The Open Access Publications collection contains peer-reviewed articles authored by Washington University School of Medicine faculty that have been published in open access journals or authorized by the publishers for open access availability. Open access works are generally defined as being publicly available online and free of most licensing and copyright restrictions. The Bernard Becker Medical Library maintains this collection in support of Washington University’s commitment to the principles of open access publishing and making the scholarly work and research results of our faculty as widely and easily available as possible.

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Submissions from 2018

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Comprehensive assessment of a hotspot with persistent bancroftian filariasis in coastal Sri Lanka, Ramakrishna U. Rao, Sandhya D. Samarasekera, Kumara C. Nagodavithana, Charles W. Goss, Manjula W. Punchihewa, Tharanga D. M. Dassanayaka, Udaya S. B. Ranasinghe, Devika Mendis, and Gary J. Weil

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Acupuncture and whole health in the Veterans Administration, Kavitha P. Reddy, David F. Drake, and Benjamin Kligler

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Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma, Nathan Redlich, Anthony M. Robinson, Kwangok P. Nickel, Andrew P. Stein, Deric L. Wheeler, Douglas R. Adkins, Ravindra Uppaluri, Randall J. Kimple, Brian A. Van Tine, and Loren S. Michel

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Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects, Allison A. Regier, David E. Larson, Ira M. Hall, and et al

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Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy, Jose Angel Regla-Nava, Annie Elong Ngono, Karla M. Viramontes, Anh-Thy Huynh, Ying-Ting Wang, Anh-Viet T. Nguyen, Rebecca Salgado, Anila Mamidi, Kenneth Kim, Michael S. Diamond, and Sujan Shresta

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Na+-leak channel, non-selective (NALCN) regulates myometrial excitability and facilitates successful parturition, Erin L. Reinl, Peinan Zhao, Wenjie Wu, Xiaofeng Ma, Chinwendu Amazu, Rachael Bok, K. Joseph Hurt, Yong Wang, and Sarah K. England

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Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse, Nicholas Rensing, Brianna Moy, Joseph L. Friedman, Rafael Galindo, and Michael Wong

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Cardiac radiation dose distribution, cardiac events and mortality in early-stage lung cancer treated with stereotactic body radiation therapy (SBRT), Leonid B. Reshko, Noah S. Kalman, Geoffrey D. Hugo, and Elisabeth Weiss

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PirVP genes causing AHPND identified in a new Vibrio species (Vibrio punensis) within the commensal Orientalis clade, Leda Restrepo, Bonny Bayot, Sebastian Arciniegas, Leandro Bajana, Irma Betancourt, Franny Panchana, and Alejandro Reyes Munoz

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Draft genome sequence of a white spot syndrome virus isolate obtained in Ecuador, Leda Restrepo, Alejandro Reyes, Leandro Bajaña, Irma Betancourt, and Bonny Bayot

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Variability in determining sepsis time zero and bundle compliance rates for the centers for medicare and medicaid services SEP-1 measure, Chanu Rhee, Sarah R. Brown, Travis M. Jones, Cara O'Brien, Anupam Pande, Yasir Hamad, Amy L. Bulger, Kathleen A. Tobin, Anthony F. Massaro, Deverick J. Anderson, David K. Warren, and Michael Klompas

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Common genetic contributions to high-risk trauma exposure and self-injurious thoughts and behaviors, Leah S. Richmond-Rakerd, Timothy J. Trull, Ian R. Gizer, Kristin McLaughlin, Emily M. Scheiderer, Elliot C. Nelson, Arpana Agrawal, Michael T. Lynskey, Pamela A.F Madden, Andrew C. Heath, Dixie J. Statham, and Nicholas G. Martin

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Systemic anti-cancer therapy in synovial sarcoma: A systematic review, Richard F. Riedel, Robin L. Jones, Antoine Italiano, Chet Bohac, Juliette C. Thompson, Kerstin Mueller, Zaeem Khan, Seth M. Pollack, and Brian A. Van Tine

