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Submissions from 2025

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Evaluating and optimizing just-in-time adaptive interventions in a digital mental health intervention (Wysa for Chronic Pain) for middle-aged and older adults with chronic pain: Protocol for a series of randomized trials, Abby L Cheng, Joanna Abraham, Sarah M Hartz, Eric B Laber, and J Philip Miller

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The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway, Hao Chen, Cole J Ferguson, Dylan C Mitchell, Isabel Risch, Amanda Titus, Joao A Paulo, Andrew Hwang, Loren K Beck, Tsen-Hsuan Lin, Sheng-Kwei Song, Carla M Yuede, Hiroko Yano, Obi L Griffith, Malachi Griffith, Steven P Gygi, Azad Bonni, Albert H Kim, and et al.

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Conventional versus advanced imaging selection for endovascular treatment of basilar artery occlusion strokes, Huanwen Chen, Joshua Osbun, and et al.

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Long-acting recombinant IL-7 (rhIL-7-hyFc) enhances the primary and memory neoantigen-specific immune response to breast cancer personalized cancer vaccines, Michael Chen, Thomas Kane, Ina Chen, Suangson Supabphol, Xiuli Zhang, Alexandra A Wolfarth, Donghoon Choi, Lijin Li, S Peter Goedegebuure, and William E Gillanders

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Multi-omic and spatial analysis of mouse kidneys highlights sex-specific differences in gene regulation across the lifespan, Siqi Chen, Ruiyang Liu, Chia-Kuei Mo, Michael C Wendl, Andrew Houston, Preet Lal, Yanyan Zhao, Wagma Caravan, Andrew T Shinkle, Atieh Abedin-Do, Nataly Naser Al Deen, Kazuhito Sato, Xiang Li, André Luiz N Targino da Costa, Yize Li, Alla Karpova, John M Herndon, Maxim N Artyomov, Joshua B Rubin, Sanjay Jain, Sheila A Stewart, Li Ding, Feng Chen, and et al.

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Innovations in intestinal organoid technology featuring an open apical surface, Ye Chen and Yi Wang

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Common and specific gene regulatory programs in zebrafish caudal fin regeneration at single-cell resolution, Yujie Chen, Yiran Hou, Qinglin Zeng, Irene Wang, Meiru Shang, Kwangdeok Shin, Christopher Hemauer, Xiaoyun Xing, Junsu Kang, Guoyan Zhao, and Ting Wang

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EchoLLM: Extracting echocardiogram entities with light-weight, open-source large language models, Jonathan Chi, Yazan Rouphail, Ethan Hillis, Ningning Ma, An Nguyen, Jane Wang, Mackenzie Hofford, Aditi Gupta, Patrick G Lyons, Adam Wilcox, Albert M Lai, Philip R O Payne, Marin H Kollef, Caitlin Dreisbach, and Andrew P Michelson

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Rates of hospitalization and death due to COVID-19 in US veterans with SARS-COV-2 infection in the XBB-, JN.1-, and KP-predominant eras, Taeyoung Choi, Yan Xie, and Ziyad Al-Aly

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Proximity proteomics provides a new resource for exploring the function of Afadin and the complexity of cell-cell adherens junctions, Wangsun Choi, Dennis Goldfarb, Feng Yan, Michael B Major, Alan S Fanning, and Mark Peifer

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Independent origins and non-parallel selection signatures of triclabendazole resistance in Fasciola hepatica, Young-Jun Choi, Bruce A Rosa, Martha V Fernandez-Baca, Rodrigo A Ore, John Martin, Pedro Ortiz, Cristian Hoban, Miguel M Cabada, and Makedonka Mitreva

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Variation in recommended treatment strategies among American surgeons for actual adult traumatic brachial plexus injury cases, Michele N Christy, Christopher J Dy, R Glenn Gaston, Bryan J Loeffler, Mihir J Desai, Steve K Lee, Harvey Chim, Jeffrey B Friedrich, Sameer K Puri, Jason H Ko, and PLANeT Study Group

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Influenza vaccine effectiveness against medically attended outpatients illness, United States, 2023-2024 season, Jessie R Chung, Stacey L House, Tara Curley, and et al.

