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Submissions from 2016

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Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy, Erik S. Musiek, David D. Xiong, Tirth Patel, Yo Sasaki, Yinong Wang, Adam Q. Bauer, Risham Singh, Samantha L. Finn, Joseph P. Culver, Jeffrey Milbrandt, and David M. Holtzman

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CoA protects against the deleterious effects of caloric overload in Drosophila, Laura Palanker Musselman, Jill L. Fink, and Thomas J. Baranski

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Spotlight on ixazomib: Potential in the treatment of multiple myeloma, Barbara Muz, Rachel N. Ghazarian, Monica Ou, Micha J. Luderer, Hubert D. Kusdono, and Abdel K. Azab

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Percutaneous pulmonary valve implantation alters electrophysiologic substrate, Hoang H. Nguyen, Shabana Shahanavaz, George F. Van Hare, David T. Balzer, Ramzi Nicolas, and Jennifer N. Avari Silva

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Type I interferon receptor deficiency in dendritic cells facilitates systemic murine norovirus persistence despite enhanced adaptive immunity, Timothy J. Nice, Lisa C. Osborne, Vesselin T. Tomov, David Artis, E. John Wherry, and Herbert W. Virgin

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Modification of claims-based measures improves identification of comorbidities in non-elderly women undergoing mastectomy for breast cancer: A retrospective cohort study, Katelin B. Nickel, Anna E. Wallace, David K. Warren, Kelly E. Ball, Daniel Mines, Victoria J. Fraser, and Margaret A. Olsen

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Behavioral weight loss treatment for youth treated with antipsychotic medications, Ginger E. Nicol, Rachel P. Kolko, Monica Mills, Thrudur Gunnarsdottir, MIchael D. Yingling, Julia A. Schweiger, Eric J. Lenze, John W. Newcomer, and Denise Wilfley

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Getting to more effective weight management in antipsychotic-treated youth: a survey of barriers and preferences, Ginger Nicol, Elizabeth Worsham, Debra Haire-Joshu, Alexis Duncan, Julia Schweiger, Michael Yingling, and Eric Lenze

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ATX-LPA 1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation, Tatsuji Nishioka, Naoaki Arima, Kuniyuki Kano, Kotaro Hama, Eriko Itai, Hiroshi Yukiura, Ryoji Kise, Asuka Inoue, Seok-Hyung Kim, Lilianna Solnica-Krezel, Wouter H. Moolenaar, Jerold Chun, and Junken Aoki

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Incessant tachycardia in a patient with advanced heart failure and left ventricular assist device: What is the mechanism?, Amit Noheria, Siva K. Mulpuru, Peter A. Noseworthy, and Samuel J. Asirvatham

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Rapid and efficient generation of regulatory T cells to commensal antigens in the periphery, Katherine Nutsch, Jiani N. Chai, Teresa L. Ai, Emilie Russler-Germain, Taylor Feehle, Cathryn R. Nagler, and Chyi-Song Hsieh

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CD4 receptor is a key determinant of divergent HIV-1 sensing by plasmacytoid dendritic cells, Meagan O'Brien, Olivier Manches, Craig Wilen, Ramya Gopal, Rumana Huq, Vernon Wu, Nicole Sunsen, and Nina Bhardwaj

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CrxRdy cat: A large animal model for CRX-associated Leber congenital amaurosis, Laurence M. Occelli, Nicholas M. Tran, Kristina Narfstrom, Shiming Chen, and Simon M. Peteresen-Jones

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Cartilage-specific knockout of the mechanosensory ion channel TRPV4 decreases age-related osteoarthritis, Christopher J. O'Conor, Sendhilnathan Ramalingam, Nicole A. Zelenski, Halei C. Benefield, Isaura Rigo, Dianne Little, Chia-Lung Wu, Di Chen, Wolfgang Liedtke, Amy L. McNulty, and Farshid Guilak

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Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic, Kerri A. Ohman, Yassar M. Hashim, Suwanna Vangveravong, Timothy M. Nywening, Darren R. Cullinan, S. Peter Goedegebuure, Jingxia Liu, Brian A. Van Tine, Herve Tiriac, David A. Tuveson, David G. DeNardo, Dirk Spitzer, Robert H. Mach, and William G. Hawkins

