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Submissions from 2024

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A dataset of digital holograms of normal and thalassemic cells, Vahid Abbasian and Arash Darafsheh

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Cathepsin C role in inflammatory gastroenterological, renal, rheumatic, and pulmonary disorders, Ali A Aghdassi, Christine Pham, Lukas Zierke, Vincent Mariaule, Brice Korkmaz, and Moez Rhimi

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Saponin TQL1055 adjuvant-containing vaccine confers protection upon Mycobacterium tuberculosis challenge in mice, Mushtaq Ahmed, Eric Farris, Rosemary V Swanson, Shibali Das, Yan Yang, Tyler Martin, and Shabaana A Khader

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DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression, Favour A Akinjiyan, Zainab Ibitoye, Peinan Zhao, Leah P Shriver, Gary J Patti, Gregory D Longmore, and Katherine C Fuh

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ARID2 mutations may relay a distinct subset of cutaneous melanoma patients with different outcomes, Favour A Akinjiyan, George Nassief, Jordan Phillipps, Tolulope Adeyelu, Andrew Elliott, Farah Abdulla, Alice Y Zhou, George Souroullas, Kevin B Kim, Ari Vanderwalde, Soo J Park, and George Ansstas

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A global multicohort study to map subcortical brain development and cognition in infancy and early childhood, Ann M Alex, Kelly Botteron, and et al.

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The association of caregiver attitudes, information sources, and trust with HPV vaccine initiation among adolescents, Akila Anandarajah, Thembekile Shato, Sarah Humble, Alan R Barnette, Heather M Brandt, Lisa M Klesges, Vetta L Sanders Thompson, and Michelle I Silver

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Public platform with 39,472 exome control samples enables association studies without genotype sharing, Mykyta Artomov, Alexander A Loboda, Maxim N Artyomov, and Mark J Daly

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An orally available compound suppresses glucagon hypersecretion and normalizes hyperglycemia in type 1 diabetes, Farzad Asadi, Subhadra C. Gunawardana, Roland E. Dolle, and David W. Piston

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Calorie restriction reduces biomarkers of cellular senescence in humans, Zaira Aversa, Susan B Racette, and et al.

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Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state, Thomas F Barrett, Bhuvic Patel, Riley D Z Mullins, Aldrin K Y Yim, Sangami Pugazenthi, Tatenda Mahlokozera, Gregory J Zipfel, Jacques A Herzog, Cameron C Wick, Nedim Durakovic, Joshua W Osbun, Matthew Shew, Craig A Buchman, Sidharth V Puram, Albert H Kim, and et al.

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Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot, Evan L. Barrios, Drew E. Del Toro, Alexandra Dram, Sandra Meszaros, Sydney Miles, Andrew H. Walton, Anne M. Drewry, Isaiah R. Turnbull, Richard S Hotchkiss, and et al.

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Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis, Denis Belitškin, Pauliina Munne, Shishir M Pant, Johanna M Anttila, Ilida Suleymanova, Kati Belitškina, Daniel Kirchhofer, James Janetka, Taivo Käsper, Sami Jalil, Jeroen Pouwels, Topi A Tervonen, and Juha Klefström

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Gut microbiome and antibiotic resistance effects during travelers' diarrhea treatment and prevention, Kevin S Blake, Drew J Schwartz, Srinand Paruthiyil, Bin Wang, Jie Ning, Harris Whiteson, Gautam Dantas, and et al.

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A quick reCAP: Discovering Cryptococcus neoformans capsule mutants, Daphne Boodwa-Ko and Tamara L Doering

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Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy, Jennifer M. Brazill, Ivana R. Shen, Clarissa S. Craft, Kristann L. Magee, Jay S. Park, Madelyn Lorenz, Amy Strickland, Natalie K. Wee, Xiao Zhang, Alec T. Beeve, Gretchen A. Meyer, Jeffrey Milbrandt, Aaron DiAntonio, and Erica L. Scheller

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Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood, Sarah J Brislin, Andrey P Anokhin, and et al.

