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Submissions from 2009

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Early results of the Ponseti method for the treatment of clubfoot associated with myelomeningocele, David J. Gerlach, Christina A. Gurnett, Noppachart Limpaphayom, Farhang Alaee, Zhongli Zhang, Kristina Porter, Melissa Kirchhofer, Matthew D. Smyth, and Matthew B. Dobbs

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The urban environment and childhood asthma (URECA) birth cohort study: Design, methods, and study population, James E. Gern, Cynthia M. Visness, Peter J. Gergen, Robert A. Wood, Gordon R. Bloomberg, George T. O'Connor, Meyer Kattan, Hugh A. Sampson, Frank R. Witter, Megan T. Sandel, Wayne G. Shreffler, Rosalind J. Wright, Samuel J. Arbes Jr, and William W. Busse

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Environment-specific combinatorial cis-regulation in synthetic promoters, Jason Gertz and Barak A. Cohen

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Sequencing human–gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites, Santhosh Girirajan, Lin Chen, Tina Graves, Tomas Marques-Bonet, Mario Ventura, Catrina Fronick, Lucinda Fulton, Mariano Rocchi, Robert S. Fulton, Richard K. Wilson, Elaine R. Mardis, and Evan E. Eichler

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The mitogen-activated protein kinase scaffold KSR1 Is required for recruitment of extracellular signal-regulated kinase to the immunological synapse, Emanuele Giurisato, Joseph Lin, Angus Harding, Elisa Cerutti, Marina Cella, Robert E. Lewis, Marco Colonna, and Andrey S. Shaw

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Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling, Hilary P. Glazer, Robert M. Osipov, Richard T. Clements, Frank W. Sellke, and Cesario Bianchi

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Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11, D. P. Goldberg, R. F. Krueger, G. Andrews, and M. J. Hobbs

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Amniotic constriction band: A multidisciplinary assessment of etiology and clinical presentation, Charles A. Goldfarb, Achara Sathienkijkanchai, and Nathaniel H. Robin

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Loss of A-type lamins and genomic instability, Ignacio Gonzalez-Suarez, Abena B. Redwood, and Susana Gonzalo

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Drosophila RISC component VIG and its homolog Vig2 impact heterochromatin formation, Elena Gracheva, Monica Dus, and Sarah C. R. Elgin

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ITAM signaling by Vav family Rho guanine nucleotide exchange factors regulates interstitial transit rates of neutrophils in vivo, Daniel B. Graham, Bernd H. Zinselmeyer, Francesca Mascarenhas, Ryan Delgado, Mark J. Miller, and Wojiech Swat

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Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis, Timothy A. Graubert, Michelle A. Payton, Jin Shao, Richard A. Walgren, Ryan S. Monahan, John L. Frater, Mark A. Walshauser, Mike G. Martin, Yumi Kasai, and Matthew J. Walter

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Reevaluating humeral length for the detection of fetal trisomy 21, Diana L. Gray, Jeffrey M. Dicke, Rachel Dickerson, Carolyn McCourt, and Anthony O. Odibo

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Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain, Karrie E. Grear, I-Fang Ling, James F. Simpson, Jennifer L. Furman, Christopher R. Simmons, Shawn L. Peterson, Frederick A. Schmitt, William R. Markesbery, Qiang Liu, Julia E. Crook, Steven G. Younkin, Guojun Bu, and Steven Estus

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Comparison of three reference methods for testing susceptibility of Staphylococci to trimethoprim-sulfamethoxazole, R. Griffith, D. Creely, P. Revell, W. Michael Dunne, and D. Shortridge

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Dyskerin, telomerase and the DNA damage response, BaiWei Gu, Monica Bessler, and Philip J. Mason

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Genetic association analysis of coronary heart disease by profiling gene-environment interaction based on latent components in longitudinal endophenotypes, C Charles Gu, Wei (Will) Yang, Aldi T. Kraja, Lisa de las Fuentes, and Victor G. Davila-Roman

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Contribution of autolysin and sortase A during Enterococcus faecalis DNA-dependent biofilm development, Pascale S. Guiton, Chia S. Hung, Kimberly A. Kline, Robyn Roth, Andrew L. Kau, Ericka Hayes, John Heuser, Karen W. Dodson, Michael G. Caparon, and Scott J. Hultgren

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Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair, Arun Gupta, Qin Yang, Raj K. Pandita, Clayton R. Hunt, Tao Xiang, Sandeep Misri, Sicong Zeng, Rakesh Kumar, Zhihui Feng, Simon N. Powell, Audesh Bhat, Tej K. Pandita, and et al