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Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect, Joseph Cichon, Thomas T Joseph, Xinguo Lu, Andrzej Z Wasilczuk, Max B Kelz, Steven J Mennerick, Charles F Zorumski, and Peter Nagele

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Functions of communication during emergency care of children with medical complexity: Caregiver perspectives, Julia A Ciurria, Jennifer Reyes Lin, Cassandra M Pruitt, and Bryan A Sisk

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Sex-specific divergences in the types and timing of infiltrating immune cells during the intervertebral disc acute injury response and their associations with degeneration, Sade W Clayton, Remy E Walk, Laura Mpofu, Garrett W D Easson, and Simon Y Tang

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Phospho-relay feedback loops control egress vs. intracellular development in Toxoplasma gondii, Ja E Claywell, Yong Fu, and L David Sibley

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Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain, Kelsey H Collins, Kristin L Lenz, Hope D Welhaven, Erica Ely, Luke E Springer, Sophie Paradi, Ruhang Tang, Lauryn Braxton, Antonina Akk, Huimin Yan, Bo Zhang, Xiaobo Wu, John P Atkinson, Arin K Oestreich, Ron K June, Christine T N Pham, and Farshid Guilak

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Compositional variation in eye-infiltrating immune cells distinguishes human uveitis subtypes, Christian Concepcion, Yu Xia, Yulia Korshunova, Gregory W Bligard, Amal Taylor, Michael A Paley, Philip A Ruzycki, and Lynn M Hassman

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ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep, Nicholas J Constantino, Caitlin M Carroll, Holden C Williams, Hemendra J Vekaria, Carla M Yuede, Kai Saito, Patrick W Sheehan, J Andy Snipes, Marcus E Raichle, Erik S Musiek, Patrick G Sullivan, Josh M Morganti, Lance A Johnson, and Shannon L Macauley

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The trapping of live neutrophils by macrophages during infection, Kelley N Cooper, Marina Terekhova, Barbara Potempa, Ana D'Aubeterre, Jerome Timbol, Si An Chen, Antoine Dufour, Shunying Jin, Maxim N Artyomov, Jan Potempa, and Juhi Bagaitkar

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Generation and characterization of a knockout mouse of an enhancer of EBF3, Emily Cordova Hurtado, Janine M Wotton, Alexander Gulka, Crystal Burke, Jeffrey K Ng, Ibrahim Bah, Juana Manuel, Hillary Heins, Stephen A Murray, David U Gorkin, Jacqueline K White, Kevin A Peterson, and Tychele N Turner

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Global guideline for the diagnosis and management of candidiasis: An initiative of the ECMM in cooperation with ISHAM and ASM, Oliver A. Cornely, Andrej Spec, and et al.

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Effects of the gut microbiota on placental angiogenesis and intrauterine growth in gnotobiotic mice, Reyan Coskun, ZeNan L Chang, Athziri Marcial Rodríguez, Haoxin Liu, Jiye Cheng, Yael Alippe, Michael S Diamond, and Jeffrey I Gordon

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SaLuDo: A randomized phase IIb/III study of lurbinectedin plus doxorubicin as first-line treatment in leiomyosarcoma, Gregory M Cote, Mia C Weiss, and et al.

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Hybrid reference genome assemblies for Leishmania (Viannia) braziliensis, a primary agent of mucocutaneous leishmaniasis, James A Cotton, Frederik Van den Broeck, Peter J Myler, Natalia S Akopyants, Matthew Berriman, and Stephen M Beverley

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Measuring stigma in pediatric oncology: A cross-sectional analysis of three global sites, Lara E Counts, Sara M Malone, and et al.

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Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development, Ya'el Courtney, Joshua P Head, Neil Dani, Olga V. Chechneva, Frederick B Shipley, Yong Zhang, Michael J Holtzman, Cameron Sadegh, Towia A Libermann, and Maria K Lehtinen

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Dendritic atoh1a+ cells serve as Merkel cell precursors during skin development and regeneration, Evan W Craig, Erik C Black, Samantha Z Fernandes, Ahlan S Ferdous, Camille E A Goo, Sheridan M Sargent, Elgene J A Quitevis, Avery Angell Swearer, Nathaniel G Yee, Jimann Shin, Lilianna Solnica-Krezel, and Jeffrey P Rasmussen