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Virtual, augmented, and mixed reality applications for surgical rehearsal, operative execution, and patient education in spine surgery: A scoping review, Tim Bui, Miguel A Ruiz-Cardozo, Harsh S Dave, Karma Barot, Michael Ryan Kann, Karan Joseph, Sofia Lopez-Alviar, Gabriel Trevino, Samuel Brehm, Alexander T Yahanda, and Camilo A Molina

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Educating future generations of surgeons across borders: Novel global linked hybrid live cadaveric peripheral nerve surgical training course, Abdus S Burahee, Liron S. Duraku, Caroline A. Hundepool, Kyle R Eberlin, Amy Moore, Christopher J. Dy, Shalimar Abdullah, Vaikunthan Rajaratnam, J. Michiel Zuidam, and Dominic M. Power

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Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations, Mika P Cadiz, Katelin A Gibson, Kennedi T Todd, David G Nascari, Nashali Massa, Meredith T Lilley, Kimberly C Olney, Md Mamun Al-Amin, Hong Jiang, David M Holtzman, and John D Fryer

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Targeting CXCR4, VLA-4, and CXCR2 for hematopoietic stem cell mobilization, Daniel Cancilla, Michael P Rettig, Darja Karpova, Haresh Thakellapalli, Megh Singh, Marvin J Meyers, Peter G Ruminski, Stephanie Christ, Ezhilarasi Chendamarai, Feng Gao, Leah Gehrs, Julie K Ritchey, Michael Prinsen, and John F DiPersio

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DGIdb 5.0: Rebuilding the Drug-Gene Interaction Database for precision medicine and drug discovery platforms, Matthew Cannon, James Stevenson, Kathryn Stahl, Rohit Basu, Adam Coffman, Susanna Kiwala, Joshua F McMichael, Kori Kuzma, Dorian Morrissey, Kelsy Cotto, Elaine R Mardis, Obi L Griffith, Malachi Griffith, and Alex H Wagner

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Low RNA disruption during neoadjuvant chemotherapy predicts pathologic complete response absence in patients with breast cancer, Marina Elena Cazzaniga, Foluso Ademuyiwa, and et al.

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Inhibiting centrosome clustering reduces cystogenesis and improves kidney function in autosomal dominant polycystic kidney disease, Tao Cheng, Aruljothi Mariappan, Ewa Langner, Kyuhwan Shim, Jay Gopalakrishnan, and Moe R. Mahjoub

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Pectoral muscle removal in mammogram images: A novel approach for improved accuracy and efficiency, Simin Chen, Debbie L Bennett, Graham A Colditz, and Shu Jiang

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Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma, Selene Clay, Katherine Rivera-Spoljaric, and et al.

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The disordered N-terminal tail of SARS-CoV-2 Nucleocapsid protein forms a dynamic complex with RNA, Jasmine Cubuk, Jhullian J Alston, J Jeremías Incicco, Alex S Holehouse, Kathleen B Hall, Melissa D Stuchell-Brereton, and Andrea Soranno

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Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel, Vikram Dalal, Mark J Arcario, John T Petroff 2nd, Brandon K Tan, Noah M Dietzen, Michael J Rau, James A J Fitzpatrick, Grace Brannigan, and Wayland W L Cheng

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Declining prevalence of Trichomonas vaginalis diagnosed by wet mount in a cohort of U.S. women with and without HIV, Elizabeth M Daubert, Jodie Dionne, Jessica Atrio, Andrea K Knittel, Seble G Kassaye, Dominika Seidman, Amanda Long, Susan Brockmann, Igho Ofotokun, Margaret A Fischl, L Stewart Massad, and Kathleen M Weber