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Effects of dance on movement control in Parkinson's disease: A comparison of Argentine tango and American ballroom, Madeleine E. Hackney and Gammon M. Earhart

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Surveillance of obesity-related policies in multiple environments: The Missouri Obesity, Nutrition, and Activity Policy Database, 2007-2009, Debra Haire-Joshu, Michael Elliott, Rebecca Schermbeck, Elsa Taricone, Scoie Green, and Ross C. Brownson

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Identifying promoter features of co-regulated genes with similar network motifs, Oscar Harari, Coral del Val, Rocío Romero-Zaliz, Dongwoo Shin, Henry Huang, Eduardo A. Groisman, and Igor Zwir

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MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks, Beth A. Helmink, Andrea L. Bredemeyer, Baeck-Seung Lee, Ching-Yu Huang, Girdhar G. Sharma, Laura M. Walker, Jeffrey J. Bednarski, Wan-Ling Lee, Tej K. Pandita, Craig H. Bassing, and Barry P. Sleckman

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Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli, Jeffrey P. Henderson, Jan R. Crowley, Jerome S. Pinker, Jennifer N. Walker, Pablo Tsukayama, Walter E. Stamm, Thomas M. Hooton, and Scott J. Hultgren

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Detecting population stratification using related individuals, Anthony L. Hinrichs, Robert Culverhouse, Carol H. Jin, and Brian K. Suarez

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Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread, Lori R. Holtz, Stacy R. Finkbeiner, Guoyan Zhao, Carl D. Kirkwood, Rosina Girones, James M. Pipas, and David Wang

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Modeling the quantitative specificity of DNA-binding proteins from example binding sites, Dana S. F. Homsi, Vineet Gupta, and Gary D. Stormo

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The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent manner, S. Sean Houshmandi, Ryan J. Emnett, Marco Giovannini, and David H. Gutmann

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Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes, Keith A. Hultman, Erine H. Budi, Daniel C. Teasley, Andrew Y. Gottlieb, David M. Parichy, and Stephen L. Johnson

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Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation, Yasudo Ido, Jens R. Nyengaard, Kathy Chang, Ronald G. Tilton, Charles Kilo, Banavara L. Mylari, Peter J. Oates, and Joseph R. Williamson

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RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival, Miyuki Inoue-Mochita, Toshihiro Inoue, David L. Epstein, Kendall J. Blumer, and Ponugoti V. Rao

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The many faces of RET dysfunction in kidney, Sanjay Jain

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Mapping of the saccharomyces cerevisiae oxa1-mitochondrial ribosome interface and identification of MrpL40, a ribosomal protein in close proximity to oxal and critical for oxidative phosphorylation complex assembly, Lixia Jia, Jasvinder Kaur, and Rosemary A. Stuart

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Mechanoregulation of proliferation, Xiaogang Jiang, Paul F. Austin, Robert A. Niederhoff, Scott R. Manson, Jacob J. Riehm, Brian L. Cook, Gina Pengue, Kanchan Chitaley, Keiko Nakayama, Keiichi I. Nakayama, and Steven J. Weintraub

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Towards comprehensive structural motif mining for better fold annotation in the "twilight zone" of sequence dissimilarity, Yi Jia, Jun Huan, Vincent Buhr, Jintao Zhang, and Leonidas N. Carayannopoulos

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Comparative genomics of protoploid Saccharomycetaceae, Mark Johnston, Robert S. Fulton, Patrick Minx, Richard Wilson, and et al

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Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease, Jeong-Sun Ju, Rodrigo A. Fuentealba, Sara E. Miller, Erin Jackson, David Piwnica-Worms, Robert H. Baloh, and Conrad C. Weihl

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Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters, Jeong-Sun Ju, Sara E. Miller, Erin Jackson, Ken Cadwell, David Piwnica-Worms, and Conrad C. Weihl

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TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate, Edmond K. Kabagambe, Stephen P. Glasser, Jose M. Ordovas, Daruneewan Warodomwichit, Michael Y. Tsai, Paul N. Hopkins, Ingrid B. Borecki, Mary Wojczynski, and Donna K. Arnett

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Homodimerization controls the fibroblast growth factor 9 subfamily’s receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix, Juliya Kalinina, Sara A. Byron, Helen P. Makarenkova, Shaun K. Olsen, Anna V. Eliseenkova, William J. Larochelle, Mohanraj Dhanabal, Steven Blais, David M. Ornitz, Loren A. Day, Thomas A. Neubert, Pamela M. Pollock, and Moosa Mohammadi

