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Submissions from 2019

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The impact of systemic precision medicine and immunotherapy treatments on brain metastases, Rowland H. Han, Gavin P. Dunn, Milan G. Chheda, and Albert H. Kim

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Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism, Oscar Harari, Li Zeran, and Arpana Agrawal

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Identification of 4-amino-thieno[2,3-d]pyrimidines as QcrB inhibitors in Mycobacterium tuberculosis, Gregory A Harrison, Anne E Mayer Bridwell, Megh Singh, Keshav Jayaraman, Leslie A Weiss, Rachel L Kinsella, Janessa S Aneke, Kelly Flentie, Miranda E Schene, Margaret Gaggioli, Samantha D Solomon, Scott A Wildman, Marvin J Meyers, and Christina L Stallings

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The role of the voltage-gated potassium channel proteins Kv8.2 and Kv2.1 in vision and retinal disease: Insights from the study of mouse gene knock-out mutations, Nathan S. Hart, Jessica K. Mountford, Valentina Voigt, Paula Fuller-Carter, Melanie Barth, Jeanne M. Nerbonne, David M. Hunt, and Livia S. Carvalho

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Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7, Breanne L. Harty, Fernanda Coelho, Sarah E. Pease-Raissi, Amit Mogha, Sarah D. Ackerman, Amy L. Herbert, Robert W. Gereau IV, Judith P. Golden, David A. Lyons, Jonah R. Chan, and Kelly R. Monk

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Molluscum contagiosum virus MC80 sabotages MHC-I antigen presentation by targeting tapasin for ER-associated degradation, Ian B. Harvey, Xiaoli Wang, and Daved H. Fremont

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A gorilla adenovirus-based vaccine against Zika virus induces durable immunity and confers protection in pregnancy, Ahmed O Hassan, Igor P Dmitriev, Elena A Kashentseva, Haiyan Zhao, Douglas E Brough, Daved H Fremont, David T Curiel, and Michael S Diamond

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White and gray matter brain development in children and young adults with phenylketonuria, Zoe Hawks, Anna M. Hood, Dov B. Lerman-Sinkoff, Joshua S. Shimony, Jerrel Rutlin, Daniel Lagoni, Dorothy K. Grange, and Desiree A. White

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Does previous hip arthroscopy affect the clinical outcomes of total hip arthroplasty?, Jacob A. Haynes, Ao Xiong, Jeffrey J. Nepple, Tonya An, Ryan M. Nunley, and John C. Clohisy

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Association of intestinal alkaline phosphatase with necrotizing enterocolitis among premature infants, Maya Heath, Rebecca Buckley, Zeromeh Gerber, Porcha Davis, Laura Linneman, Qingqing Gong, Brian Barkemeyer, Zhide Fang, Misty Good, Duna Penn, and Sunyoung Kim

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Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering, Monique R. Heitmeier, Richard C. Hresko, Rachel L. Edwards, Michael J. Prinsen, Ma Xenia G. Ilagan, Audrey R. Odom John, and Paul W. Hruz

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A multi-institutional experience of MR-guided liver stereotactic body radiation therapy, Lauren E. Henke, Olga L. Green, Parag J. Parikh, and et al

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First reported case of pediatric radiation treatment with magnetic resonance image guided radiation therapy, Lauren E. Henke, Olga L. Green, Joshua Schiff, Vivian L. Rodriguez, Sasa Mutic, Jeff Michalski, and Stephanie M. Perkins

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Postpartum diabetes screening among low income women with gestational diabetes in Missouri 2010–2015, Cynthia J. Herrick, Matthew R. Keller, Anne M. Trolard, Ben P. Cooper, Margaret A. Olsen, and Graham A. Colditz

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Mission critical partnership for infection prevention success, Karen Hoffmann and Hilary M Babcock

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Clearance of chikungunya virus infection in lymphoid tissues is promoted by treatment with an agonistic anti-CD137 antibody, Jun P. Hong, Mary K. McCarthy, Bennett J. Davenport, Thomas E. Morrison, and Michael S. Diamond

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Indirect cost of traumatic brachial plexus injuries in the United States, Thomas S. Hong, Andrea Tian, Ryan Sachar, Wilson Z. Ray, David M. Brogan, and Christopher J. Dy

