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Submissions from 2016

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Clinical and genetic features of cervical dystonia in a large multicenter cohort, Joel S. Perlmutter, Laura J. Wright, and et al

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Evaluation of machine learning and rules-based approaches for predicting antimicrobial resistance profiles in gram-negative bacilli from whole genome sequence data, Mitchell W. Pesesky, Tahir Hussain, Meghan Wallace, Sanket Patel, Saadia Andleeb, Carey-Ann D. Burhnam, and Gautam Dantas

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Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers, Adam D. Pfefferle, Yash N. Agrawal, Daniel C. Koboldt, Krishna L. Kanchi, Jason I. Herschkowitz, Elaine R. Mardis, Jeffrey M. Rosen, and Charles M. Perou

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Autofluorescence as a measure of senescence in C. elegans: Look to red, not blue or green, Zachary Pincus, Travis C. Mazer, and Frank J. Slack

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Axonal growth arrests after an increased accumulation of Schwann cells expressing senescence markers and stromal cells in acellular nerve allografts, Louis H. Poppler, Xueping Ee, Lauren Schellhardt, Gwendolyn M. Hoben, Deng Pan, Daniel A. Hunter, Ying Yan, Amy M. Moore, Alison K. Snyder-Warwick, Sheila A. Stewart, Susan E. Mackinnon, and Matthew D. Wood

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Diabetes status and being up-to-date on colorectal cancer screening, 2012 Behavioral Risk Factor Surveillance System, Nancy R. Porter, Jan M. Eberth, Marsha E. Samson, Oralia Garcia-Dominic, Eugene J. Lengerich, and Mario Schootman

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Pten cell autonomously modulates the hematopoietic stem cell response to inflammatory cytokines, Shaina N. Porter, Andrew S. Cluster, Robert A.J. Signer, Jenna Voigtmann, Darlene A. Monlish, Laura G. Schuettpelz, and Jeffrey A. Magee

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Is extended preoperative antibiotic prophylaxis for high-risk patients necessary before percutaneous nephrolithotomy?, Aaron M. Potretzke, Alyssa M. Park, Tyler M. Bauman, Jeffrey A. Larson, Joel M. Vetter, Brian M. Benway, and Alana C. Desai

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p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer, Emily Powell, Jiansu Shao, Yuan Yuan, Hsiang-Chun Chen, Shirong Cai, Gloria V. Echeverria, Nipun Mistry, Keith F. Decker, Christopher Schlosberg, Kim-Anh Do, John R. Edwards, Han Liang, David Piwnica-Worms, and Helen Piwnica-Worms

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Causal evidence for a mechanism of semantic integration in the angular gyrus as revealed by high-definition transcranial direct current stimulation, Amy Rose Price, Jonathan E. Peelle, Michael F. Bonner, Murray Grossman, and Roy H. Hamilton

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A review of policy dissemination and implementation research funded by the National Institutes of Health, 2007–2014, Jonathan Purtle, Rachel Peters, and Ross Brownson

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Direct hospital cost of outcome pathways in implant-based reconstruction with acellular dermal matrices, Ali A. Qureshi, Kristin Broderick, Susan Funk, Nancy Reaven, Marissa M. Tenenbaum, and Terence M. Myckatyn

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Measurement resources for dissemination and implementation research in health, Borsika A. Rabin, Cara C. Lewis, Wynne E. Norton, Gila Neta, David Chambers, Jonathan N. Tobin, Ross C. Brownson, and Russell E. Glasgow

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RNA microarray analysis of macroscopically normal articular cartilage from knees undergoing partial medial meniscectomy: Potential prediction of the risk for developing osteoarthritis, Muhammad Farooq Rai, Linda J. Sandell, Bo Zhang, Rick W. Wright, and Robert H. Brophy

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Diagnostics and training of affordance perception in healthy young adults - Implications for post-stroke neurorehabilitation, Jennifer Randerath and Scott H. Frey

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Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury, Michael J. Randles, Sophie Collinson, Tobias Starborg, Aleksandr Mironov, Mira Krendel, Eva Königshausen, Lorenz Sellin, Ian S. D. Roberts, Karl E. Kadler, Rachel Lennon, and Jeffrey H. Miner

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CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses, Gwendalyn J. Randolph and et al

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Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability, Gwendalyn J. Randolph and et al

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A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms, Asha Rani, Ravi Ranjan, Halvor S. McGee, Ahmed Metwally, Zahraa Hajjiri, Daniel C. Brennan, Patricia W. Finn, and David L. Perkins