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BCLAF1 restrains stress responses in hematopoietic stem cells to support expansion and repopulation, Stephanie J Crowley, Wei Yang, Lynn S White, Jun Wu, Yanan Li, Haley Schmidt, Kyunghee Choi, Jeffrey A Magee, and Jeffrey J Bednarski

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TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity, Huachun Cui, Sami Banerjee, Na Xie, Musaddique Hussain, Ashish Jaiswal, Hongli Liu, Tejaswini Kulkarni, Veena B Antony, Rui-Ming Liu, Marco Colonna, and Gang Liu

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Severe aortic stenosis and chronic myeloid leukemia: Considerations for valve management, Rebecca Cunningham, Sang Gune K Yoo, Alexander A Brescia, Karolyn A Oetjen, Iskra Pusic, and Joshua D Mitchell

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Preterm birth increases susceptibility to hyperglycemia induced glomerular alterations in male mice, Aleksandra Cwiek, Kevin M Bennett, Edwin J Baldelomar, and et al.

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Progression of otologic and nasal symptoms in primary ciliary dyskinesia throughout childhood, Isabelle Dagher, Adam J Kimple, Thomas W Ferkol, Scott D Sagel, Sharon D Dell, Carlos E Milla, Lang Li, Feng-Chang Lin, Kelli M Sullivan, Maimoona A Zariwala, Michael R Knowles, Margaret Rosenfeld, Margaret W Leigh, Stephanie D Davis, and Genetic Disorders of Mucociliary Clearance Consortium

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Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes, Vikram Dalal, Brandon K Tan, Hanrui Xu, and Wayland W L Cheng

Utility of caregiver signaling questions to detect neurocognitive impairment in children with sickle cell disease, Christina M Dandar, Lakia Kearson, Jennifer N Longoria, Brian Potter, Allison A King, Jeffrey Gossett, Clifford M Takemoto, Jane S Hankins, Guolian Kang, and Andrew M Heitzer

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Utility of caregiver signaling questions to detect neurocognitive impairment in children with sickle cell disease, Christina M Dandar, Lakia Kearson, Jennifer N Longoria, Brian Potter, Allison A King, Jeffrey Gossett, Clifford M Takemoto, Jane S Hankins, Guolian Kang, and Andrew M Heitzer

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U-rich elements drive pervasive cryptic splicing in 3' UTR massively parallel reporter assays, Khoa Dao, Courtney F Jungers, Sergej Djuranovic, and Anthony M Mustoe

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An explainable AI approach for mapping multivariate regional brain age and clinical severity patterns in Alzheimer's disease, Gauri Darekar, Taslim Murad, Hui-Yuan Miao, Deepa S Thakuri, Alzheimer’s Disease Neuroimaging Initiative, and Ganesh B Chand

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DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion, Mili Das, Suzanne E Hile, Jennifer Brewster, Jan Leendert Boer, Rachel Bezalel-Buch, Qiong Guo, Wei Yang, Peter M Burgers, Kristin A Eckert, and Catherine H Freudenreich

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Novel treatment approaches utilizing antibody-drug conjugates in breast cancer, Andrew A Davis, Jennifer Hesse, Patrícia M R Pereira, and Cynthia X Ma

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Utility of candidate genes from an algorithm designed to predict genetic risk for opioid use disorder, Christal N Davis, Alexander S Hatoum, Arpana Agrawal, and et al.

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EUS-guided fine-needle biopsy sampling of solid pancreatic masses with and without rapid onsite evaluation for commercial next-generation genomic profiling, Mohamad Dbouk, Brenton G Davis, Matthew Peller, Erika Sloan, Thomas Hollander, Juan Pablo Reyes-Genere, Ahmad Bazarbashi, Mohammad K Ismail, Gabriel Lang, Vladimir Kushnir, Dayna Early, Samuel Ballentine, Sun-Chuan Dai, Abdul Kouanda, and Koushik K Das

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Women with persistent atrial fibrillation need more than pulmonary vein isolation: Personalised extra-pulmonary vein ablation strategy vs. pulmonary vein isolation alone in the TAILORED-AF trial, Isabel Deisenhofer, Daniel H Cooper, and et al.

