The Open Access Publications collection contains peer-reviewed articles authored by Washington University School of Medicine faculty that have been published in open access journals or authorized by the publishers for open access availability. Open access works are generally defined as being publicly available online and free of most licensing and copyright restrictions. The Bernard Becker Medical Library maintains this collection in support of Washington University’s commitment to the principles of open access publishing and making the scholarly work and research results of our faculty as widely and easily available as possible.

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Submissions from 2016

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Interactions between pluripotency factors specify cis-regulation in embryonic stem cells, Chris Fiore and Barak A. Cohen

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A recombinant positive control for serology diagnostic tests supporting elimination of Onchocerca volvulus, Peter U. Fischer and et al.

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Transcription start site scanning and the requirement for ATP during transcription initiation by RNA polymerase II, James Fishburn, Eric Galburt, and Steven Hahn

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Redundant Gs-coupled serotonin receptors regulate amyloid-β metabolism in vivo, Jonathan R. Fisher, Clare E. Wallace, Danielle L. Tripoli, Yvette I. Sheline, and John R. Cirrito

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Mycobacterium tuberculosis transcription machinery: Ready to respond to host attacks, Kelly Flentie, Ashley L. Garner, and Christina L. Stallings

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Comparing aging and fitness effects on brain anatomy, Mark A. Fletcher, Kathy A. Low, Rachel Boyd, Benjamin Zimmerman, Brian A. Gordon, Chin H. Tan, Nils Schneider-Garces, Bradley P. Sutton, Gabriele Gratton, and Monica Fabiani

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Severe cholestasis and bile acid nephropathy from anabolic steroids successfully treated with plasmapheresis, Avegail Flores, Rosemary Nustas, Hoang-Lan Nguyen, and Robert S. Rahimi

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A Plasmodium promiscuous T cell epitope delivered within the Ad5 hexon protein enhances the protective efficacy of a protein based malaria vaccine, Jairo Andres Fonseca, Monica Cabrera-Mora, Elena A. Kashentseva, John Paul Villegas, Alejandra Fernandez, Amelia Van Pelt, Igor P. Dmitriev, David T. Curiel, and Alberto Moreno

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Analysis of the putative role of CR1 in Alzheimer’s disease: Genetic association, expression and function, Maria I. Fonseca, Shuhui Chu, Aimee L. Pierce, William D. Brubaker, Richard E. Hauhart, Diego Mastroeni, Elizabeth V. Clarke, Joseph Rogers, John P. Atkinson, and Andrea J. Tenner

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Decreased consumption of branched-chain amino acids improves metabolic health, Luigi Fontana, Edda Cava, Francesco Spelta, Valeria Tosti, Nicola Veronese, Beatrice Bertozzi, Terri Pietka, Arnold D. Bullock, Robert S. Figenshau, Gerald L. Andriole, and et al

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Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: A randomized clinical trial, Luigi Fontana, Dennis T. Villareal, Sai K. Das, Steven R. Smith, Simin N. Meydani, Anastassios G. Pittas, Samuel Klein, Manjushri Bhapkar, James Rochon, Eric Ravussin, John O. Holloszy, and CALERIE Study Group

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Improved cardiovascular disease outcomes in older adults, Daniel E. Forman, Karen Alexander, Ralph G. Brindis, Anne B. Curtis, Matthew Maurer, Michael W. Rich, Laurence Sperling, and Nanette K. Wenger

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Identification of genes conferring tolerance to lignocellulose-derived inhibitors by functional selections in soil metagenomes, Kevin J. Forsberg, Sanket Patel, Evan Witt, Bin Wang, Tyler D. Ellison, and Gautam Dantas

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Azathioprine therapy for steroid-resistant Henoch-Schönlein purpura: A report of 6 cases, Lampros Fotis, Paul V. Tuttle IV, Kevin W. Baszis, Peri H. Pepmueller, Terry L. Moore, and Andrew J. White

