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Submissions from 2014

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Clinical presentation and disease characteristics of femoroacetabular impingement are sex-dependent, Jeffrey J. Nepple, Cassandra N. Riggs, James R. Ross, and John C. Clohisy

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Finished sequence and assembly of the DUF1220-rich 1q21 region using a haploid human genome, Majesta O'Bleness, Veronica B. Searles, C. Michael Dickens, David Astling, Derek Albracht, Angel C.Y. Mak, Yvonne Y.Y. Lai, Chin Lin, Catherine Chu, Tina Graves, Pui-Yan Kwok, Richard K. Wilson, and James M. Sikela

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Key issues and opportunities in the evolving health-care marketplace: AOA critical issues, Kristin Olds Glavin, Daniel B. Murrey, Joel C. Porter, Donald Brunn, and Rick W. Wright

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Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration, Patrick R. O'Neill and N. Gautam

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Simultaneous bilateral or unilateral carpal tunnel release? A prospective cohort study of early outcomes and limitations, Daniel A. Osei, Ryan P. Calfee, Jeffrey G. Stepan, Martin I. Boyer, Charles A. Goldfarb, and Richard H. Gelberman

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Brain-behavior relationships in the experience and regulation of negative emotion in healthy children: Implications for risk for childhood depression, David Pagliaccio, Joan L. Luby, Katherine R. Luking, Andrew C. Belden, and Deanna M. Barch

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Multimeric assembly of host-pathogen adhesion complexes involved in apicomplexan invasion, May M. Paing and Niraj H. Tolia

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Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes, Pankaj Pal, Julie M. Fox, Michael S. Diamond, and et al

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Anti-angiogenesis therapy in the Vx2 rabbit cancer model with a lipase-cleavable Sn 2 taxane phospholipid prodrug using αvβ3-targeted theranostic nanoparticles, Dipanjan Pan, Anne H. Schmieder, Kezheng Wang, Xiaoxia Yang, Angana Senpan, Grace Cui, Kendall Killgore, Benjamin Kim, John S. Allen, Huiying Zhang, Shelton D. Caruthers, Baozhong Shen, Samuel A. Wickline, and Gregory M. Lanza

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Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice, Joanna E. Pankiewicz, Maitea Guridi, Jungsu Kim, Ayodeji A. Asuni, Sandrine Sanchez, Patrick M. Sullivan, David M. Holtzman, and Martin J. Sadowski

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Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer, Roheena Z. Panni, Dominic E. Sanford, Brian A. Belt, Jonathan B. Mitchem, Lori A. Worley, Brian D. Goetz, Pinku Mukherjee, Andrea Wang-Gillam, Daniel C. Link, David G. DeNardo, S. Peter Goedegebuure, and David C. Linehan

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Age-related changes in cervical sagittal range of motion and alignment, Moon S. Park, Seong-Hwan Moon, Hwan-Mo Lee, Tae-Hwan Kim, Jae K. Oh, Ji H. Nam, and K. D. Riew

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The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice, Charlyn G. Partridge, Gloria L. Fawcett, Bing Wang, Clay F. Semenkovich, and James M. Cheverud

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The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development, Chinmoy Patra, Kelly R. Monk, and Felix B. Engel

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Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIB procollagen and down-regulation of cholesterol and lipid homeostasis, Debabrata Patra, Elizabeth DeLassus, Guosheng Liang, and Linda J. Sandell

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An allometric scaling relationship in the brain of preterm infants, Rachel A. Paul, Christopher D. Smyser, Cynthia E. Rogers, Ian English, Michael Wallendorf, Dimitrios Alexopoulos, Erin J. Meyer, David C. Van Essen, Jeffrey J. Neil, and Terrie E. Inder

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Methodological challenges and solutions in auditory functional magnetic resonance imaging, Jonathan E. Peelle

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Photo quiz: A 58-year-old female with altered mental status, Morgan A. Pence and Carey-Ann D. Burnham

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Outcome for children with metastatic solid tumors over the last four decades, Stephanie M. Perkins, Eric T. Shinohara, Todd DeWees, and Haydar Frangoul

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Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: A decade of the PREDICT-HD study, Joel S. Perlmutter, Stacey Barton, Shineeka Kaye Smith, and et al

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A rare sequence variant in intron 1 of THAP1 is associated with primary dystonia, Joel S. Perlmutter, Brad A. Racette, Randal C. Paniello, and et al