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Delivering guideline-directed medical therapy for heart failure with reduced ejection fraction as an over-encapsulated polypill: Rationale and protocol for the COMBO-HF-X pilot crossover randomised clinical trial, Colette DeJong, Mark D Huffman, Anubha Agarwal, and et al.

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Methylomic signature of current cannabis use in two first-episode psychosis cohorts, Emma L Dempster, Emma C Johnson, and et al.

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Cancer immunotherapy clinical trials to support urgently needed access in low- and middle-income countries: A report from the SITC Global Access and Impact Committee, Jennifer Dent, Thomas A Odeny, and et al.

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INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model, Patrick A DeSouza, Matthew Ishahak, Xuan Qu, Colin McCornack, Devi Annamalai, Diane D Mao, Rajanikanth Vangipurapu, Yiwei Fu, Alexandre T Vessoni, Ryan T Cleary, Rowland H Han, Punn Augsornworawat, Timothy Woodiwiss, Darby Agovino, Braxton Sizemore, Jessica Kline, Maryam Borhani-Haghighi, Hao Chen, Sangami Pugazenthi, Hiroko Yano, Ting Wang, Luis F Z Batista, Jeffrey R Millman, and Albert H Kim

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APOBEC3A drives ovarian cancer metastasis by altering epithelial-mesenchymal transition, Jessica M. Devenport, Thi Tran, Brooke R. Harris, Dylan Fingerman, Rachel A. DeWeerd, Lojain H. Elkhidir, Danielle LaVigne, Katherine Fuh, Lulu Sun, Jeffrey J. Bednarski, Ronny Drapkin, Mary M. Mullen, and Abby M. Green

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Real-world effectiveness and safety of upadacitinib in Crohn's disease: A multicenter study, Jalpa Devi, Katherine Huang, Fnu Jaiprada, Julia Huecker, Parakkal Deepak, and et al.

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Premature ventricular contraction location and incident heart failure, Thomas A Dewland, David G Rosenthal, Edward P Gerstenfeld, Melvin M Scheinman, Alvaro Alonso, Elsayed Z Soliman, Lin Yee Chen, David S Siscovick, Nona Sotoodehnia, John S Gottdiener, Bruce M Psaty, Susan R Heckbert, Phyllis K Stein, and Gregory M Marcus

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Assessment of the sensitivity of a smartphone app to assist patients in the identification of stroke and myocardial infarction: Cross-sectional study, Amar Dhand, Rama Mangipudi, Anubodh S Varshney, Jonathan R Crowe, Andria L Ford, Nancy K Sweitzer, Min Shin, Samuel Tate, Haissam Haddad, Michael E Kelly, James Muller, and Jay S Shavadia

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Brugia malayi and other filarial parasite species in animals in areas endemic for lymphatic filariasis in Belitung District, Indonesia, Irina Diekmann, Taniawati Supali, Kerstin Fischer, Elisa Iskandar, Noviani Sugianto, Yossi Destani, Rahmat Alfian, Gary J. Weil, and Peter U. Fischer

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Spatial proteomics of Onchocerca volvulus with pleomorphic neoplasms shows local and systemic dysregulation of protein expression, Lucia S. Di Maggio, Kerstin Fischer, Bruce A. Rosa, Devyn Yates, Byoung-Kyu Cho, Jessica Lukowski, Antonia Zamacona Calderon, Minsoo Son, Young Ah Goo, Nicholas O. Opoku, Gary J. Weil, Makedonka Mitreva, and Peter U. Fischer

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Mendelian randomization study of sleep traits and risk of colorectal cancer, Olympia Dimopoulou, Yin Cao, and et al.

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Autophagy regulates Müller glial cell inflammatory activation, Teresa A Doggett, Zhenqing Zhou, Sohini Rebba, Jacqueline Unsinger, Philip A Ruzycki, and Thomas A Ferguson

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O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism, Hong Dong, Yong Zhang, Michael J Holtzman, and et al.

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Recessive genetic contribution to congenital heart disease in 5,424 probands, Weilai Dong, Sheng Chih Jin, and et al.