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A 66-year-old woman with a progressive, longitudinally extensive, tract specific, myelopathy, Elizabeth O'Keefe, Katherine E. Schwetye, John Nazarian, Richard Perrin, Robert E. Schmidt, and Robert Bucelli

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Mechanisms of Zika virus infection and neuropathogenesis, David Olagnier, Michela Muscolini, Carolyn B. Coyne, Michael S. Diamond, and John Hiscott

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The burden of Clostridium difficile infection: Estimates of the incidence of CDI from U.S. Administrative databases, Margaret A. Olsen, Yinong Young-Xu, Dustin Stwalley, Ciaran P. Kelly, Dale N. Gerding, Mohammed J. Saeed, Cedric Mahe, and Erik R. Dubberke

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Subversion of host innate immunity by uropathogenic Escherichia coli, Patrick D. Olson and David A. Hunstad

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A central line care maintenance bundle for the prevention of central line–associated bloodstream infection in non–intensive care unit settings, Caroline O'Neil, Kelly Ball, Helen Wood, Kathleen McMullen, Pamala Kremer, S. Reza Jafarzadeh, Victoria Fraser, and David Warren

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Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration, Patrick R. O'Neill, Vani Kalyanaraman, and N. Gautam

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Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele, Eileen N. Oni, Apoorva Halikere, Guohui Li, Alana J. Toro-Ramos, Mavis R. Swerdel, Jessica L. Verpeut, Jennifer C. Moore, Nicholas T. Bello, Laura J. Bierut, Alison Goate, Jay A. Tischfield, Zhiping P. Pang, and Ronald P. Hart

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Sarcoidosis presenting as granulomatous myositis in a 16-year-old adolescent, Amir B. Orandi, Eric Eutsler Eutsler, Cole Ferguson, Andrew J. White, and Maleewan Kitcharoensakkul

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Drug delivery approaches for the treatment of cervical cancer, Farideh Ordikhani, Mustafa Erdem Arslan, Raymundo Marcelo, Ilyas Sahin, Perry Grigsby, Julie K. Schwarz, and Abdel Kareem Azab

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The value of early and comprehensive diagnoses in a human fetus with hydrocephalus and progressive obliteration of the aqueduct of Sylvius: Case Report, Eduardo Ortega, Rosa I. Munoz, Nelly Luza, Francisco Geurra, Monserrat Guerra, Karin Vio, Roberto Henzi, Jaime Jaque, Sara Rodriguez, James P. McAllister, and Esteban Rodriguez

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Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway [version 1; referees: 2 approved, 2 approved with reservations], Daniel S. Ory and et al

Spinolaminar line test as a screening tool for C1 stenosis, Yasushi Oshima, Michael P. Kelly, Kwang-Sup Song, Moon Soo Park, Tapanut Chuntarapas, Katie D. Vo, Jin S. Yeom, Katsushi Takeshita, and K. Daniel Riew

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Technical performance of a novel, fully automated electrochemiluminescence immunoassay for the quantitation of β-amyloid (1–42) in human cerebrospinal fluid, Richard E. Ostlund Jr., David Gibson, and et al

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Atg5 Is essential for the development and survival of innate lymphocytes, Timothy E. O'Sulivan, Clair D. Geary, Orr-El Weizman, Theresa L. Geiger, Moritz Rapp, Gerald W. Dorn II, Michael Overholtzer, and Joseph C. Sun

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Quantitative autistic trait measurements index background genetic risk for ASD in Hispanic families, Joshua Page, John Nicholas Constantino, Katherine Zambrana, Eden Martin, Ilker Tunc, Yi Zhang, Anna Abbacchi, and Daniel Messinger

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De novo and inherited mutations in the X-linked gene CLCN4 are associated with syndromic intellectual disability and behavior and seizure disorders in males and females, E E Palmer, D K Grange, L Manwaring, and et al

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Plasmodium falciparum histidine-rich protein II compromises brain endothelial barriers and may promote cerebral malaria pathogenesis, Priya Pal, Brian P. Daniels, Anna Oskman, Michael S. Diamond, Robyn S. Klein, and Daniel E. Goldberg

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Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery, Dipanjan Pan, Christine T.N. Pham, Katherine N. Weilbaecher, Michael H. Tomasson, Samuel A. Wickline, and Gregory M. Lanza

