The Open Access Publications collection contains peer-reviewed articles authored by Washington University School of Medicine faculty that have been published in open access journals or authorized by the publishers for open access availability. Open access works are generally defined as being publicly available online and free of most licensing and copyright restrictions. The Bernard Becker Medical Library maintains this collection in support of Washington University’s commitment to the principles of open access publishing and making the scholarly work and research results of our faculty as widely and easily available as possible.

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Submissions from 2020

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Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart, Luigi Adamo, Cibele Rocha-Resende, Chieh-Yu Lin, Sarah Evans, Jesse Williams, Hao Dun, Wenjun Li, Cedric Mpoy, Prabhakar S Andhey, Buck E Rogers, Kory Lavine, Daniel Kreisel, Maxim Artyomov, Gwendalyn J Randolph, and Douglas L Mann

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Chordoma with lung metastases at initial presentation of a pediatric patient, Samiat Agunbiade, Ayman Nada, Sudhir Bhimaniya, Matthew T Whitehead, and Eman S Mahdi

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A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity, Munir Akkaya, Patrick W Sheehan, and et al

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Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons, Carolina Alquezar, Jessica B. Felix, Elizabeth McCandlish, Brian T. Buckley, Dominique Caparros-Lefebvre, Celeste M. Karch, Lawrence I. Golbe, and Aimee W. Kao

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The impact of due process and disruptions on emergency medicine education in the United States, Al'ai Alvarez, Anne Messman, Melissa Platt, Megan Healy, Elaine B Josephson, Shawn London, and Douglas Char

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The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells, David A. Anderson III, Theresa L. Murphy, Robert N. Eisenman, and Kenneth M. Murphy

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The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells, David A. Anderson III, Theresa L. Murphy, Robert N. Eisenman, and Kenneth M. Murphy

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Professional decision-making in medicine: Development of a new measure and preliminary evidence of validity, Alison L. Antes, Kelly K. Dineen, Erin Bakanas, Tyler Zahrli, Jason D. Keune, Matthew J. Schuelke, and James M. DuBois

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Composite measure of physiological dysregulation as a predictor of mortality: The Long Life Family Study, Konstantin G Arbeev, Olivia Bagley, Svetlana V Ukraintseva, Hongzhe Duan, Alexander M Kulminski, Eric Stallard, Deqing Wu, Kaare Christensen, Mary F Feitosa, Bharat Thyagarajan, Joseph M Zmuda, and Anatoliy I Yashin

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Trends in postrelapse survival in classic Hodgkin lymphoma patients after experiencing therapy failure following auto-HCT, Talha Badar, Narendranath Epperla, Aniko Szabo, Steven Borson, John Vaughn, Gemlyn George, Neeraj Saini, Abdul Rashid Shah, Romil D. Patel, Sairah Ahmed, Nirav N. Shah, Amanda F. Cashen, Mehdi Hamadani, and Timothy S. Fenske

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Integrative analysis identifies candidate tumor microenvironment and intracellular signaling pathways that define tumor heterogeneity in NF1, Jineta Banerjee, Robert J Allaway, Jaclyn N Taroni, Aaron Baker, Xiaochun Zhang, Chang In Moon, Christine A Pratilas, Jaishri O Blakeley, Justin Guinney, Angela Hirbe, Casey S Greene, and Sara Jc Gosline

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Sensitivity analysis of Monte Carlo model of a gantry-mounted passively scattered proton system, Milad Baradaran-Ghahfarokhi, Francisco Reynoso, Michael T Prusator, Baozhou Sun, and Tianyu Zhao

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Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples, Sonali P. Barwe, Anilkumar Gopalakrisnapillai, Nitin Mahajan, Todd E. Druley, E. Anders Kolb, and Erin L. Crowgey

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Structural and biophysical analysis of the CLCA1 VWA domain suggests mode of TMEM16A engagement, Kayla N Berry and Tom J Brett

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5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus, R. Blake Billmyre, Shelly Applen Clancey, Lucy X. Li, Tamara L. Doering, and Joseph Heitman

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Anellovirus dynamics are associated with primary graft dysfunction in lung transplantation, Joshua A. Blatter, Tsuyoshi Takahashi, Brigitte Mittler, Ruben G. Nava, Varun Puri, Daniel Kreisel, and David Wang

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How to Stop the Bleed: First Care Provider model for developing public trauma response beyond basic hemorrhage control, Joshua P Bobko, Dylan J Badin, Leila Danishgar, Kate Bayhan, Kevin J Thompson, William J Harris, R. Todd Baldridge, and Gerald R Fortuna

