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Submissions from 2021

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Real-world evaluation of the impact of implementation of the Virtuo blood culture system in a tertiary care hospital, Miguel A Chavez, Satish Munigala, Carey-Ann D Burnham, Melanie L Yarbrough, and David K Warren

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Structural variants are a major source of gene expression differences in humans and often affect multiple nearby genes, Alexandra J Scott, Colby Chiang, and Ira M Hall

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Structural variants are a major source of gene expression differences in humans and often affect multiple nearby genes, Alexandra J Scott, Colby Chiang, and Ira M Hall

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Trichomonas vaginalis detection in urogenital specimens from symptomatic and asymptomatic men and women by use of the cobas TV/MG test, Barbara Van Der Pol, David Eisenberg, and et al

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Autologous and allogeneic hematopoietic cell transplantation for diffuse large B-cell lymphoma–type Richter syndrome, Alex F. Herrera, Shalini Shenoy, and et al

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Current neurologic treatment and emerging therapies in CDKL5 deficiency disorder, Heather E Olson, Judith L Weisenberg, and et al.

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Genetic counseling as preventive intervention: Toward individual specification of transgenerational autism risk, Natasha Marrus, Tychele N Turner, Elizabeth Forsen, Drew Bolster, Alison Marvin, Andrew Whitehouse, Laura Klinger, Christina A Gurnett, and J N Constantino

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Falls: A marker of preclinical Alzheimer disease: A cohort study protocol, Rebecca M Bollinger, Audrey Keleman, Regina Thompson, Elizabeth Westerhaus, Anne M Fagan, Tammie Ls Benzinger, Suzanne E Schindler, Chengjie Xiong, David Balota, John C Morris, Beau M Ances, and Susan L Stark

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Outpatient prescription practices in patients with atrial fibrillation (from the NCDR PINNACLE registry), Jonathan C Hsu, Matthew R Reynolds, Yang Song, Gheorghe Doros, Steven A Lubitz, Anil K Gehi, Mintu P Turakhia, and Thomas M Maddox

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Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota, Sanghyun Lee, Gowri Kalugotla, Harshad Ingle, Rachel Rodgers, Yating Wang, Yuhao Li, Nicolette R Borella, Hongju Deng, Lindsay Droit, Ryan Hill, Stefan T Peterson, Chandni Desai, Dylan Lawrence, Megan T Baldridge, and et al

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Nanoparticle T cell engagers for the treatment of acute myeloid leukemia, Kinan Alhallak, Jennifer Sun, Barbara Muz, Amanda Jeske, Jessica Yavner, Hannah Bash, Chaelee Park, Berit Lubben, Ola Adebayo, Samuel Achilefu, John F DiPersio, and Abdel Kareem Azab

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Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice, John M Thompson, Alyssa G Ashbaugh, Yu Wang, Robert J Miller, Julie E Pickett, Daniel L J Thorek, Robert S Sterling, and Lloyd S Miller

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Is comprehensiveness critical? Comparing short and long format cognitive assessments in preclinical Alzheimer disease, Jason Hassenstab, Jessica Nicosia, Megan LaRose, Andrew J Aschenbrenner, Brian A Gordon, Tammie L S Benzinger, Chengjie Xiong, and John C Morris

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Neuropathic pain: Biomolecular intervention and imaging via targeting microglia activation, Aijun Ji and Jinbin Xu

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Expert consensus on the identification, diagnosis, and treatment of neurotrophic keratopathy, Reza Dana, Marjan Farid, Preeya K Gupta, Pedram Hamrah, Paul Karpecki, Cathleen M McCabe, Lisa Nijm, Jay S Pepose, Stephen Pflugfelder, Christopher J Rapuano, Arvind Saini, Sarah N Gibbs, and Michael S Broder

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Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization, Yan Yin, Meade E. Haller, Sangappa B. Chadchan, Ramakrishna Kommagani, and Liang Ma

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Brain white matter structure and amyloid deposition in Black and White older adults: The ARIC-PET study, Keenan A Walker, Noah Silverstein, Yun Zhou, Timothy M Hughes, Clifford R Jack, David S Knopman, A Richey Sharrett, Dean F Wong, Thomas H Mosley, and Rebecca F Gottesman

