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Submissions from 2014

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C1q nephropathy in the setting of granulomatosis with polyangiitis treated with tacrolimus, Joseph G. Maliakkal, Helen Liapis, Andrew J. White, and Sun-Young Ahn

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Calcineurin and glial signaling: Neuroinflammation and beyond, Jennifer L. Furman and Christopher M. Norris

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Capacity building for evidence-based decision making in local health departments: Scaling up an effective training approach, Julie A. Jacobs, Kathleen Duggan, Paul Erwin, Carson Smith, Elaine Borawski, Judy Compton, Luann D'Ambrosio, Scott H. Frank, Susan Frazier-Kouassi, Peggy A. Hannon, Jennifer Leeman, Avia Mainor, and Ross C. Brownson

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Cardiac and renal effects of atrasentan in combination with enalapril and paricalcitol in uremic rats, Cynthia Ritter, Sarah Zhang, Jane L. Finch, Helen Liapis, Edu Suarez, Leon Ferder, James Delmez, and Eduardo Slatopolsky

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Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes, Shali Chen, Prasanth Puthanveetil, Biao Feng, Scot J. Matkovich, Gerald W. Dorn II, and Subrata Chakrabarti

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Cardiometabolic outcomes in children and adolescents following discontinuation of long-term risperidone treatment, Chadi A. Calarge, Ginger Nicol, Janet A. Schlechte, and Trudy L. Burns

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Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling, Rebecca C. Schugar, Ashley R. Moll, D. Andre d'Avignon, Carla J. Weinheimer, Attila Kovacs, and Peter A. Crawford

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Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIB procollagen and down-regulation of cholesterol and lipid homeostasis, Debabrata Patra, Elizabeth DeLassus, Guosheng Liang, and Linda J. Sandell

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Case records of the Massachusetts General Hospital. Case 1-2014. A 32-year-old man with loss of vision and a rash, Melvin S. Blanchard, Javier M. Romero, and Mai P. Hoang

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Causal variation in yeast sporulation tends to reside in a pathway bottleneck, Kim Lorenz and Barak A. Cohen

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CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma, Ravindra Uppaluri, James S. Lewis Jr, and et al

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CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria, Kenneth M. Murphy and et al

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Cell type-specific expression analysis to identify putative cellular mechanisms for neurogenetic disorders, Xiaoxiao Xu, Alan B. Wells, David R. O'Brien, Arye Nehorai, and Joseph D. Dougherty

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Central memory CD8+ T lymphocytes mediate lung allograft acceptance, Alexander Sasha Krupnick, Xue Lin, Wenjun Li, Ryuiji Higashikubo, Bernd H. Zinselmeyer, Hollyce Hartzler, Kelsey Toth, Jon H. Ritter, Mikhail Y. Berezin, Steven T. Wang, Mark J. Miller, Andrew E. Gelman, and Daniel Kreisel

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Cervical spinal cord dimensions and clinical outcomes in adults with Klippel-Feil syndrome: A comparison with matched controls., Woojin Cho, Dong-Ho Lee, Joshua D. Auerbach, Jennifer K. Sehn, Colin E. Nabb, and K D. Riew

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Changes in medical errors after implementation of a handoff program, F. S. Cole and et al

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Characterizing the Followers and Tweets of a Marijuana-Focused Twitter Handle, Patricia Cavazos-Rehg, Melissa Krauss, Richard Grucza, and Laura Bierut

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Chemokines in the balance: Maintenance of homeostasis and protection at CNS barriers, Jessica L. Williams, David W. Holman, and Robyn S. Klein

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Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes, Pankaj Pal, Julie M. Fox, Michael S. Diamond, and et al

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Chilling acclimation provides immunity to stress by altering regulatory networks and inducing genes with protective functions in Cassava, Zheng Chen, Jing Xia, Kevin Zhang, Weixiong Zhang, and et al