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Clinical and radiographic outcomes after posterior vertebral column resection for severe spinal deformity with five-year follow-up, Max S. Riley, Lawrence G. Lenke, Todd M. Chapman Jr, Brenda A. Sides, Kathy M. Blanke, and Michael P. Kelly

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HLA epitope mismatch in haploidentical transplantation is associated with decreased relapse and delayed engraftment, Joseph Rimando, Michael Slade, John F. DiPersio, Peter Westervelt, Feng Gao, Chang Liu, and Rizwan Romee

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Circulatory insufficiency and hypotension related to the ductus arteriosus in neonates, Danielle R. Rios, Soume Bhattacharya, Philip T. Levy, and Patrick J. McNamara

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Optimizing radiation dose and fractionation for the definitive treatment of locally advanced non-small cell lung cancer, Michael C. Roach, Jeffrey D. Bradley, and Cliff G. Robinson

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Homeostatic plasticity and emergence of functional networks in a whole-brain model at criticality, Rodrigo P. Rocha, Loren Kocillari, Samir Suweis, Maurizio Corbetta, and Amos Maritan

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Using the A/T/N framework to examine driving in preclinical Alzheimer’s disease, Catherine M. Roe, Ganesh M. Babulal, Sarah H. Stout, David B. Carr, Monique M. Williams, Tammie L.S Benzinger, Anne M. Fagan, David M. Holtzman, Beau M. Ances, and John C. Morris

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Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage, Stephen C. Rogers, Allan Doctor, and et al.

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Somatic mutations in benign breast disease tissue and risk of subsequent invasive breast cancer, Thomas E. Rohan, Christopher A. Miller, Tiandao Li, Yihong Wang, Olivier Loudig, Mindy Ginsberg, Andrew Glass, and Elaine Mardis

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ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1, Nidhi Rohatgi, Wei Zou, Patrick L. Collins, Jonathan R. Brestoff, Timothy H. Chen, Yousef Abu-Amer, and Steven L. Teitelbaum

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Theoretical impact of simulated workplace-based primary prevention of carpal tunnel syndrome in a French region, Yves Roquelaure, Natacha Fouquet, Emilie Chazelle, Alexis Descatha, Bradley Evanoff, Julie Bodin, and Audrey Petit

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Differential human gut microbiome assemblages during soil-transmitted helminth infections in Indonesia and Liberia, Bruce A. Rosa, Taniawati Supali, Lincoln Gankpala, Yenny Djuardi, Erliyani Sartono, Yanjiao Zhou, Kerstin Fischer, John Martin, Rahul Tyagi, Fatorma K. Bolay, Peter U. Fischer, Maria Yazdanbakhsh, and Makedonka Mitreva

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Convergence Analysis of Micro-Lesions (CAML): An approach to mapping of diffuse lesions from carotid revascularization, Allyson C. Rosen, Salil Soman, Jyoti Bhat, Angela R. Laird, Jeffrey Stephens, Simon B. Eickhoff, P. Mickle Fox, Becky Long, David Dinishak, Mario Ortega, Barton Lane, Max Wintermark, Elizabeth Hitchner, and Wei Zhou

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Compliance with postpartum diabetes screening recommendations for patients with gestational diabetes, Joshua I. Rosenbloom and May Hsieh Blanchard

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High levels of cyclic di-GMP in Klebsiella pneumoniae attenuate virulence in the lung, David A. Rosen, Joy Twentyman, and David A. Hunstad

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The growing importance of lesion volume as a prognostic factor in patients with multiple brain metastases treated with stereotactic radiosurgery, David M. Routman, Shelly X. Bian, Kevin Diao, Jonathan L. Liu, Cheng Yu, Jason Ye, Gabriel Zada, and Eric L. Chang

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Comparison of discriminative motif optimization using matrix and DNA shape-based models, Shuxiang Ruan and Gary D. Stormo

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Gut sphingolipid composition as a prelude to necrotizing enterocolitis, B. Rusconi, X. Jiang, R. Sidhu, D. S. Ory, B. B. Warner, and P. I. Tarr

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CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites, Philip A. Ruzycki, Xiaodong Zhang, and Shiming Chen