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Racial disparities in modifiable risk factors and statin usage in Black patients with familial hypercholesterolemia, Anandita Agarwala, Nathan Bekele, Elena Deych, Michael W Rich, Aliza Hussain, Laney K Jones, Amy C Sturm, Karen Aspry, Elizabeth Nowak, Zahid Ahmad, Christie M Ballantyne, and Anne C Goldberg

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Quality of life analyses in patients with multiple myeloma: Results from the Selinexor (KPT-330) Treatment of Refractory Myeloma (STORM) phase 2b study, Gabriel Tremblay, Ravi Vij, and et al.

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Social determinants of health discussed with mothers during personal visits before and during the COVID-19 pandemic, Rachel G Tabak, Cynthia D Schwarz, Allison Kemner, Shelly Johnston, Adriana Aramburu, and Debra Haire-Joshu

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Surgical and percutaneous revascularization outcomes based on SYNTAX I, II, and residual scores: A long-term follow-up study, Eduardo Bello Martins, Whady Hueb, David L Brown, Thiago Luis Scudeler, Eduardo Gomes Lima, Paulo Cury Rezende, Paulo Rogério Soares, Cibele Larrosa Garzillo, Jaime Paula Pessoa Linhares Filho, Daniel Valente Batista, Jose Antonio Franchini Ramires, and Roberto Kalil Filho

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Genome assemblies across the diverse evolutionary spectrum of Leishmania protozoan parasites, Wesley C. Warren, Natalia S. Akopyants, Deborah E. Dobson, Christiane Hertz-Fowler, Lon-Fye Lye, Peter J. Myler, Gowthaman Ramasamy, Achchuthan Shanmugasundram, Fatima Silva-Franco, Sascha Steinbiss, Chad Tomlinson, Richard K. Wilson, and Stephen M. Beverley

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HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts, Nina H Pipalia, Syed Z Saad, Kanagaraj Subramanian, Abigail Cross, Aisha Al-Motawa, Kunal Garg, Brian S J Blagg, Len Neckers, Paul Helquist, Olaf Wiest, Daniel S Ory, and Frederick R Maxfield

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MSIsensor-ct: Microsatellite instability detection using cfDNA sequencing data, Xinyin Han, Shuying Zhang, Daniel Cui Zhou, Dongliang Wang, Xiaoyu He, Danyang Yuan, Ruilin Li, Jiayin He, Xiaohong Duan, Michael C Wendl, Li Ding, and Beifang Niu

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Protection levels of N95-level respirator substitutes proposed during the COVID-19 pandemic: Safety concerns and quantitative evaluation procedures, David Ballard, Alex Scott, Broc Burke, Jason Morris, Connie Gan, Jesse Hu, Udayabhanu Jammalamadaka, Sena Sayood, Stephen Liang, Bruno Maranhao, J. Tyler Bertroche, Nirah Shomer, Pamela Woodard, Kathleen Meacham, and et al

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A comparison of machine learning classifiers for pediatric epilepsy using resting-state functional MRI latency data, Ryan D Nguyen, Matthew D Smyth, Liang Zhu, Ludovic P Pao, Shannon K Swisher, Emmett H Kennady, Anish Mitra, Rajan P Patel, Jeremy E Lankford, Gretchen Von Allmen, Michael W Watkins, Michael E Funke, and Manish N Shah

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Adrenal vein sampling for ACTH-producing pheochromocytomas, Nicholas Leader, Alexander Ushinsky, and Christopher D Malone

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Alterations of the gut mycobiome in patients with MS, Saumya Shah, Alberto Locca, Claudia Cantoni, Laura Ghezzi, Emily Evans, Robert Mikesell, Kathleen Obert, Amber Salter, Anne H Cross, Phillip I Tarr, Laura Piccio, and et al

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Alzheimer's disease alters oligodendrocytic glycolytic and ketolytic gene expression, Erin R Saito, Justin B Miller, Oscar Harari, Carlos Cruchaga, Kathie A Mihindukulasuriya, John S K Kauwe, and Benjamin T Bikman

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American Society of Transplantation and Cellular Therapy, Center of International Blood and Marrow Transplant Research, and European Society for Blood and Marrow Transplantation clinical practice recommendations for transplantation and cellular therapies in mantle cell lymphoma, Pashna N Munshi, Brad Kahl, Amanda F Cashen, and et al.

