The Open Access Publications collection contains peer-reviewed articles authored by Washington University School of Medicine faculty that have been published in open access journals or authorized by the publishers for open access availability. Open access works are generally defined as being publicly available online and free of most licensing and copyright restrictions. The Bernard Becker Medical Library maintains this collection in support of Washington University’s commitment to the principles of open access publishing and making the scholarly work and research results of our faculty as widely and easily available as possible.

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Submissions from 2005

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Comprehensive treatment of late-onset tibia vara, J. Eric Gordon, Fred P. Heidenreich, Chris J. Carpenter, Jill Kelly-Hahn, and Perry L. Schoenecker

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Adolescent alcohol use is a risk factor for adult alcohol and drug dependence: Evidence from a twin design, Julia D. Grant, Jeffrey F. Scherrer, Michael T. Lynskey, Michael J. Lyons, Seth A. Eisen, Ming T. Tsuang, William R. True, and Kathleen K. Bucholz

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Rfam: Annotating non-coding RNAs in complete genomes, Sam Griffiths-Jones, Simon Moxon, Mhairi Marshall, Ajay Khanna, Sean R. Eddy, and Alex Bateman

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The StcE protease contributes to intimate adherence of enterohemorrhagic Escherichia coli O157:H7 to host cells, Thomas E. Grys, Matthew B. Siegel, Wyndham W. Lathem, and Rodney A. Welch

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Involvement of human MOF in ATM function, Arun Gupta, Girdhar G. Sharma, Charles S. H. Young, Manjula Agarwal, Edwin R. Smith, Tanya T. Paull, John C. Lucchesi, Kum Kum Khanna, Thomas Ludwig, and Tej K. Pandita

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Paternal alcoholism and offspring conduct disorder: Evidence for the 'common genes' hypothesis, Jon R. Haber, Theodore Jacob, and Andrew C. Heath

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Yersinia enterocolitica invasin-dependent and invasin-independent mechanisms of systemic dissemination, Scott A. Handley, Rodney D. Newberry, and Virginia L. Miller

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Deep-etch EM reveals that the early poxvirus envelope is a single membrane bilayer stabilized by a geodetic "honeycomb" surface coat, John Heuser

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Pharmacokinetic and maximum tolerated dose study of micafungin in combination with fluconazole versus fluconazole alone for prophylaxis of fungal infections in adult patients undergoing a bone marrow or peripheral stem cell transplant, J. Hiemenz, P. Cagnoni, D. Simpson, S. Devine, N. Chao, J. Keirns, W. Lau, D. Facklam, and D. Buell

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Genomics in C. elegans: So many genes, such a little worm, LaDeana W. Hillier, Alan Coulson, John I. Murray, Zhirong Bao, John E. Sulston, and Robert H. Waterston

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Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps, Anthony L. Hinrichs, Sarah Bertelsen, Laura J. Bierut, Gerald Dunn, Carol H. Jin, John S. Kauwe, and Brian K. Suarez

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Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death, William A. Holtz, Jay M. Turetzky, and Karen L. O'Malley

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Ultrasonic songs of male mice, Timothy E. Holy and Zhongsheng Guo

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Punctuated duplication seeding events during the evolution of human chromosome 2p11, Julie E. Horvath, Cassandra L. Gulden, Rhea U. Vallente, Marla Y. Eichler, Mario Ventura, John D. McPherson, Tina A. Graves, Richard K. Wilson, Stuart Schwartz, Mariano Rocchi, and Evan E. Eichler

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Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli, David A. Hunstad, Sheryl S. Justice, Chia S. Hung, Scott R. Lauer, and Scott J. Hultgren

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Mitochondrial energy metabolism in heart failure: A question of balance, Janice M. Huss and Daniel P. Kelly

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The type Iα inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane, Ivan Ivetac, Adam D. Munday, Marina V. Kisseleva, Xiang-Ming Zhang, Susan Luff, Tony Tiganis, James C. Whisstock, Tony Rowe, Phillip W. Majerus, and Christina A. Mitchell

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An improved internal mammary irradiation technique in radiation treatment of locally advanced breast cancers, Jian-Yue Jin, Eric E. Klein, Feng-Ming Kong, and Zuofeng Li

