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Submissions from 2013

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Biogeography of the ecosystems of the healthy human body, Yanjiao Zhou, Hongyu Gao, Kathie A. Mihindukulasuriya, Patricio S. La Rosa, Kristine M. Wylie, Tatiana Vishnivetskaya, Mircea Podar, Barb Warner, Phillip I. Tarr, David E. Nelson, J. D. Fortenberry, Martin J. Holland, Sarah E. Burr, William D. Shannon, Erica Sodergren, and George M. Weinstock

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Role of hypoxia-inducible factor-1α in preconditioning-induced protection of retinal ganglion cells in glaucoma, Yanli Zhu, Lihong Zhang, and Jeffrey M. Gidday

Submissions from 2012

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Metabolic reconstruction for metagenomic data and Its application to the human microbiome, Sahar Abubucker, Nicola Segata, Johannes Goll, Alyxandria M. Schubert, Jacques Izard, Brandi L. Cantarel, Beltran Rodriguez-Mueller, Jeremy Zucker, Mathangi Thiagarajan, Bernard Henrissat, Owen White, Scott T. Kelly, Barbara Methe, Patrick D. Schloss, Dirk Gevers, Makedonka Mitreva, and Curtis Huttenhower

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Common data elements for pediatric traumatic brain injury: Recommendations from the working group on demographics and clinical assessment, P. David Adelson, Jose Pineda, Michael J. Bell, Nicholas S. Abend, Rachel P. Berger, Christopher C. Giza, Gillian Hotz, and Mark S. Wainwright

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GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle, Lauren Aerni-Flessner, Melissa Abi-Jaoude, Amanda Koening, Maria Payne, and Paul W. Hruz

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Current perspectives on skeletal health and cancer progression across the disease continuum in breast cancer—The role of bisphosphonates, R. Aft

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Protection of bone in premenopausal women with breast cancer: focus on zoledronic acid, Rebecca Aft

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Effect of (Neo)adjuvant zoledronic acid on disease-free and overall survival in clinical stage II/III breast cancer, Rebecca L. Aft, Michael J. Naughton, Kathryn M. Trinkaus, and Katherine N. Weilbaecher

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Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study, Arpana Agrawal and et al

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The genetics of addiction—a translational perspective, A. Agrawal, K. J. H. Verweij, N. A. Gillespie, A. C. Heath, C. N. Lessov-Schlaggar, N. G. Martin, E. C. Nelson, W. S. Slutske, J. B. Whitfield, and M. T. Lynskey

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IL-13-induced airway mucus production is attenuated by MAPK13 inhibition, Yael G. Alevy, Anand C. Patel, Arthur G. Romero, Dhara A. Patel, Jennifer Tucker, William T. Roswit, Chantel A. Miller, Richard F. Heier, Derek E. Byers, Tom J. Brett, and Michael J. Holtzman

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Large-scale pathway-based analysis of bladder cancer genome-wide association data from five studies of European background, Gerald Andriole Jr. and et al

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Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy, Gerald L. Andriole and et al

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Radical prostatectomy versus observation for localized prostate cancer, Gerald L. Andriole and et al

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Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: A PLCO Study, G. L. Andriole and et al.

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LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A, Nataraju Angaswamy, Naohiko Fukami, Venkataswarup Tiriveedhi, George J. Cianciolo, and T Mohanakumar

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Hospital flood preparedness: A survey of 15 provinces in Central Thailand, Anucha Apisarnthanarak, Thana Khawcharoenporn, Keith F. Woeltje, and David K. Warren

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Increased serum albuterol concentrations may be associated with elevations of serum lactate in subjects with acute asthma exacerbations, Kristen Aubuchon, Kazuko Matsuda, Stacey House, John Schneider, and Lawrence Lewis

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Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope, S. Kyle Austin, Kimberly A. Dowd, Bimmi Shrestha, Christopher A. Nelson, Melissa A. Edeling, Syd Johnson, Theodore C. Pierson, Michael S. Diamond, and Daved H. Fremont

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Group VIB phospholipase A2 promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents, Shunzhong Bao, Haowei Song, Min Tan, Mary Wohltmann, Jack H. Ladenson, and John Turk

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Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling, Jacob M. Basak, Jungsu Kim, Yuriy Pyatkivskyy, Kristin R. Wildsmith, Hong Jiang, Maia Parsadanian, Bruce W. Patterson, Randall J. Bateman, and David M. Holtzman