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Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference, Dabeeru Rao and et al

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Programmatic use of molecular xenomonitoring at the level of evaluation units to assess persistence of lymphatic filariasis in Sri Lanka, Ramakrishna U. Rao, Sandhya D. Samarasekera, Kumara C. Nagodavithana, Manjula W. Punchihewa, Tharanga D. M. Dassanayaka, Gamini P. K. D, Ethan Ford, Udaya S. B. Ranasinghe, Ralph H. Henderson, and Gary J. Weil

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A framework for interpreting type I error rates from a product-term model of interaction applied to quantitative traits, Tara J. Rao and Michael A. Province

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Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development, David Razafsky, Candace Ward, Chloe Potter, Wanqiu Zhu, Yunlu Xue, Vladimir J. Kefalov, Loren G. Fong, Stephen G. Young, and Didier Hodzic

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Clec16a is critical for autolysosome function and Purkinje cell survival, Veronika Redmann, Robert C. Orchard, Ashley Milam, Sunmin Park, Christine C. Yokoyama, Amal Kambal, Darren Kreamalmeyer, Karen Green, Paul M. Allen, Robert E. Schmidt, Herbert W. Virgin, Marie K. Bosch, Maolei Xiao, David M. Ornitz, Aaron DiAntonio, Shondra M. Pruett-Miller, Sungsu Kim, Wanda L. Beatty, and et al

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Predictors of change in depressive symptoms from preschool to first grade, Trude Reinfjell, Silja Berg Kårstad, Turid Suzanne Berg-Nielsen, Joan L. Luby, and Lars Wichstrøm

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Computational neurorehabilitation: Modeling plasticity and learning to predict recovery, David J. Reinkensmeyer, Etienne Burdet, Maura Casadio, John W. Krakauer, Gert Kwakkel, Catherine E. Lang, Stephan P. Swinnen, Nick S. Ward, and Nicolas Schweighofer

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Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells, Matthew R. Reynolds, Itender Singh, Tej D. Azad, Brandon B. Holmes, Phillip B. Verghese, Hans H. Dietrich, Marc Diamond, Guojun Bu, Byung Hee Han, and Gregory J. Zipfel

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Analysis of within subjects variability in mouse ultrasonic vocalization: Pups exhibit inconsistent, state-like patterns of call production, Michael A. Rieger and Joseph D. Dougherty

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ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β, Agnieszka Robaszkiewicz, Chao Qu, Ewelina Wisnik, Tomasz Ploszaj, Ali Mirsaidi, Friedrich A. Kunze, Peter J. Richards, Paolo Cinelli, Gabriel Mbalaviele, and Michael O. Hottiger

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Implementation of a screening program for patients at risk for posttraumatic stress disorder, Carmen R. Roberts, Joanie E. Wofford, Haley M. Hoy, and Mitchell N. Faddis

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Synthetic ligands of cannabinoid receptors affect dauer formation in the nematode Caenorhabditis elegans, Pedro Reis Rodrigues, Tiffany K. Kaul, Jo-Hao Ho, Mark Lucanic, Kristopher Burkewitz, William B. Mair, Jason M. Held, Laura M. Bohn, and Matthew S. Gill

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ISG15 deficiency and increased viral resistance in humans but not mice, Marisela R. Rodriguez, Deborah J. Lenschow, and et al

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L-MYC expression maintains self-renewal and prolongs multipotency of primary human neural stem cells, Xianfang Rong, Joseph Benetatos, David L. Brody, and et al

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Stroke severity Is a crucial predictor of outcome: An international prospective validation study, Natalia S. Rost, Alex Bottle, Jin-Moo Lee, Marc Randall, Steven Middleton, Louise Shaw, Vincent Thijs, Gabriel J.E. Rinkel, Thomas M. Hemmen, and Global Comparators Stroke GOAL collaborators

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Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis, Megan K. Ruhland, Andrew J. Loza, Aude-Helene Capietto, Xianmin Luo, Brett L. Knolhoff, Kevin C. Flanagan, Brian A. Belt, Elise Alspach, Kathleen Leahy, Jingqin Luo, Andras Schaffer, John R. Edwards, Gregory Longmore, Roberta Faccio, David G. DeNardo, and Sheila A. Stewart

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Whole genome sequencing for genomics-guided investigations of Escherichia coli O157:H7 outbreaks, Brigida Rusconi, Fatemeh Sanjar, Sara S.K. Koenig, Mark K. Mammel, Phillip I. Tarr, and Mark Eppinger