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Diabetes minimally mediated the association between PM2.5 air pollution and kidney outcomes, Benjamin Bowe, Yan Xie, Yan Yan, Hong Xian, and Ziyad Al-Aly

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Polycystin 2 is increased in disease to protect against stress-induced cell death, Allison L. Brill, Tom T. Fischer, Jennifer M. Walters, Arnaud Marlier, Lorenzo R. Sewanan, Parker C. Wilson, Eric K. Johnson, Gilbert Moeckel, Lloyd G. Cantley, Stuart G. Campbell, Jeanne M. Nerbonne, Hee Jung Chung, Marie E. Robert, and Barbara E. Ehrlich

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False-negative upper extremity ultrasound in the initial evaluation of patients with suspected subclavian vein thrombosis due to thoracic outlet syndrome (Paget-Schroetter syndrome), Evan R Brownie, Ahmmad A Abuirqeba, J Westley Ohman, Brian G Rubin, and Robert W Thompson

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Workshop on the development and evaluation of digital therapeutics for health behavior change: Science, methods, and projects, Alan J Budney, Lisa A Marsch, Will M Aklin, Jacob T Borodovsky, Mary F Brunette, Andrew T Campbell, Jesse Dallery, David Kotz, Ashley A Knapp, Sarah E Lord, Edward V Nunes, Emily A Scherer, Catherine Stanger, and William C Torrey

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Use of neuroimaging to inform optimal neurocognitive criteria for detecting HIV-associated brain abnormalities, Laura M Campbell, David B Clifford, et al, and CHARTER Group

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Protective and pathogenic effects of interferon signaling during pregnancy, Rebecca L. Casazza, Helen M. Lazear, and Jonathan J. Miner

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Hematopoietic cell transplantation in patients with Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) survey, Alice Y. Chan, Jeffrey J. Bednarski, Megan A. Cooper, Shalini Shenoy, and et al

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L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction, Meenakshi A. Chellaiah, Megan C. Moorer, Sunipa Majumdar, Hanan Aljohani, Sharon C. Morley, Vanessa Yingling, and Joseph P. Stains

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miRDB: An online database for prediction of functional microRNA targets, Yuhao Chen and Xiaowei Wang

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Randomized, double-blind, placebo-controlled, flexible-dose titration study of methylphenidate hydrochloride extended-release capsules (Aptensio XR) in preschool children with attention-deficit/hyperactivity disorder, Ann C. Childress, Scott H. Kollins, Henry C. Foehl, Jeffrey H. Newcorn, Greg Mattingly, Robert J. Kupper, and Akwete L. Adjei

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LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target, Mayur Choudhary, Ebraheim N Ismail, Pei-Li Yao, Faryan Tayyari, Roxana A Radu, Steven Nusinowitz, Michael E Boulton, Rajendra S Apte, Jeffrey W Ruberti, James T Handa, Peter Tontonoz, and Goldis Malek

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Melanin deposition in two Cryptococcus species depends on cell-wall composition and flexibility, Christine Chrissian, Emma Comacho, Man Shun Fu, Rafael Prados-Rosales, Subhasish Chatterjee, Radames J.B. Cordero, Jennifer K. Lodge, Arturo Casadevall, and Ruth E. Stark

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Interpreting pathways to discover cancer driver genes with Moonlight, Antonio Colaprico, Matthew H. Bailey, and et al.

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Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis, Sarah Colijn, Vijay Muthukumar, Jun Xie, Siqi Gao, and Courtney T Griffin

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A ten-year retrospective evaluation of acute flaccid myelitis at 5 pediatric centers in the United States, 2005-2014, Margaret M. Cortese, Anita K. Kambhampati, Jennifer E. Schuster, Zaid Alhinai, Gary R. Nelson, Gloria J. Guzman Perez-Carrillo, Arastoo Vossough, Michael A. Smit, Robert C. McKinstry, Timothy Zinkus, Kevin R. Moore, Jeffrey M. Rogg, Meghan S. Candee, James J. Sejvar, and Sarah E. Hopkins

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Genome-wide association study of opioid cessation, Jiayi W Cox, Richard M Sherva, Kathryn L Lunetta, Emma C Johnson, Nicholas G Martin, Louisa Degenhardt, Arpana Agrawal, Elliot C Nelson, Henry R Kranzler, Joel Gelernter, and Lindsay A Farrer

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2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: Executive summary, Edmond M Cronin, Phillip Cuculich, and et al