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Successful preoperative bridge with extracorporeal membrane oxygenation in three neonates with D-transposition of the great vessels and pulmonary hypertension, Ahmed S. Said, Mary E. McBride, and Avihu Z. Gazit

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Physiologic impact of circulating RBC microparticles upon blood-vascular interactions, Ahmed S. Said, Stephen C. Rogers, and Allan Doctor

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An accord of nuclear receptor expression in M. tuberculosis infected macrophages and dendritic cells, Ankita Saini, Sahil Mahajan, Nancy Ahuja, Ella Bhagyaraj, Rashi Kalra, Ashok Kumar Janmeja, and Pawan Gupta

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Residual mitral regurgitation after repair for posterior leaflet prolapse- Importance of preoperative anterior leaflet tethering, Taichi Sakaguchi, Nobuyuki Kagiyama, Misako Toki, Arudo Hiraoka, Akihiro Hayashida, Toshinori Totsugawa, Kentaro Tamura, Genta Chikazawa, Hidenori Yoshitaka, and Kiyoshi Yoshida

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Academic orthopaedic leadership: Current challenges and lessons learned, Dane H. Salazar, James H. Herndon, Thomas P. Vail, Joseph D. Zuckerman, and Richard H. Gelberman

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The academic chair: Achieving success in a rapidly evolving health-care environment, Dane H. Salazar, James H. Herndon, Thomas P. Vail, Joseph D. Zuckerman, and Richard H. Gelberman

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Management of intracranial metastatic disease with Laser Interstitial Thermal Therapy, Afshin Salehi, Ashwin A. Kamath, Eric C. Leuthardt, and Albert H. Kim

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Endothelial cell CD36 optimizes tissue fatty acid uptake, Dmitri Samovski, Terri A. Pietka, Vivek S. Peche, Kooresh I. Shoghi, Nada A. Abumrad, and et al

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SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches to Clostridioides difficile prevention, Thomas J. Sandora, Kristina K. Bryant, Joseph B. Cantey, Alexis M. Elward, Deborah S. Yokoe, and Allison H. Bartlett

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Adult-onset papular purpuric gloves and socks syndrome, Monica Rosales Santillan, Jessica B. Dietert, and Richard Jahan-Tigh

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Fine particulate matter pollution and risk of community-acquired sepsis, Elisa J. Sarmiento, Justin Xavier Moore, Leslie A. McClure, Russell Griffin, Mohammad Z. Al-Hamdan, and Henry E. Wang

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LRIT1 modulates adaptive changes in synaptic communication of cone photoreceptors, Ignacio Sarria, Yan Cao, Yuchen Wang, Norianne T. Ingram, Cesare Orlandi, Naomi Kamasawa, Alexander V. Kolesnikov, Johan Pahlberg, Vladimir J. Kefalov, Alapakkam P. Sampath, and Kirill A. Martemyanov

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GUCY2D cone–rod dystrophy-6 is a “phototransduction disease” triggered by abnormal calcium feedback on retinal membrane guanylyl cyclase 1, Shinya Sato, Igor V. Peshenko, Elena V. Olshevskaya, Valdimir J. Kefalov, and Alexander M. Dizhoor

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modCHIMERA: A novel murine closed-head model of moderate traumatic brain injury, A. D. Sauerbeck, C. Fanizzi, J. H. Kim, M. Gangolli, P. V. Bayly, C. L. Wellington, D. L. Brody, and T. T. Kummer

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Genetic analysis of signal generation by the Rgt2 glucose sensor of Saccharomyces cerevisiae, Peter Scharff-Poulsen, Hisao Moriya, and Mark Johnston

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Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging, Suzanne E. Schindler, Julia D. Gray, Brian A. Gordon, Chengjie Xiong, Richard Batrla-Utermann, Marian Quan, Simone Wahl, Tammie L.S. Benzinger, David M. Holtzman, John C. Morris, and Anne M. Fagan

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Multicenter trial of a combination probiotic for children with gastroenteritis, David Schnadower and et al