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A novel intervention combining supplementary food and infection control measures to improve birth outcomes in undernourished pregnant women in Sierra Leone: A randomized, controlled clinical effectiveness trial, David Taylor Hendrixson, Kristie Smith, Patrick Lasowski, Meghan Callaghan-Gillespie, Jacklyn Weber, Peggy Papathakis, Per Ole Iversen, Aminata Shamit Koroma, and Mark J. Manary

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Anterior cruciate ligament reconstruction with concomitant meniscal repair: Is graft choice predictive of meniscal repair success?, Hytham Salem, Laura Huston, Alexander Zajichek, Eric McCarty, Armando Vidal, Jonathan Bravman, Kurt Spindler, Rachel Frank, Annunziato Amendola, Jack Andrish, Robert Brophy, Morgan Jones, Christopher Kaeding, Robert Marx, Matthew Matava, Richard Parker, Michelle Wolcott, Brian Wolf, and Rick Wright

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A phase 1/2 open label nonrandomized clinical trial of intravenous 2-hydroxypropyl-β-cyclodextrin for acute liver disease in infants with Niemann-Pick C1, Margaret Reynolds, Laura A Linneman, Sofia Luna, Barbara B Warner, Yumirle P Turmelle, Sakil S Kulkarni, Xuntian Jiang, Geetika Khanna, Marwan Shinawi, Forbes D Porter, Daniel S Ory, F. Sessions Cole, and Patricia I Dickson

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A phase 1-2 study of rovalpituzumab tesirine in combination with nivolumab plus or minus ipilimumab in patients with previously treated extensive-stage SCLC, Jyoti Malhotra, Daniel Morgensztern, and et al.

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A phase 1 study evaluating rovalpituzumab tesirine in frontline treatment of patients with extensive-stage SCLC, Christine L. Hann, Timothy F. Burns, Afshin Dowlati, Daniel Morgensztern, Patrick J. Ward, Martina M. Koch, Chris Chen, Carrianne Ludwig, Maulik Patel, Halla Nimeiri, Philip Komarnitsky, and D. Ross Camidge

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Ascaris suum informs extrasynaptic volume transmission in nematodes, Louise E Atkinson, Yang Liu, Fiona McKay, Elke Vandewyer, Charles Viau, Allister Irvine, Bruce A Rosa, Zihui Li, Qingxiao Liang, Nikki J Marks, Aaron G Maule, Makedonka Mitreva, Isabel Beets, Lingjun Li, and Angela Mousley

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A study of elective genome sequencing and pharmacogenetic testing in an unselected population, Meagan Cochran, Kelly East, Veronica Greve, Melissa Kelly, Whitley Kelley, Troy Moore, Richard M Myers, Katherine Odom, Molly C Schroeder, and David Bick

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Bioactive in situ crosslinkable polymer-peptide hydrogel for cell delivery to the intervertebral disc in a rat model, Marcos N Barcellona, Julie E Speer, Liufang Jing, Deepanjali S Patil, Munish C Gupta, Jacob M Buchowski, and Lori A Setton

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Cognitive correlates of instrumental activities of daily living performance in Parkinson disease without dementia, Erin R Foster and Tasha Doty

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Consensus recommendations on the treatment of opioid use disorder in the emergency department, Kathryn Hawk, Jason Hoppe, Eric Ketcham, Alexis LaPietra, Aimee Moulin, Lewis Nelson, Evan Schwarz, Sam Shahid, Donald Stader, Michael P Wilson, and Gail D'Onofrio

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COVID-19 in patients with neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody disease in North America: From the COViMS Registry, Scott D Newsome, Anne H Cross, Robert J Fox, June Halper, Pamela Kanellis, Bruce Bebo, David Li, Gary R Cutter, Kottil W Rammohan, and Amber Salter