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Gait-related brain activity in people with Parkinson disease with freezing of gait, Daniel S. Peterson, Kristen A. Pickett, Ryan Duncan, Joel Perlmutter, and Gammon M. Earhart

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Increased iron sequestration in alveolar macrophages in chronic obtructive pulmonary disease, Quentin Philippot, Gaetan Deslee, Tracy L. Adair-Kirk, Jason C. Woods, Derek Byers, Susan Conradi, Sandra Dury, Jeanne Marie Perotin, Francois Lebargy, Christelle Cassan, Richard Le Naour, Michael J. Holtzman, and Richard A. Pierce

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Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis, Amelia K. Pinto, Hilario J. Ramos, Xiaobo Wu, Shilpa Aggarwal, Bimmi Shrestha, Matthew Gorman, Kristin Y. Kim, Mehul S. Suthar, John P. Atkinson, Michael Gale Jr., and Michael S. Diamond

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Routine testing for anaerobic bacteria in cerebrospinal fluid cultures improves recovery of clinically significant pathogens, Meredith E. Pittman, Benjamin S. Thomas, Meghan A. Wallace, Carol J. Weber, and Carey-Ann D. Burnham

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Streptococcus pyogenes polymyxin B-resistant mutants display enhanced exportal integrity, Gary C. Port, Luis A. Vega, Andrew B. Nylander, and Michael G. Caparon

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Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference, George S. Portugal, Ream Al-Hasani, Amanda K. Fakira, Jose L. Gonzalez-Romero, Zare Melyan, Jordan G. McCall, Michael R. Bruchas, and Jose A. Moron

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Comparative analyses of proteins from Haemophilus influenzae biofilm and planktonic populations using metabolic labeling and mass spectrometry, Deborah MB Post, Jason M. Held, Margaret R. Ketterer, Nancy J. Phillips, Alexandria Sahu, Michael A. Apicella, and Bradford W. Gibson

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Missed opportunities: Racial and neighborhood socioeconomic disparities in emergency colorectal cancer diagnosis and surgery, Sandi L. Pruitt, Nicholas O. Davidson, Samir Gupta, Yan Yan, and Mario Schootman

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Molecularly targeted therapies in multiple myeloma, Pilar de la Puente, Barbara Muz, Feda Azab, Micah Luderer, and Abdel Kareem Azab

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Single-cell resolution imaging of retinal ganglion cell apoptosis in vivo using a cell-penetrating caspase-activatable peptide probe, Xudong Qiu, James R. Johnson, Bradley S. Wilson, Seth T. Gammon, David Piwnica-Worms, and Edward M. Barnett

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Epidemiology of blunt head trauma in children in U.S. Emergency Departments, Kimberly S. Quayle, Elizabeth C. Powell, Prashant Mahajan, John D. Hoyle, Frances M. Nadel, Mohammed K. Badawy, Jeff E. Schunk, Rachel M. Stanley, Michelle Miskin, Shireen M. Atabaki, Peter S. Dayan, James F. Holmes, and Nathan Kuppermann

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Opposing brain differences in 16p11.2 deletion and duplication carriers, Abid Y. Qureshi, Sophia Mueller, Abraham Z. Snyder, Pratik Mukherjee, Jeffrey I. Berman, Timothy P. L. Roberts, Srikantan S. Nagarajan, John E. Spiro, Wendy K. Chung, Elliott H. Sherr, and Randy L. Buckner

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Diffusion tensor imaging in children with unilateral hearing loss: A pilot study, Tara Rachakonda, Joshua S. Shimony, Rebecca S. Coalson, and Judith E.C. Lieu

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The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy, Cara Rada, Nan Lin, Sarah K. England, and et al

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AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake, Ramachandran Rashmi, Carl DeSelm, Cynthia Helms, Anne Bowcock, Buck E. Rogers, Janet Rader, Perry W. Grigsby, and Julie K. Schwarz

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IL-15 deficient Tax mice reveal a role for IL-1α in tumor immunity, Daniel A. Rauch, John C. Harding, and Lee Ratner

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Illustrated techniques for performing the Cox-Maze IV procedure through a right mini-thoracotomy, Jason O. Robertson, Lindsey L. Saint, Jeremy E. Leidenfrost, and Ralph J. Damiano Jr.