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Chromophore supply rate-limits mammalian photoreceptor dark adaptation, Jin-shan Wang, Soile Nymark, Rikard Frederiksen, Maureen E. Estevez, Susan Q. Shen, Joseph C. Corbo, M. Carter Cornwall, and Vladimir J. Kefalov

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Chronic allergic contact dermatitis promotes skin cancer, Shadmehr Demehri, Trevor J. Cunningham, Eva A. Hurst, Andras Schaffer, David M. Sheinbein, and Wayne M. Yokoyama

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Chronic lung allograft dysfunction following lung transplantation: Challenges and solutions, Bradford C. Bemiss and Chad A. Witt

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Circadian rhythm reprogramming during lung inflammation, Jeffrey A. Haspel and et al

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Climbing the vertebrate branch of U1A/U2B″ protein evolution, Kimberly J. Delaney, Sandra G. Williams, Mariah N. Lawler, and Kathleen B. Hall

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Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: A decade of the PREDICT-HD study, Joel S. Perlmutter, Stacey Barton, Shineeka Kaye Smith, and et al

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Clinical and pathological correlates of severity classifications in trigger fingers based on computer-aided image analysis, Tai-Hua Yang, Hsin-Chen Chen, Yung-Chun Liu, Hun-Hsuan Shih, Li-Chieh Kuo, Stephen Cha, Hsiao-Bai Yang, Dee-Shan Yang, I-Ming Jou, Yung-Nien Sun, and Fong-Chin Su

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Clinical implications for patients treated inappropriately for community-acquired pneumonia in the emergency department, Scott T. Micek, Adam Lang, Brian M. Fuller, Nicholas B. Hampton, and Marin H. Kollef

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Clinical presentation and disease characteristics of femoroacetabular impingement are sex-dependent, Jeffrey J. Nepple, Cassandra N. Riggs, James R. Ross, and John C. Clohisy

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Clinical trial design in the era of comparative effectiveness research, Anke C. Winter and Graham A. Colditz

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Clonal analysis of kit ligand a functional expression reveals lineage-specific competence to promote melanocyte rescue in the mutant regenerating caudal fin, Robert C. Tyron and Stephen L. Johnson

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Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing, Andrew E. O. Hughes, Vincent Magrini, Ryan Demeter, Christopher A. Miller, Robert Fulton, Lucinda L. Fulton, William C. Eades, Kevin Elliott, Sharon Heath, Peter Westervelt, Li Ding, Donald F. Conrad, Brian S. White, Jin Shao, Daniel C. Link, John F. DiPersio, Elaine R. Mardis, Richard K. Wilson, Timothy J. Ley, Matthew J. Walter, and Timothy A. Graubert

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Clonal architectures and driver mutations in metastatic melanomas, Li Ding, Minjung Kim, Krishna L. Kanchi, Nathan D. Dees, Charles Lu, Malachi Griffith, David Fenstermacher, Hyeran Sung, Christopher A. Miller, Brian Goetz, Michael C. Wendl, Obi Griffith, Lynn A. Cornelius, Gerald P. Linette, Joshua F. McMichael, Vernon K. Sondak, Ryan C. Fields, Timothy J. Ley, James J. Mule, Richard K. Wilson, and Jeffrey S. Weber

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CNS Amyloid-β, Soluble APP-α and-β Kinetics during BACE Inhibition, Justyna A. Dobrowolska, Bruce W. Patterson, Robert Chott, Vitality Ovod, Yuriy Pyatkivskyy, Kristin R. Wildsmith, Tom Kasten, Kevin E. Yarasheski, Randall J. Bateman, and et al

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Cognitive function in ambulatory patients with systolic heart failure: Insights from the Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial, Douglas L. Mann and et al

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Cognitive functioning in young children with type 1 diabetes, M. A. Cato, Nelly Mauras, Jodie Ambrosino, Aiden Bondurant, Amy L. Conrad, Craig Kollman, Peiyao Cheng, Roy W. Beck, Katrina J. Ruedy, Tandy Aye, Allan L. Reiss, Neil H. White, and Tamara Hershey