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Detection of pediatric upper extremity motor activity and deficits with accelerometry, Catherine R. Hoyt, Andrew N. Van, Mario Ortega, Jonathan M. Koller, Elyse A. Everett, Annie L. Nguyen, Catherine E. Lang, Bradley L. Schlaggar, and Nico U.F. Dosenbach

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Use of the WHO Access, Watch, and Reserve classification to define patterns of hospital antibiotic use (AWaRe): An analysis of paediatric survey data from 56 countries, Yingfen Hsia, Brian R. Lee, Ann Versporten, Yonghong Yang, Julia Bielicki, Charlotte Jackson, Jason Newland, Herman Goossens, Nicola Magrini, and Mike Sharland

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Regulated phosphosignaling associated with breast cancer subtypes and druggability, Kuan-lin Huang, Yige Wu, Tina Primeau, Joshua F. McMichael, Adam D. Scott, Song Cao, Michael C. Wendl, Kimberly J. Johnson, Jason Held, Sherri Davies, R. Reid Townsend, Feng Chen, David Fenyö, Shunqiang Li, Tao Liu, Li Ding, and et al.

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Obesity counseling in obstetrics and gynecology: Provider perceptions and barriers, Sarah P. Huepenbecker, Leping Wan, Andrea Leon, Diane Rosen, John Hoff, Lindsay M. Kuroki, Katherine C. Fuh, Matthew A. Powell, David G. Mutch, Graham A. Colditz, and Andrea R. Hagemann

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LncRNA MALAT1 gene polymorphisms in coronary artery disease: A case-control study in a Chinese population, Weina Hu, Hanxi Ding, An Ouyang, Xiaohong Zhang, Qian Xu, Yunan Han, Xueying Zhang, and Yuanzhe Jin

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A randomized phase II trial of nab‐paclitaxel and gemcitabine with tarextumab or placebo in patients with untreated metastatic pancreatic cancer, Zishuo Ian Hu, Andrea Wang-Gillam, and et al

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Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania, Ehud Inbar, Jahangheer Shaik, Stefano A. Iantorno, Audrey Romano, Chukwunonso O. Nzelu, Katherine Owens, Mandy J. Sanders, Deborah Dobson, James A. Cotton, Michael E. Grigg, Stephen M. Beverley, and David Sacks

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Study of Environmental Enteropathy and Malnutrition (SEEM) in Pakistan: Protocols for biopsy based biomarker discovery and validation, Najeeha T. Iqbal, Ta-Chiang Liu, Michael J. Barratt, Vanderlene L. Kung, Jeffrey I. Gordon, and et al

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MR diffusion changes in the perimeter of the lateral ventricles demonstrate periventricular injury in post-hemorrhagic hydrocephalus of prematurity, Albert M Isaacs, Christopher D Smyser, Rachel E Lean, Dimitrios Alexopoulos, Rowland H Han, Jeffrey J Neil, Sophia A Zimbalist, Cynthia E Rogers, Yan Yan, Joshua S Shimony, and David D Limbrick

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Plasmodium Niemann-Pick Type C1-Related protein is a druggable target required for parasite membrane homeostasis, Eva S. Istvan, Sudipta Das, Suyash Bhatnagar, Josh R. Beck, Edward Owen, Manuel Llinas, Suresh M. Ganesan, Jacquin C. Niles, Elizabeth Winzeler, Akhil B. Vaidya, and Daniel E. Goldberg

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Developmental pathology of congenital kidney and urinary tract anomalies, Sanjay Jain and Feng Chen

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ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges, Arijita Jash, You W. Zhou, Diana K. Gerardo, Tyler J. Ripperger, Bijal A. Parikh, Sytse Piersma, Deepa R. Jamwal, Pawel R. Kiela, Adrianus C. M. Boon, Wayne M. Yokoyama, Chyi S. Hsieh, and Deepta Bhattacharya

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Omics driven understanding of the intestines of parasitic nematodes, Douglas P. Jasmer, Bruce A. Rosa, Rahul Tyagi, and Makedonka Mitreva