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The multiple biological roles of the 3’→5’ exonuclease of Saccharomyces cerevisiae DNA polymerase δ require switching between the polymerase and exonuclease domains, Yong Hawn Jin, Parie Garg, Carrie M. W. Stith, Hanan Al-Refai, Joan F. Sterling, Laura J. W. Murray, Thomas A. Kunkel, Michael A. Resnick, Peter M. Burgers, and Dmitry A. Gordenin

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Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection, Manohar John, Indira T. Kudva, Robert W. Griffin, Allen W. Dodson, Bethany McManus, Bryan Krastins, David Sarracino, Ann Progulske-Fox, Jeffrey D. Hillman, Martin Handfield, Phillip I. Tarr, and Stephen B. Calderwood

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The IrgA homologue adhesin Iha is an Escherichia coli virulence factor in murine urinary tract infection, James R. Johnson, Srdjan Jelacic, Laura M. Schoening, Connie Clabots, Nurmohammad Shaikh, Harry L.T. Mobley, and Phillip I. Tarr

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Arthrodesis techniques in the management of stage-II and III acquired adult flatfoot deformity, Jeffrey E. Johnson and James R. Yu

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Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA Is required for pilus biogenesis in Escherichia coli, Sheryl S. Justice, David A. Hunstad, Jill Reiss Harper, Amy R. Duguay, Jerome S. Pinkner, James Bann, Carl Frieden, Thomas J. Silhavy, and Scott J. Hultgren

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An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II–restricted T cells in the absence of CD4, Henry Kao and Paul M. Allen

Comparing low coverage random shotgun sequence data from Brassica oleracea and Oryza sativa genome sequence for their ability to add to the annotation of Arabidopsis thaliana, Manpreet S. Katari, Vivekanand Balija, Richard K. Wilson, Robert A. Martienssen, and W. Richard McCombie

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Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice, Andrew L. Kau, Steven M. Martin, William Lyon, Ericka Hayes, Michael G. Caparon, and Scott J. Hultgren

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The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure, John SK Kauwe, Sarah Bertelsen, Laura Jean Bierut, Gerald Dunn, Anthony L. Hinrichs, Carol H. Jin, and Brian K. Suarez

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Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii, Asis Khan, Sonya Taylor, Chunlei Su, Aaron J. Mackey, Jon Boyle, Robert Cole, Darius Glover, Keliang Tang, Ian T. Paulsen, Matt Berriman, John C. Boothroyd, Elmer R. Pfefferkorn, J. P. Dubey, James W. Ajioka, David S. Roos, John C. Wooton, and L. D. Sibley

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Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of type I strains, A. Khan, C. Su, M. German, G. A. Storch, D. B. Clifford, and L. David Sibley

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Eradication of methicillin-resistant Staphylococcus aureus from a neonatal intensive care unit by active surveillance and aggressive infection control measures, Jad Khoury, Marilyn Jones, Autumn Grim, Wm. Michael Dunne Jr., and Vicky Fraser

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Mitochondrial uncoupling proteins in the central nervous system, Jeong Sook Kim-Han and Laura L. Dugan

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A transcription factor for cold sensation!, Susan J. Kim, Zhican Qu, Jeffrey Milbrandt, and Min Zhuo

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Pulmonary function in adolescent idiopathic scoliosis relative to the surgical procedure, Yongjung J. Kim, Lawrence G. Lenke, Keith H. Bridwell, Kyoungnam L. Kim, and Karen Steger-May

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Interchromosomal segmental duplications of the pericentromeric region on the human Y chromosome, Stefan Kirsch, Birgit Weiß, Tracie L. Miner, Robert H. Waterston, Royden A. Clark, Evan E. Eichler, Claudia Münch, Werner Schempp, and Gudrun Rappold

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LL5β: A regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction, Masashi Kishi, Terrance T. Kummer, Stephen J. Eglen, and Joshua R. Sanes

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The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKIα, Marina Kisselva, Yungfeng Feng, Michael Ward, Chunhua Song, Richard A. Anderson, and Gregory D. Longmore

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M-CSF mediates TNF-induced inflammatory osteolysis, Hideki Kitaura, Ping Zhou, Hyun-Ju Kim, Deborah V. Novack, Patrick Ross, and Steven L. Teitelbaum

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Errors in radiation oncology: a study in pathways and dosimetric impact, Eric E. Klein, Robert E. Drzymala, James A. Purdy, and Jeff M. Michalski

