Submissions from 2021
Aducanumab for Alzheimer disease: The amyloid hypothesis moves from bench to bedside, Erik S. Musiek, Teresa Gomez-Isla, and David M Holtzman
Alternative pre-mRNA splicing of the mu opioid receptor gene, OPRM1: Insight into complex mu opioid actions, Shan Liu, Wen-Jia Kang, Anna Abrimian, Jin Xu, Luca Cartegni, Susruta Majumdar, Patrick Hesketh, Alex Bekker, and Ying-Xian Pan
Cellular therapy updates in B-cell lymphoma: The state of the CAR-T, Zachary D Crees and Armin Ghobadi
Timing of antibiotic therapy in the ICU, Marin H Kollef, Andrew F Shorr, Matteo Bassetti, Jean-Francois Timsit, Scott T Micek, Andrew P Michelson, and Jose Garnacho-Montero
Untargeted metabolomic analysis of human milk from mothers of preterm infants, Lila S Nolan, Angela N Lewis, Qingqing Gong, James J Sollome, Olivia N DeWitt, Robert D Williams, and Misty Good
Cullin4 E3 ubiquitin ligases regulate male gonocyte migration, proliferation and blood-testis barrier homeostasis, Yan Yin, Liming Zhu, Qiufang Li, Pengbo Zhou, and Liang Ma
Corrections in the CHARMM36 parametrization of chloride interactions with proteins, lipids, and alkali cations, and extension to other halide anions, Esam A Orabi, Tuǧba N Öztürk, Nathan Bernhardt, and José D Faraldo-Gómez
Formylglycine-generating enzyme-like proteins constitute a novel family of widespread type VI secretion system immunity proteins, Juvenal Lopez, Nguyen-Hung Le, Ki Hwan Moon, Dor Salomon, Eran Bosis, and Mario F Feldman
Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription, Jingjing Pei, Nina R Beri, Angela J Zou, Philipp Hubel, Hannah K Dorando, Valter Bergant, Rebecca D Andrews, Jiehong Pan, Jared M Andrews, Kathleen C F Sheehan, Andreas Pichlmair, Gaya K Amarasinghe, Steven L Brody, Jacqueline E Payton, and Daisy W Leung
Plasmid-encoded H-NS controls extracellular matrix composition in a modern Acinetobacter baumannii urinary isolate, Saida Benomar, Gisela Di Venanzio, and Mario F Feldman
Phospho-Ser784-VCP drives resistance of pancreatic ductal adenocarcinoma to genotoxic chemotherapies and predicts the chemo-sensitizing effect of VCP inhibitor, Faliang Wang, Kiran Vij, Lin Li, Paarth Dodhiawala, Kian-Huat Lim, and Jieya Shao
Updates on wound infiltration use for postoperative pain management: A narrative review, Dusica M Stamenkovic, Mihailo Bezmarevic, Suzana Bojic, Dragana Unic-Stojanovic, Dejan Stojkovic, Damjan Z Slavkovic, Vladimir Bancevic, Nebojsa Maric, and Menelaos Karanikolas
Barriers to symptom management care pathway implementation in pediatric cancer, L Lee Dupuis, Allison Grimes, Emily Vettese, Lisa M Klesges, and Lillian Sung
BRAF mutations may identify a clinically distinct subset of glioblastoma, Samantha N McNulty, Katherine E Schwetye, Cole Ferguson, Chad E Storer, George Ansstas, Albert H Kim, David H Gutmann, Joshua B Rubin, Richard D Head, and Sonika Dahiya
Naturally occurring genetic variants in the oxytocin receptor alter receptor signaling profiles, Manasi Malik, Michael D Ward, Yingye Fang, Justin R Porter, Maxwell I Zimmerman, Thomas Koelblen, Michelle Roh, Antonina I Frolova, Thomas P Burris, Gregory R Bowman, Princess I Imoukhuede, and Sarah K England
Prioritization of molecular targets for antimalarial drug discovery, Barbara Forte, Daniel E Goldberg, Eva S Istvan, and et al
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria, Alvaro González-Dominguez, Raúl Montañez, Beatriz Castejón-Vega, Jéssica Nuñez-Vasco, Débora Lendines-Cordero, Chun Wang, Gabriel Mbalaviele, José M Navarro-Pando, Elísabet Alcocer-Gómez, and Mario D Cordero
RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin, Roberto Bandiera, Rebecca E Wagner, Thiago Britto-Borges, Christoph Dieterich, Sabine Dietmann, Susanne Bornelöv, and Michaela Frye
Comparative cellular analysis of motor cortex in human, marmoset and mouse, Trygve E. Bakken, Xinxin Wang, and et al
Single-cell epigenomics reveals mechanisms of human cortical development, Ryan S Ziffra, Tychele N Turner, and et al.