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Intramedullary capillary hemangioma of the thoracic spine: Case report and review of the literature., Rahul Kasukurthi, Wilson Z. Ray, Spiros L. Blackburn, Eriks A. Lusis, and Paul Santiago

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Capturing a flavivirus pre-fusion intermediate, Barbel Kaufmann, Paul R. Chipman, Heather A. Holdaway, Syd Johnson, Daved H. Fremont, Richard J. Kuhn, Michael S. Diamond, and Michael G. Rossmann

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Derived data storage and exchange workflow for large-scale neuroimaging analyses on the BIRN grid, David B. Keator, Dingying Wei, Syam Gadde, Jeremy Buckholt, Jeffrey S. Grethe, Daniel Marcus, Nicole Aucoin, and Ibrahim B. Ozyurt

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Expression of Kingella kingae type IV pili is regulated by σ54, PilS, and PilR, Thomas E. Kehl-Fie, Eric A. Porsch, Sara E. Miller, and Joseph W. StGeme III

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An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans, James M. Kelley, Laura B. Hughes, Jeffrey D. Faggard, Maria I. Danila, Monica H. Crawford, Yuanqing Edberg, Miguel A. Padilla, Hemant K. Tiwari, Andrew O. Westfall, Graciela S. Alarcon, Doyt L. Conn, Beth L. Jonas, Leigh F. Callahan, Edwin A. Smith, Richard D. Brasington Jr., David B. Allison, Robert P. Kimberly, Larry W. Moreland, Jeffrey C. Edberg, and S. Louis Bridges Jr.

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Structural determinants of autoproteolysis of the Haemophilus influenzae Hap autotransporter, Roma Kenjale, Guoyu Meng, Doran L. Fink, Twyla Juehne, Tomoo Ohashi, Harold P. Erickson, Gabriel Waksman, and Joseph W. St. Geme III

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Mutants of Taq DNA polymerase resistant to PCR inhibitors allow DNA amplification from whole blood, Milko B. Kermekchiev, Lyubka I. Kirilova, Erika E. Vail, and Wayne M. Barnes

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Helicobacter pylori’s plasticity zones are novel transposable elements, Dangeruta Kersulyte, WooKon Lee, Dharmalingam Subramaniam, Shrikant Anant, Phabiola Herrera, Lilia Cabrera, Jacqueline Balqui, Orsolya Brabas, Awdhesh Kalia, Robert H. Gilman, and Douglas E. Berg

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Phenotypic and gene expression changes among clonal type i strains of toxoplasma gondit, Asis Khan, Michael S. Behnke, Ildiko R. Dunay, Michael W. White, and L. David Sibley

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Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in mice, Asis Khan, Sonya Taylor, James W. Ajioka, Benjamin M. Rosenthal, and L. David Sibley

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IL-2 regulates SEB induced toxic shock syndrome in BALB/c mice, Aslam Ali Khan, Shilpee Priya, and Bhaskar Saha

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In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from nontumorigenic astrocytes and brain tumours, Michael A. Kiebish, Xianlin Han, Hua Cheng, and Thomas N. Seyfried

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Shoulder strength in asymptomatic individuals with intact compared with torn rotator cuffs, H. Mike Kim, Sharlene A. Teefey, Ari Zelig, Leesa M. Galatz, Jay D. Keener, and Ken Yamaguchi

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Impact speed does not determine severity of spinal cord injury in mice with fixed impact displacement, Joong Hee Kim, Tsang-Wei Tu, Philip V. Bayly, and Sheng-Kwei Song

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Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis, Kimberly Kline, Andrew L. Kau, Swaine L. Chen, Adeline Lim, Jerome S. Pinkner, Jason Rosch, Sreedhar R. Nallapareddy, Barbara E. Murray, Birgitta Henriques-Normark, Wandy Beatty, Michael G. Caparon, and Scott J. Hultgren

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Evidence-based approach for interpretation of Epstein-Barr virus serological patterns, J. S. Klutts, B. A. Ford, N. R. Perez, and A. M. Gronowski

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The Genetic Analysis Workshop 16 Problem 3: Simulation of heritable longitudinal cardiovascular phenotypes based on actual genome-wide single-nucleotide polymorphisms in the Framingham Heart Study, Aldi T. Kraja, Robert Culverhouse, E Warwick Daw, Jun Wu, Andrew Van Brunt, Michael A. Province, and Ingrid B. Borecki

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Avian cone photoreceptors tile the retina as five independent, self-organizing mosaics, Yoseph A. Kram, Stephanie Mantey, and Joseph C. Corbo