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Cryptorchidism as an obscure cause of adhesive small bowel obstruction in an adult, a case report, Savni Satoskar, Sarang Kashyap, Joshua Ziehm, Francisco Benavides, Avian Chang, and Vinay Singhal

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Differential effects of the novel neurosteroid hypnotic (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats, Srdjan M Joksimovic, Dayalan Sampath, Kathiresan Krishnan, Douglas F Covey, Vesna Jevtovic-Todorovic, Yogendra H Raol, and Slobodan M Todorovic

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Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: Results from the COVID-19 Global Rheumatology Alliance Vaccine Survey, Sebastian Eduardo Sattui, Jean Liew, Alfred Hyoungju Kim, and et al

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Efficacy and safety of belimumab in paediatric and adult patients with systemic lupus erythematosus: An across-study comparison, Hermine Brunner, Carlos Abud-Mendoza, Masaaki Mori, Clarissa Pilkington, Reema Syed, Syuji Takei, Diego Viola, Richard Furie, Sandra Navarra, Fengchun Zhang, Damon Bass, Gina Eriksson, Anne Hammer, Beulah Ji, Mohamed Okily, David Roth, Holly Quasny, and Nicolino Ruperto

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Endothelial FGF signaling is protective in hypoxia-induced pulmonary hypertension, Kel Vin Woo, Isabel Y Shen, Carla J Weinheimer, Attila Kovacs, Jessica Nigro, Chieh-Yu Lin, Murali Chakinala, Derek E Byers, and David M Ornitz

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Evaluation of admission chest X-ray findings in patients with respiratory infection during the COVID-19 pandemic, Dimitrios Velissaris, Maria Lagadinou, Themistoklis Paraskevas, Eleousa Oikonomou, Vasileios Karamouzos, Fotios Sampsonas, Markos Marangos, and Menelaos Karanikolas

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Future directions for HIV service delivery research: Research gaps identified through WHO guideline development, Nathan Ford, Ingrid Eshun-Wilson, Wole Ameyan, Morkor Newman, Lara Vojnov, Meg Doherty, and Elvin Geng

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Gut microbiome is associated with multiple sclerosis activity in children, Mary K Horton, Soe Mar, and et al

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Hypoglycemia secondary to insulinoma masking the onset of type 1 diabetes in an adolescent, Sriya Subramani, Andrew M Bellizzi, Nicholas Borcherding, Simon C Kao, Joseph Dillon, James Howe, Andrew W Norris, Michael J Tansey, and Catherina T Pinnaro

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Impact of nerve surgery on opioid and medication use in patients with chronic nerve injuries, John M Felder and Ivica Ducic

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Implementation of a non-emergent medical transportation programme at an integrated health system, Patrick G Lyons, Brett A Ramsey, Michael Welker, Megan Guinn, Janice K Ernest, Ali Kosydor, and Thomas M Maddox

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Interplay of Trypanosome Lytic Factor and innate immune cells in the resolution of cutaneous Leishmania infection, Jyoti Pant, Marie Samanovic, Maria T. Nelson, Mert K. Keceli, Joseph Verdi, Stephen M. Beverley, and Jayne Raper

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Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers, Jared M Andrews, Sarah C Pyfrom, Jennifer A Schmidt, Olivia I Koues, Rodney A Kowalewski, Nicholas R Grams, Jessica J Sun, Leigh R Berman, Eric J Duncavage, Yi-Shan Lee, Amanda F Cashen, Eugene M Oltz, and Jacqueline E Payton

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MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology, Chihiro Sato, Nipun Mallipeddi, Nupur Ghoshal, Brenton A Wright, Gregory S Day, Albert A Davis, Albert H Kim, Gregory J Zipfel, Randall J Bateman, Audrey Gabelle, and Nicolas R Barthélemy

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Memory-like differentiation enhances NK cell responses to melanoma, Nancy D Marin, Bradley A Krasnick, Michelle Becker-Hapak, Leah Conant, Simon P Goedegebuure, Melissa M Berrien-Elliott, Keenan J Robbins, Jennifer A Foltz, Mark Foster, Pamela Wong, Celia C Cubitt, Jennifer Tran, Christopher B Wetzel, Miriam Jacobs, Alice Y Zhou, David Russler-Germain, Lynne Marsala, Timothy Schappe, Ryan C Fields, and Todd A Fehniger