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Targeted detection of genetic alterations reveal the prognostic impact of H3K27M and MAPK pathway aberrations in paediatric thalamic glioma, Scott Ryall, Rahul Krishnatry, Anthony Arnoldo, Pawel Buczkowicz, Matthew Mistry, Robert Siddaway, Cino Ling, Sanja Pajovic, Man Yu, Joshua B. Rubin, Juliette Hukin, Paul Steinbok, Ute Bartels, Eric Bouffet, Uri Tabori, and Cynthia Hawkins

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Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations, Jessica L. Saben, Anna L. Boudoures, Zeenat Asghar, Alysha Thompson, Andrea Drury, Wendy Zhang, Maggie Chi, Andrew Cusumano, Suzanne Scheaffer, and Kelle H. Moley

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The Na+/Ca2+, K+ exchanger 2 modulates mammalian cone phototransduction, Keisuke Sakurai, Frans Vinberg, Tian Wang, Jeannie Chen, and Vladimir J. Kefalov

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Reducing CSF partial volume effects to enhance diffusion tensor imaging metrics of brain microstructure, Lauren E. Salminen, Thomas E. Conturo, Jacob D. Bolzenius, Ryan P. Cabeen, Erbil Akbudak, and Robert H. Paul

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Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1, Savita Sankar, Dhananjay Yellajoshyula, Bo Zhang, Bryan Teets, Nicole Rockweiler, and Kristen L. Kroll

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Epidemiology of bloodstream infections in a multicenter retrospective cohort of liver transplant recipients, Carlos A.Q. Santos, Richard S. Hotchkiss, William C. Chapman, and Margaret A. Olsen

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NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion, Yo Sasaki, Takashi Nakagawa, Xianrong Mao, Aaron DiAntonio, and Jeffrey Milbrandt

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The dimeric architecture of checkpoint Mec1ATR and Tel1ATM reveal a common structural organization, Marta Sawicka, Paulina H. Wanrooij, Vidya C. Darbari, Elias Tannous, Sarem Hailemariam, Daniel Bose, Alena V. Makarova, Peter M. Burgers, and Xiaodong Zhang

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Disruption of the Cdc42/Par6/aPKC or Dlg/ Scrib/Lgl polarity complex promotes epithelial proliferation via overlapping mechanisms, Gregory V. Schimizzi, Meghan T. Maher, Andrew J. Loza, and Gregory D. Longmore

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AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity, Edward T. Schmid, Iris K. Pang, Eugenio A. Carrera Silva, Lidia Bosurgi, Jonathan J. Miner, Michael S. Diamond, Akiko Iwasaki, and Carla V. Rothlin

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A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection, Diane J. Schmidt, Gillian Beamer, Jacqueline M. Tremblay, Jennifer A. Steele, Hyeun Bum Kim, Yaunkai Wang, Michele Debatis, Xingmin Sun, Elena A. Kashentseva, Igor P. Dmitriev, David T. Curiel, Charles B. Shoemaker, and Saul Tzipori

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Child stunting is associated with low circulating essential amino acids, Richard D. Semba, Michelle Shardell, Fayrouz A. Sakr Ashour, Ruin Moaddel, Indi Trehan, Kenneth M. Maleta, M. Isabel Ordiz, Klaus Kraemer, Mohammed A. Khadeer, Luigi Ferrucci, and Mark J. Manary

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Metabolic alterations in children with environmental enteric dysfunction, Richard D. Semba, Michelle Shardell, Indi Trehan, Ruin Moaddel, Kenneth M. Maleta, M. Isabel Ordiz, Klaus Kraemer, Mohammed Khadeer, Luigi Ferrucci, and Mark J. Manary

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Cost-effective recruitment strategies that attract underrepresented minority undergraduates who persist to STEM doctorates, Cherilynn R. Shadding, Dawayne Whittington, Latricia E. Wallace, Wambul S. Wandu, and Richard K. Wilson

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Variation in practice regarding pretreatment with dual antiplatelet therapy for patients with non–ST elevation myocardial infarction, Ali Shafiq, Javier Valle, Jae-Sik Jang, Mohammed Qintar, Kensey Gosch, David J. Cohen, Mandeep Singh, Richard Bach, and John A. Spertus

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Mice with genetic deletion of group VIA phospholipase A2β exhibit impaired macrophage function and increased parasite load in Trypanosoma cruzi-induced myocarditis, Janhavi Sharma, Jennifer R. Blase, Daniel F. Hoft, John O. Marentette, John Turk, and Jane McHowata