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A novel theta-controlled vibrotactile brain-computer interface to treat chronic pain: A pilot study, Phillip Demarest, Nabi Rustamov, James Swift, Tao Xie, Markus Adamek, Hohyun Cho, Elizabeth Wilson, Zhuangyu Han, Alexander Belsten, Nicholas Luczak, Peter Brunner, Simon Haroutounian, and Eric C Leuthardt

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Circuit-based intervention corrects excessive dentate gyrus output in the fragile X mouse model, Pan-Yue Deng, Ajeet Kumar, Valeria Cavalli, and Vitaly A Klyachko

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Selective breast/gynecologic pathology fellowship training in the United States: Experience of program directors, Mohamed Mokhtar Desouki, Ian S Hagemann, Thaer Khoury, Oluwole Fadare, Rohit Bhargava, Jennifer L Clark, Michael T Deavers, Julie M Jorns, Ashraf Khan, Ediz F Cosar, Rouzan G Karabakhtsian, Molly E Klein, Andre Pinto, and Muhammad Ali

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Thrombectomy in stroke patients with low Alberta Stroke Program Early Computed Tomography Score: Is modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 superior to mTICI 2b?, Sameh Samir Elawady, Joshua Osbun, and et al.

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Hyperbaric oxygen augments susceptibility to C. difficile infection by impairing gut microbiota ability to stimulate the HIF-1α-IL-22 axis in ILC3, José L Fachi, Laís P Pral, Helder C Assis, Sarah Oliveira, Vinícius R Rodovalho, Jefferson A C Dos Santos, Mariane F Fernandes, Valquíria A Matheus, Renata Sesti-Costa, Paulo J Basso, Marina Flóro E Silva, Niels O S Câmara, Selma Giorgio, Marco Colonna, and Marco A R Vinolo

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Reviewing the Clostridioides difficile mouse model: Insights into infection mechanisms, José L Fachi, Marco A R Vinolo, and Marco Colonna

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sc2MeNetDrug: A computational tool to uncover inter-cell signaling targets and identify relevant drugs based on single cell RNA-seq data, Jiarui Feng, S. Peter Goedegebuure, Amanda Zeng, Ye Bi, Ting Wang, Philip Payne, Li Ding, David DeNardo, William Hawkins, Ryan C. Fields, and Fuhai Li

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Responsive neurostimulation for people with drug-resistant epilepsy and autism spectrum disorder, Madeline C. Fields, Emily A. Johnson, John Zempel, and et al.

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A comparative biochemical and pathological evaluation of brain samples from knock-in murine models of Gaucher disease, Makaila L Furderer, Bahafta Berhe, Tiffany C Chen, Stephen Wincovitch, Xuntian Jiang, Nahid Tayebi, Ellen Sidransky, and Tae-Un Han

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Epidemiology and preventability of hospital-onset bacteremia and fungemia in 2 hospitals in India, Sumanth Gandra, Dorothy Sinclair, Dustin Stwalley, Jacaranda van Rheenen, David K Warren, and et al.

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Immune response to SARS-CoV-2 variants after immunization with different vaccines in Mexico, Erika Garay, Sean P J Whelan, Rebecca M DuBois, Sara M O'Rourke, Angel Eduardo Salgado-Escobar, José Esteban Muñoz-Medina, Carlos F Arias, and Susana López

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Assessing cardiac contractility from single molecules to whole hearts, Ankit Garg, Kory J. Lavine, and Michael J. Greenberg

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Optic chiasm glioma in an older adult patient, Ulviyya Gasimova, Osasu Adah, Matahi Muradova, Kaleigh Roberts, Sonika Dahiya, Rashmi Verma, and Lokesh Rukmangadachar

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Blinatumomab consolidation post-autologous stem cell transplantation in patients with diffuse large B-cell lymphoma, Armin Ghobadi, Nicole C Foley, Jared Cohen, Michael P Rettig, Amanda F Cashen, Leah Gehrs, Stephanie Christ, Emily Street, Nicholas Wallace, Julie Ritchey, Neha Mehta-Shah, Peter Westervelt, Todd A Fehniger, Brad Kahl, Nancy L Bartlett, and John F DiPersio