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Phagocytes produce prostaglandin E2 in response to cytosolic Listeria monocytogenes, Courtney E. McDougal, Zachary T. Morrow, Tighe Christopher, Seonyoung Kim, Drake Carter, David M. Stevenson, Daniel Amador-Noguez, Mark J. Miller, and John-Demian Sauer

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Reactive arthritis post-SARS-CoV-2, Faizal Ouedraogo, Rachita Navara, Rusha Thapa, and Kunj G. Patel

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Tailored stereotactic radiotherapy technique using deep inspiration breath-hold to reduce stomach dose for cardiac radioablation, Myung-Jin Cha, Phillip S Cuculich, Clifford G Robinson, and Ji Hyun Chang

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The incidence of adding-on or distal junctional kyphosis in adolescent idiopathic scoliosis treated by anterior spinal fusion to L3 was significantly higher than by posterior spinal fusion to L3, Seung-Jae Hyun, Lawrence G Lenke, Yongjung Kim, Keith H Bridwell, Meghan Cerpa, and Kathy M Blanke

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Thrombolysis improves reperfusion and the clinical outcome in tandem occlusion stroke related to cervical dissection: TITAN and ETIS pooled analysis, Gaultier Marnat, Mohammad Anadani, and et al

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Lung epithelial signaling mediates early vaccine-induced CD4 + T cell activation and Mycobacterium tuberculosis control, Shibali Das, Nancy D Marin, Ekaterina Esaulova, Mushtaq Ahmed, Amanda Swain, Bruce A Rosa, Makedonka Mitreva, Javier Rangel-Moreno, Mihai G Netea, Luis B Barreiro, Maziar Divangahi, Maxim N Artyomov, Deepak Kaushal, and Shabaana A Khader

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Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice, Sanghyun P Kim, Sridhar N Srivatsan, Monique Chavez, Cara L Shirai, Brian S White, Tanzir Ahmed, Michael O Alberti, Jin Shao, Ryan Nunley, Lynn S White, Jeff Bednarski, John R Pehrson, and Matthew J Walter

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Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease, Konstantinos-Dionysios Alysandratos, Jennifer A Wambach, F Sessions Cole, and et al

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Vesicular stomatitis virus chimeras expressing the oropouche virus glycoproteins elicit protective immune responses in mice, Sarah Hulsey Stubbs, Marjorie Cornejo Pontelli, Nischay Mishra, Changhong Zhou, Juliano de Paula Souza, Rosa Maria Mendes Viana, W Ian Lipkin, David M Knipe, Eurico Arruda, and Sean P J Whelan

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Critical care service delivery across healthcare systems in low-income and low-middle-income countries: Protocol for a systematic review, Andrew George Lim, Nicole Benzoni, and et al

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Host fecal mRNAs predicted environmental enteric dysfunction among children with moderate acute malnutrition in Sierra Leone, Akriti Singh, Isabel Potani, Stacy P Griswold, Devika Suri, Breanne Langlois, Ye Shen, Shelley M Walton, Kenneth Kwan Ho Chui, Mark J Manary, Patrick Webb, Beatrice L Rogers, and Irwin H Rosenberg

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Initial antimicrobial management of sepsis, Michael S Niederman, Rebecca M Baron, Lila Bouadma, Thierry Calandra, Nick Daneman, Jan DeWaele, Marin H Kollef, Jeffrey Lipman, and Girish B Nair

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OCT4 cooperates with distinct ATP-dependent chromatin remodelers in naïve and primed pluripotent states in human, Xin Huang, Kyoung-Mi Park, Paul Gontarz, Bo Zhang, Laura A Fischer, Chen Dong, Sabine Dietmann, Xiaoyun Xing, Shafqat A Khan, Nick Jensen, Ting Wang, Thorold W Theunissen, and et al

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Device design modifications informed by in vitro testing of bacterial attachment reduce infection rates of cochlear implants in clinical practice, Lynne Turnbull, Roger Leigh, Rosalia Cavaliere, Sarah R Osvath, Laura M Nolan, Daniel Smyth, Kristien Verhoeven, Richard A Chole, and Cynthia B Whitchurch