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Inhibition of DNA methyltransferases blocks mutant huntingtin-induced neurotoxicity, Yanchun Pan, Takuji Daito, Yo Sasaki, Yong Hee Chung, Xiaoyun Xing, Santhi Pondugula, S. Joshua Swamidass, Ting Wang, Albert H. Kim, and Hiroko Yano

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Efficacy and safety of radium-223 dichloride in symptomatic castration-resistant prostate cancer patients with or without baseline opioid use from the phase 3 ALSYMPCA trial, Christopher Parker, Steven E. Finkelstein, Jeff M. Michalski, Joe M. O'Sullivan, Oyvind Bruland, Nicholas J. Vogelzang, Robert E. Coleman, Sten Nilsson, Oliver Sartor, Rui Li, Monica A. Seger, and David Bottomley

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Urinary metabolomics identifies a molecular correlate of interstitial cystitis/bladder pain syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Cohort, Kaveri S. Parker, Jan R. Crowley, Alisa J. Stephens-Shields, Adrie van Bokhoven, M. Scott Lucia, H. Henry Lai, Gerald L. Andriole, Thomas M. Hooton, Chris Mullins, and Jeffrey P. Henderson

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Phase I dose-escalation study of the mTOR inhibitor sirolimus and the HDAC inhibitor vorinostat in patients with advanced malignancy, Haeseong Park and et al

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Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo, See-Hyoung Park, Young Min Chung, Jessica Ma, Qin Yang, Jonathan S. Berek, and Mickey C-T Hu

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Anthropometric factors and thyroid cancer risk by histological subtype: pooled analysis of 22 prospective studies, Yikyung Park and et al

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Case report: Severe cutaneous leishmaniasis in a human immunodeficiency virus patient coinfected with Leishmania braziliensis and its endosymbiotic virus, Laurent Parmentier, Alexia Cusini, Norbert Müller, Haroun Zangger, Mary-Anne Hartley, Chantal Desponds, Patrik Castiglioni, Patrick Dubach, Catherine Ronet, Stephen M. Beverley, and Nicolas Fasel

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More than ataxia: Hyperkinetic movement disorders in childhood autosomal recessive ataxia syndromes, Toni S Pearson

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Characterization of candidate genes in inflammatory bowel disease-associated risk loci, Joanna M. Peloquin, Gautam Goel, Lingjia Kong, Hailiang Huang, Talin Haritunians, R. Balfour Sartor, Mark J. Daly, Rodney D. Newberry, Dermot P. McGovern, Vijay Yajnik, Sergio A. Lira, and Ramnik J. Xavier

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Familial influences on the full range of variability in attention and activity levels during adolescence: A longitudinal twin study, Chun-Zi Peng, Julia D. Grant, Andrew C. Heath, Angela M. Reiersen, Richard C. Mulligan, and Andrey P. Anokhin

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Clinical and genetic features of cervical dystonia in a large multicenter cohort, Joel S. Perlmutter, Laura J. Wright, and et al

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Evaluation of machine learning and rules-based approaches for predicting antimicrobial resistance profiles in gram-negative bacilli from whole genome sequence data, Mitchell W. Pesesky, Tahir Hussain, Meghan Wallace, Sanket Patel, Saadia Andleeb, Carey-Ann D. Burhnam, and Gautam Dantas

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Prospective exploratory muscle biopsy, imaging, and functional assessment in patients with late-onset Pompe disease treated with alglucosidase alfa: The EMBASSY Study, Alan Pestronk and et al

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Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers, Adam D. Pfefferle, Yash N. Agrawal, Daniel C. Koboldt, Krishna L. Kanchi, Jason I. Herschkowitz, Elaine R. Mardis, Jeffrey M. Rosen, and Charles M. Perou

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Autofluorescence as a measure of senescence in C. elegans: Look to red, not blue or green, Zachary Pincus, Travis C. Mazer, and Frank J. Slack

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The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses, Subhajit Poddar, Jennifer L. Hyde, Matthew J. Gorman, Michael Farzan, and Michael S. Diamond