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Clinical and biomarker changes in dominantly inherited Alzheimer's disease, Randall J. Bateman, Anne M. Fagan, David M. Holtzman, Anna Santacruz, Virginia Buckles, Angela Oliver, Krista Moulder, John C. Morris, and et al

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Integrated signaling in developing lymphocytes: The role of DNA damage responses, Jeffrey J. Bednarski and Barry P. Sleckman

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Vpx is critical for SIVmne infection of pigtail macaques, Michael Belshan, Jason T. Kimata, Charles Brown, Xiaogang Cheng, Anna McCulley, Alison Larsen, Rajesh Thippeshappa, Vida Hodara, Luis Giavedoni, Vanessa Hirsch, and Lee Ratner

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Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer, Christina N. Bennett, Christine C. Tomlinson, Aleksandra M. Michalowski, Isabel M. Chu, Dror Luger, Lara R. Mittereder, Olga Aprelikova, James Shou, Helen Piwnica-Worms, Melinda G. Hollingshead, and Jeffrey E. Green

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Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain, Adam W. Bero, Adam O. Bauer, Floy R. Stewart, Brian R. White, John R. Cirrito, Marcus E. Raichle, Joseph P. Culver, and David M. Holtzman

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A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration, Martha R.C. Bhattacharya, Josiah Gerdts, Sarah A. Naylor, Emily X. Royse, Sarah Y. Ebstein, Yo Sasaki, Jeffrey Milbrandt, and Aaron DiAntonio

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Trigeminal neuralgia post-styloidectomy in Eagle syndrome: A case report, John W. Blackett, Daniel J. Ferraro, John J. Stephens, Joshua L. Dowling, and Jerry J. Jaboin

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Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice, Sheri L. Bonar, Susannah D. Brydges, James L. Mueller, Matthew D. McGeough, Carla Pena, Debbie Chen, Susan K. Grimston, Cynthia L. Hickman-Brecks, Soumya Ravindran, Audrey McAlinden, Deborah V. Novack, Daniel L. Kastner, Roberto Civitelli, Hal M. Hoffman, and Gabriel Mbalaviele

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A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis, Jonathan S. Boomer, Jennifer Shuherk-Shaffer, and Jonathan M. Green

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Adverse metabolic response to regular exercise: Is it a rare or common occurrence?, Claude Bouchard, Steven N. Blair, Timothy S. Church, Conrad P. Earnest, James M. Hagberg, Keijo Hakkinen, Nathan T. Jenkins, Laura Karavirta, William E. Kraus, Arthur S. Leon, D. C. Rao, Mark A. Sarzynski, James S. Skinner, Cris A. Slentz, and Tuomo Rankinen

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A novel behavioral assay for measuring cold sensation in mice, Daniel S. Brenner, Judith P. Golden, and Robert W. Gereau IV

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What's new in spine surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, and Jeffrey C. Wang

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Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression, Mathew R. Brier, Jewell B. Thomas, Abraham Z. Snyder, Tammie L. Benzinger, Dongyang Zhang, Marcus E. Raichle, David M. Holtzman, John C. Morris, and Beau M. Ances

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Molecular analysis of age and sex-related gene expression in meniscal tears with and without a concomitant anterior cruciate ligament tear, Robert H. Brophy, Muhammad Farooq Rai, Zhiqi Zhang, Adelina Torgomyan, and Linda J. Sandell

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Killed but metabolically active Leishmania infantum as a novel whole-cell vaccine for visceral leishmaniasis, Kevin W. Bruhn, Ron Birnbaum, Jacquelyn Haskell, Veena Vanchinathan, Stephanie Greger, Rupa Narayan, Pei-Lin Chang, Thu Anh Tran, Suzanne M. Hickerson, Stephen M. Beverley, Mary E. Wilson, and Noah Craft

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Altered networks in bothersome tinnitus: A functional connectivity study, Harold Burton, Andre Wineland, Mousumi Bhattacharya, Joyce Nicklaus, Keith S. Garcia, and Jay F. Piccirillo

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Evidence for adult lung growth in humans, James P. Butler, Stephen H. Loring, Samuel Patz, Akira Tsuda, Dimitriy A. Yablonskiy, and Steven J. Mentzer

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Correlates of weight gain during long-term risperidone treatment in children and adolescents, Chadi A. Calarge, Ginger Nicol, Diqiong Xie, and Bridget Zimmerman