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Tidal and diel orchestration of behaviour and gene expression in an intertidal mollusc, Y. Schnytzer, N. Simon-Blecher, J. Li, H. Waldman Ben-Asher, M. Salmon-Divon, Y. Achituv, M. E. Hughes, and O. Levy

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The role of Janus kinase signaling in graft-versus-host disease and graft versus leukemia, Mark A. Schroeder, Jaebok Choi, Karl Staser, and John F. DiPersio

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Differential regulation of Escherichia coli fim genes following binding to mannose receptors, William R. Schwan, Michael T. Beck, Chia S. Hung, and Scott J. Hultgren

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A scoring strategy for progression risk and rates of treatment completion in subjects with latent tuberculosis, Michael Scolarici, Ken Dekitani, Ling Chen, Marcia Sokol-Anderson, Daniel F. Hoft, and Soumya Chatterjee

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Cellular and humoral immunity protect against vaginal Zika virus infection in mice, Jason M. Scott, Tania J. Lebratti, Justin M. Richner, Xiaoping Jiang, Estefania Fernandez, Haiyan Zhao, Daved H. Fremont, Michael S. Diamond, and Haina Shin

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Protein production is an early biomarker for RNA‐targeted therapies, Wade K. Self, Kathleen M. Schoch, Jacob Alex, Nicolas Barthélemy, James G. Bollinger, Chihiro Sato, Tracy Cole, Holly B. Kordasiewicz, Eric Swayze, Randall J. Bateman, and Timothy M. Miller

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A spatial memory signal shows that the parietal cortex has access to a craniotopic representation of space, Mulugeta Semework, Sara C. Steenrod, and Michael E. Goldberg

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A survey of validation strategies for CRISPR-Cas9 editing, Monica F. Sentmanat, Samuel T. Peters, Colin P. Florian, Jon P. Connelly, and Shondra M. Pruett-Miller

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Functional annotation of ESR1 gene fusions in estrogen receptor-positive breast cancer, Jieya Shao, Jin Zhang, Michael Iglesia, Robert Crowder, Jeremy Hoog, Chanpheng Phommaly, Anna Rogers, Sherri R. Davies, Shunqiang Li, Cynthia X. Ma, Mark A. Watson, Christopher A. Maher, and et al

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Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons, Tayler D. Sheahan, Manouela V. Valtcheva, Lisa V. McIlvried, Melanie Y. Pullen, David A.A. Baranger, and Robert W. Gereau

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The effect of adipose-derived stem cell sheets and CTGF on early flexor tendon healing in a canine model, Hua Shen, Rohith Jayaram, Susumu Yoneda, Stephen W. Linderman, Shelly E. Sakiyama-Elbert, Younan Xia, Richard H. Gelberman, and Stavros Thomopoulos

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Deficits in burrowing behaviors are associated with mouse models of neuropathic but not inflammatory pain or migraine, Andrew J. Shepherd, Megan E. Cloud, Yu-Qing Cao, and Durga P. Mohapatra

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Angiotensin II triggers peripheral macrophage-to-sensory neuron redox crosstalk to elicit pain, Andrew J. Shepherd, Bryan A. Copits, Aaron D. Mickle, Suraj Kadunganattil, Simon Haroutounian, Manouela V. Valtcheva, Lisa A. McIlvried, Tayler D. Sheahan, Sanjay Jain, Robert W. Gereau IV, Durga P. Mohapatra, and et al

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Parathyroid hormone-related peptide elicits peripheral TRPV1-dependent mechanical hypersensitivity, Andrew J. Shepherd, Aaron D. Mickle, Suraj Kadunganattil, Hongzhen Hu, and Durga P. Mohapatra

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VEGFR-3 signaling regulates triglyceride retention and absorption in the intestine, Trevor Shew, Nathan E. Wolins, and Vincenza Cifarelli

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Validation of diffusion tensor imaging measures of nigrostriatal neurons in macaques, Joshua S. Shimony, Jerrel Rutlin, Morvarid Karimi, Linlin Tian, Abraham Z. Snyder, Susan K. Loftin, Scott A. Norris, and Joel S. Perlmutter