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Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma, Amy Barone, Rajarshi Sengupta, Nicole M. Warrington, Erin Smith, Patrick Y. Wen, Rolf A. Brekken, Barbara Romagnoli, Garry Douglas, Eric Chevalier, Michael P. Bauer, Klaus Dembowsky, David Piwnica-Worms, and Joshua B. Rubin

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Common exposure to STL polyomavirus during childhood, Efrem S. Lim, Natalie M. Meinerz, Blake Primi, David Wang, and Robert L. Garcea

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Comparative analyses of proteins from Haemophilus influenzae biofilm and planktonic populations using metabolic labeling and mass spectrometry, Deborah MB Post, Jason M. Held, Margaret R. Ketterer, Nancy J. Phillips, Alexandria Sahu, Michael A. Apicella, and Bradford W. Gibson

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Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers, Bo Zhang, Xiao Yun Xing, Jing Li, Rebecca F. Lowdon, Yan Zhou, Nan Lin, Baoxue Zhang, Vasavi Sundaram, Katherine B. Chiappinelli, Ian S. Hagemann, David G. Mutch, Paul J. Goodfellow, and Ting Wang

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Comparison of perioperative outcomes of robot-assisted partial nephrectomy and open partial nephrectomy in patients with a solitary kidney, Homayoun Zargar, Sam Bhayani, Mohamad E. Allaf, Michael Stifelman, Craig Rogers, Jeffrey Larson, Mark W. Ball, Susan Marshall, Ramesh Kumar, Amr Fergany, Steven Campbell, and Jihad Kaouk

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Comparison of placebo and best available therapy for the treatment of myelofibrosis in the phase 3 COMFORT studies, John F. DiPersio and et al

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Comparison of the stand-alone Cox-Maze IV procedure to the concomitant Cox-Maze IV and mitral valve procedure for atrial fibrillation, Christopher P. Lawrance, Matthew C. Henn, Jacob R. Miller, Laurie A. Sinn, Richard B. Schuessler, and Ralph J. Damiano Jr.

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Comparison of two methods for analysis of gene-environment interactions in longitudinal family data: The Framingham heart study, Yun Ju Sung, Jeannette Simino, Rezart Kume, Jacob Basson, Karen Schwander, and D. C. Rao

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Complete absence of the posterior arch of C1: Case report, R. Khanna, Z. A. Smith, B. J. Dlouhy, and N. S. Dahdaleh

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Complete response and prolonged disease-free survival in a patient with recurrent duodenal adenocarcinoma treated with bevacizumab plus FOLFOX6, Gayathri Nagaraj, Yousef Zarbalian, Karin Flora, and Benjamin R. Tan Jr.

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Complications associated with the periacetabular osteotomy, Ira Zaltz, Geneva Baca, Young-Jo Kim, Perry Schoenecker, Robert Trousdale, Rafael Sierra, Daniel Sucato, Ernie Sink, Paul Beaulé, Michael B. Millis, David Podeszwa, and John C. Clohisy

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Compressed sampling strategies for tomography, Yan Kaganovsky, Daheng Li, Andrew Holmgren, HyunJu Jeon, Kenneth P. MacCabe, David G. Politte, Joseph A. O'Sullivan, Lawrence Carin, and David J. Brady

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Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26–30 June 2013, Montreal, Canada, Benoit Barbeau, John Hiscott, Ali Bazarbachi, Edgar Carvalho, Kathryn Jones, Fabiola Martin, Masao Matsuoka, Edward L. Murphy, Lee Ratner, William M. Switzer, and Toshiki Watanabe

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Congenitally acquired persistent lymphocytic choriomeningitis viral infection reduces neuronal progenitor pools in the adult hippocampus and subventricular zone, Tony Sun, Michael J. Vasek, and Robyn S. Klein