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A novel secreted protein, MYR1, is central to Toxoplasma’s manipulation of host cells, Magdalena Franco, Michael W. Panas, Nicole D. Marino, Mei-Chong Wendy Lee, Kerry R. Buchholz, Felice D. Kelly, Jeffrey J. Bednarski, Barry P. Sleckman, Nader Pourmand, and John C. Boothroyd

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Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods, Rikard Frederiksen, Soile Nymark, Alexander V. Kolesnikov, Justin D. Berry, Leopold Adler IV, Yiannis Koutalos, Vladimir J. Kefalov, and M. Carter Cornwall

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ILC1s in tissue inflammation and infection, Anja Fuchs

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A new glucocerebrosidase-deficient neuronal cell model provides a tool to probe pathophysiology and therapeutics for Gaucher disease, Hideji Fujiwara, Rohini Sidhu, Benoit Renvoise, Daniel S. Ory, and et al

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Lung-protective ventilation initiated in the emergency department (LOV-ED): A study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications, Brian M. Fuller, Ian Ferguson, Nicholas M. Mohr, Robert J. Stephens, Cristopher C. Briscoe, Angelina A. Kolomiets, Richard S. Hotchkiss, and Marin H. Kollef

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Amygdala reactivity to sad faces in preschool children: An early neural marker of persistent negative affect, Michael S. Gaffrey, Deanna M. Barch, and Joan L. Luby

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Hip dysplasia in the young adult, Luca Gala, John C. Clohisy, and Paul E. Beaulé

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Association between neurological soft signs, temperament and character in patients with schizophrenia and non-psychotic relatives, Liliana Galindo, Francisco Pastoriza, Daniel Berge, Anna Mane, Marisol Picado, Antonio Bulbena, Patricia Robledo, Victor Perez, Oscar Vilarroya, and Claude Robert Cloninger

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Contribution of mesenteric lymph nodes and GALT to the intestinal Foxp3+ regulatory T-cell compartment, Duke Geem, Vu Ngo, Akihito Harusato, Benoit Chassaing, Andrew T. Gewirtz, Rodney D. Newberry, and Timothy L. Denning

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A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects, Kaushik Ghosal, Michael Haag, Philip B. Verghese, Tim West, Tim Veenstra, Joel B. Braunstein, Randall J. Bateman, David M. Holtzman, and Gary E. Landreth

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Psychometric properties of the Greek TCI-R and its clinical correlates: Schizotypy and the self-regulation of affective and cognitive functioning, Stella G. Giakoumaki, Leda Karagiannopoulou, Sandor Rozsa, Chrysoula Zouraraki, Penny Karamaouna, and C. Robert Cloninger

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Computational analysis reveals a key regulator of Cryptococcal virulence and determinant of host response, Stacey R. Gish, Ezekiel J. Maier, Brian C. Haynes, Felipe H. Santiago-Tirado, Deepa L. Srikanta, Cynthia Z. Ma, Lucy X. Li, Matthew Williams, Erika C. Crouch, Shabaana A. Khader, Michael R. Brent, and Tamara L. Doering

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Patterns of genome-wide variation in Glossina fuscipes fuscipes tsetse flies from Uganda, Andrea Gloria-Soria, W. Augustine Dunn, Erich L. Telleria, Benjamin R. Evans, Loyce Okedi, Richard Echodu, Wesley C. Warren, Michael J. Montague, Serap Aksoy, and Adalgisa Caccone

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Analysis of age-dependent trends in Ov16 IgG4 seroprevalence to onchocerciasis, Allison Golden, Dunia Faulx, Michael Kalnoky, Eric Stevens, Lindsay Yokobe, Roger Peck, Potochoziou Karabou, Meba Banla, Ramakrishna Rao, Kangi Adade, Richard G. Gantin, Kossi Komlan, Peter T. Soboslay, Tala de los Santos, and Gonzalo J. Domingo

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Developing rapport and therapeutic alliance during telemental health sessions with children and adolescents, Felissa Goldstein and Dehra Glueck