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Axonal growth arrests after an increased accumulation of Schwann cells expressing senescence markers and stromal cells in acellular nerve allografts, Louis H. Poppler, Xueping Ee, Lauren Schellhardt, Gwendolyn M. Hoben, Deng Pan, Daniel A. Hunter, Ying Yan, Amy M. Moore, Alison K. Snyder-Warwick, Sheila A. Stewart, Susan E. Mackinnon, and Matthew D. Wood

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Diabetes status and being up-to-date on colorectal cancer screening, 2012 Behavioral Risk Factor Surveillance System, Nancy R. Porter, Jan M. Eberth, Marsha E. Samson, Oralia Garcia-Dominic, Eugene J. Lengerich, and Mario Schootman

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Pten cell autonomously modulates the hematopoietic stem cell response to inflammatory cytokines, Shaina N. Porter, Andrew S. Cluster, Robert A.J. Signer, Jenna Voigtmann, Darlene A. Monlish, Laura G. Schuettpelz, and Jeffrey A. Magee

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Is extended preoperative antibiotic prophylaxis for high-risk patients necessary before percutaneous nephrolithotomy?, Aaron M. Potretzke, Alyssa M. Park, Tyler M. Bauman, Jeffrey A. Larson, Joel M. Vetter, Brian M. Benway, and Alana C. Desai

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p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer, Emily Powell, Jiansu Shao, Yuan Yuan, Hsiang-Chun Chen, Shirong Cai, Gloria V. Echeverria, Nipun Mistry, Keith F. Decker, Christopher Schlosberg, Kim-Anh Do, John R. Edwards, Han Liang, David Piwnica-Worms, and Helen Piwnica-Worms

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Causal evidence for a mechanism of semantic integration in the angular gyrus as revealed by high-definition transcranial direct current stimulation, Amy Rose Price, Jonathan E. Peelle, Michael F. Bonner, Murray Grossman, and Roy H. Hamilton

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A review of policy dissemination and implementation research funded by the National Institutes of Health, 2007–2014, Jonathan Purtle, Rachel Peters, and Ross Brownson

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Direct hospital cost of outcome pathways in implant-based reconstruction with acellular dermal matrices, Ali A. Qureshi, Kristin Broderick, Susan Funk, Nancy Reaven, Marissa M. Tenenbaum, and Terence M. Myckatyn

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Measurement resources for dissemination and implementation research in health, Borsika A. Rabin, Cara C. Lewis, Wynne E. Norton, Gila Neta, David Chambers, Jonathan N. Tobin, Ross C. Brownson, and Russell E. Glasgow

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RNA microarray analysis of macroscopically normal articular cartilage from knees undergoing partial medial meniscectomy: Potential prediction of the risk for developing osteoarthritis, Muhammad Farooq Rai, Linda J. Sandell, Bo Zhang, Rick W. Wright, and Robert H. Brophy

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Functional deficits precede structural lesions in mice with high-fat diet-induced diabetic retinopathy, Rithwick Rajagopal, Gregory W. Bligard, Sheng Zhang, Li Yin, Peter Lukasiewicz, and Clay F. Semenkovich

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Cooperative stabilization of Mycobacterium tuberculosis rrnAP3 promoter open complexes by RbpA and CarD, Jayan Rammohan, Ana Ruiz Manzano, Ashley L. Garner, Jerome Prusa, Christina L. Stallings, and Eric A. Galburt

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Diagnostics and training of affordance perception in healthy young adults - Implications for post-stroke neurorehabilitation, Jennifer Randerath and Scott H. Frey

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Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury, Michael J. Randles, Sophie Collinson, Tobias Starborg, Aleksandr Mironov, Mira Krendel, Eva Königshausen, Lorenz Sellin, Ian S. D. Roberts, Karl E. Kadler, Rachel Lennon, and Jeffrey H. Miner

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CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses, Gwendalyn J. Randolph and et al

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Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability, Gwendalyn J. Randolph and et al

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A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms, Asha Rani, Ravi Ranjan, Halvor S. McGee, Ahmed Metwally, Zahraa Hajjiri, Daniel C. Brennan, Patricia W. Finn, and David L. Perkins

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Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference, Dabeeru Rao and et al