Coronary artery calcification and plaque characteristics in people living with HIV: A systematic review and meta-analysis, Cullen Soares, Amjad Samara, Matthew F Yuyun, Justin B Echouffo-Tcheugui, Ahmad Masri, Ahmad Samara, Alan R Morrison, Nina Lin, Wen-Chih Wu, and Sebhat Erqou
Disparities in treatment decisions for abnormal uterine bleeding, Lulu Yu, Bhavana Janga, Rebecca McAlister, Donna B Jeffe, and Tammy Sonn
Patient-reported reasons for stopping care or switching clinics in Zambia: A multisite, regionally representative estimate using a multistage sampling-based approach in Zambia, Izukanji Sikazwe, Ingrid Eshun-Wilson, Kombatende Sikombe, Laura K Beres, Paul Somwe, Aaloke Mody, Sandra Simbeza, Chama Bukankala, David V Glidden, Lloyd B Mulenga, Nancy Padian, Peter Ehrenkranz, Carolyn Bolton-Moore, Charles B Holmes, and Elvin H Geng
Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish, Hyo Sik Jang, Yujie Chen, Jiaxin Ge, Alicia N Wilkening, Yiran Hou, Hyung Joo Lee, You Rim Choi, Rebecca F Lowdon, Xiaoyun Xing, Daofeng Li, Charles K Kaufman, Stephen L Johnson, and Ting Wang
Role of enhancers in development and diseases, Shailendra S Maurya
The role of community health workers in the surgical cascade: A scoping review, Helen W Li, Michael L Scanlon, Nicholas Kisilu, and Debra K Litzelman
ACES: Analysis of Conservation with an Extensive list of Species, Evin M Padhi, Jeffrey K Ng, Elvisa Mehinovic, Eleanor I Sams, and Tychele N Turner
Ceftolozane/tazobactam probability of target attainment and outcomes in participants with augmented renal clearance from the randomized phase 3 ASPECT-NP trial, Andrew F Shorr, Christopher J Bruno, Zufei Zhang, Erin Jensen, Wei Gao, Hwa-Ping Feng, Jennifer A Huntington, Brian Yu, Elizabeth G Rhee, Carisa De Anda, Sumit Basu, and Marin H Kollef
Acute appendicitis associated with Kawasaki disease: Case report and review of the literature, Kaku Kuroda and Morgan Stottlemyre
A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1, Anika V Prabhu, Insung Kang, Raffaella De Pace, Christopher A Wassif, Hideji Fujiwara, Pamela Kell, Xuntian Jiang, Daniel S Ory, Juan S Bonifacino, Michael E Ward, and Forbes D Porter
A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex, Zizhen Yao, Hanqing Liu, Fangming Xie, Stephan Fischer, Xinxin Wang, and et al
Augmented reality in spinal surgery: Highlights from augmented reality lectures at the Emerging Technologies annual meetings, Syed-Abdullah Uddin, George Hanna, Lindsey Ross, Camilo Molina, Timur Urakov, Patrick Johnson, Terrence Kim, and Doniel Drazin
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells, Myung-Chul Kim, Nicholas Borcherding, Kawther K. Ahmed, Andrew P. Voigt, Gaurav Pandey, and et al
Chyloptysis as a delayed sequela of penetrating thoracic trauma, Kyle G Mitchell, Hope Feldman, Bryan F Meyers, and Mara B Antonoff
Clinical trial and postmarketing safety of onasemnogene abeparvovec therapy, John W Day, Jerry R Mendell, Eugenio Mercuri, Richard S Finkel, Kevin A Strauss, Aaron Kleyn, Sitra Tauscher-Wisniewski, Francis Fonyuy Tukov, Sandra P Reyna, and Deepa H Chand
Combined thoracic endovascular aortic repair and endovascular aneurysm repair and the long-term consequences of altered cardiovascular haemodynamics on morbidity and mortality: Case series and literature review, Sherif Sultan, Yogesh Acharya, Mohiey Hazima, Hiba Salahat, Juan Carlos Parodi, and Niamh Hynes
Cortical feedback and gating in odor discrimination and generalization, Gaia Tavoni, David E. Chen Kersen, and Vijay Balasubramanian
CT findings and patterns of e-cigarette or vaping product use-associated lung injury: A multicenter cohort of 160 cases, Seth J Kligerman, Constantine A Raptis, Kaitlin M Marquis, and et al.