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Contributions of parental alcoholism, prenatal substance exposure, and genetic transmission to child ADHD risk : A female twin study, Valerie S. Knopik, Elizabeth P. Sparrow, Pamela A F Madden, Kathleen K. Bucholz, James J. Hudziak, Wendy Reich, Wendy S. Slutske, Julia D. Grant, Tara L. McLaughlin, Alexandre Todorov, Richard D. Todd, and Andrew C. Heath

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Noncapsulated Klebsiella pneumoniae bearing mannose-containing O antigens is rapidly eradicated from mouse lung and triggers cytokine production by macrophages following opsonization with surfactant protein D, Elena Kostina, Itzhak Ofek, Erika Crouch, Rotem Friedman, Lea Sirota, Gil Klinger, Hany Sahly, and Yona Keisari

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Microsatellite linkage analysis, single-nucleotide polymorphisms, and haplotype associations with ECB21 in the COGA data, Aldi T. Kraja, Ingrid B. Borecki, and Michael A. Province

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An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program, Aldi T. Kraja, DC Rao, Alan B. Weder, Thomas H. Mosley, Stephen T. Turner, Chao Agnes Hsiung, Thomas Quertermous, Richard Cooper, J David Curb, and Michael A. Province

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Neutrophil elastase is important for PML-retinoic acid receptor α activities in early myeloid cells, Andrew A. Lane and Timothy J. Ley

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Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis, Robert A. Larsen, Peter G. Pappas, John Perfect, Judith A. Aberg, Arturo Casadevall, Gretchen A. Cloud, Robert James, Scott Filler, and William E. Dismukes

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The offloading model for dynein function: differential function of motor subunits, Wei-Lih Lee, Michelle A. Kaiser, and John A. Cooper

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis, Teresa C. Leone, John J. Lehman, Brian N. Finck, Paul J. Schaeffer, Adam R. Wende, Sihem Boudina, Michael Courtois, David F. Wozniak, Nandakumar Sambandam, Carlos Bernal-Mizrachi, Zhouji Chen, John O. Holloszy, Denis M. Medeiros, Robert E. Schmidt, Jeffrey E. Saffitz, E. D. Abel, Clay F. Semenkovich, and Daniel P. Kelly

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Comparison of running and interrupted vesicourethral anastomoses in a porcine model, David Lieber, Veronique Tran, Jay Belani, Caroline Ames, Kevin Morissey, Yan Yan, Peter Humphrey, Ramakrishna Venkatesh, and Jaime Landman

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Combining SELEX with quantitative assays to rapidly obtain accurate models of protein-DNA interactions, Jiajian Liu and Gary D. Stormo

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Quantitative analysis of EGR proteins binding to DNA: Assessing additivity in both the binding site and the protein, Jiajian Liu and Gary D. Stormo

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A surface groove essential for viral Bcl-2 function during chronic infection in vivo, Joy Loh, Qiulong Huang, Andrew M. Petros, David Nettesheim, Linda F. van Dyk, Lucia Labrada, Samuel H. Speck, Beth Levine, Edward T. Olejniczak, and Herbert W. Virgin IV

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YB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence, Zhi Hong Lu, Jason T. Books, and Timothy J. Ley

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hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation, Mary Lynch, Li Chen, Michael J. Ravitz, Sapna Mehtani, Kevin Korenblat, Michael J. Pazin, and Emmett V. Schmidt

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Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins, Michael T. Lynskey, Elliot C. Nelson, Rosalind J. Neuman, Kathleen K. Bucholz, Pamela A.F. Madden, Valerie S. Knopik, Wendy Slutske, John B. Whitfield, Nicholas G. Martin, and Andrew C. Heath

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ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation, A. J. MacQueen, J. J. Baggett, N. Perumov, R. A. Bauer, T. Januszewski, L. Schriefer, and J. A. Waddle

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Complications of fluoroscopically guided extraforaminal cervical nerve blocks: An analysis of 1036 injections, Daniel J. Ma III, Louis A. Gilula, and K. Daniel Riew

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Clinical challenges and unmet needs in the management of complicated intra-abdominal infections, John E. Mazuski

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A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase, Michael A. Meehl, Jerome S. Pinkner, Patricia J. Anderson, Scott J. Hultgren, and Michael G. Caparon

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Phylogeography and population strucure of Aedes aegypti in Arizona, Samuel A. Merrill, Frank B. Ramberg, and Henry H. Hagedorn