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Externalizing disorders: Cluster 5 of the proposed meta-structure for DSM-V and ICD-11, R. F. Krueger and S. C. South

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Improving Gene-finding in Chlamydomonas reinhardtii: GreenGenie2, Alan L. Kwan, Linya Li, David C. Kulp, Susan K. Dutcher, and Gary D. Stormo

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A novel autotransporter adhesin is required for efficient colonization during bubonic plague, Matthew B. Lawrenz, Jonathan D. Lenz, and Virginia L. Miller

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Genetic influences on individual differences in nicotine glucuronidation, Christina N. Lessov-Schlaggar, Neal L. Benowitz, Peyton Jacob III, and Gary E. Swan

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Distinct roles for CARMIL isoforms in cell migration, Yun Liang, Hanspeter Niederstrasser, Marc Edwards, Charles E. Jackson, and John A. Cooper

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Streptolysin S inhibits neutrophil recruitment during the early stages of Streptococcus pyogenes infection, Ada Lin, Jennifer A. Loughman, Bernd H. Zinselmeyer, Mark J. Miller, and Michael G. Caparon

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KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs, Joseph Lin, Angus Harding, Emanuele Giurisato, and Andrey S. Shaw

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Leishmania major phosphoglycans influence the host early immune response by modulating dendritic cell functions, Dong Liu, Chahnaz Kebaier, Althea A. Capul, Stephen M. Beverley, Phillip Scott, and Jude E. Uzonna

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MLL fusions: Pathways to leukemia, Han Liu, Emily H.Y. Cheng, and James J.D. Hsieh

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LRP1 shedding in human brain: Roles of ADAM10 and ADAM17, Qiang Liu, Juan Zhang, Hien Tran, Marcel M. Verbeek, Karina Reiss, Steven Estus, and Guojun Bu

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Information criterion-based clustering with order-restricted candidate profiles in short time-course microarray experiments, Tianqing Liu, Nan Lin, Ningzhong Shi, and Baoxue Zhang

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Bos taurus genome assembly, Yue Liu, Xiang Qin, Xing-Zhi Henry Song, Huaiyang Jiang, Yufeng Shen, K James Durbin, Sigbjørn Lien, Matthew Peter Kent, Marte Sodeland, Yanru Ren, Lan Zhang, Erica Sodergren, Paul Havlak, Kim C. Worley, George M. Weinstock, and Richard A. Gibbs

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Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS), Zhenyi Liu, Anna C. Obenauf, Michael R. Speicher, and Raphael Kopan

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Serum human chorionic gonadotropin concentrations greater than 400,000 IU/L are invariably associated with suppressed serum thyrotropin concentrations, Christina M. Lockwood, David G. Grenache, and Ann M. Gronowski

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Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant, M Paula Longhi, Christine Trumpfheller, Juliana Idoyaga, Marina Caskey, Ines Matos, Courtney Kluger, Andres M. Salazar, Marco Colonna, and Ralph M. Steinman

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Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/insulin/IGF-receptor pathway, Meghann E. Mabon, Barbara A. Scott, and C. Michael Crowder

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Flexible Mx specification of various extended twin kinship designs, Hermine H. Maes, Michael C. Neale, Sarah E. Medland, Matthew C. Keller, Nicholas G. Martin, Andrew C. Heath, and Lindon J. Eaves

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Classification and developmental biology of congenital anomalies of the hand and upper extremity, Paul R. Manske and Kerby C. Oberg

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Proteomic analyses of native brain KV4.2 channel complexes, Celine Marionneau, Richard D. LeDuc, Henry W. Rohrs, Andrew J. Link, R. Reid Townsend, and Jeanne M. Nerbonne

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Between community and hospital: Healthcare-associated gram-negative bacteremia among hospitalized patients, Jonas Marschall, Victoria J. Fraser, Joshua Doherty, and David K. Warren

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Presence of the KPC carbapenemase gene in enterobacteriaceae causing bacteremia and its correlation with in vitro carbapenem susceptibility, Jonas Marschall, Robert J. Tibbetts, W. Michael Dunne Jr., Jonathan G. Frye, Victoria J. Fraser, and David K. Warren

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Nematode.net update 2008: Improvements enabling more efficient data mining and comparative nematode genomics, John Martin, Sahar Abubucker, Todd Wylie, Yong Yin, Zhengyuan Wang, and Makedonka Mitreva

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Extending the duration of response in chronic myelogenous leukemia: Targeted therapy with sequential tyrosine kinase inhibitors, Michael G. Martin, John F. DiPersio, and Geoffrey L. Uy