Data-driven clustering identifies features distinguishing multisystem inflammatory syndrome from acute COVID-19 in children and adolescents, Alon Geva, Philip C Spinella, and et al
Deep learning-based method to accurately estimate breast tissue optical properties in the presence of the chest wall, Menghao Zhang, Shuying Li, Yun Zou, and Quing Zhu
DICER1 tumor predisposition syndrome: An evolving story initiated with the pleuropulmonary blastoma, Iván A González, Douglas R Stewart, Kris Ann P Schultz, Amanda P Field, D Ashley Hill, and Louis P Dehner
Diffusion-weighted imaging reveals distinct patterns of cytotoxic edema in patients with subdural hematomas, David Robinson, Natalie Kreitzer, Laura B Ngwenya, Opeolu Adeoye, Daniel Woo, Jed Hartings, and Brandon Foreman
E-cadherin expression and blunted interferon response in blastic plasmacytoid dendritic cell neoplasm, Luisa Lorenzi, Silvia Lonardi, Donatella Vairo, Andrea Bernardelli, Michela Tomaselli, Mattia Bugatti, Sara Licini, Mariachiara Arisi, Lorenzo Cerroni, Alessandra Tucci, William Vermi, Silvia Clara Giliani, and Fabio Facchetti
Estimating the effects of race and social vulnerability on hospital admission and mortality from COVID-19, Joshua M Landman, Karen Steger-May, Karen E Joynt Maddox, Gmerice Hammond, Aditi Gupta, Adriana M Rauseo, Min Zhao, and Randi E Foraker
Evaluation of patient-reported delays and affordability-related barriers to care in head and neck cancer, Nicholas R Lenze, Jeannette T Bensen, Laura Farnan, Siddharth Sheth, Jose P Zevallos, Wendell G Yarbrough, and Adam M Zanation
Friends and foes: Extracellular vesicles in aging and rejuvenation, Brian V Lananna and Shin-Ichiro Imai
Generation of two induced pluripotent stem cell lines with heterozygous and homozygous GAG deletion in TOR1A gene from a healthy hiPSC line, Masuma Akter, Haochen Cui, Yi-Hsien Chen, and Baojin Ding
Histologic findings in mucosa and muscularis propria biopsied during peroral endoscopic myotomy in patients with achalasia, Xiuli Liu, Enoch Kuo, Kai Wang, Yassen B Perbtani, Dennis Yang, and Peter Draganov
How to screen for monoclonal gammopathy in patients with a suspected amyloidosis, Samuel M Rubinstein and Keith Stockerl-Goldstein
Impact of COVID-19 on gastroenterology fellowship training: A multicenter analysis of endoscopy volumes, Swathi Paleti, Anas Gremida, and et al.