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Programmatic use of molecular xenomonitoring at the level of evaluation units to assess persistence of lymphatic filariasis in Sri Lanka, Ramakrishna U. Rao, Sandhya D. Samarasekera, Kumara C. Nagodavithana, Manjula W. Punchihewa, Tharanga D. M. Dassanayaka, Gamini P. K. D, Ethan Ford, Udaya S. B. Ranasinghe, Ralph H. Henderson, and Gary J. Weil

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A framework for interpreting type I error rates from a product-term model of interaction applied to quantitative traits, Tara J. Rao and Michael A. Province

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Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development, David Razafsky, Candace Ward, Chloe Potter, Wanqiu Zhu, Yunlu Xue, Vladimir J. Kefalov, Loren G. Fong, Stephen G. Young, and Didier Hodzic

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Clec16a is critical for autolysosome function and Purkinje cell survival, Veronika Redmann, Robert C. Orchard, Ashley Milam, Sunmin Park, Christine C. Yokoyama, Amal Kambal, Darren Kreamalmeyer, Karen Green, Paul M. Allen, Robert E. Schmidt, Herbert W. Virgin, Marie K. Bosch, Maolei Xiao, David M. Ornitz, Aaron DiAntonio, Shondra M. Pruett-Miller, Sungsu Kim, Wanda L. Beatty, and et al

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Predictors of change in depressive symptoms from preschool to first grade, Trude Reinfjell, Silja Berg Kårstad, Turid Suzanne Berg-Nielsen, Joan L. Luby, and Lars Wichstrøm

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Computational neurorehabilitation: Modeling plasticity and learning to predict recovery, David J. Reinkensmeyer, Etienne Burdet, Maura Casadio, John W. Krakauer, Gert Kwakkel, Catherine E. Lang, Stephan P. Swinnen, Nick S. Ward, and Nicolas Schweighofer

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Base J represses genes at the end of polycistronic gene clusters in Leishmania major by promoting RNAP II termination, David L. Reynolds, Brigitte T. Hofmeister, Laura Cliffe, T. Nicolai Siegel, Britta A. Anderson, Stephen M. Beverley, Robert J. Schmitz, and Robert Sabatini

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Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells, Matthew R. Reynolds, Itender Singh, Tej D. Azad, Brandon B. Holmes, Phillip B. Verghese, Hans H. Dietrich, Marc Diamond, Guojun Bu, Byung Hee Han, and Gregory J. Zipfel

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Tourette syndrome research highlights 2015 [version 1; referees: 3 approved], Cheryl A. Richards and Kevin J. Black

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Challenges in drug discovery for neurofibromatosis type 1-associated low-grade glioma, Cora A. Ricker, Yuan Pan, David H. Gutmann, and Charles Keller

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Analysis of within subjects variability in mouse ultrasonic vocalization: Pups exhibit inconsistent, state-like patterns of call production, Michael A. Rieger and Joseph D. Dougherty

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ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β, Agnieszka Robaszkiewicz, Chao Qu, Ewelina Wisnik, Tomasz Ploszaj, Ali Mirsaidi, Friedrich A. Kunze, Peter J. Richards, Paolo Cinelli, Gabriel Mbalaviele, and Michael O. Hottiger

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Implementation of a screening program for patients at risk for posttraumatic stress disorder, Carmen R. Roberts, Joanie E. Wofford, Haley M. Hoy, and Mitchell N. Faddis

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Genome sequences of 15 Gardnerella vaginalis strains isolated from the vaginas of women with and without bacterial vaginosis, Lloyd S. Robinson, Justin Perry, Sai Lek, Aye Wollam, Erica Sodergren, George Weinstock, Warren G. Lewis, and Amanda L. Lewis

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Synthetic ligands of cannabinoid receptors affect dauer formation in the nematode Caenorhabditis elegans, Pedro Reis Rodrigues, Tiffany K. Kaul, Jo-Hao Ho, Mark Lucanic, Kristopher Burkewitz, William B. Mair, Jason M. Held, Laura M. Bohn, and Matthew S. Gill

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ISG15 deficiency and increased viral resistance in humans but not mice, Marisela R. Rodriguez, Deborah J. Lenschow, and et al

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L-MYC expression maintains self-renewal and prolongs multipotency of primary human neural stem cells, Xianfang Rong, Joseph Benetatos, David L. Brody, and et al