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Predictive accuracy and densitometric analysis of point-of-care immunoassay for adenoviral conjunctivitis, Spencer D Johnson, Mary K Migneco, Mathew S Margolis, Leonard W Haertter, Julia B Huecker, Richard S Buller, Gregory A Storch, Mae O Gordon, and et al

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Progression of SARS-CoV-2 seroprevalence in St. Louis, Missouri, through January 2021, Brittany K Smith, Andrew B Janowski, Arim C Fremont, Lucas J Adams, Ya-Nan Dai, Christopher W Farnsworth, Ann M Gronowski, Stephen M Roper, David Wang, and Daved H Fremont

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Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals, Elaine C Chen, Emma S Winkler, Rita E Chen, Michael S Diamond, and et al

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CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy, Miriam Y. Kim, Matthew L. Cooper, Miriam T. Jacobs, Julie K. Ritchey, Julia Hollaway, Todd A. Fehniger, and John F. DiPersio

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HPV transcript expression affects cervical cancer response to chemoradiation, Fiona J Ruiz, Matthew Inkman, Ramachandran Rashmi, Naoshad Muhammad, Nishanth Gabriel, Christopher A Miller, Michael D McLellan, Michael Goldstein, Stephanie Markovina, Perry W Grigsby, Jin Zhang, and Julie K Schwarz

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Improved integration of single-cell transcriptome and surface protein expression by LinQ-View, Lei Li, Christopher Nelson, Daved H Fremont, and et al.

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SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes, Mirza Muhammad Fahd Qadir, Manika Bhondeley, Wandy Beatty, Dina D Gaupp, Lara A Doyle-Meyers, Tracy Fischer, Ishitri Bandyopadhyay, Robert V Blair, Rudolf Bohm, Jay Rappaport, Eric Lazartigues, Richard S Vander Heide, Jay K Kolls, Xuebin Qin, and Franck Mauvais-Jarvis

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The use of dexmedetomidine in the emergency department: A cohort study, Joseph Sinnott, Christopher V Holthaus, Enyo Ablordeppey, Brian T Wessman, Brian W Roberts, and Brian M Fuller

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The impact of a community based rehabilitation program in Afghanistan: A longitudinal analysis using propensity score matching and difference in difference analysis, Jean-Francois Trani, Juanita Vasquez-Escallon, and Parul Bakhshi

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Association between diagnosis code expansion and changes in 30-day risk-adjusted outcomes for cardiovascular diseases, Lauren Gilstrap, Rishi K Wadhera, Andrea M Austin, Stephen Kearing, Karen E Joynt Maddox, and Robert W Yeh

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Evaluation of total body weight versus adjusted body weight liposomal amphotericin B dosing in obese patients, Michelle H Ting, Andrej Spec, Scott T Micek, David J Ritchie, and Tamara Krekel

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Favorable outcomes with reduced steroid use in juvenile dermatomyositis, Amir B Orandi, Lampros Fotis, Jamie Lai, Hallie Morris, Andrew J White, Anthony R French, and Kevin W Baszis

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Longitudinal metabolomics of human plasma reveals prognostic markers of COVID-19 disease severity, Miriam Sindelar, Ethan Stancliffe, Michaela Schwaiger-Haber, Dhanalakshmi S Anbukumar, Kayla Adkins-Travis, Charles W Goss, Jane A O'Halloran, Philip A Mudd, Wen-Chun Liu, Randy A Albrecht, Adolfo García-Sastre, Leah P Shriver, and Gary J Patti

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Rheumatic heart disease in the United States: Forgotten but not gone: Results of a 10 year multicenter review, Sarah R de Loizaga, Lakshmi R Gokanapudy Hahn, and et al

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A systematic review and network meta-analyses to assess the effectiveness of human immunodeficiency virus (HIV) self-testing distribution strategies, Ingrid Eshun-Wilson, Muhammad S Jamil, T Charles Witzel, David V Glidded, Cheryl Johnson, Noelle Le Trouneau, Nathan Ford, Kathleen McGee, Chris Kemp, Stefan Baral, Sheree Schwartz, and Elvin H Geng

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Temporal trends of COVID-19 mortality and hospitalisation rates: An observational cohort study from the US Department of Veterans Affairs, Miao Cai, Benjamin Bowe, Yan Xie, and Ziyad Al-Aly

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Differential classification of states of consciousness using envelope- and phase-based functional connectivity, Catherine Duclos, Michael S Avidan, and et al.