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Use of Medicare diagnosis and procedure codes to improve detection of surgical site infections following hip arthroplasty, knee arthroplasty, and vascular surgery, Michael S. Calderwood, Allen Ma, Yosef M. Khan, Margaret A. Olsen, Dale W. Bratzler, Deborah S. Yokoe, David C. Hooper, Kurt Stevenson, Victoria J. Fraser, Richard Platt, Susan S. Huang, and CDC Prevention Epicenters Program

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Performance of simplified scoring systems for hand diagrams in carpal tunnel syndrome screening, Ryan P. Calfee, Ann Marie Dale, Daniel Ryan, Alexis Descatha, Alfred Franzblau, and Bradley A. Evanoff

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The influence of insurance status on access to and utilization of a tertiary hand surgery referral center, Ryan P. Calfee, Chirag M. Shah, Colin D. Canham, Ambrose H.W. Wong, Richard H. Gelberman, and Charles A. Goldfarb

A crossover intervention trial evaluating the efficacy of a chlorhexidine-impregnated sponge in reducing catheter-related bloodstream infections among patients undergoing hemodialysis, Bernard C. Camins, Amy M. Richmond, Kathrin L. Dyer, Heather N. Zimmerman, Daniel W. Coyne, Marcos Rothstein, and Victoria J. Fraser

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Prospective trial of a pediatric ventricular assist device, Charles E. Canter and et al

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Electrophysiological correlates of stimulus-driven reorienting deficits after interference with right parietal cortex during a spatial attention task: A TMS-EEG study, Paolo Capotosto, Maurizio Corbetta, Gian Luca Romani, and Claudio Babiloni

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Listeriolysin O is strongly immunogenic independently of its cytotoxic activity, Javier A. Carrero, Hector Vivanco-Cid, and Emil R. Unanue

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89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast Tumors, Albert J. Chang, Ravindra DeSilva, Sandeep Jain, Kimberley Lears, Buck Rogers, and Suzanne Lapi

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A systematic review of body fat distribution and mortality in older people, Su-Hsin Chang, Tracey S. Beason, Jean M. Hunleth, and Graham A. Colditz

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STAT1-deficient mice spontaneously develop estrogen receptor alpha-positive luminal mammary carcinomas, Szeman Ruby Chan, William Vermi, Jingqin Luo, Laura Lucini, Charles Rickert, Amy M. Fowler, Silvia Lonardi, Cora Arthur, Larry JT Young, David E. Levy, Michael J. Welch, Robert D. Cardiff, and Robert D. Schreiber

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Testing multiple levels of influence in the intergenerational transmission of alcohol disorders from a developmental perspective: The example of alcohol use promoting peers and μ-opioid receptor M1 variation, Laurie Chassin, Matthew R. Lee, Young I. Cho, Frances L. Wang, Arpana Agrawal, Kenneth J. Sher, and Michael T. Lynskey

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Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease, Haoyan Chen, Genki Hayashi, Olivia Y. Lai, Alexander Dilthey, Peter J. Kuebler, Tami V. Wong, Maureen P. Martin, Marcelo A. Fernandez Vina, Gil McVean, Matthias Wabl, Kieron S. Leslie, Toby Maurer, Jeffrey N. Martin, Steven G. Deeks, Mary Carrington, Anne M. Bowcock, Douglas F. Nixon, and Wilson Liao

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Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 alpha (HNF4alpha) pathways to regulate liver lipid metabolism, Zhouji Chen, Matthew C. Gropler, Mayurranjan S. Mitra, and Brian N. Finck

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Influence of primary care physician availability and socioeconomic deprivation on breast cancer from 1988 to 2008: A spatio-temporal analysis, Lung-Chang Chien, Anjali D. Deshpande, Donna B. Jeffe, and Mario Schootman

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Immune Responses to West Nile Virus Infection in the Central Nervous System, Hyelim Cho and Michael S. Diamond

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Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway, Audrey Chong, Tara D. Wehrly, Robert Child, Bryan Hansen, Seungmin Hwang, Herbert W. Virgin, and Jean Celli

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The incidence of bifid c7 spinous processes, Woojin Cho, Takeshi Maeda, Yung Park, Jacob M. Buchowski, Colin E. Nabb, and K. D. Riew

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Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress, Liang Chu, Mack Y. Su, Leonard B. Maggi Jr., Lan Lu, Chelsea Mullins, Seth Crosby, Gaofeng Huang, Wee Joo Chng, Ravi Vij, and Michael H. Tomasson

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Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism, Nicole M. Chumbler, Melissa A. Farrow, Lynne A. Lapierre, Jeffrey L. Franklin, David Haslam, James R. Goldenring, and D. Borden Lacy