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Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer, Gunjal Garg, Suwanna Vangveravong, Chenbo Zeng, Lynne Collins, Mary Hornick, Yassar Hashim, David Piwnica-Worms, Matthew A. Powell, David G. Mutch, Robert H. Mach, William G. Hawkins, and Dirk Spitzer

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Conservative fluid therapy in septic shock: An example of targeted therapeutic minimization, Catherine Chen and Marin H. Kollef

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Conserved syntenic clusters of protein coding genes are missing in birds, Peter V. Lovell, Morgan Wirthlin, Larry Wilhelm, Patrick Minx, Nathan H. Lazar, Lucia Carbone, Wesley C. Warren, and Claudio V. Mello

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Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development, Gaurav Swarnkar, Kaihua Zhang, Gabriel Mbalaviele, Fanxin Long, and Yousef Abu-Amer

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Construction and radiolabeling of adenovirus variants that incorporate human metallothionein into protein IX for analysis of biodistribution, David T. Curiel and et al

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Contaminated heparin and outcomes after cardiac surgery: A retrospective propensity-matched cohort study, Heiko A. Kaiser, Arbi Ben Abdallah, Nan Lin, Bethany R. Tellor, Mohammad Helwani, Jennifer R. Smith, Marc R. Moon, and Michael S. Avidan

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Contribution of the highly conserved EaeH surface protein to enterotoxigenic Escherichia coli pathogenesis, Alaullah Sheikh, Qingwei Luo, Koushik Roy, Salwa Shabaan, Pardeep Kumar, Firdausi Qadri, and James M. Fleckenstein

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Conversion of fibroblasts to neural cells by p53 depletion, Di Zhou, Zhen Zhang, Li-Ming He, Juan Du, Fan Zhang, Chong-Kui Sun, Yu Zhou, Xiao-Wei Wang, Ge Lin, Ke-Ming Song, Ling-Gang Wu, and Qin Yang

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Copy number analysis of NIPBL in a cohort of 510 patients reveals rare copy number variants and a mosaic deletion, Yu-Wei Cheng, Christopher A. Tan, Agata Minor, Kelly Arndt, Latrice Wysinger, Dorothy K. Grange, Beth A. Kozel, Nathaniel H. Robin, Darrel Waggoner, Carrie Fitzpatrick, Soma Das, and Daniela del Gaudio

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Cortical–subcortical interactions in hypersomnia disorders: Mechanisms underlying cognitive and behavioral aspects of the sleep–wake cycle, Linda J. Larson-Prior, Yo-El Ju, and James E. Galvin

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Cost-effectiveness of family-based group treatment for child and parental obesity, Leonard H. Epstein, Rocco A. Paluch, Brian H. Wrotniak, Tinuke Oluyomi Daniel, Denise Wilfley, and Eric Finkelstein

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Cost-effectiveness of surgery and its policy implications for global health: A systematic review and analysis, Tiffany E. Chao, Ketan Sharma, Morgan Mandigo, Lars Hagander, Stephen C. Resch, Thomas G. Weiser, and John G. Meara

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Critical glycosylated residues in exon three of erythrocyte Glycophorin A engage Plasmodium falciparum EBA-175 and define receptor specificity, Nichole D. Salinas, May M. Paing, and Niraj H. Tolia

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Cross-inhibition of NMBR and GRPR signaling maintains normal histaminergic itch transmission, Zhong-Qiu Zhao, Li Wan, Xian-Yu Liu, Fu-Quan Huo, Hui Li, Devin M. Barry, Stephanie Krieger, Seungil Kim, Zhong-Chun Liu, Jinbin Xu, Buck E. Rogers, Yun-Qing Li, and Zhou-Feng Chen

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Cross talk between the Cell Wall Integrity and Cyclic AMP/Protein Kinase A pathways in Cryptococcus neoformans, Maureen J. Donlin, Rajendra Upadhya, Kimberly J. Gerik, Woei Lam, Laura G. VanArendonk, Charles A. Specht, Neil K. Sharma, and Jennifer K. Lodge