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A multimodality approach to assessing Factor I genetic variants in atypical hemolytic uremic syndrome, Anuja Java, Nicola Pozzi, Latisha D Love-Gregory, Jonathan W Heusel, Yun Ju Sung, Zheng Hu, Paula Bertram, M Kathryn Liszewski, Laura M Cline, Zhen Ren, and John P Atkinson

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Volvulus of the ileal pouch-anal anastomosis: A meta-narrative systematic review of frequency, diagnosis, and treatment outcomes, Muhammad Jawoosh, Samir Haffar, Parakkal Deepak, Alyssa Meyers, Amy L. Lightner, David W. Larson, Laura H. Raffals, M Hassan Murad, Navtej Buttar, and Fateh Bazerbachi

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Multicenter clinical evaluation of Etest meropenem-vaborbactam (bioMérieux) for susceptibility testing of Enterobacterales (Enterobacteriaceae) and Pseudomonas aeruginosa, Sophonie Jean, Sheri Garrett, Claire Anglade, Laurence Bridon, Leanne Davies, Omai B Garner, Jennifer Richards, Meghan Wallace, Mandy Wootton, and Carey-Ann D. Burnham

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The Brief Case: Erysipelothrix bacteremia and endocarditis in a 59-year-old immunocompromised male on chronic high-dose steroids, Sophonie Jean, William Lainhart, and Melanie Y. Yarbrough

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Culture of rectal swab specimens for enteric bacterial pathogens decreases time to test result while preserving assay sensitivity compared to bulk fecal specimens, Sophonie Jean, Melanie L. Yarbrough, Neil W. Anderson, and Carey-Ann D. Burnham

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CarD and RbpA modify the kinetics of initial transcription and slow promoter escape of the Mycobacterium tuberculosis RNA polymerase, Drake Jensen, Ana R. Manzano, Christina L. Stallings, and Eric A. Galburt

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p62/SQSTM1 and selective autophagy in cardiometabolic diseases, Se-Jin Jeong, Xiangyu Zhang, Astrid Rodriguez-Velez, Trent D. Evans, and Babak Razani

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Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1, Hongbing Jiang, Christian Leung, Stephen Tahan, and David Wang

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Hospital volume and outcomes for acute pulmonary embolism: Multinational population based cohort study, David Jimenez, Behnood Bikdeli, Andres Quezada, Alfonso Muriel, Jose Luis Lobo, Javier de Miguel-Diez, Luis Jara-Palomares, Pedro Ruiz-Artacho, Roger D. Yusen, Manuel Monreal, and RIETE investigators

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Transcriptional and epigenetic regulation of cardiac electrophysiology, Jesus Jimenez and Stacey L Rentschler

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The shift of obesity burden by socioeconomic status between 1998 and 2017 in Latin America and the Caribbean: A cross-sectional series study, Safia S Jiwani, Rodrigo M Carrillo-Larco, Akram Hernández-Vásquez, Tonatiuh Barrientos-Gutiérrez, Ana Basto-Abreu, Laura Gutierrez, Vilma Irazola, Ramfis Nieto-Martínez, Bruno P Nunes, Diana C Parra, and J Jaime Miranda

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Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma, Tanner M. Johanns, Christopher A. Miller, Connor J. Liu, Richard J. Perrin, Diane Bender, Dale K. Kobayashi, Jian L. Campian, Michael R. Chicoine, Ralph G. Dacey, Jiayi Huang, Edward F. Fritsch, William E. Gillanders, Maxim N. Artyomov, Elaine R. Mardis, Robert D. Schreiber, and Gavin P. Dunn

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A hypothesis-generating study of the combination of aspirin plus macrolides in patients with severe community-acquired pneumonia, Christopher Jones, Marin Kollef, and et al

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Predictors of radiographic osteoarthritis 2 to 3 years after anterior cruciate ligament reconstruction: Data from the MOON on-site nested cohort, Morgan H. Jones, Robert H. Brophy, MOON Knee Group, and et al

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Outcomes and cost-minimization analysis of cement spacers versus expandable cages for posterior-only reconstruction of metastatic spine corpectomies, Yusef Jordan, Jacob M. Buchowski, Mahati Mokkarala, Colleen Peters, and David B. Bumpass