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The effect of mesenchymal stromal cell sheets on the inflammatory stage of flexor tendon healing, Hua Shen, Ioannis Kormpakis, Necat Havlioglu, Stephen W. Linderman, Shelly E. Sakiyama-Elbert, Isaac E. Erickson, Thomas Zarembinski, Matthew J. Silva, Richard H. Gelberman, and Stavros Thomopoulos

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Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells, Daniel W. Sherbenou, Blake T. Aftab, Yang Su, Christopher R. Behrens, Arun Wiita, Aaron C. Logan, Diego Acosta-Alvear, Byron C. Hann, Peter Walter, Marc A. Shuman, Xiaobo Wu, John P. Atkinson, Jeffrey L. Wolf, Thomas G. Martin, and Bin Liu

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Cardiac arrest-induced global brain hypoxia-ischemia during development affects spontaneous activity organization in rat sensory and motor thalamocortical circuits during adulthood, Michael Shoykhet and Jason W. Middleton

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The human experience with intravenous levodopa, Shan H. Siddiqi, Natalia K. Abraham, Christopher L. Geiger, Morvarid Karimi, Joel S. Perlmutter, and Kevin J. Black

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The influence of temperament and character profiles on specialty choice and well-being in medical residents, Martin Sievert, Igor Zwir, Kevin M. Cloninger, Nigel Lester, Sandor Rozsa, and C. Robert Cloninger

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Tubular overexpression of Angiopoietin-1 attenuates renal fibrosis, Sudhir Singh, Scott R. Manson, Heedoo Lee, Yeawon Kim, Tuoen Liu, Qiusha Guo, Julio J. Geminiani, Paul F. Austin, and Ying Maggie Chen

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Study Protocol: A randomized controlled trial evaluating the effect of family-based behavioral treatment of childhood and adolescent obesity–The FABO-study, Hanna F. Skjåkødegård, Yngvild S. Danielsen, Mette Morken, Sara-Rebekka F. Linde, Rachel P. Kolko, Katherine N. Balantekin, Denise W. Wilfley, and Pétur B. Júlíusson

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High-protein intake during weight loss therapy eliminates the weight-loss-induced improvement in insulin action in obese postmenopausal women, Gordon I. Smith, Jun Yoshino, Shannon C. Kelly, Dominic N. Reeds, Adewole Okunade, Bruce W. Patterson, Samuel Klein, and Bettina Mittendorfer

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Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo, Avik Som, Sharon Bloch, Joseph E. Ippolito, and Samuel Achilefu

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Cetuximab plus platinum-based chemotherapy in head and neck squamous cell carcinoma: A randomized, double-blind safety study comparing cetuximab produced from two manufacturing processes using the EXTREME study regimen, Denis Soulieres, Jose Luis Aguilar, Eric Chen, Krzysztof Misiukiewicz, Scott Ernst, Hyun Jung Lee, Katherine Bryant, Shuang He, Coleman K. Obasaju, Shao-Chun Chang, Steve Chin, and Douglas Adkins

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A content analysis of vaping advertisements on Twitter, November 2014, Shaina J. Sowles, Melissa J. Krauss, Sarah Connolly, and Patricia A. Cavazos-Rehg

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Adhesive pili in UTI pathogenesis and drug development, Caitlin N. Spaulding and Scott J. Hultgren

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The Brief Case: Dyspnea in a profoundly immunocompromised man, Andrej Spec, Carlos A.Q. Santos, and Morgan A. Pence

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T cells from patients with Candida sepsis display a suppressive immunophenotype, Andrej Spec, Yuichiro Shindo, Carey-Ann D. Burnham, Strother Wilson, Enyo A. Ablordeppey, Evan R. Beiter, Katherine Chang, Anne M. Drewry, and Richard S. Hotchkiss

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Negative emotional reactivity as a marker of vulnerability in the development of borderline personality disorder symptoms, Stephanie D. Stepp, Lori N. Scott, Neil P. Jones, Diana J. Whalen, and Alison E. Hipwell

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Emerging executive functioning and motor development in infants at high and low risk for autism spectrum disorder, Tanya St. John, Annette M. Estes, Stephen R. Dager, Penelope Kostopoulos, Jason J. Wolff, Juhi Pandey, Jed T. Elison, Sarah J. Paterson, Robert T. Schultz, Kelly Botteron, Heather Hazlett, and Joseph Piven

