The Open Access Publications collection contains peer-reviewed articles authored by Washington University School of Medicine faculty that have been published in open access journals or authorized by the publishers for open access availability. Open access works are generally defined as being publicly available online and free of most licensing and copyright restrictions. The Bernard Becker Medical Library maintains this collection in support of Washington University’s commitment to the principles of open access publishing and making the scholarly work and research results of our faculty as widely and easily available as possible.
You can find more information about Washington University's Open Access Resolution in Becker Medical Library's Open Access subject guide “OA Resolution at WU”
Submissions from 2014
DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures, Matthew R. Northam, Elizabeth A. Moore, Tony M. Mertz, Sara K. Binz, Carrie M. Stith, Elena I. Stepchenkova, Kathern L. Wendt, Peter M. J. Burgers, and Polina V. Scherbakova
Finished sequence and assembly of the DUF1220-rich 1q21 region using a haploid human genome, Majesta O'Bleness, Veronica B. Searles, C. Michael Dickens, David Astling, Derek Albracht, Angel C.Y. Mak, Yvonne Y.Y. Lai, Chin Lin, Catherine Chu, Tina Graves, Pui-Yan Kwok, Richard K. Wilson, and James M. Sikela
Key issues and opportunities in the evolving health-care marketplace: AOA critical issues, Kristin Olds Glavin, Daniel B. Murrey, Joel C. Porter, Donald Brunn, and Rick W. Wright
The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase, Martina Olivero, Daniela Dettori, Sabrina Arena, Davide Zecchin, Erica Lantelme, and Maria Flavia Di Renzo
Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration, Patrick R. O'Neill and N. Gautam
Uveal melanoma cells utilize a novel route for transendothelial migration, Michael D. Onken, Jinmei Li, and John A. Cooper
Simultaneous bilateral or unilateral carpal tunnel release? A prospective cohort study of early outcomes and limitations, Daniel A. Osei, Ryan P. Calfee, Jeffrey G. Stepan, Martin I. Boyer, Charles A. Goldfarb, and Richard H. Gelberman
Antimicrobial susceptibility differences among mucoid and non-mucoid Pseudomonas aeruginosa isolates, Parvis Owlia, Rahim Nosrati, Reza Alaghehbandan, and Abdolaziz Rastegar Lari
Defining NELF-E RNA binding in HIV-1 and promoter-proximal pause regions, John M. Pagano, Hojoong Kwak, Colin T. Waters, Rebekka O. Sprouse, Brian S. White, Abdullah Ozer, Kylan Szeto, David Shalloway, Harold G. Craighead, and John T. Lis
Brain-behavior relationships in the experience and regulation of negative emotion in healthy children: Implications for risk for childhood depression, David Pagliaccio, Joan L. Luby, Katherine R. Luking, Andrew C. Belden, and Deanna M. Barch
Multimeric assembly of host-pathogen adhesion complexes involved in apicomplexan invasion, May M. Paing and Niraj H. Tolia
Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes, Pankaj Pal, Julie M. Fox, Michael S. Diamond, and et al
Anti-angiogenesis therapy in the Vx2 rabbit cancer model with a lipase-cleavable Sn 2 taxane phospholipid prodrug using αvβ3-targeted theranostic nanoparticles, Dipanjan Pan, Anne H. Schmieder, Kezheng Wang, Xiaoxia Yang, Angana Senpan, Grace Cui, Kendall Killgore, Benjamin Kim, John S. Allen, Huiying Zhang, Shelton D. Caruthers, Baozhong Shen, Samuel A. Wickline, and Gregory M. Lanza
Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice, Joanna E. Pankiewicz, Maitea Guridi, Jungsu Kim, Ayodeji A. Asuni, Sandrine Sanchez, Patrick M. Sullivan, David M. Holtzman, and Martin J. Sadowski
Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer, Roheena Z. Panni, Dominic E. Sanford, Brian A. Belt, Jonathan B. Mitchem, Lori A. Worley, Brian D. Goetz, Pinku Mukherjee, Andrea Wang-Gillam, Daniel C. Link, David G. DeNardo, S. Peter Goedegebuure, and David C. Linehan