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Consumption of animal-source protein is associated with improved height-for-age z scores in rural Malawian children aged 12–36 months, Yankho Kaimila, Oscar Divala, Sophia E. Agapova, Kevin B. Stephenson, Chrissie Thakwalakwa, Indi Trehan, Mark J. Manary, and Kenneth M. Maleta

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Changes in serum albumin and other nutritional markers when using sucroferric oxyhydroxide as phosphate binder among hemodialysis patients: A historical cohort study, Kamyar Kalantar-Zadeh, Linda H Ficociello, Vidhya Parameswaran, Nicolaos V Athienites, Claudy Mullon, Robert J Kossmann, and Daniel W Coyne

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Investigating the effects of stove emissions on ocular and cancer cells, Bedia Begüm Karakoçak, Sameer Patel, Nathan Ravi, and Pratim Biswas

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A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies, Celeste M Karch, Rita Martinez, Jacob A Marsh, Simon Hsu, Nupur Ghoshal, Joanne Norton, Nigel J Cairns, and et al

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Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia, Celeste M. Karch, Natalie L. Wen, and et al.

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The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain, Vyacheslav R. Karolis, Maurizio Corbetta, and Michel Thiebaut de Schotten

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Mobilized peripheral blood: An updated perspective, Darja Karpova, Michael P Rettig, and John F DiPersio

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Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells, Darja Karpova, Michael P. Rettig, Julie Ritchey, Daniel Cancilla, Stephanie Christ, Leah Gehrs, Ezhilarasi Chendamarai, Matthew Holt, Jingzhu Zhang, Grazia Abou-Ezzi, Hamza Celik, Wei Yang, Feng Gao, Linda G. Eissenberg, Peter G. Ruminski, Daniel C. Link, John F. Dipersio, and et al

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High MYC mRNA expression is more clinically relevant than MYC DNA amplification in triple-negative breast cancer, Eriko Katsuta, Li Yan, Takashi Takeshita, Kerry-Ann McDonald, Subhamoy Dasgupta, Mateusz Opyrchal, and Kazuaki Takabe

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Lack of fractalkine receptor on macrophages impairs spontaneous recovery of ribbon synapses after moderate noise trauma in C57BL/6 mice, Tejbeer Kaur, Anna C. Clayman, Andrew J. Nash, Angela D. Schrader, Mark E. Warchol, and Kevin K. Ohlemiller

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Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine, Makiko Kawaguchi, Koji Yamamoto, Naoki Takeda, Tsuyoshi Fukushima, Fumiki Yamashita, Katsuaki Sato, Kenichiro Kitamura, Yoshitaka Hippo, James W. Janetka, and Hiroaki Kataoka

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The impact of surgeon volume and training status on implant alignment in total knee arthroplasty, Gregory S Kazarian, Charles M Lawrie, Toby N Barrack, Matthew J Donaldson, Gary M Miller, Fares S Haddad, and Robert L Barrack

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Pharmacomechanical Catheter-Directed Thrombolysis in Acute Femoral-Popliteal Deep Vein Thrombosis: Analysis from a Stratified Randomized Trial, Clive Kearon, Chu-Shu Gu, Jim Julian, Samuel Goldhaber, Anthony Comerota, Heather Gornik, Timothy Murphy, Laurence Lewis, Susan Kahn, Andrei Kindzelski, Dennis Slater, Randolph Geary, Ronald Winokur, Kannan Natarajan, Alan Dietzek, Daniel Leung, Stanley Kim, and Suresh Vedantham

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Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers, Niraja Kedia, Khalid Arhzaouy, Sara K. Pittman, Yuanzi Sun, Mark Batchelor, Conrad C. Weihl, and Jan Bieschke

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Mechanisms underlying bone loss associated with gut inflammation, Ke Ke, Manoj Arra, and Yousef Abu-Amer

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Comparative evaluation of enteric bacterial culture and a molecular multiplex syndromic panel in children with acute gastroenteritis, Thomas Kellner, Brandon Parsons, Linda Chui, Byron M. Berenger, Jianling Xie, Carey-Ann D. Burnham, Phillip I. Tarr, Bonita E. Lee, Alberto Nettel-Aguirre, Jonas Szelewicki, Otto G. Vanderkooi, Xiao-Li Pang, Nathan Zelyas, Stephen B. Freedman, and Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE)