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Health outcomes in patients using no-prescription online pharmacies to purchase prescription drugs, Theodore J. Cicero and Matthew S. Ellis

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Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy, Michael A. Ciliberto, Judith L.Z. Weisenberg, and Michael Wong

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“Genomics and Translational Medicine for Information Professionals”: an innovative course to educate the next generation of librarians, Ana D. Cleveland, Kristi L. Holmes, and Jodi L. Philbrick

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Diagnosing symptomatic HIV-associated neurocognitive disorders: Self-report versus performance-based assessment of everyday functioning, David B. Clifford and et al

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Therapeutic amprenavir concentrations in cerebrospinal fluid, David G. Clifford and et al

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Marked response to VNS in a post-cingulotomy patient: Implications for the mechanism of action of VNS in TRD, Charles R. Conway, Mehret D. Gebretsadik, and Richard D. Bucholz

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Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: Study design and methods for pooling results of genetic epidemiological studies, Lynn Cornelius and et al

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Clinical preventive services in Guatemala: a cross-sectional survey of internal medicine physicians, Juan E. Corral, Lauren D. Arnold, Erwin E. Argueta, Akshay Ganju, and Joaquin Barnoya

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Novel BRAF alteration in a sporadic pilocytic astrocytoma, Sonika Dahiya, Jinsheng Yu, Aparna Kaul, Jeffrey R. Leonard, and David H. Gutmann

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Loss of ATM kinase activity leads to embryonic lethality in mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, and André Nussenzweig

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Weight perceptions and perceived risk for diabetes and heart disease among overweight and obese women, Suffolk County, New York, 2008, Susan Darlow, Melody S. Goodman, Jewel D. Stafford, Christina R. Lachance, and Kimberly A. Kaphingst

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Leishmania amazonensis arginase compartmentalization in the glycosome is important for parasite infectivity, Maria Fernanda Laranjeira da Silva, Ricardo Andrade Zampieri, Sandra M. Muxel, Stephen M. Beverley, and Lucile M. Floeter-Winter

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Antibodies against the envelope glycoprotein promote infectivity of immature Dengue Virus Serotype 2, Julia M. da Silva Voorham, Izabela A. Rodenhuis-Zybert, Nilda Vanesa Ayala Nunez, Tonya M. Colpitts, Heidi van der Ende-Metselaar, Erol Fikrig, Michael S. Diamond, Jan Wilschut, and Jolanda M. Smit

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Educating medical students in musculoskeletal surgery and medicine: How to get a course up and running at your institution: AOA Critical Issues, Charles S. Day, Joseph Bernstein, and Martin I. Boyer

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MuSiC: Identifying mutational significance in cancer genomes, Nathan D. Dees, Qunyuan Zhang, Cyriac Kandoth, Michael C. Wendl, William Schierding, Daniel C. Kobolt, Thomas B. Mooney, Matthew B. Callaway, David Dooling, Elaine R. Mardis, Richard K. Wilson, and Li Ding

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Recent progress in West Nile virus diagnosis and vaccination, Marina De Filette, Sebastian Ulbert, Mike Diamond, and Niek N. Sanders

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Social cognition in Williams syndrome: Relations between performance on the social attribution task and cognitive and behavioral characteristics, Faye van der Fluit, Michael S. Gaffrey, and Bonita P. Klein-Tasman

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A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis, John F. DiPersio and et al

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Ultrastructural studies in APP/PS1 mice expressing human ApoE isoforms: implications for Alzheimer’s disease, Krikor Dirkranian, Jungsu Kim, Floy R. Stewart, Marilyn A. Levy, and David M. Holtzman

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Guidelines for the use and interpretation of assays for monitoring autophagy, Abhinav Diwan, Seungmin Hwang, Indira Mysorekar, William A. Weiss, and et al

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Mouse transgenesis in a single locus with independent regulation for multiple fluorophores, Joseph D. Dougherty, Juliet Zhang, Huifen Feng, Shiaoching Gong, and Nathaniel Heintz

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Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells, Barbara Drobits, Martin Holcmann, Nicole Amberg, Melissa Swiecki, Roland Grundtner, Martina Hammer, Marco Colonna, and Maria Sibilia

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Implementing automated surveillance for tracking Clostridium difficile infection at multiple healthcare facilities, Erik R. Dubberke, Humaa A. Nyazee, Deborah S. Yokoe, Jeanmarie Mayer, Kurt B. Stevenson, Julie E. Mangino, Yosef M. Khan, Victoria J. Fraser, and Centers for Disease Control and Prevention Epicenter Program