Peptidergic cell-specific synaptotagmins in Drosophila: Localization to dense-core granules and regulation by the bHLH protein dimmed, Dongkook Park, Peiyao Li, Adish Dani, and Paul H. Taghert
Inputs drive cell phenotype variability, James Park, Anthony Brureau, Kate Kernan, Alexandria Starks, Sonali Gulati, Babatunde Ogunnaike, James Schwaber, and Rajanikanth Vadigepalli
Age-related changes in cervical sagittal range of motion and alignment, Moon S. Park, Seong-Hwan Moon, Hwan-Mo Lee, Tae-Hwan Kim, Jae K. Oh, Ji H. Nam, and K. D. Riew
The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice, Charlyn G. Partridge, Gloria L. Fawcett, Bing Wang, Clay F. Semenkovich, and James M. Cheverud
The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development, Chinmoy Patra, Kelly R. Monk, and Felix B. Engel
Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIB procollagen and down-regulation of cholesterol and lipid homeostasis, Debabrata Patra, Elizabeth DeLassus, Guosheng Liang, and Linda J. Sandell
An allometric scaling relationship in the brain of preterm infants, Rachel A. Paul, Christopher D. Smyser, Cynthia E. Rogers, Ian English, Michael Wallendorf, Dimitrios Alexopoulos, Erin J. Meyer, David C. Van Essen, Jeffrey J. Neil, and Terrie E. Inder
Methodological challenges and solutions in auditory functional magnetic resonance imaging, Jonathan E. Peelle
Photo quiz: A 58-year-old female with altered mental status, Morgan A. Pence and Carey-Ann D. Burnham
Bioelectric signaling regulates size in zebrafish fins, Simon Perathoner, Jacob M. Daane, Ulrike Henrion, Guiscard Seebohm, Charles W. Higdon, Stephen L. Johnson, Christiane Nusslein-Volhard, and Matthew P. Harris
Outcome for children with metastatic solid tumors over the last four decades, Stephanie M. Perkins, Eric T. Shinohara, Todd DeWees, and Haydar Frangoul
Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: A decade of the PREDICT-HD study, Joel S. Perlmutter, Stacey Barton, Shineeka Kaye Smith, and et al
A rare sequence variant in intron 1 of THAP1 is associated with primary dystonia, Joel S. Perlmutter, Brad A. Racette, Randal C. Paniello, and et al
Human cytomegalovirus pUL79 Is an elongation factor of RNA polymerase II for viral gene transcription, Yi-Chieh Perng, Jessica A. Campbell, Deborah J. Lenschow, and Dong Yu
Gait-related brain activity in people with Parkinson disease with freezing of gait, Daniel S. Peterson, Kristen A. Pickett, Ryan Duncan, Joel Perlmutter, and Gammon M. Earhart
An interferon response gene signature is associated with the therapeutic response of hepatitis C patients, Lawrence M. Pfeffer, Kui Li, Jaquelyn F. Fleckenstein, Tony N. Marion, Joel Diament, Chuan He Yang, Susan R. Pfeffer, Meiyun Fan, Elizabeth Handorf, and Charles R. Handorf
Increased iron sequestration in alveolar macrophages in chronic obtructive pulmonary disease, Quentin Philippot, Gaetan Deslee, Tracy L. Adair-Kirk, Jason C. Woods, Derek Byers, Susan Conradi, Sandra Dury, Jeanne Marie Perotin, Francois Lebargy, Christelle Cassan, Richard Le Naour, Michael J. Holtzman, and Richard A. Pierce
Levosimendan in critical illness: A literature review, Charalampos Pierrakos, Dimitrios Velissaris, Federico Franchi, Luigi Muzzi, Menelaos Karanikolas, and Sabino Scolletta
Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis, Amelia K. Pinto, Hilario J. Ramos, Xiaobo Wu, Shilpa Aggarwal, Bimmi Shrestha, Matthew Gorman, Kristin Y. Kim, Mehul S. Suthar, John P. Atkinson, Michael Gale Jr., and Michael S. Diamond
Routine testing for anaerobic bacteria in cerebrospinal fluid cultures improves recovery of clinically significant pathogens, Meredith E. Pittman, Benjamin S. Thomas, Meghan A. Wallace, Carol J. Weber, and Carey-Ann D. Burnham
Streptococcus pyogenes polymyxin B-resistant mutants display enhanced exportal integrity, Gary C. Port, Luis A. Vega, Andrew B. Nylander, and Michael G. Caparon
Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference, George S. Portugal, Ream Al-Hasani, Amanda K. Fakira, Jose L. Gonzalez-Romero, Zare Melyan, Jordan G. McCall, Michael R. Bruchas, and Jose A. Moron