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Operative versus nonoperative treatment for adult symptomatic lumbar scoliosis, Michael P. Kelly, Elizabeth L. Yanik, Christine R. Baldus, Jacob M. Buchowski, Munish C. Gupta, Lukas P. Zebala, Keith H. Bridwell, and et al

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Shared and specific genetic risk factors for lifetime major depression, depressive symptoms and neuroticism in three population-based twin samples, Kenneth S Kendler, Charles O Gardner, Michael C Neale, Steve Aggen, Andrew Heath, Lucía Colodro-Conde, Baptiste Couvyduchesne, Enda M Byrne, Nicholas G Martin, and Nathan A Gillespie

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2-pyrrolidinone and succinimide as clinical screening biomarkers for GABA-transaminase deficiency: Anti-seizure medications impact accurate diagnosis, Adam D. Kennedy, Kirk L. Pappan, Taraka Donti, Mauricio R. Delgado, Marwan Shinawi, Toni S. Pearson, Seema R. Lalani, William E. Craigen, V. Reid Sutton, Anne M. Evans, Qin Sun, Lisa T. Emrick, and Sarah H. Elsea

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Treatment of T3N0 non-small cell lung cancer with chest wall invasion using stereotactic body radiotherapy, William R. Kennedy, Prashant Gabani, John Nikitas, Pamela P. Samson, Clifford G. Robinson, Jeffrey D. Bradley, and Michael C. Roach

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Targeting innate immunity for tuberculosis vaccination, Shabaana A. Khader, Maziar Divangahi, Willem Hanekom, Philip C. Hill, Markus Maeurer, Karen W. Makar, Katrin D. Mayer-Barber, Musa M. Mhlanga, Elisa Nemes, Larry S. Schlesinger, Reinout van Crevel, Ramakrishna Vankalayapati, Ramnik J. Xavier, Mihai G. Netea, and on behalf of the Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group

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HIV-1 and SIV Infection are associated with early loss of lung interstitial CD4+ T cells and dissemination of pulmonary tuberculosis, Shabaana A. Khader and et al

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Association of blood concentrations of complement split product iC3b and serum C3 with systemic lupus erythematosus disease activity, Alfred H J Kim, Vibeke Strand, Deepali P Sen, Qiang Fu, Nancy L Mathis, Martin J Schmidt, Robin R Bruchas, Nick R Staten, Paul K Olson, Chad M Stiening, and John P Atkinson

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Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses, Kyunghee X. Kim, Shelby Payne, Aizhen Yang-Hood, Song-Zhe Li, Bethany Davis, Jason Carlquist, Babak V-Ghaffari, Jay A. Gantz, Dorina Kallogjeri, James A.J. Fitzpatrick, Kevin K. Ohlemiller, Keiko Hirose, and Mark A. Rutherford

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Three discipline collaborative radiation therapy (3DCRT) special debate: Equipment development is stifling innovation in radiation oncology, Leonard Kim, Stephanie Markovina, Samantha J Van Nest, Subarna Eisaman, Lakshmi Santanam, Julie M Sullivan, Michael Dominello, Michael C Joiner, and Jay Burmeister

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Provisional Tic Disorder is not so transient, Soyoung Kim, Deanna J. Greene, Emily C. Bihun, Jonathan M. Koller, Jacqueline M. Hampton, Haley Acevedo, Angela M. Reiersen, Bradley L. Schlaggar, and Kevin J. Black

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A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ, Wan Shin Kim, Zachary A. Shalit, Sidney M. Nguyen, Emmalie Schoepke, Alan Eastman, Thomas P. Burris, Arti B. Gaur, and Glenn C. Micalizio

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Protocol for the effectiveness of an anesthesiology control tower system in improving perioperative quality metrics and clinical outcomes: The TECTONICS randomized, pragmatic trial, Christopher R King, Joanna Abraham, Thomas G Kannampallil, Bradley A Fritz, Arbi Ben Abdallah, Yixin Chen, Bernadette Henrichs, Mary Politi, Brian A Torres, Angela Mickle, Thaddeus P Budelier, Sherry McKinnon, Stephen Gregory, Sachin Kheterpal, Troy Wildes, Michael S Avidan, and TECTONICS Research Group