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Proficient replication of the yeast genome by a viral DNA polymerase, Joseph L. Stodola, Carrie M. Stith, and Peter M. Burgers

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Oxidative DNA damage stalls the human mitochondrial replisome, Gorazd Stojkovič, Alena V. Makarova, Paulina H. Wanrooij, Josefin Forslund, Peter M. Burgers, and Sjoerd Wanrooij

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NAMPT-mediated NAD+ biosynthesis in adipocytes regulates adipose tissue function and multi-organ insulin sensitivity in mice, Kelly L. Stromsdorfer, Shintaro Yamaguchi, Myeong Jin Yoon, Anna C. Moseley, Michael P. Franczyk, Shannon C. Kelly, Nathan Qi, Shin-ichiro Imai, and Jun Yoshino

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Early pregnancy vitamin D status and risk of preeclampsia, Robert C. Strunk, Leonard B. Bacharier, and et al

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A randomized controlled trial of directive and nondirective smoking cessation coaching through an employee quitline, Walton Sumner II, Mark S. Walker, Gabrielle R. Hightstein, Irene Fischer, Yan Yan, Amy McQueen, and Edwin B. Fisher

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Fluselenamyl: A novel benzoselenazole derivative for PET detection if amyloid plaques (Aβ) in Alzheimer's disease, G.S. M. Sundaram, Dhruva D. Dhavale, Julie L. Prior, Ping Yan, John Cirrito, Nigam P. Rath, Richard Laforest, Nigel J. Cairns, Jin-Moo Lee, Paul T. Kotzbauer, and Vijay Sharma

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Mesothelin's minimal MUC16 binding moiety converts TR3 into a potent cancer therapeutic via hierarchical binding events at the plasma membrane, Yang Su, Katharina Tatzel, Xuejun Wang, Brian Belt, Pratibha Binder, Lindsay Kuroki, Matthew A. Powell, David G. Mutch, William G. Hawkins, and Dirk Spitzer

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Quantitative amyloid imaging in autosomal dominant Alzheimer’s disease: Results from the DIAN study group, Yi Su, Tyler M. Blazey, Christopher J. Owen, Jon J. Christensen, Karl Friedrichsen, Nelly Joseph-Mathurin, Qing Wang, Russ C. Hornbeck, Beau M. Ances, Abraham Z. Snyder, Lisa A. Cash, Eric McDade, Chengjie Xiong, Daniel S. Marcus, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger, and et al.

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Myeloid deletion of nemo causes osteopetrosis in mice owing to upregulation of transcriptional repressors, Gaurav Swarnkar, Kyuhwan Shim, Amjad M. Nasir, Kuljeet Seehra, Hung-Po (Tim) Chen, Gabriel Mbalaviele, and Yousef Abu-Amer

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Exploring associations between perceived home and work neighborhood environments, diet behaviors, and obesity: Results from a survey of employed adults in Missouri, Rachel Tabak, J. Aaron Hipp, Elizabeth A. Dodson, Lin Yang, Deepti Adlakha, and Ross C. Brownson

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Comparison of open gastrostomy tube to percutaneous endoscopic gastrostomy tube in lung transplant patients, Sharven Taghavi, Vishnu Ambur, Senthil Jayarajan, John Gaughan, Yoshiya Toyoda, Elizabeth Dauer, Lars Ola Sjoholm, Abhijit Pathak, Thomas Santora, and Amy J. Goldberg

Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: implications for drug development and basic cytokine biology, Katharina Tatzel, Lindsay Kuroki, Igor Dmitriev, Elena Kashentseva, David T. Curiel, S. Peter Goedegebuure, Matthew A. Powell, David G. Mutch, William G. Hawkins, and Dirk Spitzer

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Postoperative severe headache following cervical posterior surgical fixation from C2 distally, Ryoji Tauchi, Sang-Hun Lee, Jin-Young Kim, Yong-Chan Kim, Colleen Peters, Shiro Imagama, Naoki Ishiguro, Jacob Buchowski, and K. Daniel Riew

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Postoperative severe headache following cervical posterior surgical fixation from C2 distally, Ryoji Tauchi, Sang-Hun Lee, Jin-Young Kim, Yong-Chan Kim, Colleen Peters, Shiro Imagama, Naoki Ishiguro, Jacob Buchowski, and K. Daniel Riew

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A genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction, Jacquelyn Y. Taylor, Karen Schwander, Sharon L. R. Kardia, Donna Arnett, Jingjing Liang, Steven C. Hunt, D C. Rao, and Yan V. Sun