Comparative analyses of proteins from Haemophilus influenzae biofilm and planktonic populations using metabolic labeling and mass spectrometry, Deborah MB Post, Jason M. Held, Margaret R. Ketterer, Nancy J. Phillips, Alexandria Sahu, Michael A. Apicella, and Bradford W. Gibson
Network inefficiencies in autism spectrum disorder at 24 months, J R. Pruett, K Botteron, R McKinstry, and et al
Missed opportunities: Racial and neighborhood socioeconomic disparities in emergency colorectal cancer diagnosis and surgery, Sandi L. Pruitt, Nicholas O. Davidson, Samir Gupta, Yan Yan, and Mario Schootman
Molecularly targeted therapies in multiple myeloma, Pilar de la Puente, Barbara Muz, Feda Azab, Micah Luderer, and Abdel Kareem Azab
Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus, Carolyn A. Purgert, Yukitoshi Izumi, Yuh-Jin I. Jong, Vikas Kumar, Charles F. Zorumski, and Karen L. O'Malley
Synthesis of dye conjugates to visualize the cancer cells using fluorescence microscopy, Yang Pu, Rui Tang, Jianpeng Xue, W. B. Wang, Baogang Xu, and Samuel I. Achilefu
Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe, Xudong Qiu, James R. Johnson, Bradley S. Wilson, Seth T. Gammon, David Piwnica-Worms, and Edward M. Barnett
Epidemiology of blunt head trauma in children in U.S. Emergency Departments, Kimberly S. Quayle, Elizabeth C. Powell, Prashant Mahajan, John D. Hoyle, Frances M. Nadel, Mohammed K. Badawy, Jeff E. Schunk, Rachel M. Stanley, Michelle Miskin, Shireen M. Atabaki, Peter S. Dayan, James F. Holmes, and Nathan Kuppermann
Opposing brain differences in 16p11.2 deletion and duplication carriers, Abid Y. Qureshi, Sophia Mueller, Abraham Z. Snyder, Pratik Mukherjee, Jeffrey I. Berman, Timothy P. L. Roberts, Srikantan S. Nagarajan, John E. Spiro, Wendy K. Chung, Elliott H. Sherr, and Randy L. Buckner
Diffusion tensor imaging in children with unilateral hearing loss: A pilot study, Tara Rachakonda, Joshua S. Shimony, Rebecca S. Coalson, and Judith E.C. Lieu
The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy, Cara Rada, Nan Lin, Sarah K. England, and et al
Integration of multiple determinants in the neuronal computation of economic values, Anantha P. Raghuraman and Camillo Padoa-Schioppa
A comprehensive assessment of lymphatic filariasis in Sri Lanka six years after cessation of mass drug administration, Ramakrishna U. Rao, Kumara C. Nagodavithana, Sandhya D. Samarasekera, Asha D. Wijegunawardana, Welmillage D. Premakumara, Samudrika N. Perera, Sunil Settinayake, J. Phillip Miller, and Gary J. Weil
AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake, Ramachandran Rashmi, Carl DeSelm, Cynthia Helms, Anne Bowcock, Buck E. Rogers, Janet Rader, Perry W. Grigsby, and Julie K. Schwarz
Francisella tularensis Schu S4 lipopolysaccharide core sugar and o-antigen mutants are attenuated in a mouse model of tularemia, Jed A. Rasmussen, Deborah M.B. Post, Bradford W. Gibson, Stephen R. Lindemann, Michael A. Apicella, David K. Meyerholz, and Bradley D. Jones
IL-15 deficient Tax mice reveal a role for IL-1α in tumor immunity, Daniel A. Rauch, John C. Harding, and Lee Ratner
Management of anticoagulant-related intracranial hemorrhage: An evidence-based review, Bappaditya Ray and Salah G. Keyrouz
Phylogenomics and the dynamic genome evolution of the genus Streptococcus, Vincent P. Richards, Sara R. Palmer, Paulina D. Pavinski Bitar, Xiang Qin, George M. Weinstock, Sarah K. Highlander, Christopher D. Town, Robert A. Burne, and Michael J. Stanhope
Cardiac and renal effects of atrasentan in combination with enalapril and paricalcitol in uremic rats, Cynthia Ritter, Sarah Zhang, Jane L. Finch, Helen Liapis, Edu Suarez, Leon Ferder, James Delmez, and Eduardo Slatopolsky
Illustrated techniques for performing the Cox-Maze IV procedure through a right mini-thoracotomy, Jason O. Robertson, Lindsey L. Saint, Jeremy E. Leidenfrost, and Ralph J. Damiano Jr.
Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease, Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis de Lecea, and David M. Holtzman
Utilizing cytokines to function-enable human NK cells for the immunotherapy of cancer, Rizwan Romee, Jeffrey W. Leong, and Todd A. Fehniger
Genome-wide tissue-specific gene expression, co-expression and regulation of co-expressed genes in adult nematode Ascaris suum, Bruce A. Rosa, Douglas P. Jasmer, and Makedonka Mitreva
Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model, Sarah L. Rowland, Jeffrey M. Riggs, Susan Gilfillan, Mattia Bugatti, William Vermi, Roland Kolbeck, Emil R. Unanue, Miguel A. Sanjuan, and Marco Colonna
The role of neutrophil myeloperoxidase in models of lung tumor development, Amy Rymaszewski, Everett Tate, Joannes P. Yimbesalu, Andrew E. Gelman, Jason A. Jarzembowski, Hao Zhang, Kirkwood A. Pritchard Jr., and Haris G. Vikis
Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: Evidence for pleiotropy, Brooke Sadler, Gabe Haller, Arpana Agrawal, Rob Culverhouse, Kathleen Bucholz, Andy Brooks, Jay Tischfield, Eric O. Johnson, Howard Edenberg, Marc Schuckit, Nancy Saccone, Laura Bierut, and Alison Goate
How I do it: Minimally invasive Cox-Maze IV procedure, Lindsey L. Saint, Christopher P. Lawrance, Jeremy E. Leidenfrost, Jason O. Roberston, and Ralph J. Damiano Jr.
Critical glycosylated residues in exon three of erythrocyte Glycophorin A engage Plasmodium falciparum EBA-175 and define receptor specificity, Nichole D. Salinas, May M. Paing, and Niraj H. Tolia
Sonography of acute appendicitis and its mimics in children, Kiran M. Sargar and Marilyn J. Siegel
Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis, Nayan J. Sarma, Venkataswarup Tiriveedhi, Jeffrey S. Crippin, William C. Chapman, and Thalachallour Mohanakumar
Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy, Aaron D. Schenone, Jingqin Luo, Luke Montgomery, Daniel Morgensztern, Douglas R. Adkins, and Brian A. Van Tine
BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway, Brandon M. Schickling, Sarah K. England, Nukhet Aykin-Burns, Lyse A. Norian, Kimberly K. Leslie, and Victoria P. Frieden-Korovkina
Shiga toxin-producing Escherichia coli: A single-center, 11-year pediatric experience, Emily I. Schindler, Patricia Sellenriek, Gregory A. Storch, Phillip I. Tarr, and Carey-Ann D. Burnham
Dendritic cells in dengue virus infection: Targets of virus replication and mediators of immunity, Michael A. Schmid, Michael S. Diamond, and Eva Harris
Ultrastructure and composition of the Nannochloropsis gaditana cell wall, Matthew J. Scholz, Taylor L. Weiss, Robert E. Jinkerson, Jia Jing, Robyn Roth, Ursula Goodenough, Matthew C. Posewitz, and Henri G. Gerken
Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and Major Depressive Disorder, Andrew J. Schrage, Michele L. Pergadia, Pamela A. F. Madden, and et al
Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling, Rebecca C. Schugar, Ashley R. Moll, D. Andre d'Avignon, Carla J. Weinheimer, Attila Kovacs, and Peter A. Crawford
Targeting hepatic glycerolipid synthesis and turnover to treat fatty liver disease, George G. Schweitzer and Brian N. Finck
Bayesian inferences suggest that Amazon Yunga Natives diverged from Andeans less than 5000 ybp: Implications for South American prehistory, Marilia O. Scliar, Mateius H. Gouveia, Andrea Benazzo, Silvia Ghirotto, Nelson JR Fagundes, Thiago P. Leal, Wagner CS Magalhaes, Latife Pereira, Maira R. Rodrigues, Giordano B. Soares-Souza, Lilia Cabrera, Douglas E. Berg, Robert H. Gilman, Giorgio Bertorelle, and Eduardo Tarazona-Santos
Population genetic analyses of Helicobacter pylori isolates from Gambian adults and children, Ousman Secka, Yoshan Moodley, Martin Antonio, Douglas E. Berg, Mary Tapgun, Robert Walton, Archibald Worwui, Vivat Thomas, Tumani Corrah, Julian E. Thomas, and Richard A. Adegbola
Provision of no-cost, long-acting contraception and teenage pregnancy., Gina M. Secura, Tessa Madden, Colleen McNicholas, Jennifer Mullersman, Christina M. Buckel, Qiuhong Zhao, and Jeffrey F. Peipert