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Pseudomonas aeruginosa bloodstream infection: Importance of appropriate initial antimicrobial treatment, Scott T. Micek, Ann E. Lloyd, David J. Ritchie, Richard M. Reichley, Victoria J. Fraser, and Marin H. Kollef

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Mutant kinesin-2 motor subunits increase chromosome loss, Mark S. Miller, Jessica M. Esparza, Andrew M. Lippa, Fordyce G. Lux III, Douglas G. Cole, and Susan K. Dutcher

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Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species, Pat Minx, Holly Cordum, Richard Wilson, and et al

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Investigating hookworm genomes by comparative analysis of two Ancylostoma species, Makedonka Mitreva, James P. McCarter, Prema Arasu, John Hawdon, John Martin, Mike Dante, Todd Wylie, Jian Xu, Jason E. Stajich, Wadim Kapulkin, Sandra W. Clifton, Robert H. Waterston, and Richard K. Wilson

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Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: A potential risk factor for hospital mortality, Matthew Morrell, Victoria J. Fraser, and Marin H. Kollef

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Evaluation of seaFAST, a rapid fluorescent in situ hybridization test, for detection of Helicobacter pylori and resistance to clarithromycin in paraffin-embedded biopsy sections, Julie M. Morris, Alisa L. Reasonover, Michael G. Bruce, Dana L. Bruden, Brian J. McMahon, Frank D. Sacco, Douglas E. Berg, and Alan J. Parkinson

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Amprenavir and efavirenz pharmacokinetics before and after the addition of nelfinavir, indinavir, ritonavir, or saquinavir in seronegative individuals, Gene D. Morse, Susan Rosenkranz, Michael F. Para, Yoninah Segal, Robin DiFrancesco, Elizabeth Adams, Barbara Brizz, Kevin E. Yarasheski, Richard C. Reichman, and ACTG 5043 Protocol Team

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Estimation of prevalence of DSM-IV and latent class-defined ADHD subtypes in a population-based sample of child and adolescent twins, Rosalind J. Neuman, Nantawat Sitdhiraksa, Wendy Reich, Ted H.-C. Ji, Cynthia A. Joyner, Ling-Wei Sun, and Richard D. Todd

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Results of preoperative pulmonary function testing of adolescents with idiopathic scoliosis: A study of six hundred and thirty-one patients, Peter O. Newton, Frances D. Faro, Sohrab Gollogly, Randal R. Betz, Lawrence G. Lenke, and Thomas G. Lowe

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Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells, Hiroyoshi Nishikawa, Takuma Kato, Isao Tawara, Kanako Saito, Hiroaki Ikeda, Kagemasa Kuribayashi, Paul M. Allen, Robert D. Schreiber, Shimon Sakaguchi, Lloyd J. Old, and Hiroshi Shiku

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Impact of two rounds of mass drug administration using diethylcarbamazine combined with albendazole on the prevalence of Brugia timori and of intestinal helminths on Alor Island, Indonesia, Tim Oqueka, Taniawati Supali, Is Suhariah Ismid, Purnomo, Paul Rückert, Mark Bradley, and Peter Fischer

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Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors, Sunil Parikh, Jiri Gut, Eva Istvan, Daniel E. Goldberg, Diane V. Havlir, and Philip J. Rosenthal

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Development of adjacent-level ossification in patients with an anterior cervical plate, Jong-Beom Park, Yong-Sun Cho, and K. Daniel Riew

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Hypertrophy of ligamentum flavum in lumbar spinal stenosis associated with increased proteinase inhibitor concentration, Jong-Beom Park, Jin-Kyung Lee, Sung-Jin Park, and K. Daniel Riew

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Time-dependent whole-body fluorescence tomography of probe bio-distributions in mice, Sachin V. Patwardhan, Sharon R. Bloch, Samuel Achilefu, and Joseph P. Culver

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Rab3D regulates a novel vesicular trafficking pathway that is required for osteoclastic bone resorption, Nathan J. Pavlos, Jiake Xu, Dietmar Riedel, Joyce S. G. Yeoh, Steven L. Teitelbaum, John M. Papadimitriou, Reinhard Jahn, F. Patrick Ross, and Ming H. Zheng

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Genetic epidemiology of diabetes, M. Alan Permutt, Jonathon Wasson, and Nancy Cox