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Cryptococcus at work: Gene expression during human infection, Rajendra Upadhya, Maureen J. Donlin, and Jennifer K. Lodge

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Cryptococcus neoformans Dual GDP-mannose transporters and their role in biology and virulence, Zhuo A. Wang, Cara L. Griffith, Michael L. Skowyra, Nichole Salinas, Matthew Williams, Ezekiel J. Maier, Stacey R. Gish, Hong Liu, Michael R. Brent, and Tamara L. Doering

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Current clinical practice: differential management of uveal melanoma in the era of molecular tumor analyses, Thomas M. Aaberg Jr., Robert W. Cook, Kristen Oelschlager, Derek Maetzold, P. Kumar Rao, and John O. Mason III

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Current perspectives on antibody-mediated rejection after lung transplantation, Chad A. Witt and Ramsey R. Hachem

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Current surgical treatment strategies for hepatocellular carcinoma in North America, Adeel S. Khan, Kathryn J. Fowler, and William C. Chapman

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Curricular priorities for business ethics in medical practice and research: Recommendations from Delphi consensus panels, James M. DuBois, Elena M. Kraus, Kamal Gursahani, Anthony Mikulec, and Erin Bakanas

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Daily bathing with chlorhexidine-based soap and the prevention of Staphylococcus aureus transmission and infection, Melissa A. Viray, James C. Morley, Craig M. Coopersmith, Marin H. Kollef, Victoria J. Fraser, and David K. Warren

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Data dictionary services in XNAT and the Human Connectome Project, Rick Herrick, Michael McKay, Timothy Olsen, William Horton, Mark Florida, Charles J. Moore, and Daniel S. Marcus

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Data requirements for electronic surveillance of healthcare-associated infections, Keith F. Woeltje, Michael Y. Lin, Michael Klompas, Marc Oliver Wright, Gianna Zuccotti, and William E. Trick

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Decitabine in the treatment of acute myeloid leukemia in elderly patients, Priya Malik and Amanda F. Cashen

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Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis, Amelia K. Pinto, Hilario J. Ramos, Xiaobo Wu, Shilpa Aggarwal, Bimmi Shrestha, Matthew Gorman, Kristin Y. Kim, Mehul S. Suthar, John P. Atkinson, Michael Gale Jr., and Michael S. Diamond

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Defining NELF-E RNA binding in HIV-1 and promoter-proximal pause regions, John M. Pagano, Hojoong Kwak, Colin T. Waters, Rebekka O. Sprouse, Brian S. White, Abdullah Ozer, Kylan Szeto, David Shalloway, Harold G. Craighead, and John T. Lis

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Dendritic cells in dengue virus infection: Targets of virus replication and mediators of immunity, Michael A. Schmid, Michael S. Diamond, and Eva Harris

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Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming, Daniel B. Graham, Douglas G. Osborne, Joshua T. Piotrowski, Timothy S. Gomez, Grzegorz B. Gmyrek, Holly M. Akilesh, Adish Dani, Daniel D. Billadeau, and Wojciech Swat

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De novo meningitis caused by Propionibacterium acnes in a patient with metastatic melanoma, Jason P. Burnham, Benjamin S. Thomas, Sergio E. Trevino, Erin McElvania TeKippe, Carey-Ann D. Burnham, and F. Matthew Kuhlmann

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Designing vaccines to neutralize effective toxin delivery by enterotoxigenic Escherichia coli, James M. Fleckenstein and Alaullah Sheikh

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Detection of a divergent Parainfluenza 4 virus in an adult patient with influenza like illness using next-generation sequencing, Seweryn Bialasiewicz, Jodie McVernon, Terry Nolan, Stephen B. Lambert, Guoyan Zhao, David Wang, Michael D. Nissen, and Theo P. Sloots