Implementing an application programming interface for PROMIS measures at three medical centers, Michael Bass, Christian Oncken, Allison W. McIntyre, Chris Dasilva, Joshua Spuhl, and Nan E. Rothrock
Inpatient versus outpatient intravenous diuresis for the acute exacerbation of chronic heart failure, Ilia G Halatchev, Wen-Chin Wu, Paul A Heidenreich, Elma Djukic, Sumitra Balasubramanian, Kelly B Ohlms, and Jay R McDonald
Investigation of effect of modulation frequency on high-density diffuse optical tomography image quality, Weihao Fan, Hamid Dehghani, and Adam Eggebrecht
Lost in translation: A disconnect between the science and Medicare coverage criteria for continuous subcutaneous insulin infusion, Grazia Aleppo, Christopher G Parkin, Anders L Carlson, Rodolfo J Galindo, Davida F Kruger, Carol J Levy, Guillermo E Umpierrez, Gregory P Forlenza, and Janet B McGill
Multicenter, double-blind, placebo-controlled trial of seviprotimut-L polyvalent melanoma vaccine in patients with post-resection melanoma at high risk of recurrence, Craig L Slingluff, Leonel Hernandez-Aya, and et al
Neutralisation of SARS-CoV-2 lineage P.1 by antibodies elicited through natural SARS-CoV-2 infection or vaccination with an inactivated SARS-CoV-2 vaccine: An immunological study, William M Souza, Michael S Diamond, and et al.
Novel variants in KAT6B spectrum of disorders expand our knowledge of clinical manifestations and molecular mechanisms, Megan Yabumoto, Catherine Gooch, and et al
Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways, Sophia C. Parks, Susan Nguyen, Shyon Nasrolahi, Chaitra Bhat, Damian Juncaj, Dihong Lu, Raghavendran Ramaswamy, Harpal Dhillon, Hideji Fujiwara, Anna Buchman, Omar S. Akbari, Naoki Yamanaka, Martin J. Boulanger, and Adler R. Dillman
Preparing nursing homes for a second wave of coronavirus disease 2019 (COVID-19), A Rekha Murthy, Hilary Babcock, and et al.
Pretreatment neutrophil-to-lymphocyte ratio as an important prognostic marker in stage III locally advanced non-small cell lung cancer: Confirmatory results from the PROCLAIM phase III clinical trial, Tithi Biswas, Rohin Gawdi, Charulata Jindal, Sharanya Iyer, Kylie H. Kang, David Bajor, Mitchell Machtay, Yuk Ming Choi, and Jimmy T. Efird
Protocol for DRAUP: A deimplementation programme to decrease routine chest radiographs after central venous catheter insertion, Enyo Ablordeppey, Byron Powell, Virginia McKay, Shannon Keating, Aimee James, Christopher Carpenter, Marin Kollef, and Richard Griffey
Recognizing the vulnerable: Perspectives, attitudes, and interests of women with uterine factor infertility towards uterus allotransplantation, Helen Xun, Darya Fadavi, Halley Darrach, Nicole Fischer, Pooja Yesantharao, Franca Kraenzlin, Amanda Nickles Fader, James H. Segars, and Justin M. Sacks
Single-cell epigenomics reveals mechanisms of human cortical development, Ryan S Ziffra, Tychele N Turner, and et al
Somatic PIK3R1 variation as a cause of vascular malformations and overgrowth, Catherine E Cottrell, Jonathan W Heusel, Meagan Corliss, Michael J Evenson, Carrie C Coughlin, and et al.
Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor, Katherine Basore, Hongming Ma, Natasha M Kafai, Samantha Mackin, Arthur S Kim, Christopher A Nelson, Michael S Diamond, and Daved H Fremont
The antifungal pipeline: Fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin, Martin Hoenigl, Rosanne Sprute, Matthias Egger, Amir Arastehfar, Oliver A Cornely, Robert Krause, Cornelia Lass-Flörl, Juergen Prattes, Andrej Spec, George R Thompson 3rd, Nathan Wiederhold, and Jeffrey D Jenks
Upstaging and survival outcomes for non-muscle invasive bladder cancer after radical cystectomy: Results from the International Robotic Cystectomy Consortium, Umar Iqbal, Eric Kim, and et al
White matter plasticity in healthy older adults: The effects of aerobic exercise, Andrea Mendez Colmenares, Michelle W Voss, Jason Fanning, Elizabeth A Salerno, Neha P Gothe, Michael L Thomas, Edward McAuley, Arthur F Kramer, and Agnieszka Z Burzynska
X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes, John Mattick, Ramakrishna Rao, and et al
Gut microbiota-derived short-chain fatty acids protect against the progression of endometriosis, Sangappa B Chadchan, Pooja Popli, Chandrasekhar R Ambati, Eric Tycksen, Sang Jun Han, Serdar E Bulun, Nagireddy Putluri, Scott W Biest, and Ramakrishna Kommagani
Mutation of the EPHA2 tyrosine-kinase domain dysregulates cell pattern formation and cytoskeletal gene expression in the lens, Yuefang Zhou, Thomas M Bennett, Philip A Ruzycki, and Alan Shiels
Thrombolytic enzymes of microbial origin: A review, Deepti Diwan, Zeba Usmani, Minaxi Sharma, James W Nelson, Vijay Kumar Thakur, Graham Christie, Gustavo Molina, and Vijai Kumar Gupta
Frontal-posterior functional imbalance and aberrant function developmental patterns in schizophrenia, Dandan Sun, Fay Y. Womer, and et al
Genetic characterization, current model systems and prognostic stratification in PAX fusion-negative vs. PAX fusion-positive rhabdomyosarcoma, Carina A Dehner, Amy E Armstrong, Marielle Yohe, Jack F Shern, and Angela C Hirbe
Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumor growth, Alastair M McKee, Katherine N Weilbaecher, and et al
CXCL17 is dispensable during hypervirulent Mycobacterium tuberculosis HN878 infection in mice, José Alberto Choreño-Parra, Micah D Dunlap, Rosemary Swanson, Luis A Jiménez-Álvarez, Marcela Muñoz-Torrico, Silvia Guzmán-Beltrán, Joaquín Zúñiga, and Shabaana A Khader
A novel mitragynine analog with low-efficacy mu opioid receptor agonism displays antinociception with attenuated adverse effects, Soumen Chakraborty, Abdelfattah Faouzi, Sarah M Bernhard, Nitin Nuthikattu, Rahul Jilakara, Satyanarayana M Chintala, Tao Che, Susruta Majumdar, and et al
Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis, Yan Xie, Elizabeth P Newberry, Elizabeth M Brunt, Samuel J Ballentine, Saeed Soleymanjahi, Elizabeth A Molitor, and Nicholas O Davidson
Effectiveness of mRNA Covid-19 vaccine among U.S. health care personnel, Tamara Pilishvili, Jennie H. Kwon, and et al
Exploring contextual factors influencing the implementation of evidence-based care for hypertension in Rwanda: A cross-sectional study using the COACH questionnaire, Ana Baumann, Cole Hooley, Charles Goss, Vincent Mutabazi, Angela Brown, Kenneth Schechtman, Marc Twagirumukiza, Lisa de Las Fuentes, Dominic Reeds, Makeda Williams, Eugene Mutimura, Anna Bergström, Aurore Nishimwe, Cecile Ingabire, and Victor Davila-Roman
Increased blood pressure variability and the risk of probable dementia or mild cognitive impairment: A post hoc analysis of the SPRINT MIND trial, Adam de Havenon, Mohammad Anadani, Shyam Prabhakaran, Ka-Ho Wong, Shadi Yaghi, and Natalia Rost
Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism, Thomas S Postler, Vincent Peng, Dev M Bhatt, and Sankar Ghosh
Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism, Thomas S Postler, Vincent Peng, Dev M Bhatt, and Sankar Ghosh
Methodological rigor and temporal trends of cardiovascular medicine meta-analyses in highest-impact journals, Dhruv Mahtta, Ahmed Altibi, Mohamed M Gad, Amjad Samara, Amr F Barakat, Rodrigo Bagur, Hend Mansoor, Hani Jneid, Salim S Virani, Mamas A Mamas, Ahmad Masri, and Islam Y Elgendy
Clinicians' perspectives on the functions of communication in pediatric oncology, Bryan A. Sisk, Ginny L. Schulz, Erica C. Kaye, Justin N. Baker, Jennifer W. Mack, and James M. DuBois
Real-world evaluation of the impact of implementation of the Virtuo blood culture system in a tertiary care hospital, Miguel A Chavez, Satish Munigala, Carey-Ann D Burnham, Melanie L Yarbrough, and David K Warren
Structural variants are a major source of gene expression differences in humans and often affect multiple nearby genes, Alexandra J Scott, Colby Chiang, and Ira M Hall
Structural variants are a major source of gene expression differences in humans and often affect multiple nearby genes, Alexandra J Scott, Colby Chiang, and Ira M Hall
Trichomonas vaginalis detection in urogenital specimens from symptomatic and asymptomatic men and women by use of the cobas TV/MG test, Barbara Van Der Pol, David Eisenberg, and et al
Autologous and allogeneic hematopoietic cell transplantation for diffuse large B-cell lymphoma–type Richter syndrome, Alex F. Herrera, Shalini Shenoy, and et al
Current neurologic treatment and emerging therapies in CDKL5 deficiency disorder, Heather E Olson, Judith L Weisenberg, and et al.
Genetic counseling as preventive intervention: Toward individual specification of transgenerational autism risk, Natasha Marrus, Tychele N Turner, Elizabeth Forsen, Drew Bolster, Alison Marvin, Andrew Whitehouse, Laura Klinger, Christina A Gurnett, and J N Constantino
Falls: A marker of preclinical Alzheimer disease: A cohort study protocol, Rebecca M Bollinger, Audrey Keleman, Regina Thompson, Elizabeth Westerhaus, Anne M Fagan, Tammie Ls Benzinger, Suzanne E Schindler, Chengjie Xiong, David Balota, John C Morris, Beau M Ances, and Susan L Stark
Outpatient prescription practices in patients with atrial fibrillation (from the NCDR PINNACLE registry), Jonathan C Hsu, Matthew R Reynolds, Yang Song, Gheorghe Doros, Steven A Lubitz, Anil K Gehi, Mintu P Turakhia, and Thomas M Maddox
Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota, Sanghyun Lee, Gowri Kalugotla, Harshad Ingle, Rachel Rodgers, Yating Wang, Yuhao Li, Nicolette R Borella, Hongju Deng, Lindsay Droit, Ryan Hill, Stefan T Peterson, Chandni Desai, Dylan Lawrence, Megan T Baldridge, and et al
Nanoparticle T cell engagers for the treatment of acute myeloid leukemia, Kinan Alhallak, Jennifer Sun, Barbara Muz, Amanda Jeske, Jessica Yavner, Hannah Bash, Chaelee Park, Berit Lubben, Ola Adebayo, Samuel Achilefu, John F DiPersio, and Abdel Kareem Azab
Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice, John M Thompson, Alyssa G Ashbaugh, Yu Wang, Robert J Miller, Julie E Pickett, Daniel L J Thorek, Robert S Sterling, and Lloyd S Miller
Is comprehensiveness critical? Comparing short and long format cognitive assessments in preclinical Alzheimer disease, Jason Hassenstab, Jessica Nicosia, Megan LaRose, Andrew J Aschenbrenner, Brian A Gordon, Tammie L S Benzinger, Chengjie Xiong, and John C Morris
Neuropathic pain: Biomolecular intervention and imaging via targeting microglia activation, Aijun Ji and Jinbin Xu
Expert consensus on the identification, diagnosis, and treatment of neurotrophic keratopathy, Reza Dana, Marjan Farid, Preeya K Gupta, Pedram Hamrah, Paul Karpecki, Cathleen M McCabe, Lisa Nijm, Jay S Pepose, Stephen Pflugfelder, Christopher J Rapuano, Arvind Saini, Sarah N Gibbs, and Michael S Broder