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Variant allele fraction of genomic alterations in circulating tumor DNA (%ctDNA) correlates with SUV, Amin Haghighat Jahromi, Matthew Zabel, Ryosuke Okamura, Carl K Hoh, and Razelle Kurzrock

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Developing methods to detect and diagnose chronic traumatic encephalopathy during life: Rationale, design, and methodology for the DIAGNOSE CTE Research Project, Michael L Alosco, Daniel S Marcus, and et al.

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Year 1 of the Bundled Payments for Care Improvement-Advanced model, Karen E Joynt Maddox, E John Orav, Jie Zheng, and Arnold M Epstein

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Ceftolozane/tazobactam versus meropenem in patients with ventilated hospital-acquired bacterial pneumonia: Subset analysis of the ASPECT-NP randomized, controlled phase 3 trial, Jean-François Timsit, Jennifer A Huntington, Richard G Wunderink, Nobuaki Shime, Marin H Kollef, Ülo Kivistik, Martin Nováček, Álvaro Réa-Neto, Ignacio Martin-Loeches, Brian Yu, Erin H Jensen, Joan R Butterton, Dominik J Wolf, Elizabeth G Rhee, and Christopher J Bruno

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A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome, Damien Abreu, Stephen I. Stone, Toni S. Pearson, Robert C. Bucelli, Ashley N. Simpson, Stacy Hurst, Cris M. Brown, Kelly Kries, Chinyere Onwumere, Hongjie Gu, James Hoekel, Lawrence Tychsen, Gregory P. Van Stavern, Neil H. White, Bess A. Marshall, Tamara Hershey, and Fumihiko Urano

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Modulation of the effects of class Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits, Wandi Zhu, Wei Wang, Paweorn Angsutararux, Rebecca L. Mellor, Lori L. Isom, Jeanne M. Nerbonne, and Jonathan R. Silva

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Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA, Hidetaka Niizuma, Adam C. Searleman, Shugaku Takeda, Scott A. Armstrong, Christopher Y. Park, Emily H. Cheng, and James J. Hsieh

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Efficient CRISPR/Cas9 mutagenesis for neurobehavioral screening in adult zebrafish, Dana Shaw and Mayssa Mokalled

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A phase I/II study of rovalpituzumab tesirine in delta-like 3-expressing advanced solid tumors, Aaron S Mansfield, Saiama N Waqar, and et al

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Effect of alteplase use on outcomes in patients with atrial fibrillation: Analysis of the Initiation of Anticoagulation after Cardioembolic Stroke study, Shadi Yaghi, James Giles, Angela Liu, Salah Keyrouz, and et al

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Reducing cardiovascular maternal mortality by extending Medicaid for postpartum women, Janki P Luther, Daniel Y Johnson, Karen E Joynt Maddox, and Kathryn J Lindley

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DAS181 treatment of severe lower respiratory tract parainfluenza virus infection in immunocompromised patients: A phase 2 randomized, placebo-controlled study, Roy F Chemaly, Francisco M Marty, Cameron R Wolfe, Steven J Lawrence, Sanjeet Dadwal, Rosemary Soave, Jason Farthing, Stephen Hawley, Paul Montanez, Jimmy Hwang, Jennifer Hui-Chun Ho, Stanley Lewis, George Wang, and Michael Boeckh

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The clear cell sarcoma functional genomic landscape, Emanuele Panza, Benjamin B Ozenberger, Krystal M Straessler, Jared J Barrott, Li Li, Yanliang Wang, Mingchao Xie, Anne Boulet, Simon Wa Titen, Clinton C Mason, Alexander J Lazar, Li Ding, Mario R Capecchi, and Kevin B Jones