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Deciphering the factors that influence participation in studies requiring serial lumbar punctures, Gregory S Day, Tracy Rappai, Sushila Sathyan, and John C Morris

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Medulloblastoma has a global impact on health related quality of life: Findings from an international cohort, Cynthia B de Medeiros, Josh Rubin, and et al

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Prevalence and family-related factors associated with suicidal ideation, suicide attempts, and self-injury in children aged 9 to 10 years, Danielle C. DeVille, Diana Whalen, Florence J. Breslin, Amanda S. Morris, Sahib S. Khalsa, Martin P. Paulus, and Deanna M. Barch

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Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction, Xunshan Ding, Rugmani Iyer, Christopher Novotny, Daniel Metzger, Heather H. Zhou, Gordon I. Smith, Mihoko Yoshino, Jun Yoshino, Samuel Klein, Gayathri Swaminath, Saswata Talukdar, and Yingjiang Zhou

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Derivation of trophoblast stem cells from naïve human pluripotent stem cells, Chen Dong, Mariana Beltcheva, Paul Gontarz, Bo Zhang, Pooja Popli, Laura A. Fischer, Shafqat A Khan, Kyoung-Mi Park, Eun-Ja Yoon, Xiaoyun Xing, Ramakrishna Kommagani, Ting Wang, Lilianna Solnica-Krezel, and Thorold W. Theunissen

Safety and efficacy of co-administered diethylcarbamazine, albendazole and ivermectin during mass drug administration for lymphatic filariasis in Haiti: Results from a two-armed, open-label, cluster-randomized, community study, Christine Dubray, Anita Sircar, Madsen Beau de Rochars, Joshua Bogus, Abdel N. Direny, Jean Romuald Ernest, Carl Fayette, Charles W. Goss, Marisa Hast, Katiuscia O'Brian, Guy Emmanuel Pavilus, Daniel Frantz Sabin, Ryan Wiegand, Gary J. Weil, and Jean Frantz Lemoine

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A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry, Zhaohui Du, Graham A. Colditz, Mark A. Fiala, Ravi Vij, and et al.

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Murine Surf4 is essential for early embryonic development, Brian T. Emmer, Paul J. Lascuna, Vi T. Tang, Emilee N. Kotnik, Thomas L. Saunders, Rami Khoriaty, and David Ginsburg

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Confidential genetic testing and electronic health records: A survey of current practices among Huntington disease testing centers, Celeste C Eno, Stacey K Barton, Naghmeh Dorrani, Stephen D Cederbaum, Joshua L Deignan, and Wayne W Grody

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Variant R94C in TNNT2‐encoded troponin T predisposes to pediatric restrictive dardiomyopathy and sudden death through impaired thin filament relaxation resulting in myocardial diastolic dysfunction, Jordan E Ezekian, Sarah R Clippinger, Jaquelin M Garcia, Qixin Yang, Susan Denfield, Aamir Jeewa, William J Dreyer, Wenxin Zou, Yuxin Fan, Hugh D Allen, Jeffrey J Kim, Michael J Greenberg, and Andrew P Landstrom

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Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2, José Luís Fachi, Cristiane Sécca, Blanda Di Luccia, Marco Colonna, and et al

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Identifying determinants of bacterial fitness in a model of human gut microbial succession, Lihui Feng, Arjun S. Raman, Matthew C. Hibberd, Jiye Cheng, Nicholas W. Griffin, Yangqing Peng, Semen A. Leyn, Dmitry A. Rodionov, Andrei L. Osterman, and Jeffrey I. Gordon

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Dill extract induces elastic fiber neosynthesis and functional improvement in the ascending aorta of aged mice with reversal of age-dependent cardiac hypertrophy and involvement of lysyl oxidase-like-1, Wassim Fhayli, Quentin Boëté, Nadjib Kihal, Valérie Cenizo, Pascal Sommer, Walter A Boyle, Marie-Paule Jacob, and Gilles Faury

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Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients, Krisstopher Richard Flores, Fausta Viccaro, Mauro Aquilini, Stefania Scarpino, Francesco Ronchetti, Rita Mancini, Arianna Di Napoli, Davide Scozzi, and Alberto Ricci

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Continuous representations of speed by striatal medium spiny neurons, Wambura C. Fobbs, Sebastiano Bariselli, Julia A. Licholai, Nanami L. Miyazaki, Bridget A. Matikainen-Ankney, Meaghan C. Creed, and Alexxai V. Kravitz

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Emerging priorities for HIV service delivery, Nathan Ford, Elvin Geng, and et al.