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Utilizing cytokines to function-enable human NK cells for the immunotherapy of cancer, Rizwan Romee, Jeffrey W. Leong, and Todd A. Fehniger

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Genome-wide tissue-specific gene expression, co-expression and regulation of co-expressed genes in adult nematode Ascaris suum, Bruce A. Rosa, Douglas P. Jasmer, and Makedonka Mitreva

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The role of neutrophil myeloperoxidase in models of lung tumor development, Amy Rymaszewski, Everett Tate, Joannes P. Yimbesalu, Andrew E. Gelman, Jason A. Jarzembowski, Hao Zhang, Kirkwood A. Pritchard Jr., and Haris G. Vikis

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How I do it: Minimally invasive Cox-Maze IV procedure, Lindsey L. Saint, Christopher P. Lawrance, Jeremy E. Leidenfrost, Jason O. Roberston, and Ralph J. Damiano Jr.

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Critical glycosylated residues in exon three of erythrocyte Glycophorin A engage Plasmodium falciparum EBA-175 and define receptor specificity, Nichole D. Salinas, May M. Paing, and Niraj H. Tolia

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Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis, Nayan J. Sarma, Venkataswarup Tiriveedhi, Jeffrey S. Crippin, William C. Chapman, and Thalachallour Mohanakumar

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Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy, Aaron D. Schenone, Jingqin Luo, Luke Montgomery, Daniel Morgensztern, Douglas R. Adkins, and Brian A. Van Tine

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BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway, Brandon M. Schickling, Sarah K. England, Nukhet Aykin-Burns, Lyse A. Norian, Kimberly K. Leslie, and Victoria P. Frieden-Korovkina

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Shiga toxin-producing Escherichia coli: A single-center, 11-year pediatric experience, Emily I. Schindler, Patricia Sellenriek, Gregory A. Storch, Phillip I. Tarr, and Carey-Ann D. Burnham

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Dendritic cells in dengue virus infection: Targets of virus replication and mediators of immunity, Michael A. Schmid, Michael S. Diamond, and Eva Harris

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Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and Major Depressive Disorder, Andrew J. Schrage, Michele L. Pergadia, Pamela A. F. Madden, and et al

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Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling, Rebecca C. Schugar, Ashley R. Moll, D. Andre d'Avignon, Carla J. Weinheimer, Attila Kovacs, and Peter A. Crawford

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Targeting hepatic glycerolipid synthesis and turnover to treat fatty liver disease, George G. Schweitzer and Brian N. Finck

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Provision of no-cost, long-acting contraception and teenage pregnancy., Gina M. Secura, Tessa Madden, Colleen McNicholas, Jennifer Mullersman, Christina M. Buckel, Qiuhong Zhao, and Jeffrey F. Peipert

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Domain-general signals in the cingulo-opercular network for visuospatial attention and episodic memory, Carlo Sestieri, Maurizio Corbetta, Sara Spadone, Gian Luca Romani, and Gordon L. Shulman

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Absence of calcium‐independent phospholipase A2β impairs platelet‐activating factor production and inflammatory cell recruitment in Trypanosoma cruzi‐infected endothelial cells, Janhavi Sharma, Christopher S. Eickhoff, Daniel F. Hoft, John O. Marentette, John Turk, and Jane McHowat

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Immuno-PET of epithelial ovarian cancer: Harnessing the potential of CA125 for non-invasive imaging, Sai Kiran Sharma, Melinda Wuest, Monica Wang, Darryl Glubrecht, Bonnie Andrais, Suzanne E. Lapi, and Frank Wuest

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Contribution of the highly conserved EaeH surface protein to enterotoxigenic Escherichia coli pathogenesis, Alaullah Sheikh, Qingwei Luo, Koushik Roy, Salwa Shabaan, Pardeep Kumar, Firdausi Qadri, and James M. Fleckenstein

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Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9, Bang Shen, Kevin M. Brown, Tobie D. Lee, and L. David Sibley

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Functional analysis of rhomboid proteases during Toxoplasma invasion, Bang Shen, Jeffrey S. Buguliskis, Tobie D. Lee, and L. David Sibley

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Fluoroscopically guided extraforaminal cervical nerve root blocks: Analysis of epidural flow of the injectate with respect to needle tip position, Kyle Shipley, K. D. Riew, and Louis A. Gilula

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Predictors of hospital mortality among septic ICU patients with Acinetobacter spp. bacteremia: A cohort study, Andrew F. Shorr, Marya D. Zilberberg, Scott T. Micek, and Marin H. Kollef