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Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer, Gregor Tevz, Sean McGrath, Ryan Demeter, Vincent Magrini, Varinder Jeet, Anja Rockstroh, Stephen McPherson, John Lai, Nenad Bartonicek, Jiyuan An, Jyotsna Batra, Marcel E. Dinger, Melanie L. Lehman, Elizabeth D. Williams, and Colleen C. Nelson

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RNF4-dependent oncogene activation by protein stabilization, Jane J. Thomas, Mona Abed, Julian Heuberger, Rostislav Novak, Yaniv Zohar, Angela P. Beltran Lopez, Julie S. Trausch-Azar, Ma. Xenia G. Ilagan, David Benhamou, Gunnar Dittmar, Raphael Kopan, Walter Birchmeier, Alan L. Schwartz, and Amir Orian

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Role of metal-dependent regulation of ESX-3 secretion in intracellular survival of Mycobacterium tuberculosis, Emir Tinaztepe, Jun-Rong Wei, Jenelle Raynowska, Cynthia Portal-Celhay, Victor Thompson, and Jennifer A. Philips

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The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states, M. J. Toneff, A. Sreekumar, A. Tinnirello, P. Den Hollander, S. Habib, Shunqiang Li, M. J. Ellis, L. Xin, S. A. Mani, and J. M. Rosen

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Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance, Erik JM Toonen, Andreea-Manuela Mirea, Cees J. Tack, Rinke Stienstra, Dov B. Ballak, Janna A. van Diepen, Anneke Hijmans, Triantafyllos Chavakis, Wim H. Dokter, Christine TN Pham, Mihai G. Netea, Charles A. Dinarello, and Leo AB Joosten

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A disintegrin and metalloproteinase10 (ADAM10) regulates NOTCH signaling during early retinal development, Joseph A. Toonen, Adam Ronchetti, and D. J. Sidjanin

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Prevalence of asymptomatic bacteriuria in hospitalized patients, Sergio E. Trevino, Jeffrey P. Henderson, Jiami Wu, Candice Cass, and Jonas Marschall

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The impact of nighttime intensivists on medical intensive care unit infection-related indicators, Abhaya Trivedi, Kathleen M. McMullen, Hilary M. Babcock, and Marin H. Kollef

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Coronary CT angiography versus standard emergency department evaluation for acute chest pain and diabetic patients: Is there benefit with early coronary CT angiography? Results of the randomized comparative effectiveness ROMICAT II trial, Quynh A. Truong, Joshua Schulman-Marcus, Pearl Zakroysky, Eric T. Chou, John T. Nagurney, Jerome L. Fleg, David A. Schoenfeld, James E. Udelson, Udo Hoffmann, and Pamela K. Woodard

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A randomized trial comparing skin antiseptic agents at Cesarean delivery, Methodius G. Tuuli, Jingxia Liu, Molly J. Stout, Shannon Martin, Alison G. Cahill, Anthony O. Odibo, Graham A. Colditz, and George A. Macones

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Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development, Kazuhiko Uchiyama, Toshio Sakiyama, Takumu Hasebe, Mark W. Musch, Hiroyuki Miyoshi, Yasushi Nakagawa, Tong-Chuan He, Lev Lichtenstein, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa, Bana Jabri, Thaddeus Stappenbeck, and Eugene B. Chang

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Induction of protective immunity to Cryptococcal infection in mice by a heat-killed, chitosan-deficient strain of Cryptococcus neoformans, Rajendra Upadhya, Woei C. Lam, Brian Maybruck, Charles A. Specht, Stuart M. Levitz, and Jennifer K. Lodge

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Wolfram syndrome: Diagnosis, management, and treatment, Fumihiko Urano

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Guidance for the use of thrombolytic therapy for the treatment of venous thromboembolism, Suresh Vedantham, Gregory Piazza, Akhilesh K. Sista, and Neil A. Goldenberg

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Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: Prospective cohort study, Nicola Veronese, Yanping Li, JoAnn E. Manson, Walter C. Willett, Luigi Fontana, and Frank B. Hu

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Community rates of IgG4 antibodies to Ascaris haemoglobin reflect changes in community egg loads following mass drug administration, Johnny Vlaminck, Taniawati Supali, Peter Geldhof, Cornelis H. Hokke, Peter U. Fischer, and Gary J. Weil

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Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD, Erin K. Wagner, Soumya Raychaudhuri, Mercedes B. Villalonga, Anuja Java, Michael P. Triebwasser, Mark J. Daly, John P. Atkinson, and Johanna M. Seddon