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Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis, Mark J. McBride, Gary Xie, Eric C. Martens, Alla Lapidus, Bernard Henrissat, Ryan G. Rhodes, Eugene Goltsman, Wei Wang, Jian Xu, David W. Hunnicutt, Andrew M. Staroscik, Timothy R. Hoover, Yi-Qiang Cheng, and Jennifer L. Stein

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Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells, Stephen McCartney, William Vermi, Susan Gilfillan, Marina Cella, Theresa L. Murphy, Robert D. Schreiber, Kenneth M. Murphy, and Marco Colonna

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The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases delta and eta, Scott D. McCulloch, Robert J. Kokoska, Parie Garg, Peter M. Burgers, and Thomas A. Kunkel

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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP, Sarah M. McWhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishii, Shizuo Akira, Marco Colonna, Zhijian J. Chen, Katherine A. Fitzgerald, Yoshihiro Hayakawa, and Russell E. Vance

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Molecular profiling reveals diversity of stress signal transduction cascades in highly penetrant Alzheimer’s disease human skin fibroblasts, Graziella Mendonsa, Justyna Dobrowolska, Angela Lin, Pooja Vijairania, Y.-J. I. Jong, and Nancy L. Baenziger

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High-resolution sonography of the normal extrapelvic vas deferens, William D. Middleton, Nirvikar Dahiya, Cathy K. Naughton, Sharlene A. Teefey, and Cary A. Siegel

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Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic guanine nucleotide exchange activity, Ana V. Miletic, Daniel B. Graham, Kumiko Sakata-Sogawa, Michio Hiroshima, Michael J. Hamann, Saso Cemerski, Tracie Kloeppel, Daniel D. Billadeau, Osami Kanagawa, Makio Tokunaga, and Wojciech Swat

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Phasic and tonic modes of depolarization-exocytosis coupling in β-cells of porcine islets of Langerhans, Stanley Misler, Amelia M. Silva, David Barnett, and Adam S. Dickey

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Electrical activity and exocytotic correlates of biphasic insulin secretion from β-cells of canine islets of Langerhans, Stanley Misler, Zhuan Zhou, Adam S. Dickey, Amelia M. Silva, David M. Pressel, and David W. Barnett

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The value of intraoperative gram stain in revision total knee arthroplasty, Patrick M. Morgan, Peter Sharkey, Elie Ghanem, Javad Parvizi, John C. Clohisy, R. Stephen J. Burnett, and Robert L. Barrack

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Insulin resistance heralds positive cultures after severe injury, Nathan T. Mowery, Randy J. Carnevale, Oliver L. Gunter, Patrick R. Norris, Lesly A. Dossett, Marcus J. Dortch, John A. Morris Jr, and Addison K. May

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Detection and quantification of hepatitis C virus (HCV) by MultiCode-RTX real-time PCR targeting the HCV 3′ untranslated region, Elizabeth K. Mulligan, J. J. Germer, Max Q. Arens, Krista L. D'Amore, Adrian Di Bisceglie, Nathan A. Ledeboer, Michael J. Moser, Andrew C. Newman, Andy K. O'Guin, Paul D. Olivo, Diane S. Podzorski, Kimberly A. Vaughan, Joseph D. Yao, Slava A. Elagin, and Scott C. Johnson

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A Case Report Demonstrating Unambiguous Clinical Utility of Pet/CT Scanning in Recurrent Ovarian Cancer, David Mutch and Maurie Markman

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Performance evaluation of the VersaTREK blood culture system for quality control testing of platelet units, Suparna Nanua, Carol Weber, Liz Isgriggs, and W. Michael Dunne Jr.

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Molecular diversity of the antimicrobial domain of beta-defensin 3 and homologous peptides, Gerardo M. Nava, Magdalena Escorcia, and M. Pilar Castañeda

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Supplementary feeding with either ready-to-use fortified spread or corn-soy blend in wasted adults starting antiretroviral therapy in Malawi: Randomised, investigator blinded, controlled trial, MacDonald J. Ndekha, Joep J.G van Oosterhout, Eduard E. Zijlstra, Micah Manary, Haroon Saloojee, and Mark J. Manary

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TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria, Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, and William E. Seaman

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Serologic evidence of frequent human infection with WU and KI polyomaviruses, Nang L. Nguyen, Binh-Minh Le, and David Wang

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The association between increased use of labor induction and reduced rate of cesarean delivery, James M. Nicholson, Peter Cronholm, Lisa C. Kellar, Morghan H. Stenson, and George A. Macones