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Stroke severity Is a crucial predictor of outcome: An international prospective validation study, Natalia S. Rost, Alex Bottle, Jin-Moo Lee, Marc Randall, Steven Middleton, Louise Shaw, Vincent Thijs, Gabriel J.E. Rinkel, Thomas M. Hemmen, and Global Comparators Stroke GOAL collaborators

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Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis, Megan K. Ruhland, Andrew J. Loza, Aude-Helene Capietto, Xianmin Luo, Brett L. Knolhoff, Kevin C. Flanagan, Brian A. Belt, Elise Alspach, Kathleen Leahy, Jingqin Luo, Andras Schaffer, John R. Edwards, Gregory Longmore, Roberta Faccio, David G. DeNardo, and Sheila A. Stewart

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Whole genome sequencing for genomics-guided investigations of Escherichia coli O157:H7 outbreaks, Brigida Rusconi, Fatemeh Sanjar, Sara S.K. Koenig, Mark K. Mammel, Phillip I. Tarr, and Mark Eppinger

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Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma, Scott Ryall, Rahul Krishnatry, Anthony Arnoldo, Pawel Buczkowicz, Matthew Mistry, Robert Siddaway, Cino Ling, Sanja Pajovic, Man Yu, Joshua B. Rubin, Juliette Hukin, Paul Steinbok, Ute Bartels, Eric Bouffet, Uri Tabori, and Cynthia Hawkins

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Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations, Jessica L. Saben, Anna L. Boudoures, Zeenat Asghar, Alysha Thompson, Andrea Drury, Wendy Zhang, Maggie Chi, Andrew Cusumano, Suzanne Scheaffer, and Kelle H. Moley

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The Na+/Ca2+, K+ exchanger 2 modulates mammalian cone phototransduction, Keisuke Sakurai, Frans Vinberg, Tian Wang, Jeannie Chen, and Vladimir J. Kefalov

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Reducing CSF partial volume effects to enhance diffusion tensor imaging metrics of brain microstructure, Lauren E. Salminen, Thomas E. Conturo, Jacob D. Bolzenius, Ryan P. Cabeen, Erbil Akbudak, and Robert H. Paul

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Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis, Indra Sandal, Anastasios Karydis, Jiwen Luo, Amanda Prislovsky, Karen B. Whittington, Edward F. Rosloniec, Chen Dong, Deborah V. Novack, Piotr Mydel, Song Guo Zheng, Marko Z. Radic, and David D. Brand

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Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1, Savita Sankar, Dhananjay Yellajoshyula, Bo Zhang, Bryan Teets, Nicole Rockweiler, and Kristen L. Kroll

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Epidemiology of bloodstream infections in a multicenter retrospective cohort of liver transplant recipients, Carlos A.Q. Santos, Richard S. Hotchkiss, William C. Chapman, and Margaret A. Olsen

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NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion, Yo Sasaki, Takashi Nakagawa, Xianrong Mao, Aaron DiAntonio, and Jeffrey Milbrandt

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The dimeric architecture of checkpoint Mec1ATR and Tel1ATM reveal a common structural organization, Marta Sawicka, Paulina H. Wanrooij, Vidya C. Darbari, Elias Tannous, Sarem Hailemariam, Daniel Bose, Alena V. Makarova, Peter M. Burgers, and Xiaodong Zhang

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Disruption of the Cdc42/Par6/aPKC or Dlg/Scrib/Lgl polarity complex promotes epithelial proliferation via overlapping mechanisms, Gregory V. Schimizzi, Meghan T. Maher, Andrew J. Loza, and Gregory D. Longmore

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CSF sTREM2: Marking the tipping point between preclinical AD and dementia?, Suzanne E. Schindler and David M. Holtzman

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AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity, Edward T. Schmid, Iris K. Pang, Eugenio A. Carrera Silva, Lidia Bosurgi, Jonathan J. Miner, Michael S. Diamond, Akiko Iwasaki, and Carla V. Rothlin

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A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection, Diane J. Schmidt, Gillian Beamer, Jacqueline M. Tremblay, Jennifer A. Steele, Hyeun Bum Kim, Yaunkai Wang, Michele Debatis, Xingmin Sun, Elena A. Kashentseva, Igor P. Dmitriev, David T. Curiel, Charles B. Shoemaker, and Saul Tzipori