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Submissions from 2010

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Antagonism of the complement component C4 by flavivirus nonstructural protein NS1, Panisadee Avirutnan, Anja Fuchs, Richard E. Hauhart, Pawit Somnuke, Soonjeon Youn, Michael S. Diamond, and John P. Atkinson

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Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification, Scott J. Balsitis, Katherine L. Williams, Ruben Lachica, Diana Flores, Jennifer L. Kyle, Erin Mehlhop, Syd Johnson, Michael S. Diamond, P. Robert Beatty, and Eva Harris

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Identifying basal ganglia divisions in individuals using resting-state functional connectivity MRI, Kelly Anne Barnes, Alexander L. Cohen, Jonathan D. Power, Steven M. Nelson, Yannic B.L. Dosenbach, Francis M. Miezin, Steven E. Petersen, and Bradley L. Schlaggar

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Differential effects of ApoE isoforms on dendritic spines in vivo: Linking an Alzheimer's disease risk factor with synaptic alterations, Jacob M. Basak and Jungsu Kim

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A method for determining cell number in the undisturbed epithelium of the mouse lens, Steven Bassnett and Yanrong Shi

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Dynamic contact mechanics of the medial meniscus as a function of radial tear, repair, and partial meniscectomy, Asheesh Bedi, Natalie H. Kelly, Michael Baad, Alice J.S. Fox, Robert H. Brophy, Russell F. Warren, and Suzanne A. Maher

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Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii, Michael S. Behnke, John C. Wootton, Margaret M. Lehmann, Josh B. Radke, Olivier Lucas, Julie Nawas, L. David Sibley, and Michael W. White

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Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis, Avraham Beigelman, Cassandra L. Mikols, Sean P. Gunsten, Carolyn L. Cannon, Steven L. Brody, and Michael J. Walter

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Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes, Amber L. Beitelshees, Brian N. Finck, Teresa C. Leone, Sharon Cresci, Jun Wu, Michael A. Province, Elisa Fabbrini, Erik P. Kirk, Issam Zineh, Samuel Klein, John A. Spertus, and Daniel P. Kelly

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Aromatase gene polymorphisms are associated with survival among patients with cardiovascular disease in a sex-specific manner, Amber L. Beitelshees, Julie A. Johnson, Megan L. Hames, Yan Gong, Rhonda M. Cooper-DeHoff, Jun Wu, Sharon Cresci, Cynthia X. Ma, Carl J. Pepine, Michael A. Province, John A. Spertus, and Howard L. McLeod

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Sliding-clip renorrhaphy provides superior closing tension during robot-assisted partial nephrectomy, Brian M. Benway, Jose M. Cabello, Robert S. Figenshau, and Sam B. Bhayani

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Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia, Ernesto Bernal-Mizrachi, Corentin Cras-Meneur, Bo Ra Ye, James D. Johnson, and M. Alan Permutt

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The epidemiology of hematogenous vertebral osteomyelitis: A cohort study in a tertiary care hospital, Kavita P. Bhavan, Jonas Marschall, Margaret A. Olsen, Victoria J. Fraser, Neill M. Wright, and David K. Warren

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Report from the 2009 AOA North American traveling fellowship, Ryan T. Bicknell, Gregory J. Della Rocca, Wellington K. Hsu, Amanda D. Marshall, and Robert H. Brophy

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Quantification of indirect pathway inhibition by the adenosine A 2a antagonist SYN115 in Parkinson disease, Kevin J. Black, Jonathan M. Koller, Meghan C. Campbell, Debra A. Gusnard, and Stephen I. Bandak

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mmunohistological studies on neoplasms of female and male Onchocerca volvulus: Filarial origin and absence of Wolbachia from tumor cells, N. W. Brattig, A. Hoerauf, Peter U. Fischer, E. Liebau, C. Bandi, A. Debrah, M. Büttner, and W. Büttner

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What's new in spine surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, and Jeffrey C. Wang

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Classification of traumatic brain injury for targeted therapies, David Brody and et al

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Defective cAMP generation underlies the sensitivity of CNS neurons to neurofibromatosis-1 heterozygosity, Jacquelyn A. Brown, Scott M. Gianino, and David H. Gutmann

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Isocitrate dehydrogenase is important for nitrosative stress resistance in Cryptococcus neoformans, but oxidative stress resistance is not dependent on glucose-6-phosphate dehydrogenase, Sarah M. Brown, Rajendra Upadhya, James D. Shoemaker, and Jennifer K. Lodge

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Measuring the impact of public health policy, Ross C. Brownson, Rachel Seiler, and Amy A. Eyler