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Multicenter evaluation of the Xpert Norovirus assay for detection of norovirus genogroups I and II in fecal specimens, Mark D. Gonzalez, L. Claire Langley, Blake W. Buchan, Matthew L. Faron, Melanie Maier, Kate Templeton, Kimberly Walker, Elena B. Popowitch, Melissa B. Miller, Arundhati Rao, Uwe G. Liebert, Nathan A. Ledeboer, Jan Vinje, and Carey-Ann D. Burnham

A cytosolic multiprotein complex containing p85α is required for β-catenin activation in colitis and colitis-associated cancer, Tatiana Goretsky, Emily M. Bradford, Hyunji Ryu, Maryam Tahir, Mary Pat Moyer, Tianyan Gao, Linheng Li, and Terrence A. Barrett

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7-dehydrocholesterol efficiently supports Ret signaling in a mouse model of Smith-Opitz-Lemli syndrome, Myriam Gou-Fàbregas, Anna Macià, Carlos Anerillas, Marta Vaquero, Mariona Jové, Sanjay Jain, Joan Ribera, and Marco Encinas

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Finding what works: Identification of implementation strategies for the integration of methadone maintenance therapy and HIV services in Vietnam, Vivian F. Go, Giuliana J. Morales, Nguyen Tuyet Mai, Ross C. Brownson, Tran Viet Ha, and William C. Miller

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Considerations for MRI study design and implementation in pediatric and clinical populations, Deanna J. Greene, Kevin J. Black, and Bradley L. Schlaggar

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Pneumococcal hemolytic uremic syndrome and steroid resistant nephrotic syndrome, Andrew P. Groves, Patrick Reich, Binayak Sigdel, and T. Keefe Davis

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Evaluation of voltage-dependent calcium channel gamma gene families identified several novel potential susceptible genes to schizophrenia, Fanglin Guan, Tianxiao Zhang, Xinshe Liu, Wei Han, Huali Lin, Lu Li, Gang Chen, and Tao Li

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Mapping of variable DNA methylation across multiple cell types defines a dynamic regulatory landscape of the human genome, Junchen Gu, Michael Stevens, Xiaoyun Xing, Daofeng Li, Bo Zhang, Jacqueline E. Payton, Eugene M. Oltz, James N. Jarvis, Kaiyu Jiang, Theodore Cicero, Joseph F. Costello, and Ting Wang

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Activation of TRPV4 regulates respiration through indirect activation of bronchopulmonary sensory neurons, Qihai Gu, Charles R. Moss II, Kristen L. Kettelhut, Carolyn A. Gilbert, and Hongzhen Hu

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Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction, A R. Hall, N Burke, R K. Dongworth, A Dyson, J M. Vicencio, G W. Dorn II, D M. Yellon, and D J. Hausenloy

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An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK, Yan Hao, Erin Frey, Choya Yoon, Hetty Wong, Douglas Nestorovski, Lawrence B. Holzman, Roman J. Giger, Aaron DiAntonio, and Catherine Collins

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Medically relevant Acinetobacter species require a type II secretion system and specific membrane-associated chaperones for the export of multiple substrates and full virulence, Christian M. Harding, Rachel L. Kinsella, Lauren D. Palmer, Eric P. Skaar, and Mario F. Feldman

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Neuropathic pain: An updated grading system for research and clinical practice, Simon Haroutounian and et al

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Aerobic glycolysis in the frontal cortex correlates with memory performance in wild-type mice but not the APP/PS1 mouse model of cerebral amyloidosis, Richard A. Harris, Lauren Tindale, Asad Lone, Olivia Singh, Shannon L. Macauley, Molly Stanley, David M. Holtzman, Robert Bartha, and Robert C. Cumming

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Influence of white and gray matter connections on endogenous human cortical oscillations, Ammar H. Hawasli, DoHyun Kim, Noah M. Ledbetter, Sonika Dahiya, Dennis L. Barbour, and Eric C. Leuthardt

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A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons, Yukari Hayashi, Hiroshi Nishimune, Katsuto Hozumi, Yumiko Saga, Akihiro Harada, Michisuke Yuzaki, Takeshi Iwatsubo, Raphael Kopan, and Taisuke Tomita

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Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32,330 subjects from the International Cannabis Consortium, A C. Heath and et al