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Obstructive sleep apnoea, positive airway pressure treatment and postoperative delirium: Protocol for a retrospective observational study, Christopher R King, Krisztina E Escallier, Yo-El S Ju, Nan Lin, Ben Julian Palanca, Sherry Lynn McKinnon, and Michael Simon Avidan

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Dissemination and stakeholder engagement practices among dissemination & implementation scientists: Results from an online survey, Christopher E. Knoepke, M. Pilar Ingle, Daniel D. Matlock, Ross C. Brownson, and Russell E. Glasgow

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Characterization and validation of an intra-fraction motion management system for masked-based radiosurgery, Nels C. Knutson, Douglas Bollinger, S. Murty Goddu, James A. Kavanaugh, Lakshmi Santanam, Timothy J. Mitchell, Jacqueline E. Zoberi, Christina Tsien, Jiayi Huang, Clifford G. Robinson, Stephanie M. Perkins, Joshua L. Dowling, Michael R. Chicoine, Keith M. Rich, Gavin P. Dunn, Sasa Mutic, and et al

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Mouse model recapitulates the phenotypic heterogeneity of human adult T-cell leukemia/lymphoma in bone, Nicole A. Kohart, Said M. Elshafae, Wachirapan Supsahvad, Aylin Alasonyalilar-Demirer, Amanda R. Panfil, Jingyu Xiang, Wessel P. Dirksen, Deborah J. Veis, Patrick L. Green, Katherine N. Weilbaecher, and Thomas J. Rosol

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Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape, Abimbola O. Kolawole, Andrew B Janowski, David Wang, Christiane E. Wobus, and et al.

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Cherenkov luminescence imaging of shallow sources in semitransparent media, Sergey Komarov, Yongjian Liu, and Yuan-Chuan Tai

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Gestational weight gain and group prenatal care: A systematic review and meta-analysis, Michelle A. Kominiarek, Adam K. Lewkowitz, Ebony Carter, Susan A. Fowler, and Melissa Simon

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Nonlinear Z-score modeling for improved detection of cognitive abnormality, John Kornak, Nupur Ghoshal, Lynne Jones, and et al

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Associations of mitochondrial and nuclear mitochondrial variants and genes with seven metabolic traits, Aldi T. Kraja, Charles Gu, Mary F. Feitosa, Shiow J. Lin, Lihua Wang, Mary J. Wojczynski, Ruteja A. Barve, Ping An, Thomas J. Baranski, E. Warwick Daw, Lisa de Las Fuentes, Latisha D. Love-Gregory, Christine Williams, Wei Yang, D. C. Rao, Victor G. Davila-Roman, Michael Province, and et al

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Predictors of disease-free and overall survival in retroperitoneal sarcomas: A modern 16-year multi-institutional study from the United States Sarcoma Collaboration (USSC), Bradley A. Krasnick, Ryan C. Fields, and et al.

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Staphylococcus aureus infects osteoclasts and replicates intracellularly, Jennifer L Krauss, Philip M Roper, Anna Ballard, Chien-Cheng Shih, James A J Fitzpatrick, James E Cassat, Pei Ying Ng, Nathan J Pavlos, and Deborah J Veis

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Doubled lifespan and patient‐like pathologies in progeria mice fed high‐fat diet, Ray Kreienkamp, Cyrielle Billon, Gonzalo Bedia-Diaz, Carolyn J. Albert, Zacharie Toth, Andrew A. Butler, Sara McBride-Gagyi, David A. Ford, Angel Baldan, Thomas P. Burris, and Susana Gonzalo

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7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects, Andrew C. Kruegel, Rajendra Uprety, Steven G. Grinnell, Cory Langreck, Elizabeth A. Pekarskaya, Valerie Le Rouzic, Michael Ansonoff, Madalee M. Gassaway, John E. Pintar, Gavril W. Pasternak, Jonathan A. Javitch, Susruta Majumdar, and Dalibor Sames