Association of comorbidity burden with abnormal cardiac mechanics: Findings from the HyperGEN study, Senthil Selvaraj, Frank G. Aguilar, Eva E. Martinez, Lauren Beussink, Kwang-Youn A. Kim, Jie Peng, Laura Rasmussen-Torvik, Jin Sha, Marguerite R. Irvin, C. Charles Gu, Cora E. Lewis, Steven C. Hunt, Donna K. Arnett, and Sanjiv J. Shah
Domain-general signals in the cingulo-opercular network for visuospatial attention and episodic memory, Carlo Sestieri, Maurizio Corbetta, Sara Spadone, Gian Luca Romani, and Gordon L. Shulman
Memory accumulation mechanisms in human cortex are independent of motor intentions, Carlo Sestieri, Annalisa Tosoni, Valeria Mignogna, Mark P. McAvoy, Gordon L. Shulman, Maurizio Corbetta, and Gian Luca Romani
Endoluminal Negative-Pressure Therapy for Preventing Rectal Anastomotic Leaks: A Pilot Study in a Pig Model, Amber L. Shada, Laura H. Rosenberger, Mark J. Mentrikoski, Michael A. Silva, Sanford H. Feldman, and Daniel E. Kleiner
A course-based research experience: How benefits change with increased investment in instructional time, Christopher D. Shaffer, Elaine R. Mardis, Jeremy Buhler, Wilson Leung, Sarah C. R Elgin, and et al
Absence of calcium‐independent phospholipase A2β impairs platelet‐activating factor production and inflammatory cell recruitment in Trypanosoma cruzi‐infected endothelial cells, Janhavi Sharma, Christopher S. Eickhoff, Daniel F. Hoft, John O. Marentette, John Turk, and Jane McHowat
Immuno-PET of epithelial ovarian cancer: Harnessing the potential of CA125 for non-invasive imaging, Sai Kiran Sharma, Melinda Wuest, Monica Wang, Darryl Glubrecht, Bonnie Andrais, Suzanne E. Lapi, and Frank Wuest
A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion, Vijay Sharma, Jothilingam Sivapackiam, Scott E. Harpstrite, Julie L. Prior, Hannah Gu, Nigam P. Rath, and David Piwnica-Worms
Kinases and pseudokinases: Lessons from RAF, Andrey S. Shaw, Alexandr P. Kornev, Jiancheng Hu, Lalima G. Ahuja, and Susan S. Taylor
Contribution of the highly conserved EaeH surface protein to enterotoxigenic Escherichia coli pathogenesis, Alaullah Sheikh, Qingwei Luo, Koushik Roy, Salwa Shabaan, Pardeep Kumar, Firdausi Qadri, and James M. Fleckenstein
Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9, Bang Shen, Kevin M. Brown, Tobie D. Lee, and L. David Sibley
Functional analysis of rhomboid proteases during Toxoplasma invasion, Bang Shen, Jeffrey S. Buguliskis, Tobie D. Lee, and L. David Sibley
Hybrid mice reveal parent-of-origin and cis- and trans- regulatory effects in the retina, Susan Q. Shen, Ernest Turro, and Joseph C. Corbo
Fluoroscopically guided extraforaminal cervical nerve root blocks: Analysis of epidural flow of the injectate with respect to needle tip position, Kyle Shipley, K. D. Riew, and Louis A. Gilula
Predictors of hospital mortality among septic ICU patients with Acinetobacter spp. bacteremia: A cohort study, Andrew F. Shorr, Marya D. Zilberberg, Scott T. Micek, and Marin H. Kollef
The circuitry of abulia: Insights from functional connectivity MRI, J. S. Siegel, A. Z. Snyder, N. V. Metcalf, R. P. Fucetola, C. D. Hacker, J. S. Shimony, G. L. Shulman, and M. Corbetta
SIRT6 is required for normal retinal function, Dafne M. Silberman, Kenneth Ross, Pablo H. Sande, Shunsuke Kubota, Sridhar Ramaswamy, Rajendra S. Apte, and Raul Mostoslavsky
Spike-timing computation properties of a feed-forward neural network model, Drew B. Sinha, Noah M. Ledbetter, and Dennis L. Barbour
Patient age is related to decision-making, treatment selection, and perceived quality of life in breast cancer survivors, Terence T. Sio, Kenneth Chang, Ritujith Jayakrishnan, Difu Wu, Mary Politi, Dominique Malacarne, James Saletnik, and Maureen Chung
Nutraceutical intervention improves older adults' cognitive functioning, Brent J. Small, Kerri S. Rawson, Christina Martin, Sarah L. Eisel, Cyndy D. Sanberg, Cathy L. McEvoy, Paul R. Sanberg, Douglas Shytle, Jun Tan, and Paula C. Bickford
Progress in pediatric kidney transplantation, Jodi M. Smith and Vikas R. Dharnidharka
Multiple dietary supplements do not affect metabolic and cardio-vascular health, Andreea Soare, Edward P. Weiss, John O. Holloszy, and Luigi Fontana