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Histopathology of nonalcoholic fatty liver disease, Elizabeth M. Brunt and Dina G. Tiniakos

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Images in clinical medicine. Meckel's diverticulum, Brian T. Bucher and Martin S. Keller

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Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii, Jeffrey S. Buguliskis, Fabien Brossier, Joel Shuman, and L. David Sibley

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In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia, Michelle A. Burack, Johanna Hartlein, Hubert P. Flores, Lisa M. Taylor-Reinwald, Joel S. Perlmutter, and Nigel J. Cairns

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Yeast exonuclease 5 is essential for mitochondrial genome maintenance, Peter M. Burgers, Carrie M. Stith, Bonita L. Yoder, and Justin L. Sparks

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Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis, Paula I. Burgos, Zenoria L. Causey, Ashutosh Tamhane, James M. Kelley, Elizabeth E. Brown, Laura B. Hughes, Maria I. Danila, Amalia van Everdingen, Doyt L. Conn, Beth L. Jonas, Leigh F. Callahan, Edwin A. Smith, Richard D. Brasington Jr, Larry W. Moreland, Desiree M. van der Heijde, Graciela S. Alarcon, and S Louis Bridges Jr

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Novel screening agar for detection of vancomycin-nonsusceptible Staphylococcus aureus, Carey-Ann D. Burnham, Carol J. Weber, and W. Michael Dunne Jr.

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A practical, bioinformatic workflow system for large data sets generated by next-generation sequencing, Cinzia Cantacessi, Aaron R. Jex, Neil D. Young, Bronwyn E. Campbell, Anja Joachim, Matthew J. Nolan, Sahar Abubucker, Paul W. Sternberg, Shoba Ranganathan, Makedonka Mitreva, and Robin B. Gasser

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Massively parallel sequencing and analysis of the Necator americanus transcriptome, Cinzia Cantacessi, Makedonka Mitreva, Aaron R. Jex, Neil D. Young, Bronwyn E. Campbell, Ross S. Hall, Maria A. Doyle, Stuart A. Ralph, Elida M. Rabelo, Shoba Ranganathan, Paul W. Sternberg, Alex Loukas, and Robin B. Gasser

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Membrane anchoring subunits specify selective regulation of RGS9·Gbeta5 GAP complex in photoreceptor neurons, Yan Cao, Alexander V. Kolesnikov, Ikuo Masuho, Vladimir J. Kefalov, and Kirill A. Martemyanov

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Tiotropium bromide step-up therapy for adults with uncontrolled asthma, Mario Castro, Michael J. Walter, and et al

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Adducin 1 (alpha) Gly460Trp variant is associated with left ventricular geometry in Caucasians and African Americans: The HyperGEN Study, Krati Chauhan, Richard B. Devereux, D. C. Rao, Ulrich Broeckel, Charles C. Gu, Paul Hopkins, and Donna K. Arnett

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Neoadjuvant endocrine therapy in primary breast cancer: Indications and use as a research tool, Yeehong Chia, M. J. Ellis, and Cynthia Ma

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Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1, David B. Clifford and et al

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Combined hip arthroscopy and limited open osteochondroplasty for anterior femoroacetabular impingement, John C. Clohisy, Lukas P. Zebala, Jeffrey J. Nepple, and Gail Pashos

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Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound, Jacquelynn J. Cook, Kristin R. Wildsmith, David B. Gilberto, Marie A. Holahan, Gene G. Kinney, Parker D. Mathers, Maria S. Michener, Eric A. Price, Mark S. Shearman, Adam J. Simon, Jennifer X. Wang, Guoxin Wu, Kevin E. Yarasheski, and Randall J. Bateman

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Phospholipase C gamma 2 is critical for development of a murine model of inflammatory arthritis by affecting actin dynamics in dendritic cells, Viviana Cremasco, Elisa Benasciutti, Marina Cella, Marina Kisseleva, Monica Croke, and Roberta Faccio

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A PPARalpha promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes, Sharon Cresci, Janice M. Huss, Amber L. Beitelshees, Philip G. Jones, Matt R. Minton, Gerald W. Dorn II, Daniel P. Kelly, John A. Spertus, and Howard L. McLeod

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Sensitivity and specificity of the finger tapping task for the detection of psychogenic movement disorders, Susan Criswell, Callen Sterling, Laura Swisher, Bradley A. Evanoff, and Brad A. Racette