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Legionella pneumophila usurps host cell lipids for vacuole expansion and bacterial growth, Soma Ghosh, Saumya Bandyopadhyay, Danielle M. Smith, Sangeeta Adak, Clay F. Semenkovich, Laszlo Nagy, Michael J. Wolfgang, and Tamara J. O'Connor

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The chromatin landscape of healthy and injured cell types in the human kidney, Debora L Gisch, Jeannine Basta, Reetika Ghag, Charles Lu, Lisa Stout, Bo Zhang, Amanda Knoten, Shamim Mollah, Sanjay Jain, Michael Rauchman, and et al.

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How sex hormones affect migraine: An interdisciplinary preclinical research panel review, Frederick Godley III, John Meitzen, Hadas Nahman-Averbuch, Mary Angela O'Neal, David Yeomans, Nanette Santoro, Nina Riggins, and Lars Edvinsson

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Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus, Valentin Greigert, Iti Saraav, Juhee Son, Yinxing Zhu, Denise Dayao, Avan Antia, Saul Tzipori, William H Witola, Thaddeus S Stappenbeck, Siyuan Ding, and L David Sibley

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Pycallingcards: An integrated environment for visualizing, analyzing, and interpreting Calling Cards data, Juanru Guo, Wenjin Zhang, Xuhua Chen, Allen Yen, Lucy Chen, Christian A Shively, Daofeng Li, Ting Wang, Joseph D Dougherty, and Robi D Mitra

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Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity, Jakob Hakon, Miriana J Quattromani, Carin Sjölund, Daniela Talhada, Byungchan Kim, Slavianka Moyanova, Federica Mastroiacovo, Luisa Di Menna, Roger Olsson, Elisabet Englund, Ferdinando Nicoletti, Karsten Ruscher, Adam Q Bauer, and Tadeusz Wieloch

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Streamlined identification of clinically and functionally relevant genetic regulators of lower-tract urogenital development, Meade Haller, Yan Yin, Gabe Haller, Tian Li, Qiufang Li, Laura E Lamb, and Liang Ma

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NRF2 activation in Trp53;p16-deficient mice drives oral squamous cell carcinoma, Samera H Hamad, Rani S Sellers, Nathan Wamsley, Paul Zolkind, Travis P Schrank, Michael B Major, and Bernard E Weissman

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Outcomes of ceftriaxone compared with cefazolin or nafcillin/oxacillin for outpatient therapy for methicillin-sensitive Staphylococcus aureus bloodstream infections: Results from a large United States claims database, Yasir Hamad, Katelin B Nickel, Margaret A Olsen, and Ige A George

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The impact of patterns in linkage disequilibrium and sequencing quality on the imprint of balancing selection, Tristan J Hayeck, Yang Li, Timothy L Mosbruger, Jonathan P Bradfield, Adam G Gleason, George Damianos, Grace Tzun-Wen Shaw, Jamie L Duke, Laura K Conlin, Tychele N Turner, Marcelo A Fernández-Viña, Mahdi Sarmady, and Dimitri S Monos

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Control intervention design for preclinical and clinical trials: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable, Kathryn S Hayward, Emily J Dalton, Jessica Barth, Marian Brady, Leora R Cherney, Leonid Churilov, Andrew N Clarkson, Jesse Dawson, Sean P Dukelow, Peter Feys, Maree Hackett, Steve R Zeiler, and Catherine E Lang

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Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms, Fan He, Angelo Ba Laranjeira, Tim Kong, Shuyang Lin, Katrina J. Ashworth, Alice Liu, Nina M. Lasky, Daniel Ac Fisher, Maggie J. Cox, Mary C. Fulbright, Lilian Antunes-Heck, LaYow Yu, Molly Brakhane, Bei Gao, Stephen M. Sykes, Angelo D'Alessandro, Jorge Di Paola, and Stephen T. Oh