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A framework for applying natural language processing in digital health interventions, Burkhardt Funk, Shiri Sadeh-Sharvit, Ellen E Fitzsimmons-Craft, Mickey Todd Trockel, Grace E Monterubio, Neha J Goel, Katherine N Balantekin, Dawn M Eichen, Rachael E Flatt, Marie-Laure Firebaugh, Corinna Jacobi, Andrea K Graham, Mark Hoogendoorn, Denise E Wilfley, and C Barr Taylor

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Defining stage-specific activity of potent new inhibitors of Cryptosporidium parvum growth in vitro, Lisa J Funkhouser-Jones, Soumya Ravindran, and L. David Sibley

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Multicenter evaluation of the new Etest gradient diffusion method for piperacillin-tazobactam susceptibility testing of Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii complex, Sergio García-Fernández, Yohann Bala, Tom Armstrong, María García-Castillo, Carey-Ann D. Burnham, Meghan A Wallace, Dwight Hardy, Gilles Zambardi, and Rafael Cantón

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Simultaneous immunization with Omp25 and L7/L12 provides protection against brucellosis in mice, Sonal Gupta, Surender Mohan, Vikas Kumar Somani, Somya Aggarwal, and Rakesh Bhatnagar

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Intracranial glioma xenograft model rapidly reestablishes blood–brain barrier integrity for longitudinal imaging of tumor progression using fluorescence molecular tomography and contrast agents, LeMoyne Habimana-Griffin, Dezhuang Ye, Julia Carpenter, Julie Prior, Gail Sudlow, Lynne Marsala, Matthew Mixdorf, Joshua B. Rubin, Hong Chen, and Samuel Achilefu

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Ancestry specific associations of FTO gene variant and metabolic syndrome: A longitudinal ARIC study, Dale S. Hardy, Jane T. Garvin, Tesfaye B. Mersha, and Susan B. Racette

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WormBase: A modern Model Organism Information Resource, Todd W. Harris, Tim Schedl, and et al

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Perfect timing: Circadian rhythms, sleep, and immunity - an NIH workshop summary, Jeffrey A Haspel, Andrew E Gelman, Brian S Kim, and et al

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Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy, Holger Hengel, Marisa V. Andrews, Marcia C. Willing, and et al.

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The Plasmodium falciparum artemisinin susceptibility-associated AP-2 adaptin μ subunit is clathrin independent and essential for schizont maturation, Ryan C Henrici, Rachel L Edwards, Martin Zoltner, Donelly A van Schalkwyk, Melissa N Hart, Franziska Mohring, Robert W Moon, Stephanie D Nofal, Avnish Patel, Christian Flueck, David A Baker, Audrey R Odom John, Mark C Field, and Colin J Sutherland

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Cryptococcus neoformans chitin synthase 3 plays a critical role in dampening host inflammatory responses, Camaron R Hole, Woei C Lam, Rajendra Upadhya, and Jennifer K Lodge

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Effects of TDP2/VPg unlinkase activity on picornavirus infections downstream of virus translation, Autumn C Holmes, Guido Zagnoli-Vieira, Keith W Caldecott, and Bert L Semler

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Structure of a rabies virus polymerase complex from electron cryo-microscopy, Joshua A. Horwitz, Simon Jenni, Stephen C. Harrison, and Sean P. J. Whelan

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Activating immunity to fight a foe — A new path, Richard S. Hotchkiss and Steven M. Opal

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Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation, Panpan Hou, Po Wei Kang, Audrey Deyawe Kongmeneck, Nien-Du Yang, Yongfeng Liu, Jingyi Shi, Xianjin Xu, Kelli McFarland White, Mark A. Zaydman, Marina A. Kasimova, Guiscard Seebohm, Ling Zhong, Xiaoqin Zou, Mounir Tarek, and Jianmin Cui

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Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery, Jiansheng Huang, Dongdong Wang, Li-Hao Huang, and Hui Huang

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The price of the ticket: Health costs of upward mobility among African Americans, Darrell Hudson, Tina Sacks, Katie Irani, and Antonia Asher

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Refined National Institutes of Health response algorithm for chronic graft-versus-host disease in joints and fascia, Yoshihiro Inamoto, Stephanie J. Lee, Lynn E. Onstad, Mary E.D. Flowers, Betty K. Hamilton, Madan H. Jagasia, Paul J. Martin, Steven Z. Pavletic, Joseph A. Pidala, Iskra Pusic, Georgia B. Vogelsang, Daniel Wolff, and Paul A. Carpenter