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SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer’s disease, Carlos Cruchaga, John S. K. Kauwe, Kevin Mayo, Noah Spiegel, Sarah Bertelsen, Petra Nowotny, Aarti R. Shah, Richard Abraham, Paul Holligworth, Denise Harold, Michael M. Owen, Julie Williams, Simon Lovestone, Elaine R. Peskind, Ge Li, James B. Leverenz, Douglas Galasko, The Alzheimer's Disease Neuroimaging Initiative, John C. Morris, Anne M. Fagan, David M. Holtzman, and Alison M. Goate

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Lipids driving protein structure? Evolutionary adaptations in Kir channels, Nazzareno D'Avanzo, Wayland W.L. Chang, Shizhen Wang, Decha Enkvetchakul, and Colin G. Nichols

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Splenic injury during percutaneous nephrolithotomy: A case report with novel management technique, Alana C. Desai, Samay Jain, Brian M. Benway, Robert L. Grubb III, Daniel Picus, and Robert S. Figenshau

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Tuboovarian abscesses: Is size associated with duration of hospitalization & complications?, Jason DeWitt, Angela Reining, Jenifer E. Allsworth, and Jeffrey F. Peipert

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Charting the progression of disability in Parkinson disease: Study protocol for a prospective longitudinal cohort study, Leland E. Dibble, James T. Cavanaugh, Gammon M. Earhart, Terry D. Ellis, Matthew P. Ford, and Kenneth B. Foreman

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Soluble amyloid-β, effect on cerebral arteriolar regulation and vascular cells, Hans H. Dietrich, Chuanxi Xiang, Byung H. Han, Gregory J. Zipfel, and David M. Holtzman

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Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern, Deborah E. Dobson, Shaden Kamhawi, Phillip Lawyer, Salvatore J. Turco, Stephen M. Beverley, and David L. Sacks

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It's not easy being green: The viridans group streptococci, with a focus on pediatric clinical manifestations, Christpher D. Doern and Carey-Ann D. Burnham

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Mechanisms of non-apoptotic programmed cell death in diabetes and heart failure, Gerald W. Dorn II

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Cerenkov radiation energy transfer (CRET) imaging: A novel method for optical imaging of PET isotopes in biological systems, Robin S. Dothager, Reece J. Goiffon, Erin Jackson, Scott Harpstrite, and David Piwnica-Worms

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Prevention of healthcare-associated Clostridium difficile infection: What works?, Erik R. Dubberke

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Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin, Alexis Dumortier, Andre-Dante Durham, Matteo Di Piazza, Sophie Vauclair, Ute Koch, Gisele Ferrand, Isabel Ferrero, Shadmehr Demehri, Lynda Li Song, Andrew G. Farr, Warren J. Leonard, Raphael Kopan, Lucio Miele, Daniel Hohl, Daniel Finke, and Freddy Radtke

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Enhancement of anti-DIII antibodies by the C3d derivative P28 results in lower viral titers and augments protection in mice, Matthew D. Dunn, Shannon L. Rossi, Donald M. Carter, Matthew R. Vogt, Erin Mehlhop, Michael S. Diamond, and Ted M. Ross

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CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow, Kyle J. Eash, Adam M. Greenbaum, Priya K. Gopalan, and Daniel C. Link

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Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells, Brian T. Edelson, Wumesh KC, Richard Juang, Masako Kohyama, Loralyn A. Benoit, Paul A. Klekotka, Clara Moon, Jörn C. Albring, Wataru Ise, Drew G. Michael, Deepta Bhattacharya, Thaddeus S. Stappenbeck, Michael J. Holtzman, Sun-Sang J. Sung, Theresa L. Murphy, Kai Hildner, and Kenneth M. Murphy

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Improving prefrontal cortex function in schizophrenia through focused training of cognitive control, Bethany G. Edwards, Deanna M. Barch, and Todd S. Braver

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Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns, John R. Edwards, Anne H. O'Donnell, Robert A. Rollins, Heather E. Peckham, Clarence Lee, Maria H. Milekic, Benjamin Chanrion, Yutao Fu, Tao Su, Hanina Hibshoosh, Jay A. Gingrich, Fatemeh Haghighi, Robert Nutter, and Timothy H. Bestor

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MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment, Julie M. Elliott, Joseph A. Wahle, and Wayne M. Yokoyama

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Catalytic function of PLA2G6 is impaired by mutations associated with infantile neuroaxonal dystrophy but not dystonia-parkinsonism, Laura A. Engel, Zheng Jing, Daniel E. O’Brien, Mengyang Sun, and Paul T. Kotzbauer

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Modeling the cost–benefit of nerve conduction studies in pre-employment screening for carpal tunnel syndrome, Bradley A. Evanoff and Steven M. Kymes