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Accuracy of fall prediction in Parkinson disease: six-month and 12-month prospective analyses, Ryan P. Duncan, Abigail L. Leddy, James T. Cavanaugh, Leland E. Dibble, Terry D. Ellis, Matthew P. Ford, K. B. Foreman, and Gammon M. Earhart

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Whole-genome sequencing to identify mutants and polymorphisms in Chlamydomonas reinhardtii, Susan K. Dutcher, Linya Li, Huawen Lin, Leslie Meyer, Thomas H. Giddings Jr., Alan L. Kwan, and Brian L. Lewis

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AKT1 loss correlates with episomal HPV16 in vulval intraepithelial neoplasia, Arucha L. Ekeowa-Anderson, Karin J. Purdie, Karen Gibbon, Carolyn R. Byrne, Jeffrey M. Arbeit, Catherine A. Harwood, and Ryan F. L. O'Shaughnessy

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Nature and function of insulator protein binding sites in the Drosophila genome, Sarah C. R. Elgin and et al

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PAM50 breast cancer subtyping by RT-qPCR and concordance with standard clinical molecular markers, Matthew J. Ellis and et al

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Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a, Anthony R. Fehr, Nathaniel C. Gualberto, John Paul Savaryn, Scott S. Terhune, and Dong Yu

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Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis, Volker Fensterl, Jaime L. Wetzel, Srividya Ramachandran, Tomoaki Ogino, Stephen A. Stohlman, Cornelia C. Bergmann, Michael S. Diamond, Herbert W. Virgin, and Ganes C. Sen

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Interethnic differences in β-2 agonist treatment of acute asthma on electrolyte/glucose concentrations, Ian Ferguson, Kazuko Matsuda, Stacey House, John Schneider, Kristen Aubuchon, and Lawrence Lewis

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Comparison of accelerated partial breast irradiation via multicatheter interstitial brachytherapy versus whole breast radiation, Daniel J. Ferraro, Adam A. Garsa, Todd A. DeWees, Julie A. Margenthaler, Michael Naughton, Rebecca Aft, William E. Gillanders, Timothy Eberlein, Melissa A. Matesa, and Imran Zoberi

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A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis, Peter U. Fischer, Ramakrishna U. Rao, and et al

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The structure of the PapD-PapGII pilin complex reveals an open and flexible p5 pocket, Bradley Ford, Denis Verger, Karen Dodson, Ender Volkan, Maria Kostakioti, Jennifer Elam, Jerome Pinkner, Gabriel Waksman, and Scott Hultgren

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Administration of QTc prolonging medications in emergency department patients with prolonged QTc, Lucy Franjic, Stacey House, Irena Vitkovitsky, and S. Eliza Halcomb

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QTc prolongation is associated with hypokalemia and hypocalcemia in emergency department patients, Lucy Franjic, Stacey House, Irena Vitkovitsky, and S. Eliza Halcomb

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Reply to Herigon and Newland, Stephanie A. Fritz, Bernard C. Camins, Jonathan Dukes, and Gregory A. Storch

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Recurrent adult-onset hypophyseal Langerhans cell histiocytosis after radiotherapy: A case report, Ryan K. Funk, Daniel J. Ferraro, Richard J. Perrin, Kyle M. Hurth, John J. Stephens, David B. Mansur, Michael R. Chicoine, Joseph R. Simpson, and Jerry J. Jaboin

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Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104), Thomas F. Gajewski, April KS Salama, Donna Niedzwiecki, Jeffrey Johnson, Gerald Linette, Cynthia Bucher, Michelle A. Blaskovich, Said M. Sebti, Frank Haluska, and Cancer and Leukemia Group B

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The effect of changes in intraocular pressure on the risk of primary open-angle glaucoma in patients with ocular hypertension: An application of latent class analysis, Feng Gao, J. P. Miller, Stefano Miglior, Julia A. Beiser, Valter Torri, Michael A. Kass, and Mae E. Gordon

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Genome-wide association and functional follow-up reveals new loci for kidney function, Xiaoyi Gao, Mary Feitosa, Michael Province, Shamika Ketkar, Ingrid Borecki, and et al.

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Partner randomized controlled trial: Study protocol and coaching intervention, Jane M. Garbutt, Gabrielle Highstein, Yan Yan, and Robert C. Strunk