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Mechanisms and functions of chemerin in cancer: Potential roles in therapeutic intervention, Woo Jae Shin, Brian A. Zabel, and Russell K. Pachynski

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Outcomes and predictors of early infection after heart transplantation, Kendall C. Shultes, Jerrica E. Shuster, Scott Micek, Justin M. Vader, Keki Balsara, Akinobu Itoh, and Bethany R. Tellor

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Emerging applications of virtual reality in cardiovascular medicine, Jennifer N.A. Silva, Michael Southworth, Constantine Raptis, and Jonathan Silva

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Multi-radial LBP features as a tool for rapid glomerular detection and assessment in whole slide histopathology images, Olivier Simon, Rabi Yacoub, Sanjay Jain, John E. Tomaszewski, and Pinaki Sarder

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The mitochondrial single-stranded DNA binding protein from S. cerevisiae, Rim1, does not form stable homo-tetramers and binds DNA as a dimer of dimers, Saurabh P. Singh, Vandna Kukshal, Paolo De Bona, Edwin Antony, and Roberto Galletto

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Patient preferences for the treatment of shoulder and proximal biceps disorders are associated with patient age, race, sex, and activity level, Matthew V. Smith, Michelle Gosselin, Karen Steger-May, Matthew J. Matava, Rick W. Wright, and Robert H. Brophy

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Imbalance of functional connectivity and temporal entropy in resting-state networks in Autism Spectrum Disorder: A machine learning approach, Robert X. Smith, Kay Jann, Mirella Dapretto, and Danny J.J. Wang

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A rare case of endometrial cancer metastatic to the uveal choroid, Stephanie H. Smith, Sri Krishna C. Arudra, Mary M. Mullen, Marguerite Palisoul, Sonika Dahiya, P. Kumar Rao, and Premal H. Thaker

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Hypothalamic Sirt1 protects terminal Schwann cells and neuromuscular junctions from age‐related morphological changes, Alison K. Snyder-Warwick, Akiko Satoh, Katherine B. Santosa, Shin-ichiro Imai, and Albina Jablonka-Shariff

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Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation, Courtney Sobieski, Natasha Warikoo, Hong-Jin Shu, and Steven Mennerick

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Fat composition in infant formula contributes to the severity of necrotising enterocolitis, Chhinder P. Sodhi, William B. Fulton, Misty Good, Mustafa Vurma, Tapas Das, Chron-Si Lai, Hongpeng Jia, Yukihiro Yamaguchi, Peng Lu, Thomas Prindle Jr, John A. Ozolek, and David J. Hackam

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Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules, Jae‑Geun Song, Matthew R. King, Rui Zhang, Rachel S. Kadzik, Akanksha Thawani, and Sabine Petry

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Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism, Wilbur M. Song, Satoru Joshita, Yingyue Zhou, Tyler K. Ulland, Susan Gilfillan, and Marco Colonna

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Synapse maintenance and restoration in the retina by NGL2, Florentina Soto, Lei Zhao, and Daniel Kerschensteiner

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Analysis of HIV testing refusal among patients aged less than 21 years in the Pediatric Emergency Department, Kenneth Soyemi, Teddy Muisyo, Yaa KariKari, Kun-UK D. Lee, Peter Nguyen, Karen E. Simpson, Kevin Regis, and Lisa H. Reid

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Epidemiology of Staphylococcus aureus infections in patients admitted to freestanding pediatric hospitals, 2009-2016, Alicen B. Spaulding, Cary Thurm, Joshua D. Courter, Ritu Banerjee, Jeffrey S. Gerber, Jason G. Newland, Sarah K. Parker, Thomas V. Brogan, Matthew P. Kronman, Samir S. Shah, Michael J. Smith, Sameer J. Patel, Brian R. Lee, and Adam L. Hersh

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Precision antimicrobial therapeutics: The path of least resistance?, Caitlin N. Spaulding, Roger D. Klein, Henry L. Schreiber IV, James W. Janetka, and Scott J. Hultgren