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miRNA-based rapid differentiation of purified neurons from hPSCs advancestowards quick screening for neuronal disease phenotypes in vitro, Mitsuru Ishikawa, Takeshi Aoyama, Shoichiro Shibata, Takefumi Sone, Hiroyuki Miyoshi, Hirotaka Watanabe, Mari Nakamura, Saori Morota, Hiroyuki Uchino, Andrew S Yoo, and Hideyuki Okano

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Self-reported sleep disturbance in Crohn’s disease is not confrmed by objective sleep measures, Heba N. Iskandar, Emily E. Linan, Ami Patel, Renee Moore, Yi Lasanajak, C. Prakash Gyawali, Gregory S. Sayuk, and Matthew A. Ciorba

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Structure of the vesicular stomatitis virus L protein in complex with Its phosphoprotein cofactor, Simon Jenni, Louis-Marie Bloyet, Ruben Diaz-Avalos, Bo Liang, Sean P J Whelan, Nikolaus Grigorieff, and Stephen C Harrison

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Neuronal activity in the primate amygdala during economic choice, Ahmad Jezzini and Camillo Padoa-Schioppa

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Live neuron high-content screening reveals synaptotoxic activity in Alzheimer mouse model homogenates, Hao Jiang, Thomas J. Esparza, Terrance T. Kummer, Haining Zhong, Jens Rettig, and David L. Brody

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Alternative splicing of UCP1 by non-cell-autonomous action of PEMT, Jordan M. Johnson, Anthony R.P. Verkerke, J. Alan Maschek, Patrick J. Ferrara, Chien-Te Lin, Kimberly A. Kew, P. Darrell Neufer, Irfan J. Lodhi, James E. Cox, and Katsuhiko Funai

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Incidence and prediction of intraoperative and postoperative cardiac arrest requiring cardiopulmonary resuscitation and 30-day mortality in non-cardiac surgical patients, Heiko A. Kaiser, Nahel N. Saied, Andreas S. Kokoefer, Lina Saffour, Jonathan K. Zoller, and Mohammad A. Helwani

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Dual threshold optimization and network inference reveal convergent evidence from TF binding locations and TF perturbation responses, Yiming Kang, Nikhil R Patel, Christian Shively, Pamela Samantha Recio, Xuhua Chen, Bernd J Wranik, Griffin Kim, R Scott McIsaac, Robi Mitra, and Michael R Brent

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Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors, Rajvinder Karda, Jonathan D. Cooper, and et al.

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Microbiome restoration by RBX2660 does not preclude recurrence of multidrug-resistant urinary tract infection following subsequent antibiotic exposure: A case report, Eric C. Keen, Preston Tasoff, Tiffany Hink, Kimberly A. Reske, Carey-Ann D. Burnham, Gautam Dantas, Jennie H. Kwon, and Erik R. Dubberke

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Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing, Shamika Ketkar, Angela M. Verdoni, Amanda M. Smith, Celia V. Bangert, Elizabeth R. Leight, David Y. Chen, Meryl K. Brune, Nichole M. Helton, Mieke Hoock, Daniel R. George, Catrina Fronick, Robert S. Fulton, Sai Mukund Ramakrishnan, Gue Su Chang, Allegra A. Petti, David H. Spencer, Christopher A. Miller, and Timothy J. Ley

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Genomic prediction of alcohol-related morbidity and mortality, Tuomo Kiiskinen; Nina J. Mars; Teemu Palviainen; Jukka Koskela; Joel T. Rämö; Pietari Ripatti; Sanni Ruotsalainen; FinnGen, GSCAN Consortium; Aarno Palotie; Pamela A.F. Madden; Richard J. Rose; Jaakko Kaprio; Veikko Salomaa; Pia Mäkelä; Aki S. Havulinna; and Samuli Ripatti

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Genomic prediction of alcohol-related morbidity and mortality, Tuomo Kiiskinen, Nina J. Mars, Teemu Palviainen, Jukka Koskela, Joel T. Rämö, Pietari Ripatti, Sanni Ruotsalainen, FinnGen, GSCAN Consortium, Aarno Palotie, Pamela A.F. Madden, Richard J. Rose, Jaakko Kaprio, Veikko Salomaa, Pia Mäkelä, Aki S. Havulinna, and Samuli Ripatti