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Yersiniabactin is a quorum-sensing autoinducer and siderophore in uropathogenic Escherichia coli, James R Heffernan, John A Wildenthal, Hung Tran, George L Katumba, William H McCoy, and Jeffrey P Henderson

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Bioactive glycans in a microbiome-directed food for children with malnutrition, Matthew C Hibberd, Daniel M Webber, Suzanne Henrissat, Robert Y Chen, Cyrus Zhou, Hannah M Lynn, Yi Wang, Hao-Wei Chang, Evan M Lee, Janaki Lelwala-Guruge, Ye Chen, Ishita Mostafa, Subhasish Das, Mustafa Mahfuz, Michael J Barratt, Tahmeed Ahmed, Jeffrey I Gordon, and et al.

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Cognitive flexibility training for chronic pain: A randomized clinical study, Katherine J. Holzer, Marko S. Todorovic, Elizabeth A. Wilson, Aaron Steinberg, Michael S. Avidan, and Simon Haroutounian

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Androgen exposure impairs neutrophil maturation and function within the infected kidney, Teri N Hreha, Christina A Collins, Elisabeth B Cole, Rachel J Jin, and David A Hunstad

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Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma, Brendan K. Huang, Kaharu Sumino, and et al.

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Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons, Khairunisa Mohamad Ibrahim, Nicolas Massaly, Hye-Jean Yoon, Rossana Sandoval, Allie J Widman, Robert J Heuermann, Sidney Williams, William Post, Sulan Pathiranage, Tania Lintz, Azra Zec, Ashley Park, Robert W Gereau 4th, Jose A Morón, and et al.

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Patient-reported treatment response in chronic graft-versus-host disease, Annie Im, Iskra Pusic, and et al.

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A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS-FTD, Katherine E Irwin, Timothy Miller, and et al.

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Assets for integrating task-sharing strategies for hypertension within HIV clinics: Stakeholder's perspectives using the PEN-3 cultural model, Juliet Iwelunmor, Daphne Lew, and et al.

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Bridging therapy with axicabtagene ciloleucel for large B-cell lymphoma: Results from the US Lymphoma CAR-T Consortium, Michael D Jain, Miriam T Jacobs, Feng Gao, Armin Ghobadi, and et al.

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Implications of preoperative depression for lumbar spine surgery outcomes: A systematic review and meta-analysis, Saad Javeed, Braeden Benedict, Salim Yakdan, Samia Saleem, Justin K Zhang, Kathleen Botterbush, Madelyn R Frumkin, Angela Hardi, Brian Neuman, Jay F Piccirillo, Burel R Goodin, Thomas L Rodebaugh, Wilson Z Ray, Jacob K Greenberg, and et al.

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Longitudinal predictors of health-related quality of life in isolated dystonia, Johanna Junker, Joel S Perlmutter, and et al.

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Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegeneration, Michael K. Kanan, Patrick W. Sheehan, Jessica N. Haines, Pedro G. Gomez, Adya Dhuler, Collin J. Nadarajah, Zachary M. Wargel, Brittany M. Freeberg, Hemanth R. Nelvagal, Mariko Izumo, Joseph S. Takahashi, Jonathan D. Cooper, Albert A. Davis, and Erik S. Musiek

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Utilization of augmented reality head-mounted display for the surgical management of thoracolumbar spinal trauma, Michael Ryan Kann, Miguel A Ruiz-Cardozo, Samuel Brehm, Tim Bui, Karan Joseph, Karma Barot, Gabriel Trevino, Abigail Carey-Ewend, Som P Singh, Matthew De La Paz, Ahmed Hanafy, Michael Olufawo, Rujvee P Patel, Alexander T Yahanda, Alexander Perdomo-Pantoja, Magalie Cadieux, Brenton Pennicooke, Camilo A Molina, and et al.