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Genome-wide time-to-event analysis on smoking progression stages in a family-based study, Liang He, Janne Piktaniemi, Kauko Heikkila, Yi-Ling Chou, Pamela A.F. Madden, Tellervo Korhonen, Antti-Pekka Sarin, Samuli Ripatti, Jaakko Kaprio, and Anu Loukola

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Glutamine modulates macrophage lipotoxicity, Li He, Kassandra J. Weber, and Joel D. Schilling

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Electronic nutritional intake assessment in patients with urolithiasis: A decision impact analysis, Avory M. Heningburg, Anand Mohapatra, Aaron M. Potretzke, Alyssa Park, Alethea G. Paradis, Joel Vetter, Adrienne N. Kuxhausen, Leslie D. McIntosh, Anthony Juehne, Alana C. Desai, Gerald L. Andriole, and Brian M. Benway

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Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms, A C. Herman, D A. Monlish, M P. Romine, S T. Bhatt, S Zippel, and L G. Schuettpelz

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Impact of molecular profiling on overall survival of patients with advanced ovarian cancer, Thomas J. Herzog, David Spetzler, Nick Xiao, Ken Burnett, Todd Maney, Andreas Voss, Sandeep Reddy, Robert Burger, Thomas Krivak, Matthew Powell, Michael Friedlander, and William McGuire

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Transgenic soybean production of bioactive human epidermal growth factor (EGF), Yonghua He, Monica A. Schmidt, Christopher Erwin, Jun Guo, Raphael Sun, Ken Pendarvis, Brad W. Warner, and Eliot M. Herman

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Target prices for mass production of tyrosine kinase inhibitors for global cancer treatment, Andrew Hill, Dzintars Gotham, Joseph Fortunak, Jonathan Meldrum, Isabelle Erbacher, Manuel Martin, Haitham Shoman, Jacob Levi, William G. Powderly, and Mark Bower

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A high-resolution SNP array-based linkage map anchors a new domestic cat draft genome assembly and provides detailed patterns of recombination, LaDeana W. Hillier, Pat Minx, Richard K. Wilson, Wesley C. Warren, and et al

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Development of a curriculum and roadside screening tool for Law enforcement identification of medical impairment in aging drivers, Linda H. Hill, Jill Rybar, James Stowe, and Jana Jahns

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A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans, Mikko Holtta, Robert A. Dean, Eric Siemers, Kwasi G. Mawuenyega, Wendy Sigurdson, Patrick C. May, David M. Holtzman, Erik Portelius, Henrik Zetterberg, Randall J. Bateman, Kaj Blennow, and Johan Gobom

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A decade of the anaphase-promoting complex in the nervous system, Ju Huang and Azad Bonni

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Analysis of a four generation family reveals the widespread sequence-dependent maintenance of allelic DNA methylation in somatic and germ cells, Yi Huang, Song Wu, and et al

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In vitro antimicrobial susceptibility of Staphylococcus pseudintermedius isolates of human and animal origin, Romney M. Humphries, Max T. Wu, Lars F. Westblade, Amy E. Robertson, Carey-Ann D. Burnham, Meghan A. Wallace, Eileen M. Burd, Sara Lawhon, and Janet A. Hindler

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pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens, Jasreet Hundal, Beatriz M. Carreno, Allegra A. Petti, Gerald P. Linette, Obi L. Griffith, Elaine R. Mardis, and Malachi Griffith

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N-cadherin is key to expression of the nucleus pulposus cell phenotype under selective substrate culture conditions, Priscilla Y. Hwang, Liufang Jing, Jun Chen, Foon-Lian Lim, Ruhang Tang, Hyowon Choi, Kenneth M. Cheung, Makarand V. Risbud, Charles A. Gersbach, Farshid Guilak, Victor Y. Leung, and Lori A. Setton

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A broad analysis of resistance development in the malaria parasite, Eva S. Istvan, Daniel E. Goldberg, and et al

