daly, Rodney D. Newberry, Dermot P. McGovern, Vijay Yajnik, Sergio A. Lira, and Ramnik J. Xavier

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Familial influences on the full range of variability in attention and activity levels during adolescence: A longitudinal twin study, Chun-Zi Peng, Julia D. Grant, Andrew C. Heath, Angela M. Reiersen, Richard C. Mulligan, and Andrey P. Anokhin

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Clinical and genetic features of cervical dystonia in a large multicenter cohort, Joel S. Perlmutter, Laura J. Wright, and et al

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Evaluation of machine learning and rules-based approaches for predicting antimicrobial resistance profiles in gram-negative bacilli from whole genome sequence data, Mitchell W. Pesesky, Tahir Hussain, Meghan Wallace, Sanket Patel, Saadia Andleeb, Carey-Ann D. Burhnam, and Gautam Dantas

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Prospective exploratory muscle biopsy, imaging, and functional assessment in patients with late-onset Pompe disease treated with alglucosidase alfa: The EMBASSY Study, Alan Pestronk and et al

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Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers, Adam D. Pfefferle, Yash N. Agrawal, Daniel C. Koboldt, Krishna L. Kanchi, Jason I. Herschkowitz, Elaine R. Mardis, Jeffrey M. Rosen, and Charles M. Perou