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Next-generation sequencing identifies the natural killer cell microRNA transcriptome, Todd A. Fehniger, Todd Wylie, Elizabeth Germino, Jeffrey W. Leong, Vincent J. Magrini, Sunita Koul, Catherine R. Keppel, Stephanie E. Schneider, Daniel C. Koboldt, Ryan P. Sullivan, Michael E. Heinz, Seth D. Crosby, Rakesh Nagarajan, Giridharan Ramsingh, Daniel C. Link, Timothy J. Ley, and Elaine R. Mardis

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Major depression and the metabolic syndrome, Debra L. Foley, Katherine I. Morley, Pamela A.F. Madden, Andrew C. Heath, John B. Whitfield, and Nicholas G. Martin

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Structural homology between the C-terminal domain of the PapC usher and its plug, Bradley Ford, Ana Toste Rêgo, Timothy J. Ragan, Jerome Pinkner, Karen Dodson, Paul C. Driscoll, Scott Hultgren, and Gabriel Waksman

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Statistical design of personalized medicine interventions: The Clarification of Optimal Anticoagulation through Genetics (COAG) trial, Benjamin French, Jungnam Joo, Nancy L. Geller, Stephen E. Kimmel, Yves Rosenberg, Jeffrey L. Anderson, Brian F. Gage, Julie A. Johnson, Jonas H. Ellenberg, and COAG Investigators

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Age-related synaptic loss of the medial olivocochlear efferent innervation, Benjamin Fu, Colleen Le Prell, Dwayne Simmons, Debin Lei, Angela Schrader, Amelia B. Chen, and Jianxin Bao

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Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking, Rodrigo A. Fuentealba, Qiang Liu, Juan Zhang, Takahisa Kanekiyo, Xiaoyan Hu, Jin-Moo Lee, Mary Jo LaDu, and Guojun Bu

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VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans, Keiko Fujikawa, Takeshi Iwata, Kaoru Inoue, Masakazu Akahori, Hanako Kadotani, Masahiro Fukaya, Masahiko Watanabe, Qing Chang, Edward M. Barnett, and Wojciech Swat

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Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes, Kei Fujimoto, Eric L. Ford, Hung Tran, Burton M. Wice, Seth D. Crosby, Gerald W. Dorn II, and Kenneth S. Polonsky

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The impact of packed red blood cell transfusion on clinical outcomes in patients with septic shock treated with early goal directed therapy, Brian M. Fuller, Mithil Gajera, Christa Schorr, David Gerber, R. Phillip Dellinge, Joseph Parrillo, and Sergio Zanotti

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Identification of hookworm DAF-16/FOXO response elements and direct gene targets, Xin Gao, Zhengyuan Wang, John Martin, Sahar Abubucker, Xu Zhang, Makedonka Mitreva, and John M. Hawdon

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Physical Work Exposures: Comparing Self-Reported, Observer-Rated and O*NET Ratings, Bethany T. Gardner, David A. Lombardi, Ann Marie Dale, Alfred Franzblau, and Bradley Evanoff

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To-and-fro murmur in the young due to major congenital cardiac defects: Is cardiac auscultation obsolete?, Avihu Z. Gazit, Gautam K. Singh, and Mark C. Johnson

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Dyskerin ablation in mouse liver inhibits rRNA processing and cell division, Jingping Ge, David A. Rudnick, Jun He, Dan L. Crimmins, Jack H. Ladenson, Monica Bessler, and Philip J. Mason

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Multicenter study of clinical performance of the 3M rapid detection RSV test, Christine C. Ginocchio, Ella Swierkosz, Alexander J. McAdam, Mario Marcon, Gregory A. Storch, Alexandra Valsamakis, Stefan Juretschko, José Romero, and Belinda Yen-Lieberman

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Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo, Leonid Gitlin, Loralyn Benoit, Christina Song, Marina Cella, Susan Gilfillan, Michael J. Holtzman, and Marco Colonna

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Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease, Alison M. Goate, Carlos Cruchaga, Petra Nowotny, John C. Morris, Kevin Mayo, and et al.