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Murine acute promyelocytic leukemia cells can be recognized and cleared in vivo by adaptive immune mechanisms, Jessica L. Pollock, Andrew A. Lane, Kelly Schrimpf, and Timothy J. Ley

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Comparison of a novel endoscope holder and traditional camera assistant for laparoscopic simple nephrectomy in a porcine model, Sejal S. Quayle, W. Collyer, R. Vanlangedonck, and Jaime Landman

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Comorbidity between ADHD and symptoms of bipolar disorder in a community sample of children and adolescents, Wendy Reich, Rosalind J. Neuman, Heather E. Volk, Cynthia A. Joyner, and Richard D. Todd

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Epigenetic inactivation and aberrant transcription of CSMD1 in squamous cell carcinoma cell lines, Toni M. Richter, Benton D. Tong, and Steven B. Scholnick

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Targeted and restricted complement activation on acrosome-reacted spermatozoa, Rebecca C. Riley-Vargas, Susan Lanzendorf, and John P. Atkinson

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Evolutionary models for insertions and deletions in a probabilistic modeling framework, Elena Rivas

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Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis, Paul M. Robben, Marie LaRegina, William A. Kuziel, and L. David Sibley

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Incubation of metanephroi with vitamin D3 increases numbers of glomeruli, Sharon A. Rogers, David Droege, Adriana Dusso, and Marc R. Hammerman

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Complex transcriptional control links NikABCDE-Dependent nickel transport with hydrogenase expression in Escherichia coli, Jessica L. Rowe, G. Lucas Starnes, and Peter T. Chivers

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CAGER: Classification analysis of gene expression regulation using multiple information sources, Jianhua Ruan and Weixiong Zhang

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Genetic analysis of the maximum drinks phenotype, Scott F. Saccone, Nancy L. Saccone, Rosalind J. Neuman, and John P. Rice

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Omega-3 fatty acids decreased irritability of patients with bipolar disorder in an add-on, open label study, Kemal Sagduyu, Mehmet E. Dokucu, Bruce A. Eddy, Gerald Craigen, Claudia F. Baldassano, and Aysegül Yıldız

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Potassium channels in C. elegans, Lawrence B. Salkoff, Aguan Wei, Beravan Baban, Alice Butler, Gloria L. Fawcett, Gonzalo Ferreira, and Celia M. Santi

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Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling, Danielle K. Scheidenhelm, Jennifer Cresswell, Carrie A. Haipek, Timothy P. Fleming, Robert W. Mercer, and David H. Gutmann

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Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals, Jian-Su Shao, Su-Li Cheng, Joyce M. Pingsterhaus, Nichole Charlton-Kachigian, Arleen P. Loewy, and Dwight A. Towler

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Varying rates of Clostridium difficile-associated diarrhea at prevention epicenter hospitals, SeJean Sohn, Michael Climo, Daniel Diekema, Victoria Fraser, Loreen Herwaldt, Susan Marino, Gary Noskin, Trish Perl, Xiaoyan Song, Jerome Tokars, David Warren, Edward Wong, Deborah S. Yokoe, Theresa Zembower, and Kent A. Sepkowitz

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Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes, John Spieth, LaDeana W. Hillier, Richard K. Wilson, and et al

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Overview of gene structure, John Spieth and Daniel Lawson

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Clinical outcome at a minimum of five years after reconstruction of the anterior cruciate ligament, Kurt P. Spindler, Todd A. Warren, J. Claiborne Callison Jr., Michelle Secic, Sheryl B. Fleisch, and Rick W. Wright

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Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription, Joseph P. Stains and Roberto Civitelli

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Non-linear heart rate variability and risk stratification in cardiovascular disease, Phyllis K. Stein and Anand Reddy

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Toward an understanding of risk factors for binge-eating disorder in black and white women: A community-based case-control study, Ruth H. Striegel-Moore, Christopher G. Fairburn, Denise E. Wilfley, Kathleen M. Pike, Faith-Anne Dohm, and Helena C. Kraemer

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Natural peptides selected by diabetogenic DQ8 and murine I-Ag7 molecules show common sequence specificity, Anish Suri, James J. Walters, Michael L. Gross, and Emil R. Unanue

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Age-dependent changes in susceptibility of suckling mice to individual strains of Helicobacter pylori, Hiroyuki Suto, Maojun Zhang, and Douglas E. Berg

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Making connections between novel transcription factors and their DNA motifs, Kai Tan, Lee Ann McCue, and Gary D. Stormo