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Conservation and global distribution of non-canonical antigens in enterotoxigenic Escherichia coli, F. Matthew Matthew Kuhlmann, John Martin, Tracy H. Hazen, Tim J. Vickers, Madeline Pashos, Pablo C. Okhuysen, Oscar G. Gómez-Duarte, Elizabeth Cebelinski, Dave Boxrud, Felipe Del Canto, Roberto Vidal, Firdausi Qadri, Makedonka Mitreva, David A. Rasko, and James M. Fleckenstein

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Intestinal macromolecular transport supporting adaptive immunity, Devesha H. Kulkarni and Rodney D. Newberry

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Durability of symptomatic responses obtained with adjunctive vagus nerve stimulation in treatment-resistant depression, Arun Kumar, Mark T. Bunker, Scott T. Aaronson, Charles R. Conway, Anthony J. Rothschild, Giacomo Mordent, and Augustus J. Rush

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Genome-wide analysis of heterogeneous nuclear ribonucleoprotein (hnRNP) binding to HIV-1 RNA reveals a key role for hnRNP H1 in alternative viral mRNA splicing, Sebla B. Kutluay, Ann Emery, Srinivasa R. Penumutchu, Dana Townsend, Kasyap Tenneti, Michaela K. Madison, Amanda M. Stukenbroeker, Chelsea Powell, David Jannain, Blanton S. Tolbert, Ronald I. Swanstrom, and Paul D. Bieniasz

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A national survey of testing and management of asymptomatic carriage of C. difficile, Preeta K. Kutty, Susan E. Beekmann, Ronda L. Sinkowitz-Cochran, Erik R. Dubberke, David T. Kuhar, L. C. McDonald, and Philip M. Polgreen

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Trends in medical imaging during pregnancy in the United States and Ontario, Canada, 1996 to 2016, Marilyn L. Kwan, James R. Duncan, and et al

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Proteomic and phosphoproteomic analysis reveals that neurokinin-1 receptor (NK1R) blockade with aprepitant in human keratinocytes activates a distinct subdomain of EGFR signaling: Implications for the anti-pruritic activity of NK1R antagonists, Shawn G Kwatra, Emily Boozalis, Amy H Huang, Cory Nanni, Raveena Khanna, Kyle A Williams, Yevgeniy R Semenov, Callie M Roberts, Robert F Burns, Madison Krischak, and Madan M Kwatra

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Impact of an electronic hard-stop clinical decision support tool to limit repeat Clostridioides difficile toxin enzyme immunoassay testing on test utilization, Jennie H Kwon, Kimberly A Reske, Tiffany Hink, Ronald Jackups, Carey-Ann D Burnham, and Erik R Dubberke

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Application of an antibiotic spectrum index in the neonatal intensive care unit, Alexandra C Lahart, Christopher C McPherson, Jeffrey S Gerber, Barbara B Warner, Brian R Lee, and Jason G Newland

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Importance of the conserved carboxyl-terminal CNOT1 binding domain to tristetraprolin activity in vivo, Wi S. Lai, Deborah J. Stumpo, Melissa L. Wells, Artion Gruzdev, Stephanie N. Hicks, Cindo O. Nicholson, Zhengfeng Yang, Roberta Faccio, Michael W. Webster, Lori A. Passmore, and Perry J. Blackshear

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A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys, Blue B. Lake, Song Chen, Masato Hoshi, Nongluk Plongthongkum, Diane Salamon, Amanda Knoten, Anitha Vijayan, Ramakrishna Venkatesh, Eric H. Kim, Derek Gao, Joseph Gaut, Kun Zhang, and Sanjay Jain

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Chitosan biosynthesis and virulence in the human fungal pathogen Cryptococcus gattii, Woei C Lam, Rajendra Upadhya, Charles A Specht, Abigail E Ragsdale, Camaron R Hole, Stuart M Levitz, and Jennifer K Lodge

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Disparities in health information-seeking behaviors and fatalistic views of cancer by sexual orientation identity: A nationally representative study of adults in the United States, Marvin E. Langston, Lindsay Fuzzell, Marquita W. Lewis-Thames, Saira Khan, and Justin X. Moore

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Multicenter study demonstrates standardization requirements for mold identification by MALDI-TOF MS, Anna F. Lau, Kaitlin F. Mitchell, Meghan A. Wallace, Carey-Ann D. Burnham, and et al