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Overview of COVID-19 infection, treatment, and prevention in children, Carol M Kao

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Emergent microenvironments of nucleoli, Matthew R King, Kiersten M Ruff, and Rohit V Pappu

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A feasibility trial of skin surface motion-gated stereotactic body radiotherapy for treatment of upper abdominal or lower thoracic targets using a novel O-ring gantry, Kendall Kiser, Joshua Schiff, Eric Laugeman, Taeho Kim, Olga Green, Casey Hatscher, Hyun Kim, Shahed Badiyan, Matthew Spraker, Pamela Samson, Clifford Robinson, Alex Price, and Lauren Henke

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Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements, Lisa Kobayashi Frisk, Manish Verma, Faruk Bešlija, Chen-Hao P Lin, Nishighanda Patil, Sumana Chetia, Jason W Trobaugh, Joseph P Culver, and Turgut Durduran

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Knee flexion angle of fixation during anterolateral ligament reconstruction or lateral extra-articular tenodesis: A systematic review and meta-analysis of lateral extra-articular reinforcement techniques performed in conjunction with ACL reconstruction, David A Kolin, Jeffrey J Nepple, and et al.

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A phase I trial of pevonedistat in combination with ruxolitinib for the treatment of myelofibrosis, Tim Kong, Nicole Gaudin, Karyn Gordon, Maggie J Cox, Amy W Zhou, and Stephen T Oh

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The effect of breastfeeding practices of undernourished mothers in rural Sierra Leone on infant growth and mortality, Aminata Shamit Koroma, Kevin B Stephenson, Per O Iversen, Mark J Manary, and David Taylor Hendrixson

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Predicting proximal tubule failed repair drivers through regularized regression analysis of single cell multiomic sequencing, Nicolas Ledru, Parker C Wilson, Yoshiharu Muto, Yasuhiro Yoshimura, Haojia Wu, Dian Li, Amish Asthana, Stefan G Tullius, Sushrut S Waikar, Giuseppe Orlando, and Benjamin D Humphreys

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Complement receptor 1 is the human erythrocyte receptor for Plasmodium vivax erythrocyte binding protein, Seong-Kyun Lee, Cécile Crosnier, Paola Carolina Valenzuela-Leon, Brian L P Dizon, John P Atkinson, Jianbing Mu, Gavin J Wright, Eric Calvo, Karthigayan Gunalan, and Louis H Miller

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Elevating Voices, Addressing Depression, Toxic Stress, and Equity through Group Prenatal Care: A pilot study, Shannon N Lenze, Kelly McKay-Gist, Rachel Paul, Melissa Tepe, Katherine Mathews, Sara Kornfield, Cheron Phillips, Richelle Smith, Amanda Stoermer, and Ebony B Carter

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Human whole-exome genotype data for Alzheimer's disease, Yuk Yee Leung, Carlos Cruchaga, and et al.

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Primary non-function of hepatic allograft with preexisting microvesicular steatosis/foamy degeneration and mild large-droplet macrovesicular steatosis, Melissa E Limia, Xiu Li Liu, Jennifer Yu, and Kathleen Byrnes

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A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions, Runzhi Li, Yang Zan, Decai Wang, Xuequn Chen, Anmin Wang, Haoyuan Tan, Guorong Zhang, Siyuan Ding, Chen Shen, Hao Wu, and Shu Zhu

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Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury, Kim H H Liss, Muhammad Mousa, Shria Bucha, Andrew Lutkewitte, Jeremy Allegood, L Ashley Cowart, and Brian N Finck

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Rapid and accurate remethylation of DNA in Dnmt3a- deficient hematopoietic cells with restoration of DNMT3A activity, Yang Li, Haley J Abel, Michelle Cai, Taylor A LaValle, Tiankai Yin, Nichole M Helton, Amanda M Smith, Christopher A Miller, and Timothy J Ley