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Impact of gender and caregiving responsibilities on academic success in hematology, Allison A. King, Sara K. Vesely, Emily Vettese, Sadie Cook, Adam Cuker, Wendy Stock, Morgan Homer, Josel Fritz, and Lilian Sung

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Synthetic and genomic regulatory elements reveal aspects of cis-regulatory grammar in mouse embryonic stem cells, Dana M. King, Clarice Kit Yee Hong, James L. Shepherdson, David M. Granas, Brett B. Maricque, and Barak A. Cohen

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The dual-specificity kinase DYRK1A modulates the levels of cyclin L2 to control HIV replication in macrophages, Javan K. Kisaka, Lee Ratner, and George B. Kyei

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Frequency and clinical significance of localized adverse events following mass drug administration for lymphatic filariasis in an endemic area in South India, Vijesh Sreedhar Kuttiatt, Roopali K Somani, Subramanian Swaminathan, Kaliannagounder Krishnamoorthy, Gary J Weil, and Jambulingam Purushothaman

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Neural mechanisms of economic choices in mice, Masaru Kuwabara, Ningdong Kang, Timothy E. Holy, and Camillo Padoa-Schioppa

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T cell response kinetics determines neuroinfection outcomes during murine HSV infection, Aisha G Lee, Jason M Scott, Maria Rita Fabbrizi, Xiaoping Jiang, Dorothy K Sojka, Mark J Miller, Megan T Baldridge, Wayne M Yokoyama, and Haina Shin

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Staphylococcus aureus toxin suppresses antigen-specific T cell responses, Brandon Lee, Reuben Olaniyi, Jakub M Kwiecinski, and Juliane Bubeck Wardenburg

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Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease, Jiyeon Lee, Do Eon Kim, Percy Griffin, Patrick W Sheehan, Dong-Hou Kim, Erik S Musiek, and Seung-Yong Yoon

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Electrical impedance myography for reducing sample size in Duchenne muscular dystrophy trials, Melanie L Leitner, Kush Kapur, Basil T Darras, Michele Yang, Brenda Wong, Laura Dalle Pazze, Julaine Florence, Martin Buck, Laura Freedman, Jose Bohorquez, Seward Rutkove, and Craig Zaidman

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Structural basis for adhesion G protein-coupled receptor Gpr126 function, Katherine Leon, Rebecca L. Cunningham, Joshua A. Riback, Ezra Feldman, Jingxian Li, Tobin R. Sosnick, Minglei Zhao, Kelly R. Monk, and Demet Araç

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Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation, Antonin Levy, Aline Stedman, Eric Deutsch, Françoise Donnadieu, Herbert W. Virgin, Philippe J. Sansonetti, and Giulia Nigro

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ASCOT identifies key regulators of neuronal subtype-specific splicing, Jonathan P. Ling, Christopher Wilks, Rone Charles, Patrick J. Leavey, Devlina Ghosh, Lizhi Jiang, Clayton P. Santiago, Bo Pang, Anand Venkataraman, Brian S. Clark, Abhinav Nellore, Ben Langmead, and Seth Blackshaw

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Six-year follow-up of a trial of antenatal vitamin D for asthma reduction, Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman Mirzakhani, George T. O'Connor, Megan Sandel, Avraham Beigelman, Leonard B. Bacharier, Robert S. Zeiger, Michael Schatz, Bruce W. Hollis, and Scott T. Weiss

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A novel histological index for evaluation of environmental enteric dysfunction identifies geographic-specific features of enteropathy among children with suboptimal growth, Ta-Chiang Liu, Kelley VanBuskirk, Lori R. Holtz, I. Malick Ndao, Michael H. Isaacs, John D. Pfeifer, Phillip I. Tarr, and et al.

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The tip of the VgrG spike is essential to functional type VI secretion system assembly in Acinetobacter baumannii, Juvenal Lopez, Pek Man Ly, and Mario F Feldman

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Lack of neurosteroid selectivity at δ vs. γ2-containing GABAA receptors in dentate granule neurons, Xinguo Lu, Charles F Zorumski, and Steven Mennerick

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Gene-by-gene interactions associated with the risk of conotruncal heart defects, Chen Lyu, Daniel M Webber, Stewart L MacLeod, Charlotte A Hobbs, Ming Li, and National Birth Defects Prevention Study

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Five-year outcomes of transcatheter or surgical aortic-valve replacement, Raj R. Makkar, Alan Zajarias, and et al.

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Molecular characterization of sarcomatoid clear cell renal cell carcinoma unveils new candidate oncogenic drivers, Gabriel G. Malouf, James J. Hsieh, and et al.