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CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability, Stoyan Ivanov, Ki-Wook Kim, Kathrin Werth, Michael W. Johnson, Brian T. Saunders, Peter L. Wang, Jesse W. Williams, Carlos Briseño, Marco Colonna, Emmanuel L. Gautier, Bernd H. Zinselmeyer, Gwendalyn J. Randolph, and et al

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A review of complications and outcomes following vertebral column resection in adults, Sravisht Iyer, Venu M. Nemani, and Han Jo Kim

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A review of complications and outcomes following vertebral column resection in adults, Sravisht Iyer, Venu M. Nemani, and Han Jo Kim

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GABA and endocannabinoids mediate depotentiation of Schaffer collateral synapses induced by stimulation of temperoammonic inputs, Yukitoshi Izumi and Charles F. Zorumski

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Socio-demographic differences in toxic release inventory siting and emissions in metro Atlanta, Ryan Johnson, Kim Ramsey-White, and Christina H. Fuller

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Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain, Patrick Kanju, Yong Chen, Whasil Lee, Michele Yeo, Suk Hee Lee, Joelle Romac, Rafiq Shahid, Ping Fan, David M. Gooden, Sidney A. Simon, Ivan Spasojevic, Robert A. Mook, Rodger A. Liddle, Farshid Guilack, and Wolfgang B. Liedtke

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Alzheimer’s disease risk polymorphisms regulate gene expression in the ZCWPW1 and the CELF1 loci, Celeste M. Karch, Lubov A. Ezerskiy, Sarah Bertelsen, Alzheimer's Disease Genetic Consortium (ADGC), and Alison M. Goate

Wnt protein signaling reduces nuclear acetyl-CoA levels to suppress gene expression during osteoblast differentiation, Courtney M. Karner, Emel Esen, Jiakun Chen, Fong-Fu Hsu, John Turk, and Fanxin Long

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Adenosine A1 receptor protects against cisplatin ototoxicity by suppressing the NOX3/STAT1 inflammatory pathway in the cochlea, Tejbeer Kaur, Vikrant Borse, Sandeep Sheth, Kelly Sheehan, Sumana Ghosh, Srinivasan Tupal, Sarvesh Jajoo, Debashree Mukherjea, Leonard P. Rybak, and Vickram Ramkumar

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Antibody response to the hypervariable region-1 interferes with broadly neutralizing antibodies to hepatitis C virus, Zhen-yong Keck, Christine Girard-Blanc, Wenyan Wang, Patrick Lau, Adam Zuiani, Felix A. Rey, Thomas Krey, Michael S. Diamond, and Steven K. H. Foung

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Glutamatergic retinal waves, Daniel Kerschensteiner

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Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes, Asis Khan, Michael S. Behnke, L David Sibley, and et al

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A brushfire in the eye, Mehnaz Khan, P. Kumar Rao, and Rajesh C. Rao

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Development of a residency program in radiation oncology physics: an inverse planning approach, Rao F H Khan and Peter B. Dunscombe

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Lymphovascular space invasion and lack of downstaging after neoadjuvant chemotherapy are strong predictors of adverse outcome in young women with locally advanced breast cancer, Shariq S. Khwaja, Jennifer Ivanovich, Todd A. DeWees, Laura Ochoa, Daniel F. Mullen, Maria Thomas, Julie A. Margenthaler, Amy Cyr, Michael Naughton, Souzan Sanati, Timothy J. Eberlein, William E. Gillanders, Rebecca L. Aft, Jacqueline E. Zoberi, and Imran Zoberi

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Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort, Adam S. Kibel and et al

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Cervical radiculopathy: Incidence and treatment of 1,420 consecutive cases, Han Jo Kim, Venu M. Nemani, Chaiwat Piyaskulkaew, Samuel Romero Vargas, and K. Daniel Riew

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Germ cell and tumor associated piRNAs in the medaka and Xiphophorus melanoma models, Susanne Kneitz, Rasmi R. Mishra, Domitille Chalopin, John Postlethwait, Wesley C. Warren, Ronald B. Walter, and Manfred Schartl