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Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study, Kara M. Donovan, Joshua D. Adams, Ki Yun Park, Phillip Demarest, Gansheng Tan, Jon T. Willie, Peter Brunner, Jenna L. Gorlewicz, and Eric C. Leuthardt

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LYSET facilitates integration of both the N- and C-terminal transmembrane helices/cytoplasmic domains of GlcNAc-1-phosphotransferase, Baraj Doray, Benjamin C Jennings, Xi Yang, Lin Liu, Varsha Venkatarangan, Stuart Kornfeld, and Ming Li

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Phase 2 open-label study of sacituzumab govitecan as second-line therapy in patients with extensive-stage SCLC: Results from TROPiCS-03, Afshin Dowlati, Anne C Chiang, Andrés Cervantes, Sunil Babu, Erika Hamilton, Shu Fen Wong, Andrea Tazbirkova, Ivana Gabriela Sullivan, Cédric van Marcke, Antoine Italiano, Jilpa Patel, Sabeen Mekan, Tia Wu, and Saiama N Waqar

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Using community engagement to create a telecoaching intervention to improve self-management in adolescents and young adults with cystic fibrosis: Qualitative study, Christina L Duncan, Emily F Muther, Jennifer J Lindwall, Kristine Durkin, Elizabeth Ruvalcaba, Eliza Williamson, Corrine Ahrabi-Nejad, Evelyn Bord, Angela Green, Megan L Harrison, and Deepika Polineni

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Comparing Isocitrate dehydrogenase inhibitors with procarbazine, lomustine, and vincristine chemotherapy for oligodendrogliomas, Gerardo Duran, Diego Pichardo-Rojas, Ahmed Hashim Ali, Peter Passias, Angela Downes, Wilson Z Ray, Gregory J Zipfel, Hakeem J Shakir, Andrew Bauer, Andrew Jea, Ian F Dunn, Jeffrey A Zuccato, Christopher S Graffeo, and M Burhan Janjua

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Accuracy and reliability of video-based range-of-motion assessments in postreconstruction brachial plexus patients, Christopher J. Dy, Stephen J. DeMartini, Eshan Sane, David M. Brogan, and PLANet Study Group

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Tacrolimus IPV group membership does not consistently track with electronically monitored or self-reported adherence in adolescent and young adult kidney transplant recipients, Cyd K. Eaton, Cozumel S. Pruette, Kristin A. Riekert, Nazanin Yousefzadeh, Ahna L. Pai, Sandra Amaral, Vikas R. Dharnidharka, Bärbel Knäuper, Jodi M. Smith, Susan L. Furth, and Bethany J. Foster

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Dual-vector rAAVrh8 gene therapy for GM2 gangliosidosis: A phase 1/2 trial, Florian Eichler, Xuntian Jiang, and et al.

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Head-to-head preclinical treatment design prioritizes promising therapies for neurofibromatosis type 1 optic glioma clinical translation, Talia Eligator, Jit Chatterjee, Shintaro Yamada, Anthony Kirchner, Hareesh B Nair, Jason R Fangusaro, and David H Gutmann

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Pilot first-in-human CCR2 PET/CT to detect abdominal aortic aneurysm wall instability, Santiago Elizondo-Benedetto, Deborah Sultan, Ryan Wahidi, Mahdjoub Hamdi, Mohamed S Zaghloul, Shahab Hafezi, Batool Arif, Laura K McDonald, Kitty Harrison, Dakkota Thies, Gyu Seong Heo, Hannah Luehmann, Lisa Detering, J Westley Ohman, Zachary J Wanken, Luis A Sanchez, Joseph E Ippolito, Jie Zheng, Robert J Gropler, Richard Laforest, Yongjian Liu, and Mohamed A Zayed

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First-in-human phase I study of a CD16A bispecific innate cell engager, AFM24, targeting EGFR-expressing solid tumors, Anthony El-Khoueiry, Todd A Fehniger, Mark Foster, Melissa M Berrien-Elliott, and et al.

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Compression of the ulnar nerve by the arcade of Struthers: Look and you shall find, Shady Elmaraghi, Ruby Taylor, Isaac Tung, Megan M Patterson, and Susan E Mackinnon

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Molecular subtyping of hypertensive disorders of pregnancy, Michal A Elovitz, Antonia I Frolova, and et al.