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Determinative developmental cell lineages are robust to cell deaths, Jian-Rong Yang, Shuxiang Ruan, and Jianzhi Zhang

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Developmental changes in the organization of functional connections between the basal ganglia and cerebral cortex, Deanna J. Greene, Timothy O. Laumann, Joseph W. Dubis, S. Katie Ihnen, Maital Neta, Jonathan D. Power, John R. Pruett Jr, Kevin J. Black, and Bradley L. Schlaggar

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Developmental differences in masked form priming are not driven by vocabulary growth, Adeetee Bhide, Bradley L. Schlaggar, and Kelly Anne Barnes

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Development and feasibility of a home-based education model for families of children with sickle cell disease, Catherine Hoyt Drazen, Regina Abel, Terianne Lindsey, and Allison A. King

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Diabetes and pancreatic cancer survival: A prospective cohort-based study, Adetunji T. Toriola, Rachael Z. Stolzenberg-Solomon, L. Dalidowitz, David C. Linehan, and Graham A. Colditz

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Diabetes mellitus increases risk for colorectal adenomas in younger patients, Hongha T. Vu, Nneke Ufere, Yan Yan, Jean S. Wang, Dayna S. Early, and Jill E. Elwing

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Differential expression of miRNAs in colon cancer between African and Caucasian Americans: Implications for cancer racial health disparities, Ellen Li, Ping Ji, Nengtai Ouyang, Yuanhao Zhang, Xin Yu Wang, Deborah C. Rubin, Nicholas O. Davidson, Roberto Bergamaschi, Kenneth R. Shroyer, Stephanie Burke, Wei Zhu, and Jennie L. Williams

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Differential induction of TLR3-dependent innate immune signaling by closely related parasite species, Daniel P. Beiting, Lucia Peixoto, Natalia S. Akopyants, Stephen M. Beverley, E. John Wherry, David A. Christian, Christopher A. Hunter, Igor E. Brodsky, and David S. Roos

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Differentiating c8-t1 radiculopathy from ulnar neuropathy: A survey of 24 spine surgeons, Geoffrey E. Stoker, Han J. Kim, and K. D. Riew

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Diffusion tensor imaging in children with unilateral hearing loss: A pilot study, Tara Rachakonda, Joshua S. Shimony, Rebecca S. Coalson, and Judith E.C. Lieu

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Discrimination between thermodynamic models of cis-regulation using transcription factor occupancy data, Robert D. Zeigler and Barak A. Cohen

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Distinct lysosome phenotypes influence inflammatory function in peritoneal and bone marrow-derived macrophages, Kassandra Weber and Joel D. Schilling

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Distinguishing West Nile virus infection using a recombinant envelope protein with mutations in the conserved fusion-loop, Stefan Chabierski, Luisa Barzon, Anna Papa, Matthias Niedrig, Jonathan L. Bramson, Justin M. Richner, Giorgio Palu, Michael S. Diamond, and Sebastian Ulbert

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Distribution and medical impact of loss-of-function variants in the Finnish founder population, Nathan O. Stitziel and et al

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Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system, Justyna A. Dobrowolska, Tom Kasten, Yafei Huang, Tammie L. S. Benzinger, Wendy Sigurdson, Vitaliy Ovod, John C. Morris, and Randall J. Bateman

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Diverse viral glycoproteins as well as CD4 co-package into the same human immunodeficiency virus (HIV-1) particles, Devon A. Gregory, Grace Y. Olinger, Tiffany M. Lucas, and Marc C. Johnson

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DLS 5.0 - The biomechanical effects of dynamic locking screws, Stefan Dobele, Michael Gardner, Steffen Schroter, Dankward Hontzsch, Ulrich Stockle, and Thomas Freude

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DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures, Matthew R. Northam, Elizabeth A. Moore, Tony M. Mertz, Sara K. Binz, Carrie M. Stith, Elena I. Stepchenkova, Kathern L. Wendt, Peter M. J. Burgers, and Polina V. Scherbakova