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A digital intervention to promote self-management self-efficacy among community-dwelling individuals with stroke: Pilot randomized controlled trial, Zhaoying Li, Yating Lei, Quoc Bui, Olivia DePaul, Ginger E Nicol, David C Mohr, Sunghoon I Lee, Mandy W M Fong, Christopher L Metts, Stephanie E Tomazin, and Alex W K Wong

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Transcription factor interactions explain the context-dependent activity of CRX binding sites, Kaiser J. Loell, Ryan Z. Friedman, Connie A. Myers, Joseph C. Corbo, Barak A. Cohen, and Michael A. White

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Direct prediction of intrinsically disordered protein conformational properties from sequence, Jeffrey M Lotthammer, Garrett M Ginell, Daniel Griffith, Ryan J Emenecker, and Alex S Holehouse

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The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses, Hongming Ma, Lucas J Adams, Saravanan Raju, Alan Sariol, Natasha M Kafai, Hana Janova, William B Klimstra, Daved H Fremont, and Michael S Diamond

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Fast and slow: Recording neuromodulator dynamics across both transient and chronic time scales, Pingchuan Ma, Peter Chen, Elizabeth I Tilden, Samarth Aggarwal, Anna Oldenborg, and Yao Chen

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Contrast response function estimation with nonparametric Bayesian active learning, Dom C P Marticorena, Quinn Wai Wong, Jake Browning, Ken Wilbur, Samyukta Jayakumar, Pinakin Gunvant Davey, Aaron R Seitz, Jacob R Gardner, and Dennis L Barbour

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Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells, Sumit K Matta, Hinissan P Kohio, Pallavi Chandra, Adam Brown, John G Doench, Jennifer A Philips, Siyuan Ding, and L David Sibley

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Disease characteristics, treatments, and outcomes of patients with pulmonary arterial hypertension treated with selexipag in real-world settings from the SPHERE registry (SelexiPag: tHe usErs dRug rEgistry), Vallerie McLaughlin, Harrison W Farber, Kristin B Highland, Anna R Hemnes, Murali M Chakinala, Kelly M Chin, Michelle Han, Michelle Cho, Tobore Tobore, Mohammad Rahman, and Nick H Kim

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Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques, Katherine McMahan, Adrianus C M Boon, and et al.

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Eosinophils restrain humoral alloimmunity after lung transplantation, Zhongcheng Mei, Yuriko Terada, Yuhei Yokoyama, Andrew E. Gelman, Daniel Kreisel, and et al.

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Lysosome-related organelles contain an expansion compartment that mediates delivery of zinc transporters to promote homeostasis, Adelita D Mendoza, Nicholas Dietrich, Chieh-Hsiang Tan, Daniel Herrera, Jennysue Kasiah, Zachary Payne, Ciro Cubillas, Daniel L Schneider, and Kerry Kornfeld

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DNA combing versus DNA spreading and the separation of sister chromatids, Alice Meroni, Sophie E Wells, Carmen Fonseca, Arnab Ray Chaudhuri, Keith W Caldecott, and Alessandro Vindigni

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Circadian immunity from bench to bedside: A practical guide, Huram Mok, Elaine Ostendorf, Alex Ganninger, Avi J. Adler, Guy Hazan, and Jeffrey A. Haspel

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Core requirements of frailty screening in the emergency department: An international Delphi consensus study, Elizabeth Moloney, Christopher R Carpenter, and et al.

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Implementation and outcomes of a pilot collaborative surgical hydrocele training in Côte d'Ivoire, Kevin Montes, Georgina Angoa, Catherine M Bjerum, Adama Guira, Olivier K Kouadio, Allassane F Ouattara, Gary J Weil, Peter U Fischer, Aboulaye Meite, Benjamin G Koudou, and Philip J Budge

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Structural biases in disordered proteins are prevalent in the cell, David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse, and Shahar Sukenik