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Factors that influence female orthopaedic surgeons' decision to pursue a career in sports medicine: A mixed-methods study, Nichelle M Enata, Katherine M Gerull, Ahmed Hanafy, Mary K Mulcahey, Derrick M Knapik, and Matthew V Smith

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Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis, Emma C Erlich, Quazim A Alayo, Ayoung Kim, Jichang Han, Rachel L Mintz, Christopher G Huckstep, Heather S Ruiz, Rachael L Field, Taylor J Dunning, Leila S Saleh, Mark H Hoofnagle, Farshid Guilak, Jonathan R Brestoff, Rafael S Czepielewski, Gwendalyn J Randolph, and et al.

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Differences in risk appraisal and neural activity in adolescents with a history of misconduct, Elizabeth S Escalante, Jessica S Flannery, Michael T Perino, and Eva H Telzer

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Nuclear EGFR in breast cancer suppresses NK cell recruitment and cytotoxicity, Angelica Escoto, Ryan Hecksel, Chance Parkinson, Sara Crane, Benjamin Atwell, Shyanne King, Daniela Ortiz Chavez, Alison Jannuzi, Barbara Sands, Benjamin G Bitler, Todd A Fehniger, Andrew L Paek, Megha Padi, and Joyce Schroeder

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Succinate dehydrogenase B (SDHB) overexpression with enzymatic dysfunction defines a distinct subtype of undifferentiated pleomorphic sarcoma, Miguel Esperança-Martins, Brian A Van Tine, Alliny C S Bastos, and et al.

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Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity, Jack Euesden, Muhammad Ali, Chloe Robins, Praveen Surendran, Padhraig Gormley, Alzheimer’s Disease Neuroimaging Initiative, David Pulford, and Carlos Cruchaga

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Late adverse event reporting from medical device manufacturers to the US Food and Drug Administration: Cross sectional study, Alexander O Everhart, Pinar Karaca-Mandic, Rita F Redberg, Joseph S Ross, and Sanket S Dhruva

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Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection, José L Fachi, Tihana Trsan, Silvia Penati, Susan Gilfillan, Siyan Cao, Krzysztof L Hyrc, Xiuli Liu, Patrick Fernandes Rodrigues, Bishan Bhattarai, Marco Colonna, and et al.

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Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging, Amelia Farinas, Daniel Western, Jigyasha Timsina, Carlos Cruchaga, and et al.

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Systemic inflammation is associated with worse outcomes from SARS-CoV-2 infection but not neutralizing antibody, Christopher W Farnsworth, Brittany Roemmich, John Prostko, Gerard Davis, Gillian Murtagh, Laurel Jackson, Christopher Jacobson, Nicolette Jeanblanc, Timothy Griffiths, Edwin Frias, and David J Daghfal

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Widespread pain phenotypes impact treatment efficacy results in randomized clinical trials for interstitial cystitis/bladder pain syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain network study, John T. Farrar, Siobhan Sutcliffe, and et al.

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Phosphorylation toggles the SARS-CoV-2 Nucleocapsid protein between two membrane-associated condensate states, Bruna Favetta, Huan Wang, Jasmine Cubuk, Arjun Singh, Mayur Barai, Cesar Ramirez, Haiyan Zheng, Adam J Gormley, N Sanjeeva Murthy, Gregory Dignon, Andrea Soranno, Zheng Shi, and Benjamin S Schuster

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Baby Open Brains: An open-source dataset of infant brain segmentations, Eric Feczko, Dimitrios Alexopoulos, Christopher D Smyser, and et al.

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Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline, Rui Feng, Sarah F Rosen, Irshad Ansari, Sebastian John, Michael B Thomsen, Oshri Avraham, Cedric G Geoffroy, and Valeria Cavalli

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Statistical properties of functional connectivity MRI enrichment analysis in school-age autism research, Austin S Ferguson, Tomoyuki Nishino, Natasha Marrus, John R Pruett Jr, Alexandre A Todorov, and et al.

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WHF roadmap on single pill combination therapies, Enrico G Ferro, Mark Huffman, Orly Vardeny, and et al.