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The circuitry of abulia: Insights from functional connectivity MRI, J. S. Siegel, A. Z. Snyder, N. V. Metcalf, R. P. Fucetola, C. D. Hacker, J. S. Shimony, G. L. Shulman, and M. Corbetta

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SIRT6 is required for normal retinal function, Dafne M. Silberman, Kenneth Ross, Pablo H. Sande, Shunsuke Kubota, Sridhar Ramaswamy, Rajendra S. Apte, and Raul Mostoslavsky

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Spike-timing computation properties of a feed-forward neural network model, Drew B. Sinha, Noah M. Ledbetter, and Dennis L. Barbour

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Patient age is related to decision-making, treatment selection, and perceived quality of life in breast cancer survivors, Terence T. Sio, Kenneth Chang, Ritujith Jayakrishnan, Difu Wu, Mary Politi, Dominique Malacarne, James Saletnik, and Maureen Chung

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Multiple dietary supplements do not affect metabolic and cardio-vascular health, Andreea Soare, Edward P. Weiss, John O. Holloszy, and Luigi Fontana

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells, Dorothy K. Sojka, Beatrice Plougastel-Douglas, Liping Yang, Melissa A. Pak-Wittel, Maxim N. Artyomov, Yulia Ivanova, Chao Zhong, Julie M. Chase, Paul B. Rothman, Jenny Yu, Joan K. Riley, Jinfang Zhu, Zhigang Tian, and Wayne M. Yokoyama

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Dynamic radiographic criteria for detecting pseudarthrosis following anterior cervical arthrodesis, Kwang-Sup Song, Chaiwat Piyaskulkaew, Tapanut Chuntarapas, Jacob M. Buchowski, Han Jo Kim, Moon Soo Park, Hyun Kang, and K. Daniel Riew

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State practitioner insights into local public health challenges and opportunities in obesity prevention: A qualitative study, Katherine A. Stamatakis, Moira Lewis, Elaine C. Khoong, and Claire LaSee

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Unexpected abrupt increase in left ventricular assist device thrombosis, Randall C. Starling, Nader Moazami, Scott C. Silvestry, Gregory Ewald, Joseph G. Rogers, Carmelo A. Milano, J Eduardo Rame, Michael A. Acker, Eugene H. Blackstone, John Ehrlinger, Lucy Thuita, Maria M. Mountis, Edward G. Soltesz, Bruce W. Lytle, and Nicholas G. Smedira

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Expression of nampt in hippocampal and cortical excitatory neurons is critical for cognitive function, Liana Roberts Stein, David F. Wozniak, Joshua T. Dearborn, Shunsuke Kubota, Rajendra S. Apte, Yukitoshi Izumi, Charles F. Zorumski, and Shin-ichiro Imai

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Impact of radiation therapy on survival in patients with triple‑negative breast cancer, Lauren T. Steward, Feng Gao, Marie A. Taylor, and Julie A. Margenthaler

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Arterial spin labeling versus BOLD in direct challenge and drug-task interaction pharmacological fMRI, Stephanie B. Stewart, Jonathan M. Koller, Meghan C. Campbell, and Kevin J. Black

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Distribution and medical impact of loss-of-function variants in the Finnish founder population, Nathan O. Stitziel and et al

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Differentiating c8-t1 radiculopathy from ulnar neuropathy: A survey of 24 spine surgeons, Geoffrey E. Stoker, Han J. Kim, and K. D. Riew

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Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline, Nicholas Stong, Zhong Deng, Ravi Gupta, Sufen Hu, Shiela Paul, Amber K. Weiner, Evan E. Eichler, Tina Graves, Catrina C. Fronick, Laura Courtney, Richard K. Wilson, Paul M. Lieberman, Ramana V. Davuluri, and Harold Riethman

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Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation, Robert Strunk and et al

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Single nucleotide variants in transcription factors associate more tightly with phenotype than with gene expression, Priya Sudarsanam and Barak A. Cohen

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Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons, Daniel W. Summers, Aaron DiAntonio, and Jeffrey Milbrandt

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TCAB1: A potential target for diagnosis and therapy of head and neck carcinomas, Chong-kui Sun, Xiao-bo Luo, Ya-ping Gou, Ling Hu, Kun Wang, Chao Li, Zhen-ting Xiang, Ping Zhang, Xiang-li Kong, Chao-liang Zhang, Qin Yang, Jing Li, Li-ying Xiao, Yan Li, and Qian-ming Chen