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Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions, Caitlin N. Spaulding, Henry Louis Schreiber IV, Weili Zheng, Karen W. Dodson, Jennie E. Hazen, Matt S. Conover, Fengbin Wang, Pontus Svenmarker, Areli Luna-Rico, Olivera Francetic, Magnus Andersson, Scott Hultgren, and Edward H. Egelman

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EQUAL cryptococcus score 2018: A European confederation of medical mycology score derived from current guidelines to measure QUALity of clinical cryptococcosis management, Andrej Spec, Carlos Mejia-Chew, William G. Powderly, and Oliver A. Cornely

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines, Philip D. Stahl and et al

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines, Philip D. Stahl and et al

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Acetabular wedge augments for uncontained tibial plateau defects in revision total knee arthroplasty, Jeffrey B. Stambough, Jacob A. Haynes, Robert L. Barrack, and Ryan M. Nunley

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Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease, Thaddeus S. Stappenbeck, Aaron Ver Heul, Ta-Chiang Liu, and et al

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New anthropometric classification scheme of preoperative nutritional status in children: A retrospective observational cohort study, Anne Stey, Joni Ricks-Oddie, Sheila Innis, Shawn J. Rangel, R. Lawrence Moss, Bruce L. Hall, Albert Dibbins, and Erik D. Skarsgard

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An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery, Nathan O. Stitziel and et al

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Household-level factors associated with relapse following discharge from treatment for moderate acute malnutrition, Heather C. Stobaugh, Beatrice L. Rogers, Patrick Webb, Irwin H. Rosenberg, Chrissie Thakwalakwa, Kenneth M. Maleta, Indi Trehan, and Mark J. Manary

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Automated real-time collection of pathogen-specific diagnostic data: Syndromic infectious disease epidemiology, Gregory A. Storch and et al

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The zinc finger transcription factor PLAGL2 enhances stem cell fate and activates expression of ASCL2 in intestinal epithelial cells, Ashlee M. Strubberg, Daniel A. Veronese Paniagua, Tingting Zhao, Leeran Dublin, Thomas Pritchard, Peter O. Bayguinov, James A.J. Fitzpatrick, and Blair B. Madison

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Obstructive sleep apnea as an independent predictor of postoperative delirium and pain: Protocol for an observational study of a surgical cohort [version 2; referees: 2 approved], Patricia Strutz, William Tzeng, Brianna Arrington, Vanessa Kronzer, Sherry McKinnon, Arbi Ben Abdallah, Simon Haroutounian, and Michael S. Avidan

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Bilateral versus single lung transplantation: Are two lungs better than one?, Melanie P. Subramanian and Bryan F. Meyers

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Surgical resection versus stereotactic body radiation therapy for stage I NSCLC: Can randomized trials provide the solution?, Melanie P. Subramanian and Bryan F. Meyers

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Systemic activation of activin A signaling causes chronic kidney disease-mineral bone disorder, Toshifumi Sugatani

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Understanding mechanisms of genetic risk for adolescent internalizing and externalizing problems: The mediating role of parenting and personality, Jinni Su, Sally I-Chun Kuo, Kathleen K. Bucholz, Howard J. Edenberg, John R. Kramer, Marc Schuckit, and Danielle M. Dick

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Chemogenetic isolation reveals synaptic contribution of δ GABAA receptors in mouse dentate granule neurons, Min-Yu Sun, Hong-Jin Shu, Ann Benz, John Bracamontes, Gustav Akk, Charles F. Zorumski, Joe Henry Steinbach, and Steven J. Mennerick

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Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes, Shishuo Sun, Pengcheng Tan, Xiaoheng Huang, Wei Zhang, Chen Kong, Fangfang Ren, and Xiong Su

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Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies, Yi Su, Shaney Flores, Russ C. Hornbeck, Benjamin Speidel, Andrei G. Vlassenko, Brian A. Gordon, Robert A. Koeppe, William E. Klunk, Chengjie Xiong, John C. Morris, and Tammie L.S. Benzinger