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PUNCH CD3-OLS: A phase 3 prospective observational cohort study to evaluate the safety and efficacy of fecal microbiota, live-jslm (REBYOTA) in adults with recurrent Clostridioides difficile infection, Paul Feuerstadt, Teena Chopra, Whitfield Knapple, Nicholas W Van Hise, Erik R Dubberke, Brian Baggott, Beth Guthmueller, Lindy Bancke, Michael Gamborg, Theodore S Steiner, Daniel Van Handel, and Sahil Khanna

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The single-cell immune profile throughout gestation and its potential value for identifying women at risk for spontaneous preterm birth, Dorien Feyaerts, Maïgane Diop, Jose Galaz, Jakob F Einhaus, Petra C Arck, Anke Diemert, Virginia D Winn, Mana Parast, Cynthia Gyamfi-Bannerman, Jelmer R Prins, Nardhy Gomez-Lopez, and Ina A Stelzer

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Sociodemographic differences in logins and engagement with the electronic health coach messaging feature of a mobile app to support opioid and stimulant use recovery: Results from a 1-month observational study, Lindsey M Filiatreau, Hannah Szlyk, Alex T Ramsey, Erin Kasson, Xiao Li, Zhuoran Zhang, and Patricia Cavazos-Rehg

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Accelerating earlier access to anti-TNF-α agents with biosimilar medicines in the management of inflammatory bowel disease, Gionata Fiorino, Ashwin Ananthakrishnan, Russell D Cohen, Raymond K Cross, Parakkal Deepak, Francis A Farraye, Jonas Halfvarson, and A Hillary Steinhart

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Tracking and mitigating imprint erasure during induction of naive human pluripotency at single-cell resolution, Laura A Fischer, Brittany Meyer, Monica Reyes, Joseph E Zemke, Jessica K Harrison, Kyoung-Mi Park, Ting Wang, Harald Jüppner, Sabine Dietmann, and Thorold W Theunissen

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Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization, Skye R S Fishbein, Anna L DeVeaux, Sakshi Khanna, Aura L Ferreiro, James Liao, Wesley Agee, Jie Ning, Bejan Mahmud, Miranda J Wallace, Tiffany Hink, Kimberly A Reske, Candice Cass, Janaki Guruge, Sidh Leekha, Sunaina Rengarajan, Erik R Dubberke, and Gautam Dantas

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Clinical validation of a vaginal cervical cancer screening self-collection method for at-home use: A nonrandomized clinical trial, Megan B Fitzpatrick, Colleen McNicholas, Lindsay Kuroki, and et al.

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Risk factors for development of stroke in patients with continuous-flow left ventricular assist device support as destination therapy, Ioana B Florea, Nadia H Bakir, Meghan O Kelly, Joel D Schilling, Gregory A Ewald, Akinobu Itoh, Marc R Moon, Spencer J Melby, Ralph J Damiano, Kunal D Kotkar, and Muhammad F Masood

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Open access dataset and common data model for pulse oximeter performance data, Nicholas Fong, Leonid Shmuylovich, and et al.

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Brain age modeling and cognitive outcomes in young adults with and without sickle cell anemia, Andria L Ford, Slim Fellah, Yan Wang, Kira Unger-Levinson, Maria Hagan, Martin N Reis, Amy Mirro, Josiah B Lewis, Chunwei Ying, Kristin P Guilliams, Melanie E Fields, Hongyu An, Allison A King, and Yasheng Chen

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ACL injuries in Major League Soccer: A 10-Year analysis of injury rate and return to play, and performance metrics by player position, Brian Forsythe, Catherine Hand, Camden Bohn, Francis Hand, Vahram Gamsarian, Daanish Khazi-Syed, Joshua Chang, Vikranth Mirle, Eric Giza, Robert Brophy, Danyal Nawabi, and Bert Mandelbaum

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Active learning of enhancers and silencers in the developing neural retina, Ryan Z Friedman, Avinash Ramu, Sara Lichtarge, Yawei Wu, Lloyd Tripp, Daniel Lyon, Connie A Myers, David M Granas, Maria Gause, Joseph C Corbo, Barak A Cohen, and Michael A White

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In vivo CRISPR screening in head and neck cancer reveals Uchl5 as an immunotherapy target, Cong Fu, Zahra Alipour, Douglas R Adkins, Rebecca D Chernock, and et al.