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RET signaling is required for survival and normal function of nonpeptidergic nociceptors, Judith P. Golden, Masato Hoshi, Mohammed A. Nassar, Hideki Enomoto, John N. Wood, Jeffrey Milbrandt, Robert W. Gereau IV, Eugene M. Johnson Jr, and Sanjay Jain

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Human mucosal associated invariant T cells detect bacterially infected cells, Marielle C. Gold, Stefanie Cerri, Susan Smyk-Pearson, Meghan E. Cansler, Todd M. Vogt, Jacob Delepine, Ervina Winata, Gwendolyn M. Swarbrick, Wei-Jen Chua, Yik Y. L. Yu, Olivier Lantz, Matthew S. Cook, Megan D. Null, David B. Jacoby, Melanie J. Harriff, Deborah A. Lewinsohn, Ted H. Hansen, and David M. Lewinsohn

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The Haemophilus influenzae HMW1C protein is a glycosyltransferase that transfers hexose residues to asparagine sites in the HMW1 adhesin, Susan Grass, Cheryl F. Lichti, R. Reid Townsend, Julia Gross, and Joseph W. St. Geme III

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Developmental origin of preBötzinger complex respiratory neurons, Paul A. Gray, John A. Hayes, Guang Y. Ling, Isabel Llona, Srinivasan Tupal, Maria C.D. Picardo, Sarah E. Ross, Tsutomu Hirata, Joshua G. Corbin, Jaime Eugenín, and Christopher A. Del Negro

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Serological evidence of human klassevirus infection, Alexander L. Greninger, Lori Holtz, Gagandeep Kang, Donald Ganem, David Wang, and Joseph L. DeRisi

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Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy, Naomi Gronich, Azad Kumar, Yuwei Zhang, Igor R. Efimov, and Nikolai M. Soldatov

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Vesicular neurotransmitter transporter trafficking in vivo: Moving from cells to flies, Anna Grygoruk, Hao Fei, Richard W. Daniels, Bradley R. Miller, Audrey Chen, Aaron DiAntonio, and David E. Krantz

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Histone modifications during mammalian oocyte maturation: Dynamics, regulation and functions, Ling Gu, Qiang Wang, and Qing-Yuan Sun

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The effects of a secondary task on forward and backward walking in Parkinson’s disease, Madeleine E. Hackney and Gammon M. Earhart

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Organogenetic tolerance, Marc R. Hammerman

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Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection, Thomas J. Hannan, Indira U. Mysorekar, Chia S. Hung, Megan L. Isaacson-Schmid, and Scott J. Hultgren

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Current strategies for the prevention and management of central line-associated bloodstream infections, Zhuolin Han, Stephen Y. Liang, and Jonas Marschall

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Thymoglobulin induction dosing strategies in a low-risk kidney transplant population: Three or four days?, Karen L. Hardinger, Rafia S. Rasu, Rebecca Skelton, Brent W. Miller, and Daniel C. Brennan

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Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step, Brooke Harmon, Nancy Campbell, and Lee Ratner

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Development and preliminary reliability testing of an assessment of patient independence in performing a treatment program: Standardized scenarios, Marcie Harris-Hayes, Gregory W. Holtzman, Jeanne A. Earley, and Linda R. Van Dillen

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Robot-assisted partial nephrectomy: Evaluation of learning curve for an experienced renal surgeon, Mohammed Haseebuddin, Brian M. Benway, Jose M. Cabello, and Sam B. Bhayani

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A surface-based analysis of hemispheric asymmetries and folding of cerebral cortex in term-born human infants, Jason Hill, Donna Dierker, Jeffrey Neil, Terrie Inder, Andrew Knutsen, John Harwell, Timothy Coalson, and David Van Essen

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Reducing the incidence of intraventricular catheter-related ventriculitis in the neurology-neurosurgical intensive care unit at a tertiary care center in St Louis, Missouri: An 8-year follow-up study, Hitoshi Honda, Jeffrey C. Jones, Martha C. Craighead, Michael N. Diringer, Ralph G. Dacey, and David K. Warren

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The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine, John R. Hornick, Jinbin Xu, Suwanna Vangveravong, Zhude Tu, Jonathan B. Mitchem, Dirk Spitzer, Peter Goedegebuure, Robert H. Mach, and William G. Hawkins

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Sliding set-points of immune responses for therapy of autoimmunity, Chyi-Song Hsieh and Jhoanne Lynne Bautista

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Reproducibility of placental volume and vasculature indices obtained by 3-dimensional power Doppler sonography, Kristina M. Huster, Kimberly Haas, Jean Schoenborn, Dominique McVean, and Anthony O. Odibo

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Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization, Yuji Ito, Steven L. Teitelbaum, Wei Zou, Yi Zheng, James F. Johnson, Jean Chappel, F. Patrick Ross, and Haibo Zhao

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A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing, Xiaoping Jiang, Patricia E. Litkowski, Amanda A. Taylor, Ying Lin, B. J. Snider, and Krista L. Moulder

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Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination, Yanhong Ji, Alicia J. Little, Joydeep K. Banerjee, Bingtao Hao, Eugene M. Oltz, Michael S. Krangel, and David G. Schatz