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Pif1 removes a Rap1-dependent barrier to the strand displacement activity of DNA polymerase δ, Katrina N. Koc, Saurabh P. Singh, Joseph L. Stodola, Peter M. Burgers, and Roberto Galletto

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The yersiniabactin-associated ATP binding cassette proteins YbtP and YbtQ enhance Escherichia coli fitness during high-titer cystitis, Eun-Ik Koh, Chia S. Hung, and Jeffrey P. Henderson

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Rapid quantitative pharmacodynamic imaging with Bayesian estimation, Jonathan M. Koller, M. Jonathan Vachon, G. Larry Bretthorst, and Kevin J. Black

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A new device to noninvasively estimate the intraocular pressure produced during ocular compression, Michael S. Korenfeld and David K. Dueker

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Review of external ocular compression: Clinical applications of the ocular pressure estimator, Michael S. Korenfeld and David K. Dueker

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Enhanced zone II flexor tendon repair through a new half hitch loop suture configuration, Ioannis Kormpakis, Stephen W. Linderman, Stavros Thomopoulos, and Richard H. Gelberman

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Training the next generation of biomedical investigators in glycosciences, Stuart Kornfeld and et al

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Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease, Aldi T. Kraja and et al

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T-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine, Thomas Krausgruber, Chris Schiering, Krista Adelmann, Oliver J. Harrison, Agnieszka Chomka, Claire Pearson, Philip P. Ahern, Matthew Shale, Mohamed Oukka, and Fiona Powrie

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Hyperexpansion of RNA bacteriophage diversity, Siddharth R. Krishnamurthy, Andrew B. Janowski, Guoyan Zhao, Dan Barouch, and David Wang

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The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders, Sean Kristjansson, Vivia V. McCutcheon, Arpana Agrawal, Michael T. Lynskey, Elizabeth Conroy, Dixie J. Statham, Pamela A.F. Madden, Anjali K. Henders, Alexandre A. Todorov, Kathleen K. Bucholz, Louisa Degenhardt, Nicholas G. Martin, Andrew C. Heath, and Elliot C. Nelson

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Simulating serial-target antibacterial drug synergies using flux balance analysis, Andrew S. Krueger, Christian Munck, Gautam Dantas, George M. Church, James Galagan, Joseph Lehar, and Morten O. A. Sommer

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Ultrasound modulates ion channel currents, Jan Kubanek, Jingyi Shi, Jon Marsh, Di Chen, Cheri Deng, and Jianmin Cui

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Inhibition of calcium-dependent protein kinase 1 (CDPK1) in vitro by pyrazolopyrimidine derivatives does not correlate with sensitivity of Cryptosporidium parvum growth in cell culture, Theresa B. Kuhlenschmidt, Florentine U. Rutaganira, Shaojun Long, Keliang Tang, Kevan M. Shokat, Mark S. Kuhlenschmidt, and L. David Sibley

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Angiotensin converting enzyme (ACE) inhibitor extends Caenorhabditis elegans life span, Sandeep Kumar, Nicholas Dietrich, and Kerry Kornfeld

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Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1, Chaitanya Kurhade, Loreen Zegenhagen, Elvira Weber, Sharmila Nair, Kristin Michaelson-Preusse, Julia Spanier, Nelson O. Gekara, Andrea Kroger, and Anna K. Overby

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Migraine and risk of cardiovascular disease in women: Prospective cohort study, Tobias Kurth, Anke C. Wnter, A. Heather Eliassen, Rimma Dushkes, Kenneth J. Mukamal, Eric B. Rimm, Walter C. Willett, JoAnn E. Manson, and Kathryn M. Rexrode

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Tankyrase inhibition aggravates kidney injury in the absence of CD2AP, S. Kuusela, H. Wang, A. A. Wasik, H. Suleiman, and S. Lehtonen

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The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation, Amy Langdon, Nathan Crook, and Gautam Dantas

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Development of Zr-89-Ontuxizumab for in vivo TEM-1/endosialin PET applications, Sara E. S. Lange, Alex Zheleznyak, Matthew Studer, Daniel J. O'Shannessy, Suzanne E. Lapi, and Brian A. Van Tine