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Widespread contribution of transposable elements to the innovation of gene regulatory networks, Vasavi Sundaram, Yong Cheng, Zhihai Ma, Daofeng Li, Xiaoyun Xing, Peter Edge, Michael P. Snyder, and Ting Wang

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Whole genome sequence analysis of the simulated systolic blood pressure in Genetic Analysis Workshop 18 family data: Long-term average and collapsing methods, Yun Ju Sung, Jacob Basson, and Dabeeru C. Rao

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Comparison of two methods for analysis of gene-environment interactions in longitudinal family data: The Framingham heart study, Yun Ju Sung, Jeannette Simino, Rezart Kume, Jacob Basson, Karen Schwander, and D. C. Rao

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Congenitally acquired persistent lymphocytic choriomeningitis viral infection reduces neuronal progenitor pools in the adult hippocampus and subventricular zone, Tony Sun, Michael J. Vasek, and Robyn S. Klein

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Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development, Gaurav Swarnkar, Kaihua Zhang, Gabriel Mbalaviele, Fanxin Long, and Yousef Abu-Amer

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Proteasome inhibitors activate autophagy involving inhibition of PI3K-Akt-mTOR pathway as an anti-oxidation defense in human RPE cells, Bingrong Tang, Jingjing Cai, Lin Sun, Yiping Li, Jia Qu, Barbara Joy Snider, and Shengzhou Wu

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Genome sequence of Escherichia coli O157:H7 strain 2886-75, associated with the first reported case of human infection in the United States, Phillip I. Tarr and et al

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The role of muscle loading on bone (re)modeling at the developing enthesis, Alexander M. Tatara, Justin H. Lipner, Rosalina Das, H. Mike Kim, Nikunj Patel, Eleni Ntouvali, Matthew J. Silva, and Stavros Thomopoulos

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Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile Virus infection, Larissa B. Thackray, Bimmi Shrestha, Justin M. Richner, Jonathan J. Miner, Amelia K. Pinto, Helen M. Lazear, and Michael Gale Jr.

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Mycobacterium ulcerans infection imported from Australia to Missouri, USA, 2012, Benjamin Stuart Thomas, Thomas C. Bailey, Julu Bhatnagar, Jana M. Ritter, Brian D. Emery, Omar W. Jassim, Ian Kerst Hornstra, and Sarah L. George

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Using written narratives in public health practice: A creative writing perspective, Tess Thompson and Matthew W. Kreuter

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Mechanistically distinct mouse models for CRX-associated retinopathy, Nicholas M. Tran, Alan Zhang, Xiaodong Zhang, Julie B. Huecker, Anne K. Hennig, and Shiming Chen

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Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial ischemia reperfusion injury, Huei-Ping Tzeng, Sarah Evans, Feng Gao, Kari Chambers, Veli K. Topkara, Natarajan Sivasubramanian, Philip M. Barger, and Douglas L. Mann

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Species D human adenovirus type 9 exhibits better virus-spread ability for antitumor efficacy among alternative serotypes, Junji Uchino, David T. Curiel, and Hideyo Ugai

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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2, Jason D. Ulrich, Mary Beth Finn, Yaming Wang, Alice Shen, Thomas E. Mahan, Hong Jiang, Floy R. Stewart, Laura Piccio, Marco Colonna, and David M. Holtman

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Cryptococcus at work: Gene expression during human infection, Rajendra Upadhya, Maureen J. Donlin, and Jennifer K. Lodge

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CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma, Ravindra Uppaluri, James S. Lewis Jr, and et al

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Origin and consequences of the relationship between protein mean and variance, Francesco Luigi Massimo Vallania, Marc Sherman, Zane Goodwin, Ilaria Mogno, Barak Alon Cohen, and Robi David Mitra

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Listening effort and accented speech, Kristen J. Van Engen and Jonathan E. Peelle

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Speckle contrast optical tomography: A new method for deep tissue three-dimensional tomography of blood flow, Hari M. Varma, Claudia P. Valdes, Anna K. Kristoffersen, Joseph P. Culver, and Turgut Durduran

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Treatment of gram - positive infections in critically ill patients, Cristina Vazquez-Guillamet and Marin H. Kollef